Liptonorm amatenga nawo gawo popanga mafuta a cholesterol. Mankhwalawa amakhudza ntchito ya ma LDL receptors, potero amachepetsa chiopsezo chotenga ma atherosulinosis ndi ma cell ena a mtima. Zinthu zomwe adamupangira zimakulolani kuti muchepetse kunenepa, koma mankhwalawa sangatchulidwe njira yochepetsera kunenepa. Ndi chithandizo chake, zotsatira zokhazo zomwe zimapezeka kudzera mu maphunziro ndi zakudya ndizothandizidwa. Monga chida chodziyimira payekha, mankhwalawa sagwiritsidwa ntchito, chifukwa samagwira mwamphamvu mokwanira.
Dzinalo Losayenerana
Atorvastatin
Liptonorm amatenga nawo gawo popanga mafuta a cholesterol.
ATX
C10AA05
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa mokhazikika. Imatembenuza gulu lokonzekera gawo limodzi. Zomwe zimagwira ntchito zowonetsera kutsika kwa lipid ndi atorvastatin, ndipo zimagwiritsidwa ntchito ngati mchere wamchere. Piritsi ili ndi 10 kapena 20 mg. Kuphatikiza apo, zinthu zina zomwe zimagwira ntchito zina zimagwiritsidwa ntchito (nthawi zambiri zimagwiritsidwa ntchito kuti mupeze mawonekedwe omwe mukufuna):
- calcium carbonate;
- ma cellcose a microcrystalline;
- lactose;
- Zaka 80;
- hydroxypropyl cellulose;
- mtanda;
- magnesium wakuba.
Mapiritsiwo amaphimbidwa ndi zokutira zapadera, zomwe zimapangitsa kuti pang'onopang'ono kumasulidwa kwa zinthu zogwira ntchito. Chifukwa cha izi, mulingo waukali wa mankhwalawa umachepetsedwa pang'ono. Chifukwa chake, simuyenera kutafuna mankhwalawa, chifukwa izi zimathandizira kuti amasulidwe azomwe amapanga.
Mapiritsiwo amaphimbidwa ndi zokutira zapadera, zomwe zimapangitsa kuti pang'onopang'ono kumasulidwa kwa zinthu zogwira ntchito.
Zotsatira za pharmacological
Mothandizidwa ndi mankhwalawa, kuchepa kwa zomwe zili lipoproteins otsika, zomwe zimakhudzana ndi kayendedwe ka plasma cholesterol, zimadziwika. Amayambitsa kusokonezeka kwamitsempha yama mtima: amathandizira pakuthamanga kwamafuta pamakoma a mitsempha, chitukuko cha atherosulinosis, myocardial infarction, ndi stroke. Nthawi zambiri, kuchepetsa lumen ya ziwiya kumadziwika, zomwe zimapangitsa kutsekeka kwa magazi.
Mothandizidwa ndi mankhwalawa, ndizotheka kupewa kutulutsa zovuta kwambiri, chifukwa gawo lomwe limapangika pakapangidwe kake limathandizira kuchepetsa zomwe zili za lipid mthupi. Mankhwalawa ndi a gulu la ma statins (kutsitsa cholesterol yamagazi).
Pharmacodynamics imakhazikitsidwa ndikuphwanya tchuthi cha mgwirizano wa HMG-CoA reductase, enzyme yomwe imalimbikitsa kusintha kwa HMG-CoA kukhala mevalonic acid. Mphamvu yofunikayo imatheka chifukwa cha kuyanjana kwa mamolekyulu azinthu zomwe zimagwira ndi tsamba la coenzyme A receptor, yomwe imayang'anira kulumikizana ndi HMG-CoA reductase.
Nthawi zambiri, kuchepetsa lumen ya ziwiya kumadziwika, zomwe zimapangitsa kutsekeka kwa magazi.
Zotsatira zoyenera zimapezeka chifukwa cha kutsika kwakukulu pakupanga kwa mevalonate, komwe ndi koyambira pakukonzekera kolesterol. Zotsatira zake, kuchuluka kwa cholesterol mkati mwa maselo kumatsika, zomwe zimathandizira kuyambitsa ntchito ya LDL receptors komanso kuchepa kwa cholesterol.
