Neurontin ndi kukonzekera kofanana mu spatial dongosolo ku neurotransmitter GABA (gamma-aminobutyric acid). Poyamba, zinthu zomwe zimagwiritsidwa ntchito ngati mankhwalawa zimawonedwa ngati anticonvulsant. Ndipo zaka zochepa zokha pambuyo pake, kuwongolera kwake pochiza matenda angapo ammbuyo yopweteka ya neurogenic kuwululidwa.
Dzinalo Losayenerana
INN - Gabapentin.
Neurontin ndi kukonzekera kofanana mu spatial dongosolo ku neurotransmitter GABA (gamma-aminobutyric acid).
Dzina lamalonda ku Latin ndi Neurontin.
ATX
Khodi ya ATX ndi N03AX12.
Kutulutsa mafomu ndi kapangidwe kake
Amapangidwa monga mapiritsi ndi makapisozi, zomwe zimagwira ntchito yomwe ndi gabapentin.
Werengani werengani za mitundu inanso:
Neurinu 600 - malangizo ogwiritsira ntchito.
Neur 300 - kodi amatumiziridwa chiyani?
Mapiritsi
Chojambulidwa cha Ellipse, chophatikizidwa ndi notch ndi NT kulemba. Kumbali inayo ya piritsi, kutengera mtundu wa zomwe zimagwira, manambala amasindikizidwa:
- pa mapiritsi a 600 mg gabapentin a 16;
- 800 mg - 26.
Mapiritsi okhala ndi zotsekemera.
Zomwe zimapangidwira, kuwonjezera pa zomwe zimagwira, zimaphatikizapo zinthu zothandiza:
- poloxamer-407;
- wowuma;
- E572.
Kuchuluka kwawo zimatanthauzanso kuchuluka kwa zinthu zoyambira.
Makapisozi
Makapisozi amapangidwa ndi kuchuluka kwa gabapentin:
- 100 mg
- 300 mg;
- 400 mg
Makapisozi amasiyanasiyana maonekedwe (mtundu wa kapisozi wa gelatin) ndi kulembapo.
Amasiyana maonekedwe (mtundu wa kapisozi wa gelatin) ndi zilembo. Makapisozi 100 mg ndi oyera, 300 mg ndi achikaso achikasu, ndi 400 mg ndi lalanje. Kuphatikiza pa gabapentin, makapisozi amaphatikizapo zotuluka:
- shuga mkaka monohydrate;
- wowuma;
- magnesium hydroxylate.
Makapisozi amakhalanso osiyana kukula - Ayi. 3, 1, 0 mwanjira yotsatizana.
Zotsatira za pharmacological
Ngakhale mawonekedwe ofanana ndi GABA, gabapentin samangirira GABAA ndi GABAA receptors. Mphamvu za analgesic zimafotokozedwa ndi kuthekera kwa chinthucho kumangira zigawo zina za calcium tubule ions yomwe ili mu Presynaptic cleft ya mitsempha yam'mbuyo ya nyanga zam'mbuyo za chingwe cha msana.
Ngati mitsempha ya distal (kutali) yawonongeka, kuchuluka kwa α2-δ kugonjera kumawonjezeka kwambiri. Kuyambitsa kwawo kumawonjezera kutuluka kwa Ca2 + mu cell kudzera mu nembanemba, komwe kumapangitsa kutsika kwake ndikuchepetsa nthawi yomwe ingagwire ntchito. Pankhaniyi, zinthu zosangalatsa zogwiritsa ntchito (ma neurotransmitters) - glutamate ndi zinthu P - zimatulutsidwa kapena kupangidwa, ma ionotropic glutamate receptors adamulowetsa.
Mphamvu ya analgesic ya Neurontin imachitika chifukwa chakuletsa kufalikira kwa zizindikiro zopweteka pamlingo wa msana.
