Mwanjira yam'mapiritsi, Novostat sapezeka, iyi ndi mtundu wa mankhwalawa omwe palibe. Zimapangidwa kokha ngati mawonekedwe a makapisozi. Mankhwalawa ali ndi tanthauzo la hypolipidemic, amagwiritsidwa ntchito ngati mankhwala kusintha matenda a cholesterol komanso monga anti-sclerotic.
Mitundu yomwe ilipo ndi kapangidwe kake
Mankhwala amapezeka m'mapiritsi, zomwe zimagwira ntchito mwa iwo ndi atorvastatin calcium calcium.
Thupi la makapisozi ndi loyera komanso lolimba, chivindikirocho chimakhala ndi mtundu wachikasu. Gawo lalikulu limapezeka mu 10, 20, 40 kapena 80 mg. Kuphatikizidwa kwina kumayimiriridwa ndi lactose monohydrate, sodium lauryl sulfate, cellulose, calcium carbonate, povidone ndi magnesium stearate. Kashiamuyo imapangidwa ndi gelatin ndi kuwonjezera kwa titanium dioxide ndi utoto wa E172.
Mapaketi am'm cell ali ndi makapisozi 10 ndipo amagawidwa m'mabokosi kuchuluka kwa matuza atatu.
Mapaketi am'm cell ali ndi makapisozi 10 ndipo amagawidwa m'mabokosi kuchuluka kwa matuza atatu. Makapu amatha kugulitsidwa mumitsuko ya pulasitiki ya 10, 20, 30, 40, 50, 60 kapena 100 ma PC. M'katoni mudayikidwa 1 yokhoza.
Dzinalo Losayenerana
INN ya mankhwalawa ndi Atorvastatin.
ATX
Mankhwalawa ali ndi code ya ATX ya C10AA05.
Zotsatira za pharmacological
Mphamvu yakuchiritsa ya Novostat imaperekedwa chifukwa cha gawo lomwe limagwira - atorvastatin. Pulogalamuyi ndi ya statins ndipo ikuwonetsa katundu wa hypocholesterolemic. Imalepheretsa ntchito ya HMG-CoA reductase, ngati mpikisano woletsa komanso kusankha kosankha. Ma enzyme omwe atchulidwa ndi chiyambi cha njira yodalirana ya sodium acid, imodzi mwazomwe zimachokera ku cholesterol.
Mphamvu yakuchiritsa ya Novostat imaperekedwa chifukwa cha gawo lomwe limagwira - atorvastatin.
Atorvastatin imathandizanso kuwonjezeka kwa chiwerengero cha hepatoreceptors enieni, zomwe zimatsogolera pakuwonjezeka kwa kuchepa kwa lowensens lipoproteins (LDL). Chifukwa cha mankhwalawa, ndende imagwa:
- cholesterol yathunthu - ndi 40% (pafupifupi);
- apoB - mwa 51%;
- LDL - ndi 42%;
- triglycerides - mwa 24%.
Nthawi yomweyo, kuwonjezeka kwa kukwera kwambiri kwa cholesterol-lipoproteins (HDL) ndi apoA kumadziwika.
Mankhwalawa ndi othandizanso kwa odwala omwe ali ndi vuto la homozygous la mabanja hypercholesterolemia, lomwe siligwirizana ndi zochita za mankhwala ena ochepetsa lipid. Chifukwa chotenga, mwayi wokhala ndi mikwingwirima, matenda ena amtima, ischemia yokhala ndi angina pectoris ndi vuto la mtima, kufa kwa mtima kumachepa. Palibe zowonongeka ndi mutagenic zomwe zidapezeka.
Pharmacokinetics
Atorvastatin amalowetsedwa m'mimba kwambiri, mpaka kufika pama plasma ambiri patatha maola 1-2 atawongolera, koma bioavailability sichidutsa 14% chifukwa cha malabsorption ndi chochitika choyamba. Pafupifupi 98% imamangiriza mapuloteni amwazi, motero hemodialysis ilibe ntchito. Pamaso pa chakudya, kuchuluka kwa mankhwala omwe amalowa m'magazi kumachepera.
Ndi kuwonongeka kwa chiwindi, kuchuluka kwa atorvastatin kumawonjezeka kwambiri.
Metabolism ya mankhwala amapezeka makamaka m'chiwindi. Malinga ndi ntchito ya pharmacological, ena mwa ma metabolites ake sakhala otsika poyerekeza ndi zinthu zoyambira - amatenga pafupifupi 70% ya zoletsa zomwe zimapangitsa kuti HMG-CoA ichulukenso. Ndi mkodzo, zosaposa 2% ya mlingo wotengedwa umachotsedwa.
Ndi kuwonongeka kwa chiwindi, kuchuluka kwa atorvastatin kumawonjezeka kwambiri. Hafu ya moyo wa mankhwalawa ndi maola 14, koma njira yothandizira achire imatha mpaka maola 30 mutatha kumwa 1 mlingo wa Novostat.
