Mapiritsi a Lisinopril ali ndi tanthauzo la antihypertensive. Mankhwala ndi a ACE zoletsa. Mukamagwiritsa ntchito mankhwalawa, ndikofunikira kutsatira malangizo omwe mungagwiritse ntchito ndi malingaliro a dokotala. Izi zikuthandizani kuti mulandire kwambiri pazomwe mumalandira komanso kupewa zovuta.
Dzinalo
Dzina lamalonda la mankhwalawa ku Russia komanso dzina lodana ndi mayiko ena onse (INN) ndi Lisinopril. Mu Latin, mankhwalawa amatchedwa Lisinopril.
Mapiritsi a Lisinopril ali ndi tanthauzo la antihypertensive.
ATX
Mu gulu la mautomiki apadziko lonse komanso mankhwala othandizira, mankhwalawa ali ndi code C09AA03.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwira pakamwa. Imapezeka mu mawonekedwe a mapiritsi ozungulira, omwe amasiyana ndi utoto kutengera mlingo. Mankhwala osokoneza bongo a 2,5 mg ali ndi lalanje lolemera. Mlingo wa 5 mg ndi lalanje. Mlingo wa 10 mg ndi pinki. Mankhwala pa mlingo wa 20 mg ali ndi chipolopolo choyera.
Chofunikira chachikulu cha mankhwalawa ndi lisinopril dihydrate. Kuphatikizikako kungaphatikizeponso zinthu monga:
- chimakopa;
- calcium hydrogen phosphate;
- wowuma;
- magnesium wakuba;
- silicon dioxide;
- iron oxide;
- ma cellcose a microcrystalline;
- croscarmellose sodium;
- talc;
- calcium hydrogen phosphate;
- lactose monohydrate.
Kuphatikizidwa kwa zinthu zowonjezera kumadalira wopanga. Mapiritsi amapezeka m'matumba a 10-14 pcs.
Zotsatira za pharmacological
Mankhwalawa amachepetsa ntchito ya mtima wa angiotensin. Izi zimabweretsa kuchepa kwa aldosterone ndi kuwonjezeka kwa endo native vasodilating GHG. Chifukwa cha izi, kuthamanga kwa magazi sikungokhala okhazikika, komanso katundu pa myocardium amachepetsedwa ndipo kukana kwake pazowonongeka kumawonjezeka. Kutenga lisinopril otsika zotumphukira mtima kukana. Kupanikizika m'matumbo omwe ali m'mapapu kumachepa. Kutulutsa kwamtima kumakhala bwino.
Ndi kugwiritsa ntchito mwadongosolo, mankhwalawa amakakamizidwa ndi renin-angiotensin dongosolo la mtima. Izi zimakuthandizani kuti muchepetse mawonekedwe a myocardial hypertrophy. Mtima ndi mphamvu ya mankhwalawa amachepetsa mwayi womwalira mwadzidzidzi komanso kutsekeka kwa magazi. Kugwiritsa ntchito lisinopril kumalepheretsa kuyambika kwa ischemia komanso kubwereza kwachiwiri kwa myocardial. Izi zimawonjezera chiyembekezo chamoyo wodwala.
Kugwiritsa ntchito lisinopril kumalepheretsa kuyambika kwa ischemia komanso kubwereza kwachiwiri kwa myocardial.
Pharmacokinetics
Mlingo woyamwa pambuyo pa makonzedwe umachokera ku 25%. Zinthu zogwira ntchito pafupifupi sizimangiriza kumaproteni amwazi. Mankhwala othandizira amayamba kuonekera pambuyo pa ola limodzi. Kuzindikira kwakukulu kumangofika maola 6-7 okha. Pakadali pano, chidachi chimakhala ndi mphamvu zambiri. Kutalika kwa kusunga kwa zinthu zogwira ntchito mthupi ndi maola 24. Biotransformation sizimachitika, motero, mankhwalawa amachotsedwa ndi impso osasinthika. Hafu ya moyo imachitika maola 12 okha.
Ndi chiyani?
Kulandila kwa lisinopril kumasonyezedwa kwa matenda oopsa. Mankhwalawa amatha kugwiritsidwa ntchito ngati chida chodziimira pawokha, kapena kuphatikiza ndi mankhwala ena omwe amachepetsa magazi.
Monga gawo la mankhwala ophatikiza, kutenga Lisinopril limodzi ndi okodzetsa, kuphatikizapo Indapamide, ndi chifukwa chomveka chakulephera kwa mtima.
Kuikidwa kwa Lisinopril kumathandizanso kupatsirana kwa myocardial, ngati mankhwalawa adayikidwa tsiku loyamba pambuyo poti aukire. Mankhwalawa amakupatsani mwayi wothandizira ntchito ya mtima ndikupewa kugwiranso ntchito kwakamanzere kwamitseko yamanzere.
