Odwala odwala matenda ashuga amadziwa bwino kufunika kokhalitsa ndende yamagazi. Izi zimapewe zovuta zoyambitsa matendawa. Nthawi zambiri, ma endocrinologists amakupatsani mankhwala operekera pakamwa, kuphatikiza Diabinax.
Dzinalo Losayenerana
Gliclazide
Mankhwalawa ali ndi dzina lodziwika bwino padziko lonse lapansi - Gliclazide.
ATX
A10VB09
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka pokhapokha ngati pali piritsi lolimba: lozungulira, lofiirira kumphepete ndi notch mbali imodzi, yoyera. Gawo lililonse lamankhwala lili ndi 0,02, 0,04 kapena 0,08 g wa zinthu zomwe zimagwira. Zotsatirazi zimaphatikizidwa monga zokopa zina zam'mapiritsi:
- MCC;
- aerosil;
- wowuma ndi sodium wowuma glycolate;
- talc;
- povidone;
- sodium methylparaben;
- magnesium wakuba;
- madzi.
Phukusi la makatoni limakhala ndi matuza 1, 2, 3, 4, 5, kapena 6 okhala ndi mapiritsi 10 kapena 20 pachilichonse.
Zotsatira za pharmacological
Malire ochepetsa shuga a mankhwalawa amatengera mphamvu ya yogwira pophika njira zotchingira potaziyamu za ATP zotengera pancreatic. Zotsatira zake, njira za calcium zimatsegulidwa komanso kuchuluka kwa calcium ion mu cytoplasm kumawonjezera, izi zimapangitsa kuti ma vesicles omwe ali ndi insulini kupita ku membrane komanso kuchuluka kwa mahomoni kulowa m'magazi.
Mankhwalawa akhoza kuvomerezedwa kwa odwala omwe ali ndi kulemera kwakukulu, chifukwa sizimayambitsa kulemera.
Chithandizo chogwira ntchito makamaka chimakhudza kutulutsidwa koyambirira kwa insulin poyankha hyperglycemia atatha kudya. Izi zimasiyanitsa ndi zina kuchokera ku m'badwo wa 2 wa sulfonylurea 2. Pankhaniyi, mankhwalawa akhoza kuvomerezedwa kwa odwala omwe ali ndi kulemera kwakukulu, chifukwa sizimayambitsa kulemera.
Kuphatikiza pakuwonjezera katemera wa insulin mu madzi a m'magazi, mankhwalawa amatha kulimbikitsa njira zamagwiritsidwe ntchito ka glucose chifukwa cha activation ya minofu cell glycogen synthetase, komanso imatha kukopa njira zotsatirazi:
- kuchepa kwa chidwi cha mtima adrenergic receptors;
- Kuchepetsa kuphatikiza kupatsidwa zinthu za m'magazi ndi kuphatikiza, kusintha kwa kayendetsedwe ka michere;
- kuchepetsa mafuta m'thupi;
- kubwezeretsa kwa mtima kupindika.
Chifukwa cha izi, mankhwalawa amatha kubwezeretsanso magazi m'magazi, chifukwa chake, amachepetsa kuchepa kwa mapuloteni kudzera mu impso ndikulepheretsa kuwonongeka kwina kwa zotengera zam'mimba mu shuga mellitus.
Pharmacokinetics
Wothandizira pakamwa wa hypoglycemic amalowetsedwa kwathunthu m'matumbo, omwe samayimira chakudya. M'magazi, opitilira 90% amamangidwa ku hemoprotein, okufika pamtunda wapamwamba kwambiri patatha pafupifupi maola 4 pambuyo pa kuperekedwa.
Hafu ya moyo imakhala pafupifupi maola 12, chifukwa chake mankhwalawa amakhala pafupifupi tsiku limodzi. Kamodzi mu hepatobiliary system, imasinthika. Chimodzi mwazinthu zomwe zimapangidwa chimakhudzanso mtima wamitsempha. Pafupifupi 70% ya mlingo wovomerezeka mu mawonekedwe a metabolites amapezeka mu mkodzo, pafupifupi 12% mu ndowe.
