Baeta (Byetta) ndi othandizira a hypoglycemic omwe angagwiritsidwe ntchito pochiza matenda amtundu wa 2 ngati mankhwala amodzi kapena kuphatikiza ndi mankhwala ena omwe ali ndi vuto lofananalo. Chithandizo chatsopano chamankhwala chatsopanochi chimakupatsani mwayi wolamulira kuchuluka kwa shuga m'magazi, ndikuwongolera chilimbikitso cha wodwalayo komanso kulemera kwa thupi.
Dzinalo Losayenerana
INN Bayeta - Exenatide.
Baeta ndi hypoglycemic wothandizira kupangira matenda amtundu wa II shuga, mankhwala othandiza kwambiri popanga mankhwala.
ATX
Mankhwalawa ndi a gulu la mankhwala opanga ma hypoglycemic othandizira othandizira matenda a shuga a insulin, ndipo ali ndi code ya AXX ya A10X.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka mu mawonekedwe a jekeseni wothandizidwa ndi subcutaneous makonzedwe. Ndi madzi owoneka bwino, opanda mtundu ndi fungo. Yake yogwira mankhwala exenatide imakhala ndi 250 μg pa 1 ml ya yankho. Udindo wa zosungunulira umaseweredwa ndi madzi a jakisoni, ndipo kudzazidwa kothandizira kumayimiriridwa ndi metacresol, sodium acetate trihydrate, acetic acid, ndi mannitol (zowonjezera E421).
Njira yothetsera 1.2 kapena 2.4 ml imathiridwa m'makalata agalasi, omwe amayikidwa mu cholembera cha syringe - analogue ya jakisoni wa insulin. Katakitala wakunja. Pali syringe imodzi yokha ndi mankhwala m'bokosi.
Kukonzekera kosasunthika kosasinthika kumapezeka komwe kumapezeka mu ufa wa fomu pokonzekera osakaniza oyimitsidwa. Mafuta omwe amayamba amagwiritsidwanso ntchito ngati jekeseni wa subcutaneous. Dongosolo la ufa (2 mg) limathiridwa mu cartridge yomwe imayikidwa mu cholembera. Chithunzichi chimaphatikizira chosakanikirana ndi malangizo.
Bayeta ndi kapu yamagalasi yokhala ndi jakisoni wovulaza wa subcutaneous makonzedwe, yoyikidwa mu ma syringes otayika.
Zotsatira za pharmacological
Zotsatira za mankhwalawa zimaperekedwa ndi ntchito ya exenatide (exendin-4).
Chipangizo chopangira ichi ndi unyolo wa amino peptide wopanga zinthu 39 za amino acid.
Izi ndi mawonekedwe a enteroglucagon, mahomoni a peptide omwe amapezeka m'thupi la munthu, omwe amatchedwanso glucagon-peptide-1, kapena GLP-1.
Ma insretins amapangidwa ndi maselo a kapamba ndi matumbo pambuyo chakudya. Ntchito yawo ndikuyambitsa insulin katulutsidwe. Chifukwa cha kufanana kwake ndi zinthu zamafuta izi, exenatide imakhudzanso thupi. Kuchita ngati GLP-1 mimetic, ikuwonetsa zochizira zotsatirazi:
- imalimbikitsa kutulutsa kwa insulin ndi ma pancreatic β-cell ndi kuwonjezeka kwa plasma glucose;
- Amachepetsa katulutsidwe wa glucagon, osasokoneza zomwe hypoglycemia imachita;
- amaletsa ntchito yam'mimba, ndikuchepetsa;
- amawongolera kudya;
- amachepetsa kuchuluka kwa chakudya;
- amalimbikitsa kuchepa thupi.