Chidachi sichingowonetsa lipid-kutsitsa kwenikweni, komanso chimateteza mitsempha yamagazi pakukula kwa zotsatira zoyipa chifukwa cha kuletsa mphamvu ya kapangidwe ka maselo a endothelial. Kufunika kwake kumatheka chifukwa choletsa kupanga isoprenoids.
Kuphatikiza apo, mankhwalawa amawonetsera zinthu zina: amakonzanso mawonekedwe amkati mwamitsempha yamagazi, amatulutsa kapangidwe ka magazi. Imadziwoneka ngati antioxidant, antiproliferative. Pali kuchuluka kwa HDL, apolipoprotein A.
Ubwino wa Liptonorm ndi kuthekera kwake kolimbikitsa kuchuluka kwa cholesterol mwa odwala omwe ali ndi vuto la majini.
Ubwino wina wa Liptonorm ndi kuthekera kwake kolimbikitsa cholesterol kwa odwala omwe ali ndi majini achilengedwe (hypercholesterolemia). Komanso, mankhwala ambiri otsitsa lipid sangathe kulimbana ndi ntchitoyi.
Pharmacokinetics
Chidacho chimatengedwa ndi makoma am'mimba kuti chitha kugaya pafupifupi. Kuchuluka kwa atorvastatin mu plasma kukhazikika pambuyo pa 60-120 mphindi. Kudya kumakhudza kuchuluka kwa gawo lino, komabe, kuchuluka kwa zochita zake sikunasinthe. Izi zikutanthauza kuti zomwe zili mu LDL zimatsika ndimphamvu yofanana chifukwa chotenga piritsi la Liptonorm pamimba yopanda kanthu komanso chakudya.
The bioavailability wa mankhwalawa ndi ochepa ndipo 14%. Izi zikufotokozedwa ndi mphamvu ya chilengedwe acidic m'mimba pa mankhwala pa gawo loyambilira komanso kagayidwe. Mlingo wa kugwira kwake ntchito umatsimikizidwanso ndi kuchuluka kwa atorvastatin. Kumangiriza kumapuloteni amwazi ndiokwera kwambiri (98%). Kusintha kwa gawo lalikulu kumachitika m'chiwindi, izi zimathandizidwa ndi ma enzymes CYP3A4, CYP3A5 ndi CYP3A7. Zotsatira za njirayi ndikumasulidwa kwa mankhwala omwe amawonetsa ntchito zotsitsa lipid.
Chidacho chimatengedwa ndi makoma am'mimba kuti chitha kugaya pafupifupi.
Kufunikira kwake kumakwaniritsidwa kwambiri ndi ma metabolites. Zotsatira zomwe zimapezeka ndi Liptonorm therapy zimatha nthawi yayitali: kuyambira maola 20 mpaka 30. Pambuyo pake, zomwe atorvastatin zimachepa. Theka la moyo limatenga maola 14. Komanso, njira yayikulu yochotsera chinthu chogwira ntchito m'thupi ndi ndi bile. Ndipo kuchuluka kochepa komwe kumatsimikizika kumkodzo (mpaka 2%). Tiyenera kukumbukira kuti kuchuluka kwa atorvastatin m'mawa ndi gawo limodzi lachitatu kuposa madzulo.
Zizindikiro zogwiritsidwa ntchito
Ndikulimbikitsidwa kugwiritsa ntchito chida ichi:
- Kuchulukitsa kambiri pazomwe zili lipoproteins otsika.
- Kuwonjezeka kosalamulirika kwa kuchuluka kwa cholesterol m'magazi (hypercholesterolemia), kuphatikiza ndi zochitika za chikhalidwe chomwecho zomwe zimayambitsidwa ndi zovuta zamtundu. Pankhaniyi, tikulimbikitsidwa kuti mupereke mankhwalawa limodzi ndi mankhwala ena, monga njira yothandizira yochepetsera thupi motsutsana ndi zakudya.
