Momwe mungagwiritsire ntchito mankhwala Vazotens N?

Matenda ofala kwambiri pamtima ndi matenda oopsa. Mankhwala ake, magulu angapo a mankhwalawa amagwiritsidwa ntchito omwe ali ndi njira zosiyanasiyana zochitira mankhwalawa. Mbali yofunikira yomwe imakhudza kufa kwa matenda a mtima ndi kuchuluka kwa magazi. Kuwongolera momwe manambala amapanikizidwe, mankhwalawa Vazotens N. amagwiritsidwa ntchito.

Kuwongolera momwe manambala amapanikizidwe, mankhwalawa Vazotens N. amagwiritsidwa ntchito.

Dzinalo Losayenerana

Losartan osakanikirana ndi diuretic (hydrochlorothiazide).

ATX

C09D A01

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi omwe ali ndi utoto-film. Mapiritsi akupezeka mu zotsatirazi:

1. Piritsi 1 ili ndi 100 mg ya losartan ndi 25 mg ya hydrochlorothiazide, mapiritsi 1 a 10, matuza atatu paphukusi.
2. Piritsi 1 imakhala ndi 50 mg ya losartan ndi 12.5 mg ya hydrochlorothiazide, m'mapiritsi 1 amodzi, matuza 10 paphukusi.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi omwe ali ndi utoto-film.

Zotsatira za pharmacological

Njira yayikulu yogwirira ntchito ndikutseka ma receptors a angiotensin II, omwe ndi chinthu chofunikira kwambiri m'thupi mwa thupi mothandizidwa ndi ziwiya. Angiotensin, yolumikizana ndi zolandilira zake pazitseko zamitsempha yamagazi, imawapangitsa kuti azilumikizana ndi thupi lonse, zomwe zimapangitsa kuti magazi azikhala ochepa. Kuphatikizika kwa chinthuchi kumachitika mu minyewa yaimpso kuchokera ku puloteni ya renin motsogozedwa ndi puloteni ya angiotensin.

Kuletsa ma angiotensin receptors sikumayambitsa vasoconstriction, chifukwa chomwe kuwonjezeka kwa kukakamiza kumachitika. Chithandizo chogwira ntchito cha mankhwalawa chimangogwirizana ndi ma angiotensin 2 receptors, mwakutero sizipangitsa zotsatira zina zolandirira zina.

Njira yayikulu yogwirira ntchito ndikutseka ma receptors a angiotensin II, omwe ndi chinthu chofunikira kwambiri m'thupi mwa thupi mothandizidwa ndi ziwiya.

Limagwirira a hydrochlorothiazide: kuchuluka kwamkodzo, kuchepa kwa mavuto chifukwa kuchotsedwa kwa madzi owonjezera mthupi.

Pharmacokinetics

Losartan imatengedwa mwachangu kuchokera m'matumbo, pomwe imalowa m'chiwindi ndikuyenda biotransformation. 33% yokha ya mlingo womwe umatengedwa ndiwosapika. Pakati pa biotransfform, losartan amasinthidwa kukhala metabolite yogwira. Ndiwothandizitsa kuyerekezera ndipo sikhala otsika poyerekeza ndi losartan pogwira ntchito.

Yapamwamba kwambiri yogwira thupi m'thupi imapangidwa pambuyo 2 mawola. Mphamvu ya piritsi limodzi imatha maola 24. Cumulative hypotensive zotsatira za mankhwalawa zimayamba kwakanthawi 1 mpaka 3 milungu.

Zizindikiro zogwiritsidwa ntchito

Zizindikiro zazikulu zovomerezeka ndiz:

1. Matenda oopsa.
2. Matenda oopsa a chiyambi osiyanasiyana.
3. Kuthamanga kwa magazi mwa achinyamata ndi ana aang'ono.
4. Kukonzanso mankhwala kwa pambuyo-infarction zinthu.
5. Kulephera kwa mtima (monga cholowa m'malo mwa zinthu kuchokera pagulu la angiotensin-kutembenuza enzyme inhibitors).