Gabapentin amangogwira ma receptors okhazikitsidwa, osakhudza kuyambitsidwa kwa calcium mu ma receptors osagwira. Mphamvu ya analgesic ya Neurontin imachitika chifukwa chakuletsa kufalikira kwa zizindikiro zopweteka pamlingo wa msana. Kuphatikiza apo, mankhwalawa amakhudza machitidwe ena:
- Receptors a NMDA;
- sodium ion njira;
- opioid dongosolo;
- njira za monoaminergic.
Kuphatikiza pa kulepheretsa kwa mafupa a msana, mphamvu yowonjezera idawululidwa. Mankhwalawa amagwira pa mlatho, cerebellum ndi vestibular nuclei, yomwe imalongosola osati zotsatira za analgesic, komanso katundu wa anticonvulsant, kuthetsa chizolowezi cha opioids ndipo adayamba kale kusazindikira.
Chifukwa chake, mankhwalawa amagwira ntchito osati kokha poletsa kupweteka kwambiri, komanso kuchepetsa ululu wambiri.
Pharmacokinetics
Kuchita bwino kwa Neurontin kumadalira mlingo. Pambuyo pakukonzekera kwa pakamwa kwa 300 ndi 600 mg ya chinthu, kupukusa kwake m'mimba ndi 60% ndi 40%, motero, ndipo amachepetsa ndikuwonjezeka. Mankhwalawa amakhudzana pang'ono ndi mapuloteni a plasma (3-5%). Voliyumu yogawa ndi ~ 0.6-0.8 l / kg. Mutatenga 300 mg ya gabapentin, kuchuluka kwambiri (2.7 μg / ml) kwa madzi am'magazi kumachitika pambuyo pa maola awiri ndi atatu.
Mankhwalawa amakhudzana pang'ono ndi mapuloteni a plasma (3-5%).
Gabapentin amapititsa msanga zotchinga zamagazi. Zochita zake zamadzimadzi ndi 5-35% ya plasma, ndipo muubongo - mpaka 80%. Mu thupi, chinthucho sichimachita biotransfform ndipo chimalulutsidwa ndi impso osasinthika. Mlingo wa chotsekera umadalira chilolezo cha metabolinine (kuchuluka kwa madzi am'madzi am'madzi kuchokera kumphindi 1). Odwala ndi yachilendo aimpso ntchito, theka moyo wa mankhwala pambuyo limodzi mlingo ndi maola 4.7-8.7.
Kodi chimathandiza ndi chiyani?
Gawani mpumulo wa zowawa zopweteka komanso zopweteka ndi:
- matenda amisempha;
- postherpetic neuralgia;
- kutupa kwa mitsempha ya trigeminal;
- matenda ashuga komanso antchito;
- aakulu discogenic ululu syndromes ndi osteochondrosis, radiculopathy;
- carpal tunnel syndrome;
- kuchuluka kwa ubongo wa spasmodic;
- syringomyelia;
- ululu wammbuyo.
Mukamatenga Neurontin, sikuti kupweteka kwa neuropathic komwe kumayimitsidwa. Mankhwalawa amagwiritsidwa ntchito ngati prophylactic analgesia isanafike ntchito yovuta kwambiri. Kumayambiriro kwake kumathandizira kuchepetsa kuchuluka kwa mankhwala oletsa kupweteka omwe amagwiritsidwa ntchito pambuyo pa ntchito, ndikuchepetsa kwambiri kupweteka.
Mankhwalawa sangathe kuyimitsa kupweteka kwapoyamba (mwachindunji m'dera la opaleshoni), komanso kukhudza ululu wachiwiri (wakutali ndi gawo la opaleshoni) womwe umayamba chifukwa cha mawotchi.
Mankhwalawa amagwiritsidwa ntchito ngati khunyu ngati anticonvulsant. Mu mawonekedwe amodzi amodzi omwe amagwiritsidwa ntchito pothandiza kukomoka pang'ono.
Contraindication
Zoyeserera pakugwiritsa ntchito Neurontin ndi:
- chizolowezi cha ziwengo;
- zaka mpaka zaka zitatu.
Kutsutsana ndikugwiritsa ntchito Neurontin ndimtundu wa ziwengo.