Mtundu wachiwiri wa matenda ashuga, pancreatic β-cell ntchito imalephera, zomwe zimapangitsa kuti insulin itulutsidwe. Exenatide amakhudza magawo onse a insulin secretion. Koma panthawi imodzimodzi, kukula kwa ntchito ya β-maselo oyambitsidwa ndi iye amachepetsa ndi kuchepa kwa ndende ya glucose. Kudya kwa insulin kumayima panthawi yomwe index ya glycemic ibwerera mwachizolowezi. Chifukwa chake, kuyambitsa mankhwala omwe akufunsidwa kumachepetsa mwayi wokhala ndi hypoglycemia.
Kafukufuku wachipatala awonetsa kuti chithandizo choterechi chimapereka mwayi wowongolera shuga wamagazi mwa odwala omwe ali ndi matenda a shuga a 2.
Pharmacokinetics
Pambuyo pa utsogoleri wa Baeta mwanjira ya jakisoni wansinga, mankhwalawo amayamba kulowetsedwa m'magazi, mpaka kufika pakufika msanga pafupifupi maola awiri.
Chiwerengero chonse cha exenatide chimawonjezeka molingana ndi kuchuluka kwa mlingo womwe umalandiridwa mu 5-10 μg.
Mankhwala Baeta amafika pakukweza kwake m'magazi 2 pambuyo pa kuponderezedwa ndipo amachotsedwa m'thupi pakatha maola 10.
Kusintha kwa mankhwalawa kumachitika ndi zida za impso, michere ya proteinolytic imathandizira kagayidwe kake. Zimatenga pafupifupi maola 5 kuti muchotse gawo lalikulu la mankhwalawo m'thupi, mosasamala Mlingo womwe umagwiritsidwa ntchito. Kuyeretsa kwathunthu kwa thupi kumatenga maola 10.
Zizindikiro zogwiritsidwa ntchito
Mankhwala akuwonetsedwa kuti akakonzedwa mokwanira m'magazi a shuga. Byetu angagwiritsidwe ntchito ngati mankhwala a hypoglycemic a monotherapy. Kuchita jakisoni koteroko kumathandiza ngati chakudya choyenera chikutsatiridwa ndikuchita zolimbitsa thupi nthawi zonse.
Mankhwalawa atha kuphatikizidwa mu maphunziro ophatikizika ndi kusakwanira kwa mankhwalawa ndi ena antiglycemic othandizira. Kuphatikiza zingapo kwa mankhwala ndi Bayeta ndikuloledwa:
- Sulfonylurea derivative (PSM) ndi Metformin.
- Metformin ndi Thiazolidinedione.
- PSM yokhala ndi Thiazolidinedione ndi Metformin.
Malingaliro oterewa amatsogolera kuchepa kwa kuthamanga kwa shuga m'magazi ndikatha kudya, komanso glycemic hemoglobin, yomwe imakweza kuwongolera kwa glycemic kwa odwala.
Bayeta imalembedwa kuti ikonzedwe kokwanira ka glycemic, ndipo itha kugwiritsidwanso ntchito ngati monotherapy.
Contraindication
Mankhwala sangathe kugwiritsidwa ntchito ngati matenda a shuga 1. Zotsutsa zina:
- kuchuluka kosavuta kutulutsa;
- tsankho ku zowonjezera zowonjezera;
- ketoacidosis;
- kuwonongeka kwa chakudya cham'mimba, limodzi ndi kuchepa kwa ntchito ya minofu ya m'mimba;
- yoyamwitsa kapena pakati;
- kulephera kwambiri kwaimpso;
- wazaka 18.
Kuyamwitsa ndi imodzi mwazinthu zotsutsana pakugwiritsa ntchito mankhwala a Bayet.
Kutenga bayetu?
Dokotala ali ndi udindo wopereka mankhwalawo, kudziwa kuchuluka kwa Mlingo komanso kuyang'anira wodwala yemwe ali ndi matenda ashuga. Ndikulimbikitsidwa kwambiri kuti musamadzipewe mankhwala omwe mumalandira.
Jekeseni imayendetsedwa pansi pakhungu pakhungu, chachikazi kapena pamimba. Tsamba la jakisoni la mankhwalawa silikuwonetsa kukhudzika kwake.