Zizindikiro zogwiritsidwa ntchito
Kuphatikiza pa mankhwala othandizira pakudya ndi masewera olimbitsa thupi, mankhwalawa amadziwitsidwa kuti apeze mphamvu ya ma hypolipidemic - kutsitsa cholesterol, LDL, kuwongolera kuchuluka kwa apolipoprotein B ndi mankhwala a triglyceride. Zisonyezero zogwiritsidwa ntchito:
- hypercholesterolemia (pulayimale, yodziwika kapena yotsutsana);
- hyperglyceridemia;
- kuphatikiza Hyperlipidemia:
- kuphwanya lipoprotein kagayidwe;
- dysproteinemia mtundu II (a ndi b);
- Fredrickson mtundu IV lipid matenda, owonetsa kukana zakudya;
- dysbetalipoproteinemia ndi zovuta zokhudzana ndi izi.
Chida china chikuyendetsedwa kupewetsa matenda amtima, mosasamala ndi mayendedwe a cholesterol:
- odwala matenda ashuga;
- osuta;
- odwala oopsa;
- odwala omwe ali ndi HDL yochepa;
- anthu omwe ali ndi chibadwa chofuna matenda a mtima.
Mankhwalawa amagwiritsidwanso ntchito kwa odwala omwe ali ndi hypercholesterolemia ndi kupewa kwachiwiri, kukwiya, kugunda kwa mtima, kutsekeka kwa mtima komanso kuchepetsa ngozi. Komanso, mankhwalawa adapangidwa ngati kuli koyenera, kuti achite njira zobwezeretsanso khoma la mtima (revascularization).
Contraindication
Mankhwalawa sayenera kumwedwa ndi hypersensitivity to atorvastatin, lactose tsankho kapena magawo ena a mankhwalawa. Zotsutsa zina:
- matenda a chiwindi
- kuchuluka kwa chiwindi michere;
- uchidakwa wambiri;
- matenda owopsa;
- kagayidwe kachakudya matenda;
- kufooka kwakuthupi;
- mimba ndi kuyamwitsa;
- zaka mpaka 10.
Novostat amaletsedwa ndi kufooka kwakuthupi.
Ndi chisamaliro
Kusamala makamaka kuyenera kuchitika pakakhala vuto la electrolyte, kusokonezeka kwa endocrine, mbiri yokhudza kukanika kwa hepatic. Sitikulimbikitsidwa kusankha Natostat kwa ana ndi achinyamata.
Momwe angatenge
Choyamba muyenera kuyesa kusintha cholesterol m'njira zina, komanso kusamala ndi chithandizo cha matenda oyamba ndikuchepetsa thupi (ndi kunenepa kwambiri kapena chizolowezi chake).
Makapu aledzera mosasamala nthawi yatsiku kapena chakudya. The achire zotsatira sizingachitike mwachangu - masabata awiri ayenera kuti wadutsa chiyambireni kutenga Novostat. Ndipo pakatha milungu 4 vutoli limakhala lokwanira ndipo lidzakhalabe mpaka kumapeto kwa njira yothandizira achire. Dokotalayo amamuuza kuti athetse muyezo wake ndikuwonetsetsa momwe wodwalayo alili. Mlingo wa tsiku ndi tsiku umatengera mulingo wa cholesterol, zolinga zochizira komanso kuyankha kwa munthu payekha pakalandira chithandizo.
Plasma lipid concentration imayang'aniridwa nthawi zonse ndipo mankhwala amasinthidwa. Pazifukwa zodzitetezera, mankhwalawa amagwiritsidwa ntchito pang'ono.
Ndi matenda ashuga
Statin imayambitsa kuwonjezeka pang'ono kwa ndende ya glucose, yomwe imathetsedwa mosavuta ndi zakudya, masewera olimbitsa thupi komanso mankhwala antidiabetic. Kusintha kwa Mlingo sikofunikira.
Makapu aledzera mosasamala nthawi yatsiku kapena chakudya.
Zotsatira zoyipa
Zosiyanasiyana zimachitika.
Kuchokera ku ziwalo zamagetsi
Zoyipa zowunikira.
Kuchokera minofu ndi mafupa
Myopathy, myositis, arthralgia, minofu kukokana.
Matumbo
Dyspepsia, kusowa kwa chakudya, kutsegula m'mimba, kapamba.
Hematopoietic ziwalo
Kutsika kwa magazi.
Pakati mantha dongosolo
Migraines, kusowa tulo, neuropathy, paresthesia, mafupa minofu kufinya, chizungulire.
Kuchokera ku urethra, pali kufooka kwa mamangidwe ake.
Kuchokera ku kupuma
Bronchospasm.