Mankhwalawa sanatchulidwe kulephera kwamtima komanso kosalekeza.

Chizindikiro chachikulu cha kumwa mankhwalawa ndi ochepa matenda oopsa.

Chizindikiro chachikulu chomwa mankhwalawo ndi matenda oopsa.

Contraindication

Mankhwalawa ali ndi zotsutsana zotsatirazi:

• kulephera kwa aimpso ndi creatinine chilolezo chotsika 30 ml mphindi imodzi;
• wachiwiri ndi wachitatu trimester wa mimba ndi nthawi yonse yoyamwitsa;
• pachimake komanso matenda osatha a chiwindi;
• wodwala ali ndi biliary cirrhosis, hepatocellular carcinoma.

Ndi chisamaliro

Ngati wodwalayo ali ndi mphamvu ya mafupa a m'magazi a stenosis kapena a impso artery stenosis wachiwiri, mankhwalawa amagwiritsidwa ntchito pokhapokha atazindikira kuopsa kwake komanso zotsatira zabwino.

Mankhwalawa ali ophatikizika chifukwa cha kulephera kwa impso.

Wogulitsa mankhwala amalembedwa kuti ateteze maselo a chiwindi.

Mankhwalawa amatsutsana panthawi ya mkaka wa m`mawere.

Momwe mungatenge vasotens N

Musanayambe chithandizo, ndikofunikira kuti mupeze thupi lonse. Ma lipids am'magazi ndi zizindikiro zofunika pakukonzekera matenda oopsa komanso kupewa zovuta zake. Amaphatikizapo kuchuluka kwa cholesterol, triglycerides ndi otsika kachulukidwe lipoprotein, popeza zinthuzi zimathandizira popanga mapangidwe a atherosranceotic.

Mlingo wa mankhwala achikulire 1 piritsi 1 nthawi patsiku. Ngati ndi kotheka, muyenera kusankha kumwa mankhwala. Ndi kugwiritsa ntchito pafupipafupi, kuthamanga kwa magazi kumachepa komanso kukhazikika pakatha masabata anayi atamwa mankhwalawa.

Ndi vuto la mtima, mankhwalawa amayenera kugwiritsidwa ntchito kamodzi patsiku. Gwiritsani ntchito mankhwalawa mosamala. Zotsatira zake zimatha kuwongoleredwa ndi kutha kwa mphumu ya mtima komanso kutupa m'miyendo. Ngati mulibe mphamvu ya mankhwalawa, mutha kukulitsa kukodzetsa kwamankhwala osokoneza bongo.

Mlingo wa mankhwala achikulire 1 piritsi 1 nthawi patsiku.

Ndi matenda ashuga

Odwala omwe ali ndi matenda a shuga amakhala ndi matenda a impso. Matendawa amafanana ndi matenda aimpso. Izi zikuyenera kukumbukiridwa mukamapereka mankhwala, chifukwa umakhudzidwa makamaka ndi impso, ndipo kuchedwa mu zinthu zomwe zimagwira m'thupi kumathandizira zotsatira zoyipa za mankhwalawa.

Zotsatira zoyipa

Zotsatira zosafunikira zimatha kuchitika m'magulu osiyanasiyana.

Matumbo

Mukamamwa mankhwalawa, kupweteka kwam'mimba, mapando otayirira, nseru, ndi kusanza nthawi zambiri kumachitika. Kudzimbidwa komanso kusabereka kumachitika pafupipafupi. Ndikothekanso kuwonjezera michere ya chiwindi m'maphunziro a labotale.

Mukamamwa mankhwalawa, kupweteka kwam'mimba nthawi zambiri kumachitika.

Kuchokera ku minculoskeletal system

Nthawi zambiri pamakhala kupweteka kumbuyo, kupweteka m'miyendo. Minofu kukokana kumachitika kangapo.