Poyamba, mlingo umodzi ndi 0,005 mg (5 μg). Jakisoni amaperekedwa musanadye chakudya cham'mawa komanso chamadzulo. Kusiyana kwakanthawi pakati pa kukhazikitsidwa kwa mankhwalawa ndi chiyambi cha chakudya sikuyenera kupitirira 1 ora.
Pakati pa zakudya zazikulu, zomwe zimagwirizanitsidwa ndi kugwiritsa ntchito mankhwalawa, osachepera maola 6 ayenera kudutsa.
Pakatha mwezi umodzi chithandizo, limodzi mlingo umatha kuwirikiza. Jakisoni wosaiwalika sikutanthauza kuchuluka kwa mankhwalawa ndi kuperekera kwa mankhwala. Mukatha kudya Bayetu sayenera kudulidwa.
Momwemonso kugwiritsidwa ntchito kwa mankhwalawa pofunsa ndi sulfonylurea kukonzekera, adokotala amatha kuchepetsa kuchuluka kwa zotsatira zakumapeto chifukwa chakukula kwa vuto la hypoglycemic. Chithandizo chophatikiza ndi Thiazolidinedione ndi / kapena Metformin sichitengera kusintha kwa Mlingo woyamba wa mankhwalawa.
Zotsatira zoyipa
Zotsatira zoyipa zomwe zimachitika chifukwa cha exenatide zimakhala zolimbitsa thupi ndipo sizifuna kuti discontinuation ya mankhwala (kupatula zina). Nthawi zambiri, pamayambiriro a mankhwalawa ndi Bayeta wokhala ndi mulingo wa 5 mg kapena 10 mg, nseru imawonekera, yomwe imadutsa yokha kapena mutasintha mlingo wa mankhwalawa.
Kuchepetsa mphuno ndi njira zoyipa zomwe Bayeta amachita, nthawi zambiri zimawonekera koyamba pa chithandizo.
Matumbo
Nthawi zambiri, odwala amakhala ndi vuto logaya m'mimba. Odwala amadandaula za nseru, kuchepa kwa chilala, kusanza, kukanika, kupweteka kwam'mimba. Kutheka Reflux, maonekedwe a belching, flatulence, kudzimbidwa, kuphwanya kwa kuzindikira kwa kukoma. Milandu ingapo ya kapamba owopsa amadziwika.
Hematopoietic ziwalo
Akaphatikizidwa ndi warfarin, magazi amawundana. Milandu yokhudza magazi yanenedwapo.
Pakati mantha dongosolo
Nthawi zambiri odwala amakhala ndi migraines. Amatha kumva chizungulire kapena kusowa tulo masana.
Kuchokera kwamikodzo
Kuwonongeka kwa impso, kuwonjezereka kwa odwala omwe apezeka ndi vuto laimpso, kulumpha kwa serum creatinine.
Pa khungu
Pamalo jakisoni, zizindikiro zoyipa zitha kuonedwa.
Matupi omaliza
Thupi lawo siligwirizana n`zotheka mawonekedwe a khungu totupa, kuyabwa, redness, kutupa. Mawonekedwe a anaphylactic samawonedwa kawirikawiri.
Khungu la Itchy limakhala losavomerezeka pakugwiritsa ntchito mankhwala a Bayet.
Zokhudza mphamvu pakuwongolera njira
Kafukufuku wapadera panjira iyi sanachitike. Iyenera kuganizira njira yomwe ingayambire hypoglycemia pophatikiza mankhwalawa ndi basal Insulin kapena PSM ndikuchita njira zodzitetezera.
Malangizo apadera
Ngati mtundu, mawonekedwe, kapena kufanana kwa jakisoni wamadzi wasintha, sungagwiritsidwe ntchito. Muyenera kutsatira njira yoyenera yothandizira mankhwalawa. Jekeseni sakutchulidwa mu intramuscularly kapena kudzera m'mitsempha.
