Diabeteson MV - njira yolimbana ndi matenda ashuga

Chidachi chapangira zochizira matenda a shuga a mtundu wachiwiri. Chithandizo chogwira mtima chimapangitsa maselo a pancreatic kupanga ma insulin ambiri kuti achepetse shuga.

Dzinalo Losayenerana

Gliclazide.

Diabeteson MV cholinga chake ndi kuchiza matenda amtundu wa 2 shuga.

ATX

A10BB09.

Kutulutsa mafomu ndi kapangidwe kake

Wopezeka mu mawonekedwe a piritsi:

• Ma PC 15., Atanyamula matuza a 2 kapena 4 ma PC. ndi malangizo ogwiritsira ntchito osungidwa pakatoni;
• 30 ma PC., Mapangidwe ofananawo a matuza 1 kapena 2 pa paketi iliyonse.

Piritsi 1 ili ndi 60 mg yogwira - gliclazide.

Zothandiza:

• hypromellose 100 cP;
• anhydrous colloidal silicon dioxide;
• maltodextrin;
• magnesium wakuba;
• lactose monohydrate.

Diabeteson MV imapezeka mu piritsi.

Zotsatira za pharmacological

Hypoglycemic wothandizira.

Chomwe chimagwiritsidwa ntchito ndi mtundu wa sulfonylurea. Poyerekeza ndi ma analogi, imakhala ndi nayitrogeni wokhala ndi chomangira cha endocyclic mu mphete ya heterocyclic. Chifukwa cha gliclazide m'magazi, kuchuluka kwa glucose kumachepa, ndipo insulin secretion imalimbikitsidwa ndi maselo a beta a islets a Langerhans.

Kuchuluka kwa C-peptide ndi insulin ya postprandial imapitirira 2 years atalandira chithandizo.

Kudya shuga kwamitundu yachiwiri ya shuga, mukamamwa mankhwalawa, kumathandizira kubwezeretsa pachimake cha insulin ndikulimbitsa gawo lake lachiwiri. Katulutsidwe amakula kwambiri ndi shuga.

Kuchuluka kwa C-peptide ndi insulin ya postprandial imapitirira 2 years atalandira chithandizo.

Imakhala ndi hemovascular effect. Chithandizo chogwira ntchito chimakhudza njira zomwe zimathandizira kukulitsa zovuta za matenda ashuga, monga:

• kuchepa kwa ndende ya thromboxane B2 ndi beta-thromboglobulin activation;
• zoletsa zosakwanira zomata ndi kuphatikizika kwa zinthu izi.

Imalimbikitsa ntchito ya minofu plasminogen activator ndi kubwezeretsa kwa fibrinolytic ntchito ya mtima endothelium.

Pharmacokinetics

Kuyamwa kwathunthu kwa yogwira amapezeka pambuyo kumeza mankhwala, kaya kudya. Pali kuwonjezeka pang'onopang'ono kwa ndende ya plasma maola 6 oyamba. Kukonzanso kwamapulogalamuwa ndi maola 6-12. Kusalolera kwamunthu payekha.

Mpaka 95% yazinthu zomwe zimagwira ntchito zimagwirira pamapuloteni a plasma. Kuchuluka kwa magawa ndi malita 30. Kutenga piritsi 1 patsiku kumasunga ndende ya gliclazide m'magazi koposa tsiku.

Metabolism imachitika makamaka m'chiwindi.

Metabolism imachitika makamaka m'chiwindi. Palibe metabolites yogwira mu plasma. Ma metabolabol omwe amachotsedwa makamaka ndi impso, ochepera 1% - osasinthika. Kutha kwa theka-moyo ndi maola 12-20.

Zizindikiro zogwiritsidwa ntchito

Mankhwala wololedwa pakamwa potsatira milandu:

• Pamaso pa matenda a shuga a 2 omwe amakhala ndi mphamvu yochepa yochokera pakudya, zolimbitsa thupi ndi kuchepa thupi;
• popewa mavuto: kwambiri glycemic kuwunika momwe odwala alili kuti achepetse kuchepetsedwa kwa micro- (retinopathy, nephropathy) ndi macrovascular zotsatira (stroko, myocardial infarction).

Diabeteson MV ndi mankhwala pamaso pa mtundu 2 matenda a shuga ndi otsika dzuwa la ntchito zakudya, zolimbitsa thupi ndi kuwonda.