Mankhwala amagwiritsidwa ntchito kusintha mawonekedwe a glycemic mwa odwala omwe ali ndi matenda a shuga a 2.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amagwiritsidwa ntchito kusintha mawonekedwe a glycemic mwa odwala omwe ali ndi matenda a shuga a 2. Izi zimathandiza kupewa zovuta ndi zovuta zoyambitsidwa ndi hyperglycemia.
Contraindication
Pochiza matenda a shuga 1, kugwiritsa ntchito mankhwala sikungathandize chifukwa cha kuwonongeka kwa ma cell a pancreatic beta. Sizikulimbikitsidwa kuti mugwiritse ntchito mwa ana, amayi omwe ali ndi pakati komanso oyembekezera, komanso motere:
- kuwonongeka kwa matendawa: matenda a shuga a ketoacidosis, chikomokere kapena matenda a shuga;
- kwambiri aimpso kapena kwa chiwindi kusakwanira;
- pathologies momwe kufunika kwa insulin kumachulukira kwambiri: matenda, kuvulala, kuwotcha, kuchitapo kanthu kwa opaleshoni;
- chithokomiro chithokomiro;
- gliclazide tsankho;
- munthawi yomweyo makonzedwe a imidazole (fluconazole, miconazole, etc.).
Momwe mungatenge Diabinax
Mankhwalawa amalimbikitsidwa kuti amwe pakamwa kawiri patsiku kwa maola 0,5-1 asanadye chakudya cham'mawa komanso asanadye, asambe ndi madzi. Mlingo watsiku ndi tsiku umakhazikitsidwa potengera mbiri ya glycemic, kupezeka kwa matenda ophatikizika, kuwopsa kwa mawonetseredwe azachipatala.
Itha kuphatikizidwa ndi othandizira a hypoglycemic ochokera m'magulu ena (osati ochokera ku sulfonylurea), komanso ndi insulin.
Ndi matenda ashuga
Ndikulimbikitsidwa kuyamba ndi Mlingo wothandiza kwambiri - 20-40 mg pa mlingo. Mlingo wapakati watsiku ndi tsiku ndi 160 mg m'mitundu iwiri. Mlingo waukulu kwambiri wovomerezeka tsiku lililonse ndi 320 mg.
Zotsatira zoyipa za Diabinax
Kuchepetsa mankhwalawa mankhwala osokoneza bongo a poxin amatha kuyambitsa zovuta:
- mawonekedwe a khungu: zidzolo, kuyabwa, urticaria;
- kusinthika kusokonezeka kwa hematopoietic dongosolo: thrombocytopenia, leukopenia, kuchepa magazi;
- mutu, chizungulire;
- jaundice.
Zinthu zomwe zimagwiritsidwa ntchito zimatha kukulitsa chidwi cha zotsatira zoyipa. Mwa zina zodandaula, mawonekedwe a dyspeptic, monga:
- nseru
- kusanza
- kuchepa kwa chakudya;
- kutsegula m'mimba
- gastralgia.
Pakhoza kukhala magawo a kutsika kwa shuga m'magazi ndi zizindikiro zotsatirazi:
- kufooka
- palpitations
- kumverera kwa njala;
- mutu;
- kunjenjemera m'thupi, ndi zina zambiri.
Zokhudza mphamvu pakuwongolera njira
Pokhudzana ndi zovuta zomwe zingachitike, wodwalayo ayenera kusamala posamalira zida zovuta zaukadaulo.
Malangizo apadera
Kuchiza ndi mankhwalawa kumachitika potsatira zakudya zomwe zili ndi shuga wochepa komanso michere ina yazopangidwazo. Koma tikulimbikitsidwa kuti kudya mokwanira kumakhala kokwanira malinga ndi kupezeka kwa zakudya komanso mavitamini okhala ndi zinthu zina. Wodwala ayenera kudziwitsidwa kuti posintha zakudya, kuchepa thupi, matenda owopsa, chithandizo cha opaleshoni, kusintha kwa mankhwalawa kapena kusintha kwa mankhwala kungakhale kofunikira.
