Mapiritsi a rosuvastatin a cholesterol: malangizo ogwiritsira ntchito

Rosuvastatin ndi mankhwala omwe amateteza kagayidwe ka lipid, komwe kali m'gulu la ma statins. Imagwira pa mfundo yotsutsana - statin imamangika gawo lina la coenzyme receptor lomwe limagwirizana ndi enzyme. Gawo lachiwirili limakhudzidwa ndikusintha kwazinthu kuti zikhale mevalonate, yomwe ndi yapakatikati pakuphatikizidwa kwa cholesterol. Kuletsa zochitika za zinthu zina kumayambitsa njira zina, zotulukapo zake ndizakuti mkati mwa maselo mulingo wa cholesterol umachepa. Pambuyo zoterezi, ntchito otsika kachulukidwe lipoproteins kuchuluka, cholesterol catabolism amakhala.

Mphamvu yothetsa matenda a cholesterol yokwanira imatheka poyambitsa lipoprotein yotsika kwambiri, ndipo izi zimatheka chifukwa cha kuchuluka kwa mankhwala omwe ali pamwambawa. Kusintha uku kumachitika chifukwa cha kuchuluka kwa zinthu zomwe zikugwiritsidwa ntchito. Kubwereza kopitilira kamodzi kumayankhula za zabwino zake.

Statin imakhudza kuchuluka kwa triglyceride mosasamala pochepetsa cholesterol yonse. Komanso, mankhwalawa amakhudza kupewa kwa mapangidwe a atherosulinosis. Ndi kutenga nawo mbali, prophylaxis imachitika, yomwe imalimbikitsa kukonzanso kwamakoma amitsempha yamagazi, komanso kukonza magazi.

Pambuyo pa kuyamba kwa chithandizo, zotsatira zake zimadziwika pambuyo masiku asanu ndi awiri, ndipo patatha milungu ingapo zotsatira zake zimakhala pazokwanira. Pakatha mwezi umodzi wa mankhwala, apogee yochitapo kanthu imayamba, yomwe imapitilira. Kuchuluka kwa zinthu m'magazi ndi minyewa kumatha kuthandizidwa pambuyo pa maola 5 ogwidwa. Imadziunjikira m'chiwindi, kenako imachoka ndi ndowe. Pafupifupi 10% sikuwonetsedwa.

Chofunikira chachikulu cha mankhwalawa ndi rosuvavstatin.

Monga zowonjezera zina, kapangidwe kake ka mankhwala kama:

• hypromellose;
• wowuma;
• titanium dioxide;
• utoto wa carmine;
• ma cellcose a microcrystalline;
• colloidal silicon dioxide;
• triacetin;
• magnesium wakuba.

Mtengo wa mankhwalawa ku Russia ndi wochokera pa ma ruble 330 phukusi lililonse. Mutha kuzigula kumalo osungirako mankhwala aliwonse, m'mizinda yambiri, koma kokha ndi mankhwala. Mapiritsi amatha kusungidwa kwa zaka 2 kuyambira tsiku lotulutsidwa. Khalani pamalo owuma osavomerezeka ndi ana.

Kudya kwa mapiritsi a rosuvastatin kuyenera kukhala kokhazikika pamalangizo azachipatala.

Ayenera kutumizidwa ndi katswiri yemwe amadziwa mbiri komanso thanzi la wodwalayo.

Chifukwa chake, ndikofunikira koyamba kukaona dokotala.

Zizindikiro zimaphatikizapo:

1. Mkhalidwe wa cholesterol yokwanira yotchedwa chachikulu hypercholesterolemia.
2. Njira zodzitetezera motsutsana ndi chitukuko cha atherosulinosis ndi zovuta zake. Izi zimaphatikizapo kugunda kwa mtima, stroke, angina pectoris, matenda a mtima. Mwambiri, awa ndi anthu azaka za 50+.
3. Hypertriglyceridemia - kuchuluka kwamafuta a triglycerides (mafuta aulere) m'magazi.
4. Mchiberekero (achibale) homozygous hypercholesterolemia.
5. Matenda a mtima omwe amayamba chifukwa cha cholesterol yayikulu. Pankhaniyi, imagwiritsidwa ntchito limodzi ndi njira zina.