Ndi chisamaliro
Odwala ndi aimpso kulephera ayenera mankhwala mankhwala mosamala mu ulamuliro wa kulenga ntchito. Popeza amathandizidwa pa hemodialysis, kusintha kwa mankhwala kumafunika.
Momwe mungatenge neurontin?
Mankhwala amatengedwa pakamwa, kutsukidwa ndi madzi, mosasamala kanthu za kudya. Mutha kugawa piritsi pakati, kuthana ndi chiopsezo. Kuchiza koyambirira kumachitika molingana ndi chiwembu chotsatira:
- Tsiku loyamba - 300 mg kamodzi patsiku;
- Tsiku la 2 - 300 mg kawiri pa tsiku;
- Tsiku la 3 - 300 mg katatu patsiku.
Dongosolo lotere likuwonetsedwa kwa odwala akuluakulu ndi achinyamata ochokera zaka 12. Ngati kusiya mankhwala kumafunika, ndiye kuti kumachitika pang'onopang'ono, kutsitsa mlingo kwa masiku osachepera 7, mosasamala kanthu za mawonekedwe.
Mankhwala amatengedwa pakamwa, kutsukidwa ndi madzi, mosasamala kanthu za kudya.
Nthawi zina, odwala akuluakulu amatha kuyamba kulandira chithandizo cha mlingo wa 900 mg ndi kuwonjezeka pang'onopang'ono kwa 300 mg tsiku lililonse tsiku lililonse la 2-3. Mlingo wapamwamba wa tsiku ndi tsiku ndi 3600 mg. Imafikiridwa mu masabata atatu. Muvuto lalikulu la wodwalayo, mlingo umawonjezeredwa m'miyeso yaying'ono kapena mipata yayikulu pakati pazopangidwa.
Zochizira khunyu, mankhwalawa ayenera kugwiritsidwa ntchito mosalekeza. Pankhaniyi, tsiku lililonse mlingo umawerengeredwa ndi dokotala.
Kumwa mankhwala a shuga
Amagwiritsidwa ntchito ngati mankhwala osankha popereka ululu wa matenda ashuga polyneuropathy. Ndikulimbikitsidwa kupereka mankhwala kwa 300 mg patsiku madzulo, pang'onopang'ono (masiku awiri aliwonse) ndikukulitsa mlingo mpaka 1800 mg patsiku.
Amagwiritsidwa ntchito ngati mankhwala osankha popereka ululu wa matenda ashuga polyneuropathy.
Ndingatenge nthawi yayitali bwanji?
Mankhwala tikulimbikitsidwa kuti kumwedwa zosaposa miyezi 5, chifukwa Njira yayitali ya chithandizo sichinaphunzire. Ndi nthawi yayitali, katswiri amayenera kudziwa kufunika kosakhalitsa nthawi yayitali.
Zotsatira zoyipa za Neurotin
Nthawi zambiri, mwa zoyipa zomwe zimachitika chifukwa chmamwa mankhwalawa, chizungulire komanso kusinza kwambiri zimadziwika. Nthawi zambiri, mankhwalawa amawononga machitidwe osiyanasiyana.
Matumbo
Nthawi zambiri zimadziwika:
- kuphwanya matumbo;
- kuyanika kwa oropharynx;
- kupanga gasi kwambiri;
- kusanza, kusanza
- mavuto a dyspeptic;
- matenda a chingamu;
- zodetsa nkhawa.
Mu nthawi ya chithandizo chamankhwala, zochitika zapadera za pancreatitis zidalembedwa.
Hematopoietic ziwalo
Nthawi zambiri amapezeka leukopenia, ochepa matenda oopsa ndipo samakonda thrombocytopenia.
Pakati mantha dongosolo
Zowonetsedwa nthawi zambiri:
- kugona
- discoordination;
- kufooka
- paresthesia;
- kugwedezeka
- kuiwalika
- kuphwanya zamkati;
- kuponderezana kwa Reflex.