Gwiritsani ntchito mu ukalamba
Okalamba, kugwiritsa ntchito mankhwalawa kuli ndi mwayi wambiri poyerekeza ndi mankhwala omwe akhala akugwira gululi. Mankhwalawa amachititsa kuti mahomoni atulutsidwe koyambirira, chifukwa chake chiopsezo cha hypoglycemia pakadali pano chimachepa. Ndi chithandizo chamanthawi yayitali, kuchepa kwa mphamvu ya mankhwalawa komanso kufunika kowonjezera tsiku ndi tsiku ndizotheka.
Kupatsa ana
Mankhwalawa ali contraindified mu zaka 18, chifukwa Palibe chidziwitso pa chitetezo chogwiritsa ntchito.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Munthawi ya bere, kugwiritsa ntchito mankhwala obwera 2 a sulfonylurea sikofunikira, malinga ndi gulu la FDA omwe amapatsidwa kalasi C. Popeza kusapezeka kwa maphunziro kumatsimikizira kusapezeka kwa teratogenic komanso embryotoxic zotsatira za mwana akamamwa mankhwalawa, kugwiritsa ntchito kwake kumatsutsana kwa amayi apakati.
Palibe chidziwitso pakulanda kwa zinthu zomwe zimagwira mkaka wa m'mawere. Ngati ndi kotheka, nthawi yake yoyamwitsa azimayi samayamwitsa.
The ntchito aimpso kuwonongeka
Ndi kuvulala kwambiri kwa aimpso, komwe kumadziwika ndi kuchepa kwa GFR pansipa 15 ml / min, mankhwalawa ndi otsutsana. Chithandizo chikuchitika mosamala ndi kulephera kwambiri aimpso, koma Mlingo womwewo amagwiritsidwa ntchito monga afotokozedwazi.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ndi mavuto a dongosolo la hepatobiliary, kuchuluka kwa mankhwalawa m'magazi ndikotheka. Izi zimawonjezera chiopsezo cha hypoglycemia. Chifukwa chake, mankhwalawa sangathe kulembedwa kwa odwala omwe ali ndi vuto lalikulu la chiwindi.
Mukamamwa mankhwala Mlingo woyenera kwambiri kwa munthu, zizindikiro za kuchepa kwa glycemia zimayamba.
Mankhwala ochulukirapo a Diabinax
Mukamamwa mankhwala Mlingo woyenera kwambiri kwa munthu, zizindikiro za kuchepa kwa glycemia zimayamba. Mkhalidwe uwu umadziwika ndi kuwonongeka m'moyo wamisala yosiyanasiyana: kuchokera kufooka wamba mpaka kukhumudwa. Ndi bongo wodziwika bwino, ukomoka umatha.
Chithandizo: kubwezeretsa shuga m'magazi. Odwala omwe ali ndi vuto lofooka la thanzi amapatsidwa mankhwala okhala ndi shuga mkati, ndipo vuto lakhungu, shuga liyenera kuperekedwa kudzera m'mitsempha.
Kuchita ndi mankhwala ena
Mlingo wa kuchepa kwa glycemia ukuwonjezeka ndi nthawi imodzi ndi awa:
- tetracyclines;
- sulfonamides;
- salicylates (kuphatikizapo acetylsalicylic acid);
- anticoagulants osadziwika;
- anabolic steroids;
- beta-blockers;
- mafupa;
- chloramphenicol;
- fenfluramine;
- fluoxetine;
- guanethidine;
- Mao zoletsa;
- pentoxifylline;
- theophylline;
- khofi
- phenylbutazone;
- cimetidine.
Popereka mankhwala a Gliclazide ndi acarbose, ena mwa zotsatira za hypoglycemic anawonedwa.