Nthawi zina, mankhwalawa amakhala ndi mphamvu zochepa, chifukwa amawamwa pofanana ndi mankhwala ena. Zabwino zolimbitsa thupi zimawonedwa mu shuga; onenepa kwambiri; hyperchilomicronemia.

Nthawi zina amagwiritsidwa ntchito ngati kuwonjezera pa zakudya polimbana ndi atherosulinosis.

Pali contraindication wopitilira umodzi mu mankhwalawa; pali zambiri zowonetsera. Izi ndichifukwa cha zinthu zina zomwe zimachitika. Ma pathologies onse amatha kutsimikiziridwa ndi dokotala, kotero, kudzipereka kungakulitse mkhalidwe waumoyo.

Madotolo amatanthauza zotsutsana kwathunthu:

• Zaka mpaka 18.
• Kusalolera payekhapayekha pazigawo.
• Nthawi yobereka mwana ndi kuyamwitsa.
• Amayi azaka zakubadwa omwe sagwiritsa ntchito njira zodalirika zolerera, zomwe zimawonjezera mwayi wokhala ndi pakati panthawi yamankhwala.
• Matenda a chiwindi omwe amapezeka mu mawonekedwe owopsa komanso amathandiziridwa ndi vuto lalikulu lachiberekero, mu kuwonongeka kwa hepatocytes ndi kuwonjezeka kwa hepatic transaminases m'magazi.
• Ntchito munthawi yomweyo cyclosporine.
• Matenda a myopathy, kapena chibadwa chathu.

Mankhwala a 40 mg ndi oletsedwa kwa anthu omwe amakonda kuthandizira myopathy, komanso uchidakwa wambiri, njira zomwe zimakulitsa kuchuluka kwa rosuvastatin m'magazi, ndi vuto laimpso. Kwa anthu amtundu wa Mongoloid, mankhwalawa amakhalanso osavomerezeka, chifukwa chofala cha myopathy.

Popereka mankhwala, dokotala amayenera kuonetsetsa kuti wodwala alibe zotsutsana.

Mankhwalawa amapezeka mwa mapiritsi a 5, 10, 20, 40 mg. Iliyonse yaiwo imakutidwa ndi chipolopolo chapadera.

Amalandira kwa wodwala pokhapokha ngati sangachite bwino popanda mankhwala, nthawi yonse yomwe imakhala miyezi itatu.

Zimathandizira kuwonjezera kutanuka kwa mitsempha yamagazi ndi kulimbikitsidwa kwawo. Malonda ngati Rosuvastatin ali ndi malangizo okhazikika ogwiritsira ntchito, mtengo wololera komanso kuwunika kwabwino kwa wodwala.

Kuti mankhwalawa agwire ntchito moyenera momwe mungathere, pali mfundo zingapo zovomerezeka:

1. Piritsi imatsukidwa ndi madzi ambiri (osachepera 60 ml). Osatafuna mapiritsi, kuthyola kapena kuswa kuti muchepetse mulingo. Zochita zoterezi zimatha kusokoneza m'mimba, komanso kuchepa kwa kuperewera kwa zinthu.
2. Mukamagwiritsa ntchito Rosuvastatin, simuyenera kuyenda pakudya, koma simungamwe mapiritsi ndi chakudya. Kulandila kuyenera kukhala nthawi iliyonse tsiku lililonse. Madokotala ati nthawi yabwino kwambiri ndi m'mawa.
3. Kukhazikitsa nthawi ndikofunikira, osachepera maola 24 ayenera kudutsa kuchokera nthawi yomwe mugwiritsa ntchito.
4. Kuchulukitsa kuchuluka kwa zinthu zomwe zimagwiritsidwa ntchito nthawi kuyenera kuchitidwa pang'onopang'ono kuti thupi lizisintha. Kutumizira koyamba sikuyenera kupitirira 10 g. Zosintha ziyenera kuchitika pakadutsa milungu iwiri, ngati nthawiyo siyikusamalidwa, chiopsezo cha mavuto.