Kuchulukana kosalamulirika kwa kuchuluka kwa cholesterol m'mwazi ndi chisonyezo chogwiritsira ntchito mankhwalawa.
Contraindication
Osagwiritsira ntchito wothandizirayo pamafunso osakhudzidwa ndi chinthu chomwe chikugwirira ntchito kapena mankhwala ena omwe akuphatikizidwa. Pali zoletsa pa kugwiritsa ntchito vuto la chiwindi ndi impso. Ziwalo izi ndizomwe zimayambitsa kusintha kwa atorvastatin, motero ndikofunikira kupewa kupsinjika kwakukulu pa iwo.
Ndi chisamaliro
Zotsutsana:
- matenda a chiwindi osagwirizana ndi mawonekedwe owopsa (mbiri);
- metabolic ndi endocrine mavuto;
- kusintha kwa magazi-electrolyte bwino;
- njira za septic;
- zinthu zopweteketsa mtima zomwe ndizovuta kuzilamulira;
- kuvulala
- machitidwe.
Kodi kutenga Liptonorm?
Chithandizo chimayamba ndi 10 mg patsiku (mlingo uwu uyenera kumwedwa kamodzi). Ndiye kuchuluka kwake kumawonjezedwa poganizira kuchuluka kwa cholesterol m'magazi. Kusintha kwa mlingo kumaloledwa kuchitidwa sabata iliyonse iliyonse. Mtengo wokwanira wa kuchuluka kwa atorvastatin tsiku lililonse ndi 80 mg. Mlingowu ndiwofanananso ndi hypercholesterolemia yoyambitsidwa ndi zovuta zamtundu.
Ndi matenda ashuga
Gwiritsani ntchito mankhwalawa mosamala, komabe, mulingo womwewo sukufotokozedwayi. Chovomerezeka kugwiritsa ntchito regimen yovomerezeka yamankhwala (10 mg patsiku).
Zotsatira zoyipa
Chipangizocho chimakwiyitsa maonekedwe ambiri. Komanso, pamakhala chiwopsezo cha kupezeka kwawo machitidwe a machitidwe osiyanasiyana.
Mu shuga mellitus, mankhwala mosamala.
Kuchokera ku ziwalo zamagetsi
Kusakwanira kwa hydrate ya mucous nembanemba, ulesi wa maso, kumva kuwonongeka, kutaya kwamaso, kusokonezeka kwa malo okhala, kulawa (kusintha kapena kutayika kwathunthu).
Kuchokera minofu ndi mafupa
Zovuta zotupa, nyamakazi, tendosynovitis ndi matenda ena otupa, komanso kupweteka kwamtundu wosiyanasiyana (arthralgia, myalgia, etc.), mgwirizano wolumikizana, kukweza mamvekedwe a minofu yofewa, myopathy.
Matumbo
Ululu wam'mimba, kutentha kwa mtima, nseru, kuphwanya magazi kapena kudzimbidwa, kuchepa kapena kuchuluka kwa chilimbikitso, matenda otupa amachokera kumayendedwe osiyanasiyana, kutaya magazi m'mimba, jaundice wa hepatitis, hepatitis ndi hepatic colic, kusanza.
Hematopoietic ziwalo
Zochitika zosiyanasiyana zamatumbo zomwe zimatsatiridwa ndikusintha kwa kapangidwe ka magazi: kuchepa magazi, thrombocytopenia, etc.
Pakati mantha dongosolo
Kuzindikira kugona tulo, chizungulire, kufooka, kugona, paresthesia ndi neuropathy, kukumbukira kukumbukira (kusintha kosinthika), kukomoka, kukhumudwa, kupuwala nkhope.
Kuchokera ku kupuma
Nthawi zambiri anati kukula kwa matenda a rhinitis, bronchitis. Pafupifupi amapezeka ndi chibayo, mphumu ya bronchial.