Chizindikiro chogwiritsa ntchito lisinopril chimadwalanso matenda a shuga. Mu matendawa, samagwiritsidwa ntchito pokhazikika pakukhazikitsa magazi, komanso kuchepetsa albuminuria mwa odwala omwe amadalira insulin.
Contraindication
Mankhwalawa sangathe kugwiritsidwa ntchito pochiza anthu omwe ali ndi hypersensitivity pazinthu zake payekha. Kugwiritsa ntchito mankhwalawa sikuti kwa odwala omwe apulumuka pakuthana impso. Mikhalidwe yomwe kutenga Lisinopril osavomerezeka ndi:
- aimpso mtsempha wamagazi stenosis;
- aimpso kuwonongeka;
- Hyperkalemia
- ochepa hypotension;
- matenda a zolumikizana minofu;
- Edema ya Quincke;
- kufooka kwa mafupa;
- gout
- kuchepa kwa magazi
- Hyperuricemia
- kutsekeka kwa mtima, kupewa kutuluka kwa magazi;
- collagenosis.
Muzochitika izi, ngakhale kugwiritsidwa ntchito mosamala kwambiri kwa Lisinopril kumatha kubweretsa zotsatira zosayembekezereka.
Kodi amatenga lisinopril?
Palibe chifukwa chothira mankhwalawo pansi pa lilime kapena kupasuka. Piritsi imayenera kutengedwa pakamwa ndikusambitsidwa ndi madzi pang'ono. Mankhwalawa amakhala ndi nthawi yayitali, choncho muyenera kumwa kamodzi patsiku. Kugwiritsa ntchito mankhwalawa kuyenera kukhala kwadongosolo.
Ndi mawonekedwe ofunikira a matenda oopsa ndi matenda oopsa, mlingo woyambira si woposa 10 mg.
Ngati ndi kotheka, kuti magazi azithamanga, magazi amathanso kuwonjezeka mpaka 20-30 mg tsiku lililonse.
Mlingo sayenera kupitirira 40 mg patsiku.
Mwanthawi yayitali kulephera kwa mtima, mlingo woyambira ndi 2.5 mg. Mlingo ukuwonjezeka pang'onopang'ono. Mulingo waukulu ndi 10 mg patsiku.
Pa mavuto ati?
Ngakhale ngati pali kuchepa, koma kuthamanga kwa magazi, ichi ndichizindikiro cha kumwa mankhwalawo. Kusintha kwa Mlingo kumachitika mpaka magazi atayamba abwinobwino.
Nthawi yanji?
Kuti mukwaniritse kufunika kwa kuchepetsa kuthamanga kwa magazi, mankhwalawa amayenera kumwedwa.
Piritsi la Lisinopril liyenera kumwedwa pamlomo ndikusambitsidwa ndi madzi pang'ono.
Musanadye kapena musanadye
Kudya sikukhudza kuyamwa kwa zinthu zomwe zimagwira komanso kuthandizira kwa mankhwalawa.
Kutalika kwake?
Zotsatira pambuyo makonzedwe zimayambira 18 mpaka 24 maola.
Nthawi yovomera ndi chiyani?
Kutalika kwa mankhwalawa ndi lisinopril kumatsimikiziridwa pozindikira momwe wodwalayo amadziwira komanso zotsatira zake.
Kumwa mankhwala a shuga
Ndi nephropathy mwa munthu wodwala insulin wodwala matenda a shuga, mlingo woyambira sayenera kupitirira 10 mg, koma mtsogolomo, malinga ndi zidziwitso, ukhoza kuwonjezeka mpaka 20 mg patsiku. Kutalika kwa chithandizo kumatengera kuuma kwa mkhalidwe wa wodwalayo.
Zotsatira zoyipa
Pamaso munthu tsankho kwa munthu zigawo zikuluzikulu za mankhwala, matupi awo sagwirizana. Angioedema a nkhope, lilime, ndi zina. Edema yotheka ya Quincke. Potengera maziko a mankhwalawa ndi Lisinopril, mawonekedwe a zovuta zoyipa zam'mimba, hematopoiesis, chapakati mantha dongosolo, etc.
Matumbo
Nthawi zina, kumwa mankhwala kumatha kupangitsa kumva kupweteka kwamkamwa. Mwina kusintha kukoma. Kupweteka kwam'mimba ndi dyspepsia zidadziwika.
Hematopoietic ziwalo
Ndi mankhwala a nthawi yayitali, odwala omwe amamwa mankhwalawa amapeza magazi m'thupi. Zotsatira zoyipa zimawonetsedwa ndi agranulocytosis, leukopenia ndi thrombocytopenia.