Pakati mantha dongosolo

Kulandila losartan nthawi zambiri kumayendetsedwa ndi chizungulire komanso kuchepera - mutu. Nthawi zina, paresthesia, kunjenjemera kwa malekezero, migraine imatha kuchitika. Nthawi zina - kuzindikira kwakanthawi kochepa.

Kuchokera ku kupuma

Pa mankhwala ndi mankhwalawa, chifuwa, matenda a chaparrhal a chapamwamba kupuma thirakiti, mphuno ndi mphuno.

Mankhwala ndi mankhwala, kutsokomola kumachitika.

Pa khungu

Kuwonetsedwa kwa urticaria kapena kuyabwa khungu ndikotheka. Zinthu izi ndizosafunikira ndipo zimadutsa kumapeto kwa chithandizo. Muzochitika zazikulu, mankhwala amatha kugwiritsidwa ntchito pochepetsa mavuto.

Kuchokera ku genitourinary system

Mwina kukodza pafupipafupi komwe kumachitika ndi hydrochlorothiazide.

Kuchokera pamtima

Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali komanso osagwirizana kumawonjezera chiopsezo cha ischemic stroke komanso kulowetsedwa kwa myocardial mwa anthu omwe ali ndi atherosclerosis.

Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali komanso mosasamala kumawonjezera chiopsezo cha matenda a ischemic.

Matupi omaliza

Musanagwiritse ntchito mankhwalawa, ndikofunikira kuyesa kuyesa kwa chidwi cha munthu payekha. Ngati thupi lanu siligwirizana mu urticaria kapena kuyabwa khungu, kugwiritsa ntchito mankhwalawa ndizoletsedwa.

Thupi lawo siligwirizana, monga angioedema kapena mawonetseredwe a vasculitis, ndizotheka pakukhazikitsa. Izi ndizosowa kwambiri, koma kukula kwake sikungatheke pokhapokha ngati mukumwa mankhwala osokoneza bongo.

Zokhudza mphamvu pakuwongolera njira

Losartan sichikhudza mwachindunji gawo lamkati lamanjenje, koma chizungulire nthawi zambiri chimachitika pakati pamavuto. Kutengera izi, pakukonzekera mankhwalawa ndikofunika kupewa kugwiritsa ntchito magalimoto kapena zida zomwe zimafunikira chidwi.

Kwa nthawi yayitali ya chithandizo, ndikofunikira kupewa magalimoto.

Malangizo apadera

Popeza kugwiritsa ntchito mankhwalawa kungayambitse kuchepa kwa potaziyamu m'thupi, kugwiritsidwa ntchito limodzi ndi zinthu zomwe zili ndi potaziyamu, okhudza potaziyamu - zomwe zimakhudza dongosolo la aldosterone ndikuyambitsa kuchepa kwa potaziyamu m'thupi) komanso mankhwala omwe mwanjira inayake angayambitse kuchuluka kwa potaziyamu m'magazi am'magazi, ndi osayenera chifukwa chiopsezo cha hyperkalemia.

Ngati mukufunika kumwa mankhwala omwe amakhudza kapangidwe kazinthu zamagetsi zamagazi (makamaka potaziyamu), muyenera kuyezetsa kawirikawiri potaziyamu m'magazi.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Mankhwalawa, monga gulu lina lililonse la angiotensin II receptor inhibitors, ndiwotsimikizika kuti agwiritsidwe ntchito ndi amayi apakati wachiwiri ndi wachitatu trimester, komanso nthawi yonse yoyamwitsa. Ngati pakufunika kuchepetsa kuthamanga kwa magazi panthawi yomwe muli ndi pakati, ndikofunikira kuti musankhe mankhwalawa kuchokera ku magulu ena achire.

Mankhwalawa ndiwotsimikizika kuti agwiritsidwe ntchito ndi amayi apakati wachiwiri ndi wachitatu trimester.

Kupangira Vazotenza N kwa ana

Palibe zambiri zokhudzana ndi kugwiritsa ntchito mankhwalawa kwa anthu ochepera zaka 18. Kutengera izi, mankhwalawa ali osavomerezeka kwa ana, popeza ndizosatheka kuneneratu za momwe matupi awo angakhalire.