Mothandizidwa ndi acarbose, machitidwe a zotsatira za hypoglycemic anawonedwa. Ndipo kusowa kapena kuchepa kwa kagwiritsidwe ntchito ka mankhwalawa kunawonedwa ndi munthawi yomweyo ndi zinthu zotsatirazi:
- barbiturates;
- chlorpromazine;
- glucocorticosteroids;
- sympathomimetics;
- glucagon;
- nicotinic acid;
- estrogens;
- ma progestin;
- mapiritsi oteteza kubala;
- okodzetsa;
- rifampicin;
- mahomoni a chithokomiro;
- mchere wa lithiamu.
Mankhwala kumawonjezera zochitika za yamitsempha yamagazi yam'mimba panthawi ya mankhwala a mtima glycosides.
Kuyenderana ndi mowa
Mwa anthu omwe amagwiritsa ntchito nthawi yomweyo ethanol ndi glycazide, kuchuluka kwa hypoglycemia kumawonjezeka, ndipo zotsatira zoyipa ngati disulfiram. Mosamala, chithandizo chimalembedwa kwa odwala omwe akudwala mowa.
Analogi
Kwa mankhwala aku India ku Russia, ma analogi otsatirawa aantchito yogwiritsidwa ntchito amaperekedwa:
- Glidiab;
- Diabetes;
- Gliclazide;
- Diabefarm MV;
- Gliclazide MV, etc.
Kupita kwina mankhwala
Mankhwalawa amayikidwa ndi dokotala ndipo amapatsidwa mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Mlingo wofunikira pakulamulira matenda a glycemic woyenera uyenera kusankhidwa kwa wodwala, chifukwa chake mankhwalawa sagulitsidwa popanda mankhwala.
Mtengo wa Diabinax
Mankhwalawa adalembedwa mu Vital and Essential Dilisi. Mitengo yake imayendetsedwa. Mtengo wa piritsi limodzi mu 20 mg pa avareji mtengo 1.4 ma ruble, 40 mg - kuchokera ku 2.4 mpaka 3.07 rubles, ndi 80 mg - 1.54 rubles.
Zosungidwa zamankhwala
Phukusi la mankhwalawa limasungidwa pamatenthedwe osakwana +25 ° C pamalo otetezedwa ndi dzuwa komanso chinyontho Pewani kufikira ana.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Mankhwalawa amapangidwa ndi kampani ya India Shreya Life Science, yokhala ndi ofesi yoimira Russia kuyambira 2002.
Mankhwalawa amayikidwa ndi dokotala ndipo amapatsidwa mankhwala.
Ndemanga za Diabinax
Elizabeth, wazaka 30, Nizhny Novgorod
Agogo anapezeka ndi matenda a shuga zaka 5 zapitazo. Kuyambira pamenepo amamwa mankhwalawa kawiri pa tsiku. Nthawi ndi nthawi timamuwunika mayeso ake osala magazi - amakhala mokhazikika. Agogo amalekerera chithandizo. The endocrinologist adalimbikitsa kumwa pafupipafupi.
Stanislav, wazaka 65, Chelyabinsk
Mankhwala mapiritsi m'mawa asanadye chakudya cham'mawa. Ndakhala ndikugwiritsa ntchito mankhwalawa kwa theka la chaka tsopano. Ndikumva bwino: Nditha kugwiranso ntchito, kutopa pang'ono, ludzu lachepa. Sipakhala mwayi w kumwa mankhwalawa chifukwa cha zovuta zovuta kwambiri.
Regina, wazaka 53, Voronezh
Chifukwa chogwira ntchito molimbika, mavuto azaumoyo adayamba: malinga ndi kafukufuku, adapeza shuga wambiri wamwazi. Pambuyo pa kufufuza, mapiritsi 0,5 a mankhwalawo adayikidwa asanadye kadzutsa ndi chakudya chamadzulo. Ndimavomereza pafupipafupi, koma onetsetsani kuti mwatsata chakudya. Kuwerengera magazi konse kunabwezeretsa mwakale.