Kuzindikira kwamlingo kapena kuchepa thupi kwa wodwalayo sikuti kukuwonetsani kuti mukumwa mankhwala osokoneza bongo, kusintha kwa mlingo wake komanso pafupipafupi pakugwiritsa ntchito.
Potengera kuyambitsa kwa exenatide, ma antibodies amatha kupangidwa mthupi. Izi sizikhudza kuwonekera kwa zizindikiro zammbali.
Gwiritsani ntchito mu ukalamba
Mankhwala a pharmacokinetics samatengera zaka za odwala. Chifukwa chake, palibe chifukwa chosinthira mlingo wa okalamba.
Kukalamba sikukulepheretsa kugwiritsa ntchito mankhwala a Bayet, komanso sikutanthauza kusintha kwa mankhwalawa.
Kupatsa ana
Mphamvu ya exenatide m'thupi la ana sinaphunziridwe, kuchuluka kwa mphamvu yake komanso kuchuluka kwa chitetezo kwa ana ndi achinyamata sikudziwika. Chifukwa chake, malire azaka zogwiritsira ntchito mankhwalawa ndi zaka 18.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Pa nthawi yobala mwana komanso nthawi yodyetsa zachilengedwe, mankhwalawa saikidwa kwa amayi.
The ntchito aimpso kuwonongeka
Ngati kulephera kwa impso ndi kofatsa kapena pang'ono, ndiye kuti muyezo wa mankhwalawo suyenera kusinthidwa (mulingo woyenera umagwiritsidwa ntchito).
Ndi pathologies yayikulu, chilolezo chitha kuchepetsedwa mpaka 10, chifukwa chake, Bayete sinafotokozeredwe odwala.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Chifukwa chakuti nkhawa yayikulu yothetsa exenatide imagwera impso, zolakwika za chiwindi kapena chikhodzodzo sindikuwunikira chifukwa chogwiritsa ntchito mankhwalawa ndipo sikuti akuletsa ziletso.
Kulephera kwa chiwindi kapena chikhodzodzo sindikuchita zotsutsana ndi mankhwalawa.
Mankhwala osokoneza bongo a Byeta
Kugwiritsa ntchito Mlingo wambiri wa exenatide kumabweretsa hypoglycemia. Poterepa, jakisoni kapena dontho la glucose limafunikira. Zizindikiro za bongo:
- kulumikizana;
- kusanza
- shuga wa m'madzi ochepa;
- pallor of integument;
- kuzizira;
- mutu
- thukuta
- arrhythmia;
- mantha
- kuchuluka kwa kuthamanga kwa magazi:
- kugwedezeka.
Arrhythmia ndi chimodzi mwazizindikiro za Bayet.
Kuchita ndi mankhwala ena
Sakanizani yankho ndi mankhwala ena a jakisoni mu syringe imodzi yoletsedwa.
Muyenera kukumbukira kutsika kwam'mimba pansi pa zochita za exenatide mukamamwa mankhwala osokoneza bongo mkati, chifukwa kuchuluka kwa mayamwidwe ndi mayamwidwe kumatha kuchepetsedwa kwambiri. Ndalama zotere ziyenera kutengedwa nthawi yayitali asanakhazikitsidwe kwa Byeta, nthawi yocheperako ndi ola limodzi. Ngati mankhwalawa amafunika kumwa ndi chakudya, ndiye kuti ayenera kukhala chakudya chomwe sichimalumikizidwa ndi jakisoni wa wothandizila wa hypoglycemic.
Proton pump zoletsa ayenera kumwedwa patatha maola 4 jekeseni kapena ola limodzi lisanachitike.
Pogwiritsa ntchito warfarin kapena kukonzekera kwanyanjayi, kuwonjezeka kwa nthawi ya prothrombin ndikotheka. Chifukwa chake, kuphatikizika kwa magazi kuyenera kuyendetsedwa.
Ngakhale kugwiritsidwa ntchito kophatikizana kwa Bajeta ndimankhwala omwe amalepheretsa kuchepa kwa HMG-CoA sikuyambitsa kusintha kwakukulu pakuphatikizika kwa magazi, tikulimbikitsidwa kuwunikira cholesterol.