Pa matenda aliwonse, mumakhala mulitali wa algorithm ndi mlingo wa mankhwala. Muyenera kuyang'anira aliyense wa iwo, chifukwa thupi limachita mosiyanasiyana ndi ma pathologies osiyanasiyana. Malamulo olandirira ndalama:

• pamaso pa hyperlipidemia, 10 mg ayenera kumwedwa kamodzi patsiku, njira ya mankhwala ndi miyezi 12-18, kutengera mphamvu ya chitukuko cha matenda;
• mankhwalawa atherosulinosis ikuchitika ndi gawo loyambirira la 5 mg, ndi kuchuluka kwa 60 mg, kotero ndikofunikira kuthandizidwa motere, chaka chimodzi ndi theka;
• mankhwalawa matenda a mtima a mtima amachitika ndi gawo loyambirira la mamililita 5 a mapiritsi, nthawi ya chithandizo ndi chaka chimodzi ndi theka;
• mankhwalawa matenda ena a mtima dongosolo, woyamba kutenga kuchuluka kwa 5 mg, ntchito zina amasinthidwa ndi katswiri, kutengera zoopsa ndi mphamvu;
• popewa matenda amtima omwe ali ndi cholesterol yayikulu, 5 mg ayenera kumwedwa tsiku lililonse, ndipo adotolo amasankha kutalika kwake kutengera mawonekedwe a wodwalayo;
• kupewa matenda a shuga, 10 mg ya mankhwalawa ayenera kumwedwa, nthawi ya chithandizo ndi miyezi 18, ndikuwunikira pafupipafupi miyezi isanu ndi umodzi.

Sikulimbikitsidwa kuti ana ndi achinyamata azitenge, chifukwa kafukufuku m'derali sanamalize ndipo zomwe zimachitika mthupi la ana sizimamveka.

Zotsatira zoyipa zimatha kuchitika makamaka chifukwa chophwanya mlingo wololedwa.

Ambiri aiwo samatchulidwa komanso amakhala ndi nthawi yochepa.

Kugwiritsa ntchito mankhwalawa mosayenerera kumayambitsa chitukuko cha mikhalidwe yomwe tafotokozayi.

Kutengera mphamvu ya thupi, zotsatira zoyipa zimachitika, monga:

1. Matumbo a pakhungu: chisokonezo chopondapo, nseru, kusanza, kupweteka kwam'mimba, kapamba.
2. Mchitidwe wamsempha: kupweteka mutu, kukhumudwa, kusakhazikika pamalingaliro, chizungulire, kudzimva kufooka kwa thupi, kumawonjezera nkhawa.
3. Musculoskeletal system: kupweteka kwa minofu kosatha, kutupa kwa minofu yam'mimba ndikuwonongeka kwake.
4. Dongosolo la genitourinary: hematuria ndi proteinuria ndizotheka.
5. Chifuwa: kuyabwa kwambiri, zotupa pakhungu, uritisaria.
6. Endocrine dongosolo: kukula kwa matenda a shuga a 2.

Kuphatikiza pa zovuta zomwe tafotokozazi, chibayo, chifuwa cham'mimba, mphumu ya bronchial, sinusitis, gastritis, kuchuluka kwa magazi, angina pectoris, arrhythmia, palpitations, bronchitis, nyamakazi, kupweteka kumbuyo, kupweteka pachifuwa, ecchymosis, periodontal abscess sichachilendo.

Ngati zotsatira zoyipa zayamba kuwoneka, muyenera kuzilandira ndikusintha momwe zilili, kapena kusiya. Muyeneranso kuyamba mankhwalawa pofuna kuthetsa zizindikirazo kuti mukhale ndi thanzi labwino.