Pakati mantha dongosolo
Popeza mankhwalawo salowa mu zotchinga mu magazi, chiwopsezo cha mavuto obwera chifukwa cha dongosolo lamanjenje ndi chochepa. Zizindikiro zomwe zingakhalepo zimaphatikizaponso kusinthasintha kwa kugona, kugona mosalekeza, asthenia, kukokana miyendo usiku.
Kuchokera ku genitourinary system
Kugwiritsira ntchito kwa nthawi yayitali ya lisinopril kumapangitsa kuti minyewa ikhale yopweteka. Mwina kukula kwa anuria, proteinuria, proteinuria.
Kuchokera ku kupuma
Nthawi zambiri, mukamamwa Lisinopril, chifuwa chowuma chimawoneka ngati mavuto. Nthawi zina, bronchospasm ndi kupuma movutikira kumachitika.
Pa khungu
Zotsatira zoyipa kuchokera pakhungu zimawoneka kawirikawiri. Kuyang'ana kotheka, kuwonjezera chidwi cha dzuwa. Alopecia ndi thukuta ndizosowa kwambiri.
Malangizo apadera
Ndiwosamala mwapadera, mankhwalawa amayenera kugwiritsidwa ntchito pochiza anthu omwe ali ndi vuto la kuchepa kwa mitsempha komanso matenda a mtima, chifukwa ndi zochitika zamtunduwu, kuchepa kwambiri kwa magazi kumatha kudzetsa vuto la mtima. Mikhalidwe zingapo zimasiyanitsidwa momwe kugwiritsa ntchito chida ichi sikulimbikitsidwa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mimba ndi contraindication chotenga lisinopril. Mankhwalawa alibe mutagenic, koma amalimbikitsa chiopsezo cha kufa kwa neonatal. Mothandizidwa ndi chinthu chogwira ntchito, kukula kwa oligohydramnios kumatha kuchitika. Mwanayo atha kuzengereza kutulutsa zinthu za mafupa.
Kutenga mankhwalawa ndi mkazi panthawi yoyembekezera kumawonjezera mwayi wokhala mwana atayamba kulephera impso, kufooka kwa miyendo, ndi pulmonary hypoplasia. Ngati mankhwalawo ali oyenera panthawi yoyamwitsa, mkazi ayenera kukana kuyamwitsa mwana.
Kupangira Lisinopril kwa Ana
Mankhwalawa salembedwa kwa ana osakwana zaka 18.
Gwiritsani ntchito mu ukalamba
Kwa odwala okalamba, mlingo wa mankhwalawa umasankhidwa payekha. Ndikofunikira kuwongolera kusintha kwa magawo amwazi.
Zokhudza mphamvu pakuwongolera njira
Mankhwalawa wogwiritsidwa ntchito mwadongosolo angapangitse kuchepa kwa chidwi. Kulandila kwake sikumaletsa kuyendetsa galimoto, koma wodwala ayenera kusamala.
Bongo
Milandu yama bongo osowa kwambiri. Amatha kuchitika ndi mlingo umodzi woposa 50 mg. Zomwe zikuwonetsa bongo zikuphatikiza:
- kudzimbidwa
- kugona
- matenda aikodzo;
- kutsika kwa kuthamanga kwa magazi;
- nkhawa komanso kusakwiya.
Popeza kuti palibe mankhwala othandizira pakumwa mankhwalawa, chithandizo cha mankhwalawa chimaphatikizapo makamaka kupweteka kwam'mimba ndikugwiritsira ntchito mankhwala othandizira. Njira zina zimalimbana ndikuchotsa mawonekedwe awonetsedwe.
Kuchita ndi mankhwala ena
Anthu omwe akudwala matenda a shuga kapena matenda a impso, kugwiritsa ntchito nthawi imodzi ya lisinopril kumayesedwa chifukwa choopsa kwambiri chotenga matenda a hyperkalemia ndi kufa msanga.
Mankhwala okhala ndi mankhwala oletsa kupweteka kwambiri angayambitse magazi kuchepa kwambiri.
Osagwiritsa ntchito choletsa ACE ichi ndi antipsychotic ndi triceclic antidepressants.
Kugwiritsa ntchito lisinopril ndi estramustine ndi baclofen sikulimbikitsidwa. Kuyang'anira munthawi yomweyo kumathandizira kuoneka ngati zovuta zoyipa. Kugwiritsa ntchito mankhwala osokoneza bongo a lisinopril pamodzi.
Ndi chisamaliro
Ndi makonzedwe omwewo a mankhwala omwe si a antiidal a antiidal, okodzetsa komanso mankhwala okhala ndi potaziyamu omwe ali ndi Lisinopril, zotsatira zake zimakhala zopanda mphamvu. Izi za ACE inhibitor zimatha kupititsa patsogolo zotsatira za mankhwala a hypoglycemic, chifukwa chake, mukaphatikizidwa, muyenera kuwongolera shuga la magazi. Kukhazikitsa pamodzi kwa beta-blockers ndi lisinopril kumawonjezera zotsatira za omaliza.