Kawirikawiri kumwa mankhwala kumayambitsa kusokonezeka kwa magazi, matenda amisala, monga kudana, phobias, nkhawa, kumayambitsa kuphwanya malingaliro.
Kuchokera kwamikodzo
Kutali milandu hyperactivity a chikhodzodzo, pachimake aimpso kulephera. Zilonda zama bakiteriya, kuphatikizira matenda amkodzo thirakiti, nthawi zambiri zimadziwika.
Kuchokera ku minculoskeletal system
Nthawi zambiri, chithandizo chimatsatiridwa ndi:
- myalgia;
- arthralgia;
- minofu kukokana ndi teak.
Pa khungu
Nthawi zambiri pamakhala zosokoneza zina:
- kudzikuza;
- kuphwanya;
- ziphuphu
- zotupa;
- kuyabwa.
Alopecia, redness, ndi zotupa pa mankhwala sizachilendo.
Matupi omaliza
Zotsatira zam'mimba zimawonetsedwa ndi pathologies a khungu, kugwedezeka kwa anaphylactic sikunachitike kwenikweni.
Zokhudza mphamvu pakuwongolera njira
Mukamamwa mankhwalawa, sikulimbikitsidwa kuyendetsa magalimoto kapena kugwira ntchito ndi njira zoopsa musanakhazikitse zotsatira zoyipa za mankhwalawa pazokhudzana ndi mitsempha ya neuromuscular.
Malangizo apadera
Odwala omwe adamwa mankhwalawo adanenanso za magawo omwe amachititsa kudzipha. Chifukwa chake, ndikofunikira kuyang'anitsitsa momwe psycho-imakhalira m'maganizo mwa odwala poika kukonza kwa zopatuka.
Ngati zizindikiro za pancreatitis yayikulu ikuwonekera, lingaliro la kusiya mankhwala limalemedwa.
Ndi kusiya kwa mankhwala mankhwalawa khunyu, kupweteka kumayamba.
Ndi kusiya kwa mankhwala mankhwalawa khunyu, kupweteka kumayamba. Mankhwala amatengedwa ngati osagwira mankhwalawa kukomoka kwakukulu komanso mwina kungawalimbikitse. Chifukwa chake, perekani mankhwalawa kwa odwala omwe ali ndi paroxysms osakanikirana mosamala.
Ndi makonzedwe apanthawi yomweyo a opioid ndi Neurontin, kupsinjika kwa CNS kumatha kukulitsa - kuwunika momwe wodwalayo asinthira ndikusintha kwa mlingo wofunikira ndikofunikira.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala munthawi ya bere amadziwikanso pomwe amapezeka pakanthawi kovulaza mluza. Palibe chifukwa chowongolera ntchito ya mankhwala a m'magazi.
Chifukwa mankhwalawa amapezeka mwachinsinsi cha chithokomiro cha mayi, pakudyetsa, ndikofunikira kusokoneza kudyetsa kwachilengedwe kwa mwana ndikusamutsa kwa osakaniza.
Mankhwala munthawi ya bere amadziwikanso pomwe amapezeka pakanthawi kovulaza mluza.
Kulembera Neurontin ana
Kuchiza ndi Neurinu mpaka zaka 3 sikunachitike. Pa zaka 3-12 zaka, mlingo woyambira ndi 10-15 mg / tsiku. Iagawidwa pawiri. Kuti mukwaniritse zochizira, zimachulukitsa pang'onopang'ono, mpaka 40 mg / tsiku. Ndikofunikira kutsatira gawo la maola 12 pakati pama phwando.
Gwiritsani ntchito mu ukalamba
Mu gulu la okalamba (> zaka 65), kuwonongeka kwa ntchito yowonjezera chifukwa cha njira zokhudzana ndi zaka nthawi zambiri kumapezeka, chifukwa chake, mwa odwala, ulamuliro wa clearinine ndi wofunikira.