Mankhwala aliwonse ayenera kuperekedwa ndi adokotala okha, chifukwa ali ndi mphamvu yokhudza matupi athu.

Ngati ntchito molakwika, kumwa mankhwalawa kumadzetsa zovuta zingapo.

Popereka mankhwala a Rosuvastatin, dokotala ayenera kuganizira za momwe thupi limaperekera malangizo kwa odwala.

Malangizowa amathandizira kuthandizira kwambiri. Mawonekedwe a mankhwala:

• ngati mankhwalawa atengedwa kwa nthawi yayitali komanso pamlingo waukulu, ndiye kuti ntchito za CPK ziyenera kuyang'aniridwa nthawi ndi nthawi, izi ndizofunikira kuti muchepetse kuwonongeka kwa minofu, makamaka mwa anthu omwe amakonda zotere, ngati mulingo wokwezedwa, chithandizo chiyenera kuyimitsidwa nthawi yomweyo;
• munthawi yomweyo mankhwala omwe ali ndi vuto lofanana ndi awo ayenera kuchitika mosamala kwambiri;
• adotolo ayenera kudziwitsa wodwalayo pasadakhale za zovuta zomwe zimapangitsa minofu, kuti ngati ikuphwanya kuyankha mwachangu;
• patatha mwezi umodzi kukonzanso kwa kuchuluka kwa magazi, mayeso amachitika chifukwa cha cholesterol ndi lipids;
• kanthawi kochepa musanalandire chithandizo komanso milungu iwiri itatha, muyenera kupenda chiwindi chonse, kudziwa momwe chimagwirira ntchito;
• Muyenera kuwunika wodwalayo kuti athe kuyamwa, chifukwa chipangizocho chili mu chida;
• nthawi ndi nthawi, muyenera kudziwa kuchuluka kwa shuga, chifukwa zomwe zimagwira zimasokoneza kagayidwe kachakudya, chifukwa cha mtundu wa 2 shuga umayamba;
• ngati mukugwiritsa ntchito mitundu ina ya mankhwala mofananamo, adotolo ayenera kudziwitsidwa;
• kufooka kwa minyewa kumatha kuchitika pakumwera kwa kumwa mankhwalawo, chifukwa chake muyenera kufunsa katswiri woyenera;
• mphamvu ya rosuvastatin pa chithokomiro cha chinyezi sichimamveka bwino;
• Ngati muli ndi pakati pa nthawi yamankhwala, phwando limayima kuti lisakhudze mwana wosabadwayo;
• Mlingo wokwezeka, ndikofunikira kuwongolera ntchito ya impso;
• Kugwiritsanso ntchito kwa mapiritsi ndi zakumwa zoledzeretsa kudzapangitsa kusintha kwa chiwindi kosasintha, mogwirizana ndi izi mowa umayenera kusiyidwa, kapena kuvutitsidwa kuyenera kuchepetsedwa;
• chiletso chimagwiranso ntchito ngati kugwiritsidwa ntchito kwa mankhwala a mahomoni;
• anticoagulants ophatikizidwa ndi rosuvastatin amayambitsa magazi akulu.

Mankhwalawa ali ndi ma analogue ochulukirapo, omwe mwa iwo mumakhalanso mankhwalawa.

Njira ina yotsatsira rosuvastatin ndi:

1. Rosucard - ma ruble 560;
2. Tevastor - 341 ma ruble;
3. Roxer - 405 ma ruble;
4. Krestor - kuchokera ku 1800 rubles;
5. Mertenil - kuchokera ku ma ruble 507;
6. Rosart - kuchokera ku ma ruble 570;
7. Simvastatin - kuchokera ku ma ruble 120;
8. Suvardio - kuchokera ku ma ruble 900 (ochokera kumayiko ena).

Amasiyana mu mtengo, wopanga ndi dzina, ndipo malinga ndi momwe amagwirira ntchito amakhala ofanana.

Mankhwala Rosuvastatin amawunikiranso mu kanema munkhaniyi.