Kuchokera ku genitourinary system
Matenda a urogenital thirakiti, kutupa, kutulutsa magazi mu maliseche, nephritis, matenda opatsirana pogonana (mwa amuna), kuvuta kukodza.
Kuchokera pamtima
Ululu pachifuwa, kuwonjezeka kwa mtima, kupweteka mutu, kutsika kapena kukweza nkhawa, ndi kutupa kwamitsempha yamagazi.
Matupi omaliza
Mawonetsedwe amtundu wamachitidwe osagwirizana amachitika: zotupa, kuyabwa, kutupa, kuvuta kupuma chifukwa cha angioedema, chidwi chowala, erythema, limodzi ndi kutulutsidwa kwakukulu.
Zokhudza mphamvu pakuwongolera njira
Palibe chidziwitso chokhudza milandu yomwe amatenga Liptonorm mosokoneza thupi pakumayendetsa galimoto.
Malangizo apadera
Pa mankhwala, wothandiziridwayo amasintha momwe chiwindi chilili. Ndikofunika kuyang'anitsitsa ntchito ya gululo musanayambe chithandizo, nthawi ndi pambuyo pake. Tiyenera kukumbukira kuti kusintha kwa ntchito ya michere ya chiwindi kumawonedwa m'miyezi itatu yoyambirira itatha maphunziro.
Ngati zizindikiro za kupsinjika kwakukulu zikuwonekera mu matenda a musculoskeletal system, chiwindi kapena impso, chithandizo chatha.
Ngati zizindikiro za zovuta za matenda a chiwindi kapena impso, chithandizo chatha.
Gwiritsani ntchito mu ukalamba
Chidacho chimaloledwa kugwiritsidwa ntchito, kusintha kwa mankhwalawa sikuchitika nthawi yomweyo.
Kupatsa ana
Kwa odwala osakwana zaka 18, mankhwalawa ali osavomerezeka.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa amaletsedwa kuti agwiritsidwe ntchito panthawi ya gestation komanso panthawi yoyamwitsa, chifukwa zotsatira zake zabwino sizitsimikiziridwa mu milandu iyi.
The ntchito aimpso kuwonongeka
Sichikuperekedwa chifukwa cholephera thupi.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ndi matenda a cirrhosis, mankhwala omwe ali m'magazi amawonjezeka nthawi zambiri. Pazifukwa izi, sizikugwiritsidwa ntchito. Sitha kugwiritsidwa ntchito pakulephera kwa chiwindi (kuopsa kwa A ndi B malinga ndi dongosolo la Mwana-Pugh), kuwonjezeka kwa kuchuluka kwa hepatic transaminases ya etiology yosadziwika ndi matenda ena a chiwalochi mothandizidwa, kuphatikizapo omwe amadziwika ndi matenda opatsirana. Kuti muchepetse chiwindi cha hepatic, kusintha kwa mankhwalawa sikofunikira.
Ndi matenda a cirrhosis, mankhwala omwe ali m'magazi amawonjezeka nthawi zambiri.
Bongo
Ndi kuwonjezeka kwa zoyipa motsutsana ndi maziko a kuchuluka kwa mankhwalawa, chithandizo cha mankhwala chimachitika, kupweteka kwam'mimba kumachitika, ma sorbents ndi omwe amapatsidwa. Pankhaniyi, hemodialysis ndiyosatheka kugwiritsa ntchito. Ndikofunikira kusamalira ntchito zoyambirira za thupi.
Kuchita ndi mankhwala ena
Mankhwala omwe amafunsidwa amaphatikizidwa ndi cyclosporins, Erythromycin, Clarithromycin, mankhwala antifungal, immunosuppressants, ngati phindu liposa kuvulaza. Pogwiritsa ntchito munthawi yomweyo atorvastatin ndi zinthu izi, kuwonjezereka kwa anthu oyamba kumadziwika. Kugwiritsa ntchito ma proteinase inhibitors pamankhwala kumapereka zotsatira zomwezo.
Kuzunza kwa Digoxin kumawonjezeka ndi 20%. Atorvastatin imagwiranso ntchito pa njira zina zakulera zamkamwa momwemonso.