Kuphatikiza kwa mankhwalawa komwe kumafunsidwa ndi Lisinopril sikuyambitsa kusintha kwa kuthamanga kwa magazi kwa wodwala.
Kuphatikiza kwa jakisoni ndi makonzedwe apakamwa pokhudzana ndi kulera kwapakamwa sikutanthauza kusintha kwa mlingo.
Sikoyenera kuti muzisamalira panjira zapakati pa jekeseni la Bayeta ndikumwa mankhwala - omwe amachokera ku sulfanylurea.
Ndi kaphatikizidwe / kayendedwe kamodzi ka Bayeta ndi Warfarin, ndikofunikira kuti magazi azisokonekera.
Kuyenderana ndi mowa
Ndikosayenera kumwa mowa kapena mankhwala akumwa.
Analogi
Pali mitundu iwiri yokha ya mankhwala - Exenatide ndi Baeta Long. Otsatirawa a hypoglycemic ali ndi zotere:
- Victoza;
- Attokana;
- Guarem;
- Novonorm;
- Jardins et al.
Generic Baeta - Bydureon (Bydureon).
Victoza ndi othandizira a hypoglycemic omwe amakhalanso ndi Bayeta.
Kupita kwina mankhwala
Palibe mwayi waulere kwa mankhwalawa.
Kodi ndingagule popanda kulandira mankhwala?
Mutha kugula Baeta mu pharmacy kokha mwa mankhwala.
Mtengo
Mtengo wa mankhwalawa ndi 1.2 ml - kuchokera ku ma ruble 5339.
Zosungidwa zamankhwala
Mankhwalawa amayenera kusungidwa m'malo osavomerezeka kwa ana, kutentha kwa + 2 ... + 8 ° C, kupewa kuzizira.
Tsiku lotha ntchito
Mwanjira yake yoyambirira, mankhwalawa amasungidwa kwa zaka ziwiri. Mukatsegula phukusi, liyenera kugwiritsidwa ntchito masiku 30.
Moyo wa alumali wa mankhwala a Bayeta ndi zaka 2 momwe zidalili kale ndipo masiku 30 atatsegula phukusi.
Wopanga
Dziko lomwe adalembedwako ndi Great Britain. Komabe, kupanga mankhwalawa kumachitika ndi kampani yopanga mankhwala ku India ya Macleods Pharmaceuticals Ltd.
Ndemanga
Alla, wazaka 29, Stavropol.
Gulani Baitu mayi. Zodula, koma zosavuta kugwiritsa ntchito. Poyamba, amayi ankadandaula kuti anali ndi vuto, koma posakhalitsa zinaleka. Shuga ndi okhazikika, chifukwa chake tidzapitiliza kugwiritsa ntchito mankhwalawa.
Veronika, wazaka 34, a Danilov.
Ndinkawerenganso malangizowa, ndinkaona kuti sindinasangalale nawo pamndandanda wazotsatira zoyipa. Pambuyo pa jakisoni ndidadwala. Ndinaopanso kupereka mlingo wotsatira. Koma mwamuna wanga adati ndadzinyenga ndekha. Amanena zoona. Jakisoni wotsatira sanalinso wopweteka kwambiri. Dokotalayo ananena kuti mulingo sayenera kugawidwa, ndipo pambuyo pake anawonjezera. Tsopano samadwaladwala, pokhapokha nthawi zina pamakhala kusokonezeka m'mimba.
Olga, wazaka 51, mzinda wa Azov.
Ndinayamba kugwiritsa ntchito mankhwalawa kuthandiza Metformin. Anadya m'masiku oyamba mwamphamvu - chikhumbo chake chinali chitatha.Kenako thupi linazolowera. Magawo adayamba kuchepa, koma chidwi chidayambiranso. Tsopano ndizachidziwikire chifukwa ku America Bayetu amalembera omwe akufuna kuchepa thupi.