Kuyenderana ndi mowa
Mukamamwa mankhwalawa, mowa uyenera kupewedwa. Kugwiritsa ntchito limodzi mankhwala ndi mowa kumatha kuyambitsa matenda oopsa.
Analogi
Mafanizo a Lisinopril, omwe mankhwalawa amasinthidwa nthawi zambiri ndi:
- Enalapril.
- Kutha.
- Anaprilin.
- Losartan.
- Ramipril.
- Bisoprolol.
- Moxonidine.
- Captopril.
- Prestarium.
- Diroton.
Kusintha kwa Lisinopril ndi analogue kumayikidwa ndi dokotala ngati wodwala akukumana ndi zovuta zina.
Kupita kwina mankhwala
Mankhwalawa amagawidwa m'mafakisoni popanda mankhwala a dokotala.
Kodi ndingagule popanda kulandira mankhwala?
Tchuthi chotsutsana ndi malo ogulitsa mankhwala amalola aliyense kuti agule mankhwala.
Mtengo wa lisinopril
Mtengo wa mankhwalawa umadalira mlingo, kuchuluka kwa mapiritsi ndi paketi ndi kampani yopanga. Mtengo wa Lisinopril Avant (Ukraine) 5 mg kuchokera ku 65 mpaka 70 rubles. Mankhwala okhala ndi mlingo wa 10 mg atenga pa 62 mpaka 330 rubles. Mankhwala okhala ndi mlingo wa 20 mg amatengera 170 mpaka 420 rubles.
Zosungidwa zamankhwala
Kutentha kwambiri kwa mankhwalawa ndi 25 + C.
Tsiku lotha ntchito
Kutalika kwakusungira ndi zaka 3 kuyambira tsiku lopangira.
Opanga
Kuphatikizidwa kwa zinthu zina pakupanga mankhwala kumadalira kampaniyo komanso dziko lomwe akupanga. Mankhwalawa amapangidwa ndi opanga awa:
- Zothandiza (Ukraine).
- VERTEX (Russia).
- Teva (Israeli).
- Stada (kuphatikiza kwa Russia ndi Germany).
- Farmland (Belarus).
- Akrikhin (Russia).
- Ratiopharm (Germany).
Ndemanga za Lisinopril
Mankhwalawa agwiritsidwa ntchito kwazaka zambiri kuchiritsa anthu omwe ali ndi vuto la kuthamanga kwa magazi, chifukwa chake, ali ndi ndemanga zambiri kuchokera kwa odwala ndi mtima.
Madokotala
Svyatoslav, wazaka 45, Ryazan
Ndakhala ndikugwira ntchito yamtima wazaka zoposa 15. Nthawi zambiri ndimalimbikitsa kutenga Lisinopril kwa odwala, chifukwamankhwalawa samayambitsa zotsatira zoyipa komanso amathandiza kuti wodwalayo azikhala wodekha. Ngakhale mutagwiritsa ntchito chida ichi kwa nthawi yayitali, luso la chida sichimachepa.
Irina, wazaka 38, Arkhangelsk
Pazochita zake, katswiri wazamtima kamodzi adakumana ndi zovuta zoyipa chifukwa chotenga Lisinopril. Mankhwala amaloledwa bwino ndi thupi la odwala ambiri ndipo nthawi yomweyo amalola kuchepa kwa magazi.
Wolandira
Svetlana, wazaka 45, Vladivostok
Kwa nthawi yayitali, adadwala matenda owonetsa kuthamanga kwa magazi, ndipo pokhapokha adaganiza zolumikizana ndi mtima. Dokotala adalangiza kugwiritsa ntchito lisinopril. Mankhwalawa athandiza kwambiri. Pasanathe sabata limodzi ndinayamba kumva bwino.
Vladimir, wazaka 60, Moscow
Ndakhala ndikuvutika ndi zowonjezereka kwa zaka zoposa 15. Ndinayesa mankhwala ambiri pamalangizo a katswiri wazamtima. Kwa zaka zopitilira 2 ku Lisinopril. Zimathandiza kukhazikika pakukakamiza, koma osamwa mowa mukamamwa. Kuphatikiza kwanga kwayambitsa kusokonekera.
Kristina, wazaka 58, Rostov-on-Don
Ndakhala ndikusunga Lisinopril kwa zaka zopitilira 3. Mankhwalawa athandiza kukhazikika kwa magazi. Ndizotheka kuti muyenera kutenga m'mawa. Ndisanayambe kudya chakudya cham'mawa ndimamwa mankhwalawa ndikumva bwino tsiku lonse.