Pogwiritsa ntchito munthawi yomweyo mankhwalawa komanso Colestipol, pali kuwonjezeka kwakukulu pamlingo wa chithandizo chamankhwala.
Warfarin ikhoza kuchepa kwakanthawi nthawi ya prothrombin. Pambuyo masabata awiri, chizindikirochi chimakhala chofanana.
Pogwiritsa ntchito munthawi yomweyo mankhwalawa komanso Colestipol, pali kuwonjezeka kwakukulu pamlingo wa chithandizo chamankhwala.
Kuyenderana ndi mowa
Mankhwalawa amatha kugwiritsidwa ntchito kuti athetse njira zomwe zingayambitse zizindikiro za kusiya, koma nthawi yomweyo ndi zakumwa zoledzeretsa musamamwe.
Analogi
M'malo mogwira mtima:
- Torvacard
- Atorvastatin;
- Liprimar.
Liptonorma Pharmacy Vacation Milandu
Mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Palibe zotheka.
Mtengo Liptonorm
Mtengo ku Moscow ndi 238 rubles. M'madera ena, mtengo wake ungasiyane pang'ono.
Zosungidwa zamankhwala
Kutentha kovomerezeka kwa mpweya - kosaposa + 25 ° ะก.
Tsiku lotha ntchito
Nthawi yogwiritsira ntchito mankhwalawa osataya katundu ndi zaka 2 kuyambira tsiku lopangidwa.
Wopanga Liptonorm
Pharmstandard, Russia.
Ndemanga yakuchepetsa za Liptonorm
Valeria, wazaka 43, Simferopol.
Metabolism yanga imachepetsedwa m'moyo, chifukwa chake kulemera kowonjezera. Ndinaphunzira kuti mankhwalawa amathandizira kuti ndisamangokhala bwino, ndinawagula nthawi yomweyo. Poyerekeza ndi zakudya zoyenera komanso katundu wokwanira, sindinawone zotulukazo, mwina ndichifukwa choti njira zomwe zagwiritsidwa ntchito ndizokwanira kwa ine, ndipo ndikadali koyambirira kuti ndikwaniritse mankhwala.
Anna, wazaka 35, Krasnoyarsk.
Njira yabwino yothetsera. Ndili ndi kulemera kwambiri (+ 20 kg nditakhala ndi pakati). Ndakhala ndikumwa mankhwalawa kwa nthawi yayitali, zotulukapo zake zikuwonekera bwino: kulemera kwasiya kukula, pang'onopang'ono koma kuchepa kwenikweni. Zochita zolimbitsa thupi ndizochepa kwambiri chifukwa chosowa nthawi, ndimayesetsa kutsatira zakudya zoyenera.Adagwiritsanso ntchito mankhwala othandizira ofanana ndi matenda a homeopathic komanso amagwiritsa ntchito mankhwala azachikhalidwe mpaka atapeza njira yabwinoko.
Madokotala amafufuza
Alekhine, E. B., dokotala wa opaleshoni, wazaka 38, Krasnodar.
Chida chothandiza kwambiri. Kuchira kwathunthu sikumapereka, koma kumagwira ntchito bwino ngati njira yothandizira, imathandizira njira yobwezeretsa mitsempha yamagazi.
Ndemanga Zahudwala
Olga, wazaka 35, Samara.
Poyerekeza ndi matenda ashuga, mavuto ambiri adawonekera, kuphatikizapo kunenepa kwambiri. Sindikudziwa chifukwa chake, koma kwa ine mankhwalawo ndiwachabe ngati cholinga ndichofunika kuchepetsa thupi. Amachita zinthu mofooka. Zotsatira za Liptonorm ngati njira yothandizira magwiridwe antchito a mtima ndizambiri. Zizindikiro zina zapita, mpumulo wafika.
Gennady, wazaka 39, Stary Oskol.
Adatenga mankhwalawo kuti achepetse cholesterol yamagazi. Pa mankhwala, zotsatira zake. Atasiya kumwa, mavuto onse azaumoyo adabweranso.