Kuchokera ku genitourinary system
Kutopa kofooka, kulephera kwa impso.
Kuchokera pamtima
Kutuluka magazi.
Kuchokera kumbali ya kagayidwe
Kusintha kwa shuga.
Nthawi zina, mapiritsi amatha kuyambitsa dazi.
Matupi omaliza
Urticaria, dazi, anaphylaxis.
Zokhudza mphamvu pakuwongolera njira
Muyenera kupewa kuchita zinthu zofunikira kwambiri.
Malangizo apadera
Osagwiritsa ntchito kuwonda - mankhwalawa alibe katundu.
Gwiritsani ntchito mu ukalamba
Palibe chifukwa chosinthira mlingo.
Kusintha kwa magazi mwa okalamba sikofunikira.
Kupatsa ana
Simungathe kupereka mankhwalawa kwa ana osakwana zaka 10. Amagwiritsidwa ntchito ngati hyperlipidemia ngati mwana ali pachiwopsezo kapena ngati ali ndi chiyembekezo chobadwa nacho cha matenda amtima omwe ali ndi chiwopsezo chachikulu cha kufa. Mankhwalawa amagwiritsidwa ntchito moperewera pakudya. M'mbuyomu, muyenera kuchita masewera olimbitsa thupi ndikuchiza matendawo. Chiwopsezo chokhala ndi myopathy ndikweza.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa sangatengedwe ndi amayi oyembekezera komanso azimayi amsinkhu wobereka, mwayi wokhala ndi pakati ndiwambiri chifukwa chonyalanyaza njira zolerera. Amayi olera nawonso samapereka mankhwala mpaka kuthe kumaliza kuyamwitsa.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Zambiri matenda a chiwindi kapangidwe kake ndi kuchuluka kwa transaminases ndizosokoneza kwambiri kutenga Novostat.
Bongo
Kusokonezeka kwa chiwindi ndi rhabdomyolysis. Ndikulimbikitsidwa kuti muzitsuka m'mimba ndikutenga sorbent. Mankhwalawa amangokhala chizindikiro.
Ngati bongo, kuphwanya chiwindi ndikotheka.
Kuchita ndi mankhwala ena
Kugwiritsa ntchito pamodzi kwa Novostat ndi Erythromycin, Cyclosporin, Niacin, azoles ndi fibroic acid kukonzekera kumawonjezera chiopsezo cha myopathy. Mlingo waukulu wa mankhwalawa ungayambitse kulumpha kwa digoxin. Erythromycin, clarithromycin ndi msuzi wa mphesa umachulukitsa milingo ya atorvastatin. Kusintha kotheka kwa magawo a pharmacodynamic a ethinyl estradiol ndi norethisterone kulera. Pamaso pa colestipol, ma lipid omwe amatsitsa ma lipid onse amathandizika.
Kuyenderana ndi mowa
Ndikulimbikitsidwa kuti musamwe mowa.
Analogi
Zomwe zimagwiritsidwa ntchito ndi Novostat ndi gawo limodzi la mankhwala:
- Atorvastatin;
- Atoris;
- Torvacard
- Tulip;
- Livostor;
- Atorvacor ndi ena
Zomwe zimagwira ku Novostat ndi gawo la Tulip.
Malo opumulira a Novostat ku pharmacy
Palibe mankhwala pagulu la anthu.
Kodi ndingagule popanda kulandira mankhwala?
Amatulutsidwa pokhapokha paphikidwe.
Mtengo
Makapisozi 10 mg amtengo kuchokera ku ma ruble 60. kwa ma PC 10.
Zosungirako za Novostat
Mankhwalawa amayenera kusungidwa pamatenthedwe mpaka + 25 ° C kutali ndi dzuwa.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Ku Russia, Novostat imapangidwa ndi ALSI Pharma CJSC ndi Biocom CJSC.
Ndemanga za Novostat
Polina, wazaka 24, Lipetsk
Mankhwalawa adalembedwa kuti agogo chifukwa cha cholesterol yayikulu. Anamwa mankhwalawa kwa nthawi yayitali, mkhalidwe wake unakhala bwino. Chokha chomwe chinali chofunikira kuyang'anira nthawi zonse kuti agogo ake asaphwanye zakudya. Ndife okhutira ndi momwe mankhwalawo amathandizira;
Olga, wazaka 54, Vyazemsky
Chifukwa cha cholesterol yayikulu, ndimayenera kutenga ma kapisozi awa, ndipo ndimapitilirabe kuchipatala, nthawi zambiri ndimayezetsa magazi ndikumadya. Panalibe zoyipa. Kapena mwina anali ofooka, ndipo ine sindinalabadire. Kukhala bwino kunayamba kuyenda bwino kwinakwake mu sabata limodzi. Popeza ndamwa maphunziro onse, kwanthawi yoyamba mu nthawi yayitali nditha kunena kuti ndikumva bwino.