Gwiritsani ntchito mu ukalamba

Mlingo wa losartan mu okalamba siwosiyana ndi Mlingo wa akulu. Koma anthu achikulire nthawi zambiri amakhala ndi zovuta ndi impso ndi chiwindi, zomwe zimayenera kuganiziridwa popereka mankhwala.

The ntchito aimpso kuwonongeka

Pankhani ya serum creatinine mu ndende ya 500 μmol (chizindikiro ichi chikufanana ndi gawo 2 la matenda a impso), muyeso wa mankhwalawo sungasinthidwe, chifukwa ntchito yotsalira ya aimpso imakwanira kuti ichotse mankhwalawa panthawi yake.

Mlingo wa losartan mu okalamba siwosiyana ndi Mlingo wa akulu.

Ngati creatinine chilolezo chotsika 30 ml mphindi imodzi, ndiye kugwiritsa ntchito mankhwalawo ndizoletsedwa, chifukwa ngakhale hemodialysis imakayikira zamkati mwazinthu zomwe zikuchitika m'thupi.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Ndi kulephera kwa chiwindi, simungathe kupereka mankhwala, popeza kagayidwe kake kogwira ntchito kamadalira chiwindi.

Bongo

Ngati bongo wambiri, ochepa ochepa hypotension angathe kuchitika, zomwe zingachititse kuti mugwedezeke, kugwa komanso kuti musataye chikumbumtima. Chithandizo cha Syndrome chimagwiritsidwa ntchito kubwezeretsa kuthamanga kwa magazi. Hemodialysis siyothandiza pochotsa mankhwala ochulukirapo m'thupi.

Kuchita ndi mankhwala ena

Pochiza matenda oopsa, nthawi zina zimakhala zothandiza kugwiritsa ntchito mankhwala angapo ochokera m'magulu osiyanasiyana kuti mukwaniritse zowunikira. Nthawi zambiri, zinthuzi zimapezeka kale m'mapiritsi. Kuphatikiza kopambana ndi mankhwalawa kumaphatikizapo zomwe zimaphatikizaponso thiazide diuretics (woimira wamkulu wa gululi - hydrochlorothiazide) kapena calcium Channel blockers (woimira wamkulu wagululi ndi zotsatira zazitali - amlodipine).

Pochiza matenda oopsa, nthawi zina zimakhala zothandiza kugwiritsa ntchito mankhwala angapo ochokera m'magulu osiyanasiyana kuti mukwaniritse zowunikira.

Kugwiritsa ntchito kwa angiotensin-kutembenuza chinthu, monga lisinopril, palimodzi ndi zinthu kuchokera ku gulu la blockers, sikulimbikitsidwa, popeza momwe limagwirira ntchito ikuyenera kuchita pazinthu zomwezo, koma pazolumikizana zosiyanasiyana. Izi zimatchedwa awiri blockade of renin-angiotensin system. Kuphatikiza kumeneku sikuthandizira kuchiritsa kwathito, koma kumawonjezera kuwopsa kwa mankhwala m'thupi.

Kugwiritsa ntchito ndi angiotensin-kutembenuza ma enzyme inhibitors kumatha kuwonjezera kuchuluka kwa lithiamu m'magazi. Kuzungulira kwakukulu kwa lifiyamu kumakhala ndi poizoni m'thupi. Kuphatikiza kwa mankhwalawa kuyenera kupewedwa.

Mukamagwiritsa ntchito mankhwala osokoneza bongo omwe amaletsa kutupa (mankhwala omwe amaletsa cycloo oxygenase 2), kufooka kwa zotsatira za hypotensive kungayambike limodzi ndi mankhwalawa. Kugwiritsidwa ntchito kwa mankhwalawa kumayambitsa kuchepa kwa potaziyamu m'thupi, zomwe zimawopseza mavuto ndi mtima.