Contraindication

Mankhwala sanatchulidwe zotsatirazi milandu:

• Hypersensitivity kwa gliclazide ndi zina za mankhwala, kuphatikizapo kuti sulfonamides;
• mtundu 1 shuga;
• kutenga miconazole;
• mimba ndi mkaka wa m`mawere;
• matenda a shuga ndi chikomokere;
• kukanika kwa hepatic kapena aimpso;
• matenda ashuga ketoacidosis.

Mankhwala amadziwikanso ndi ana.

Iwo ali osavomerezeka ntchito odwala glucose-galactose malabsorption, galactosemia, kobadwa nawo lactose tsankho.

Ndi chikomine cha matenda ashuga, mankhwalawa sanalembedwe.

Nthawi ya bere, kuikidwa kwake kumatsutsana.

Ndi chidakwa, mankhwalawa ayenera kumwedwa mosamala.

Mukalamba, Diabeteson CF iyenera kumwedwa mosamala.

Ndi chisamaliro

Chenjezo lomwe mankhwalawa amagwiritsidwa ntchito:

• uchidakwa;
• pituitary kapena adrenal, aimpso kapena chiwindi kulephera;
• kusowa kwa shuga-6-phosphate dehydrogenase;
• mtima matenda;
• ntchito kwa nthawi yayitali a glucocorticosteroids;
• Zakudya zopanda malire kapena zosasamalidwa;
• ukalamba.

Momwe mungatenge diabeteson MV?

Mlingo wa tsiku ndi tsiku ndi 0,5-2 mapiritsi 1 nthawi patsiku. Mapiritsiwo amamezedwa kwathunthu popanda kuphwanya ndi kutafuna.

Mapiritsiwo amamezedwa kwathunthu popanda kuphwanya ndi kutafuna.

Ziphaso zomwe zikusowa sizimalipira kuchuluka kwa kuchuluka kwa madyerero otsatirawa.

Mlingowo umatsimikiziridwa ndi dokotala kutengera mulingo wa HbA1c ndi shuga ya magazi.

Chithandizo ndi kupewa matenda ashuga

Yambani chithandizo ndi piritsi la ½. Ngati chiwongolero chokwanira chikuchitika, ndiye kuti mankhwalawa akukwanira kuti akonzedwe. Ngati glycemic control ilibe vuto, mankhwalawa amawonjezeka ndi 30 mg pambuyo pa mwezi umodzi wambiri wa kumwa mankhwalawo pokhapokha ngati mankhwala ataperekedwa kale, kusiyapo odwala omwe matendawa a glucose sanatsike pambuyo pa maphunziro a milungu iwiri. Kwa chomaliza, mlingo umakulitsidwa patatha masiku 14 kuyambika kwa makonzedwe.

Mlingo wambiri watsiku ndi tsiku ndi 120 mg.

Yambani chithandizo ndi piritsi la ½.

Kwa odwala omwe ali pachiwopsezo cha kukhala ndi hypoglycemia, mlingo wocheperako (mapiritsi a 0.5) ndi omwe amapatsidwa.

Pofuna kupewa zovuta za matenda ashuga, mlingo wa mankhwalawa umakulitsidwa pang'onopang'ono kufika pa 120 mg / tsiku. Kumwa mankhwalawo kumayendetsedwa ndi zochitika zolimbitsa thupi ndi zakudya mpaka gawo la HbA1c lifike. Mankhwala, mankhwalawa amatha kugwiritsidwa ntchito:

• Insulin
• alpha glucosidase inhibitor;
• zotumphukira za thiazolidatedione;
• Metformin.

Kumwa mankhwalawo kumaperekedwa ndi zakudya.

Ntchito Yomanga

Wopanga thupi amafunikira maphunziro a insulini kuti achepetse thupi. Mu masewerawa, ndiwotchuka chifukwa chakuti:

• kugulitsidwa mwaulere m'masitolo am'magazi;
• sizimabweretsa ngozi;
• imakhala yofatsa thupi.

Kugwiritsa ntchito mankhwalawa kuyenera kuphatikizidwa ndi zakudya zabwino kwambiri za othamanga. Ndikofunika kuphika kapena kuphika. Mankhwala amatengedwa pa chopanda kanthu m'mimba theka la ola musanadye. Osamadya chakudya mukamaphunzitsidwa ndi ± ola limodzi musanaphunzire komanso mutatha.