Mankhwala osokoneza bongo a neurotin
Ndi limodzi makonzedwe a mlingo waukulu, mawonetsedwe otsatirawa adanenedwa:
- kuwonongeka kwamawonekedwe;
- kukulira moyo wabwino;
- dyspemia (matenda osokoneza bongo);
- hypersomnia (kugona tulo masana);
- ulesi;
- kuphwanya matumbo.
Ngati mulingo wadutsa, makamaka kuphatikiza ndi Neurontin ndi mankhwala ena a neurotropic, chikomokere chimatha.
Pa mlingo waukulu, jakisoni woyenera ndi kuyeretsa magazi kowonjezera nthawi zambiri amaperekedwa kwa odwala omwe ali ndi vuto la impso.
Kuchita ndi mankhwala ena
Neurontin ikagwiritsidwa ntchito limodzi ndi opium poppy zotumphukira, zizindikiro za kupsyinjika kwa CNS zitha kudziwika. Zosintha mu pharmacodynamics za Neurontin mukamamwa antiepileptic mankhwala sizinadziwike.
Kuphatikiza kwa mankhwala ndi ma antacid kumachepetsa kugaya kwa Neurotin ndi pafupifupi 1/4.
Venoruton ndi ena a venotonics amaphatikizidwa ndi ntchito yogwira mankhwala ndipo angafotokozedwe kuti asapange zotsatira zoyipa kuzungulira kwa magazi.
Ndi mawonekedwe owoneka bwino amomwe thupi siligwirizana, ma antihistamines, monga Cetrin, amagwiritsidwa ntchito limodzi ndi mankhwalawa.
Ndi mawonekedwe owoneka bwino amomwe thupi siligwirizana, ma antihistamines, monga Cetrin, amagwiritsidwa ntchito limodzi ndi mankhwalawa.
Kuyenderana ndi mowa
Sitikulimbikitsidwa kumwa mowa ndi mankhwala nthawi yomweyo, chifukwa onse ali ndi vuto pa chapakati mantha dongosolo. Komabe, mankhwalawa amagwiritsidwa ntchito pochiza kudalira mowa. Amachepetsa kulakalaka mowa, amachotsa kusowa tulo komanso kukhumudwa.
Analogi
Pali maulumikizano angapo a Neurotin:
- Convalis;
- Droplet;
- Egipentin;
- Gabalept;
- Wimpat;
- Gabastadine
- Tebantin;
- Gabapentin;
- Katena.
Kupita kwina mankhwala
Ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala akutsatsa omwe ali osavomerezeka kuti asapusitsidwe.
Mtengo wa Neurontin
Mtengo wake ndi ma ruble 962-1729.
Zosungidwa zamankhwala
Sungani pa kutentha kosaposa 25 ° C, kuchokera kwa ana.
Mankhwala akutsatsa omwe ali osavomerezeka kuti asapusitsidwe.
Tsiku lotha ntchito
Osapitirira zaka 2.
Wopanga
Pfizer (Germany).
Ndemanga za Neurontin
Alexey Yuryevich, wa zaka 53, Kaluga: "Ndakhala ndikudwala matenda am'mimba kwa nthawi yayitali. Kwa chaka chimodzi tsopano, adotolo adalengeza kuti alandire Neurontin 300. Poyamba matendawa anali abwino, koma tsopano afooka. Ndikupitiliza kumwa mankhwalawa, koma ndikuganiza kuti chifukwa cha kutalika kwa chithandizo sizothandiza. "
Konstantin, wazaka 38, Odessa: "Dotolo adamuuza kuti apite ku Neurontin. Adatenga mlingo womwe adotolo adamuuza, kutsatira dongosolo.Munthawi imeneyi kunalibe zoyipa zomwe zinkawopsa, ndipo mankhwalawa amagwira ntchito bwino. "
Olga, wazaka 42, Melitopol: "Nditatha kutenga Neurontin, mphamvuyo idapitilira kwa nthawi yayitali, sindinamva chizungulire, miyendo yanga imakhala yofooka. Ndikhulupirira kuti mankhwalawa ndi othandiza komanso amathandizira kuti muchepetse kupweteka."