Chenjezo liyenera kuphatikizidwa pophatikiza mankhwalawa, ndipo ngati magawo a labotale akasintha kapena wodwalayo akayamba kuvuta, kuganiziridwaku kuyenera kuthandizanso kuchepetsa mankhwalawo kapena kutulutsa imodzi ya mankhwalawo.

Kuyenderana ndi mowa

Popeza mankhwalawa amaphatikizidwa m'chiwindi, mowa uyenera kupewedwa mukamamwa mankhwalawo. Izi zimachepetsa katundu pa chiwindi ndikuwongolera ntchito yake.

Popeza mankhwalawa amaphatikizidwa m'chiwindi, mowa uyenera kupewedwa mukamamwa mankhwalawo.

Analogi

Analogue monga Lozart imaperekedwa pamsika.

Kusiyana pakati pa Vazotenza ndi Vazotenza N

Powonjezera kalata H pa dzina la mankhwalawa akuti kuwonjezera pa chinthu chachikulu chomwe chimagwira, hydrochlorothiazide, yomwe ndi diuretic, ikuphatikizidwa. Izi zikuyenera kuganiziridwa popereka mankhwala, chifukwa kupezeka kwa hydrochlorothiazide kumawonjezera mphamvu yowonjezera ndi zotsatira zake zoyipa.

Vacotenza N malo opumulira

Kodi ndingagule popanda kulandira mankhwala?

Monga mankhwala onse kuchokera ku gulu la angiotensin II receptor blockers, limagawidwa kuchokera ku mankhwala osagwiritsa ntchito mankhwala.

Mtengo wa Vazotens N

Mtengo umasiyanasiyana kuchokera ku 250 mpaka 650 rubles.

Monga mankhwala onse kuchokera ku gulu la angiotensin II receptor blockers, limagawidwa kuchokera ku mankhwala osagwiritsa ntchito mankhwala.

Zosungidwa zamankhwala

Mankhwalawa amasungidwa m'matumba ake oyamba firiji. Pewani kufikira ana.

Tsiku lotha ntchito

Zaka 3 kuyambira tsiku lopangira lomwe lasonyezedwa pa phukusi.

Wopanga Vazotenza N

Actavis (Iceland).

Ndemanga za Vasotense N

Madokotala

Sergey, wa zaka 52, wazamakhalidwe, Moscow

Angiotensin receptor inhibitors ndi mankhwala ofunika kwambiri pochizira matenda oopsa kwa akuluakulu. Nthawi zambiri timagwiritsa ntchito losartan ngati mankhwala oyenera mu odwala omwe amadandaula kuti akutsokomola pambuyo pogwiritsa ntchito zoletsa za ACE.

Oksana, wazaka 48, wothandizira wamkulu, Chelyabinsk

Mankhwala othandiza pochiza matenda oopsa mu gawo lachiwiri ndi lachitatu. Ndimapereka kwa odwala kuti ndi mankhwala abwino, pamene losartan yokha siyikwanira kuchepetsa kukakamiza.

Odwala

Alexander, wazaka 57, Kazan

Ndakhala ndikumwa mankhwalawa kwa zaka zoposa 10, chifukwa ndimadwala matenda oopsa. Ndinkakonda kutenga lisinopril, koma panali chifuwa chomwe sichitha kuchotsedwa. Dokotala wabanjali adati chinali chovuta cha lisinopril, ndipo adandisunthira mankhwala osokoneza bongo kuchokera ku gulu la angiotensin receptor inhibitors. Ndi losartan ndikosavuta kuwongolera kuthamanga kwa magazi, ndipo chifuwa chazimiririka.

Dmitry, wazaka 68, Astrakhan

Ndakhala ndikuvutika ndi matenda oopsa kwa zaka zoposa 20. Chaposachedwa, madotolo adazindikira kulephera kwa mtima. Iwo adati izi zidachitika chifukwa chobwezerera matenda oopsa, ndipo adalamula mankhwalawa. Ndekha, ndimaona kuti kupuma movutikira kwachepa pang'ono ndipo mphamvu zowonjezereka zawonjezeka, zomwe ndikusangalala.