Mankhwalawa amatengedwa katatu patsiku. Mlingo umatsimikiziridwa ndi kuchuluka kwa othamanga. Kuchulukitsa kumayambitsa kudya kwambiri, tk. Kuchepetsa shuga kumafunikira chindalama mu chakudya chamafuta ambiri.

Wopanga thupi amafunikira maphunziro a insulini kuti achepetse thupi.

Zotsatira zoyipa

Mukamagwiritsa ntchito gliclazide, monga mankhwala ena a sulfonylurea, mankhwalawa angayambitse hypoglycemia mukadumpha zakudya kapena zosemphana ndi zina. Zizindikiro zotsatirazi zadziwika:

• bradycardia;
• kupuma kosakhazikika;
• kumverera kosowa thandizo;
• kulephera kuzindikira ndi chitukuko cha chikomokere ndi chiopsezo cha kufa;
• Chizungulire
• kukokana
• kutopa;
• kufooka
• paresis;
• kugwedezeka
• kulephera kudziletsa;
• kusawona bwino ndi kuyankhula;
• aphasia;
• Kukhumudwa
• idachepetsa chidwi;
• chisokonezo cha chikumbumtima;
• wokongola
• kusokonekera;
• kusanza ndi kusanza
• chisokonezo cha kugona;
• kumverera kochulukirapo kwa njala;
• mutu.

Ngakhale kumwa mankhwala kungayambitse nseru, kusanza.

Diabeteson MB ikhoza kuyambitsa zovuta kugona.

Mankhwala angayambitse chizungulire.

Mankhwalawa amatha kupweteketsa mutu.

Zotsatira za adrenergic zimanenedwanso:

• angina pectoris;
• arrhythmia;
• Kuda nkhawa
• tachycardia;
• palpitations
• kuthamanga kwa magazi;
• khungu la chithaphwi;
• Hyperhidrosis.

Kuyesedwa kwa Laborator kunazindikira kuti kuphwanya chiwindi ndi ntchito ya chitukuko cha cholestasis ndikotheka.

Zizindikiro za matendawa zimaletsa kudya zakudya zamafuta. Kutenga zotsekemera sikugwira ntchito. Sitikulimbikitsidwa kuti mutenge zotengera zina za sulfonylurea.

Zotsatira zoyipa za mankhwalawa zimapweteketsa mtima.

Diabeteson CF imakhala yovuta.

Diabeteson MV imatha kuyambitsa kuthamanga kwa magazi.

Matumbo

Kuti muchepetse zotsatira zoyipa, muyenera kumwa mankhwalawa pakudya cham'mawa. Izi zikuphatikiza:

• kusanza ndi kusanza
• kudzimbidwa
• kutsegula m'mimba
• kupweteka kwam'mimba.

Hematopoietic ziwalo

Zosawonetseka kwambiri:

• granulocytopenia;
• leukopenia;
• thrombocytopenia
• kuchepa magazi

Makamaka kusinthidwa pakukwaniritsidwa kwa mankhwalawo.

Diabeteson MB imatha kupweteka m'mimba.

Pakati mantha dongosolo

Otsatirawa akuti:

• kuzindikira kwa chilengedwe;
• chizungulire chachikulu.

Kuchokera kwamikodzo

Osadziwika.

Pa mbali ya ziwalo zamasomphenya

Zosokoneza zowoneka ndizotheka ndikusintha kwa shuga m'magazi. Zodziwika kwambiri za nthawi yoyamba ya chithandizo.

Ngati musintha shuga m'magazi anu pomwa mankhwalawo, mawonekedwe anu a m'maso amatha kusokonezeka.

Pa khungu

Zowonekera:

• Stevens-Johnson syndrome;
• erythema;
• Edema ya Quincke;
• kuyabwa
• poermal necrolysis yoopsa;
• zotupa, incl. maculopapullous;
• urticaria.

Pa mbali ya chiwindi ndi biliary thirakiti

Otsatirawa akuti:

• matenda a chiwindi;
• kuchuluka kwa chiwindi michere (zamchere phosphatase. AST, ALT).

Chithandizo chimasiya pamene chodwala matenda a cholestatic jaundice chachitika.

Nthawi zina, chiwindi chimatha kuthandizidwa ndi Diabeteson MV.

Malangizo apadera

Mankhwalawa amaperekedwa kwa odwala omwe amadya zakudya zamafuta ochulukirapo nthawi zonse ndi chakudya cham'mawa. Maonekedwe a hypoglycemia amathandizidwa ndi:

• zolimbitsa thupi nthawi yayitali;
• kumwa mankhwala angapo a hypoglycemic nthawi imodzi;
• Zakudya zochepa zopatsa mphamvu;
• mowa.

Zizindikiro zoyimitsa siziletsa kuyambiranso. Ndi zizindikiro zazikulu, wodwala amapezeka kuchipatala.

Chiwopsezo cha hypoglycemia chikuwonjezereka ndi:

• bongo;
• aimpso ndi kwambiri chiwindi kulephera;
• adrenal ndi pituitary kusakwanira;
• matenda a chithokomiro;
• kusagwirizana pakati pa kuchuluka kwa chakudya chotengedwa ndi zolimbitsa thupi;
• munthawi yomweyo mankhwala angapo ogwira ntchito;
• kulephera kwa wodwalayo kuthana ndi vuto lakelo;
• Kusintha kwa kadyedwe, kulumpha chakudya, kusala, kusakhazikika komanso kuperewera kwa m'thupi.

Chiwopsezo cha hypoglycemia chikuwonjezeka ndi matenda a chithokomiro.

Kuyenderana ndi mowa

Ngati uchidakwa umayikidwa mosamala. Kumwa mowa kumayambitsa glycemia.

Zokhudza mphamvu pakuwongolera njira

Odwala amauzidwa za hypoglycemia. Ayenera kusamala pochita zinthu zomwe zimafuna kuti munthu azitsatira komanso kuthamanga kwa ma psychomotor zimachitikira, makamaka pamagawo oyambira a chithandizo.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Zambiri pazomwe zimagwiritsidwa ntchito pazomwe zimagwiritsidwa ntchito pathupi sizipezeka. Poyeserera nyama, palibe teratogenic zotsatira zomwe zapezeka.

Ndi mimba yomwe munakonzekera ndi kuyambika kwake pamankhwala, tikulimbikitsidwa kuti m'malo mwa hypoglycemic yothandizira pakamwa.

Chifukwa cha kusowa kwa chidziwitso cha kudya kwa yogwira mkaka wa m'mawere, kumwa mankhwalawa panthawi yoyamwitsa kumatsutsana.

Zambiri pazomwe zimagwiritsidwa ntchito pazomwe zimagwiritsidwa ntchito pathupi sizipezeka.

Kupangira Diabeteson MV kwa ana

Palibe zambiri pazokhudza mankhwalawa kwa ana aang'ono.

Gwiritsani ntchito mu ukalamba

Mphamvu zazikulu za paracokinetic magawo okalamba sizinawonedwe.

The ntchito aimpso kuwonongeka

Kulephera kwambiri kwaimpso, insulin imalimbikitsidwa. Mu magawo ofewa komanso olimbitsa a matenda awa, mlingo sasinthidwa.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Otsatiridwa kwambiri chiwindi kulephera.

Kulephera kwambiri kwaimpso, insulin imalimbikitsidwa.

Bongo

Ngati mulingo wambiri, hypoglycemia imayamba. Ngati zizindikiro zoyenera za matendawa zikuwoneka popanda zizindikiro za mitsempha komanso chikumbumtima chovulala, onjezerani chakudya chamagulu ochulukirapo mu chakudya, sinthani zakudya ndi / kapena muchepetseni mlingo.

Mitundu ikuluikulu ya mikhalidwe ya hypoclycemic, yodziwika ndi zovuta zingapo zamitsempha, kuphatikizapo kukhumudwa ndi chikomokere, zomwe zimafuna kuchipatala mwachangu.

Ngati hypoglycemic coma kapena kuyambika kwake kukayikiridwa, yankho la glucose 20-30% mu voliyumu ya 50 ml limaperekedwa kwa wodwalayo kudzera m'mitsempha. Kuti mukhale ndi shuga m'magazi pamwamba pa 1 g / l, njira ya 10% dextrose imayendetsedwa. Kwa maola 48, mkhalidwe wa wodwalayo umayang'aniridwa, pambuyo pake dokotala akuganiza zofunikira pakuwunikanso.

Kutsegula m'mimba sikuyenda bwino, chifukwa zinthu zomwe zimagwira ntchito zimaphatikizidwa ndi mapuloteni a plasma.

Ngati mulingo wambiri, hypoglycemia imayamba.

Kuchita ndi mankhwala ena

Ndikofunikira kuganizira kuphatikiza kwa mankhwalawa ndi ma anticoagulants, popeza atatengedwa, mphamvu yotsirizira imatha.

Kuphatikiza kophatikizidwa

Miconazole imayambitsa kukomoka kwa hypoglycemic mukamagwiritsa ntchito gel osakaniza pakamwa komanso kutsata kwadongosolo.

Osavomerezeka kuphatikiza

Izi zikuphatikiza:

1. Phenylbutazone ndi zokhudza zonse makonzedwe chifukwa kuchuluka hypoglycemic kwenikweni. Ndikwabwino kugwiritsa ntchito mankhwala ena motsutsana ndi kutupa.
2. Ethanol, yomwe imakulitsa hypoglycemia mpaka kukula kwa chikomokere. Kukana ndikofunikira osati kokha kuchokera ku mowa, komanso ku mankhwala omwe ali ndi ichi.
3. Danazole - amathandiza kuwonjezera kuchuluka kwa shuga m'magazi.

Danazole - amathandiza kuwonjezera kuchuluka kwa shuga m'magazi.

Kuphatikiza komwe kumafunikira kusamala

Izi zimaphatikizapo kuphatikiza kwa mankhwalawa ndi mankhwala ena. Wonjezerani chiopsezo cha hypoglycemia:

• beta-blockers;
• othandizira ena a hypoglycemic: Insulin, Acarbose, agonists a GLP-1, thiazolidinidione, Metformin, dipeptidyl peptidase-4 zoletsa;
• Fluconazole;
• MAO ndi ACE zoletsa;
• histamine H2 receptor blockers;
• sulfonamides;
• NSAIDs
• Clarithromycin

Kuchuluka kwa shuga wamagazi:

• Chlorpromazine mu Mlingo wambiri;
• glucocorticosteroids;
• Terbutaline, Salbutamol, Ritodrin ndi mtsempha wamkati.

Maninil ndizofanizira zamankhwala a Diabeteson MV.

Analogs a Diabeteson MV

Izi zikuphatikiza:

• Maninil;
• Gliclazide MV;
• Glidiab;
• Glucophage;
• Diabefarm MV.

Substitital amagwiritsidwa ntchito atatha kufunsa dokotala.

Zomwe zili bwino: Diabetes kapena Diabeteson MV?

Diabeteson MV imasiyana ndi Diabeteson pamlingo wamasulidwa a yogwira ntchito. "MV" ndi kumasulidwa kosinthidwa.

Nthawi ya mayamwidwe a glycoside ku Diabeteson siopitilira maola 2-3. Mlingo - 80 mg.

CF imatengedwa 1 nthawi patsiku, imakhala yofatsa, chiopsezo cha hypoglycemia ndi chocheperako.

Diabeteson MV imasiyana ndi Diabeteson pamlingo wamasulidwa a yogwira ntchito.

Kupita kwina mankhwala

Mankhwala (Diabeteson MR mu Chilatini) ndi mankhwala.

Mtengo wa Diabeteson MV

Mtengo wapakati ndi ma ruble 350.

Zosungidwa zamankhwala

Pamalo osafikirika ndi ana, pamawonekedwe osaposa + 25 ° C.

Tsiku lotha ntchito

Zaka 2

Wopanga

1. "Laboratories Serviceier Service", France.
2. Serdix LLC, Russia.

Ndemanga za Diabeteson MV

Madokotala

Shishkina E.I., Moscow

Kuchita bwino ndikokwera. Zotsatira zoyipa sizimawonedwa. Imayamba kuchitapo kanthu mwachangu. Mankhwala abwino a shuga.

Anthu odwala matenda ashuga

Diana, wazaka 55, Samara

Dotolo adakhazikitsa 60 ml / tsiku, koma m'mawa kupezeka kwa glucose kunali 10-13. Ndi kuchuluka kwa mapiritsi 1.5 mapiritsi, mmawa watsika mpaka 6 mm. Kuchita masewera olimbitsa thupi pang'ono komanso zakudya kumathandizanso.