Extentsef ndi mankhwala othandiza ku gulu la cephalosporins, omwe amagwiritsidwa ntchito kuchulukitsa kwa matenda opatsirana. Ndi makonzedwe oyenera a intramuscular, alibe zotsatira zoyipa ndipo amathandizira kuchira kwachangu.
Dzinalo Losayenerana
Cefepime.
ATX
Khodi malinga ndi ATX ndi J01DE01. Amawerengedwa kuti IV m'badwo wa cephalosporin.
Fomu Yopanga: ufa wogwiritsa ntchito makolo.
Kutulutsa mafomu ndi kapangidwe kake
Fomu Yopanga: ufa wogwiritsa ntchito makolo. Amayikidwa mu botolo la 500 kapena 1000 mg ya cefepime hydrochloride.
Zotsatira za pharmacological
Thupi limasiyananso ndi ma virus. Imagwira ntchito pazinthu zotere:
- Staphylococcus spp., Kuphatikiza ma ma virus angapo omwe amapanga kapena samapanga penicillinase;
- kuchuluka kwa mavuto a streptococci, Corynebacterium diphtheriae;
- nyama zopanda gram Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Klebsiella spp., Haemophilus influenzae, Enterobacter aerogene, Neisseria gonorrhoeae.
Ma protein okhala ndi ma protein okhala ndi ma protein (P morgani, P. vulgaris, P. rettgeri) samva chidwi ndi maantibayotiki. Cefazolin sachita rickettsia, ma virus, bowa ndi protozoa. Momwemo tikulephera mapangidwe a khoma la bakiteriya.
Pharmacokinetics
Mankhwalawa amangopangidwira kuti aingidwe m'matumbo a minofu ndikulowetsa mtsempha. Sangatengedwe pakamwa. Pambuyo pa jakisoni, mankhwalawo amalowa m'magazi ndikufikiratu ndende yake pasanathe mphindi 60. Zotsatira zimasungidwa mkati mwa maola 8-12. Chifukwa chake, jakisoni samavomerezeka nthawi zambiri: ngakhale muzovuta kwambiri, ndikulimbikitsidwa kuperekera mankhwalawa maola 8 aliwonse.
Extentsef imapangidwira kuti ingoikamo minofu minofu ndi kulowa m'mitsempha;
Cefazolin imadutsa chotchinga kuchokera mu madzi amniotic ndikulowetsa m'magazi a chingwe. Imapezeka mkaka wa m'mawere m'malo otsika.
Imalowerera ndendende kudzera mu nembanemba kulowa m'zigawo zina za odwala.
Mitsempha ya mtsempha wamagazi imathandizira kuyambika mwachangu ndikuwonjezera pazinthu zochizira m'magazi. Koma pankhaniyi, chidachi chimakhala ndi moyo wautali theka - maola 2-2,5 okha.
Zizindikiro zogwiritsidwa ntchito
Mankhwala akuwonetsedwa zochizira:
- matenda a m'munsi kupuma thirakiti - bronchitis ndi kuchulukitsa kwa matenda a bronchitis, chibayo;
- matenda opatsirana a excretory ziwalo - pyelonephritis, cystitis, urethritis;
- khungu ndi minyewa matenda;
- prostatitis;
- matenda am`mimba - peritonitis, zotupa za biliary thirakiti;
- matenda azamankhwala;
- septicemia;
- bakiteriya meningitis.
Mankhwala akuwonetsa zochizira matenda am'munsi kupuma thirakiti - bronchitis ndi kuchulukitsa kwa matenda a bronchitis, chibayo.
Amagwiritsidwanso ntchito pochiza neutropenia.
Contraindication
Sizoletsedwa kumwa mankhwala a antibacterial a kalasi ya cephalosporin ndi hypersensitivity kwa iwo, pakati.
Ndi chisamaliro
Kusamala ndikofunikira kupereka mankhwala a matenda a impso, mbiri yakusokonekera kwamatumbo thirakiti.
Momwe mungatengere Extentsef
Mankhwalawa amaperekedwa kudzera mu mnofu komanso mu mtsempha wa magazi. Kuti jekeseni minofu minofu, kapangidwe kake vial sitimadzipereka 2 kapena 4 ml ya lidocaine. Kenako osakaniza wokonzedwayo amalowetsedwa mkatikati mwa minofu.
Mwa mtsempha wa mtsempha, mankhwalawa amadzipaka ndi isotonic solution, 5% shuga kapena deionised madzi osabala. Mwanjira imeneyi, mankhwalawa amalowetsedwa m'mitsempha. Ndi kukapanda kuleka, njirayi imatenga theka la ola.
Ndi zoletsedwa kusakaniza mankhwalawo ndi zinthu zina zomwe zimagwirizana mu syringe.
Mlingo wa mankhwalawa umasiyanasiyana malinga ndi zotere:
- ndi matenda a kwamikodzo mawonekedwe ofatsa kwambiri kukula - 0.5-1 g mu mtsempha kapena minofu minofu maola 12 aliwonse;
- ndi ma bacteria ena obaya - 1 g mu mtsempha kapena ma intramuscularly maola 12 aliwonse;
- woopsa matenda - 2 g kudzera m`kati maola 12 aliwonse;
- moyo wowopsa - 2 g kudzera mu magazi kwa maola asanu ndi atatu alionse.
Kutalika konse kwa mankhwalawa kuyambira masiku 7 mpaka 10. Kugwiritsanso ntchito mankhwalawa sikugwira ntchito.
Mankhwalawa amagwiritsidwa ntchito pokonzekera wodwalayo komanso kupewa mavuto obwera pambuyo pake. Kuchita izi kumachepetsa mwayi wotenga matenda pambuyo pa cholecystectomy (kuchotsedwa kwa ndulu) ndi vagsterectomy. Kugwiritsira ntchito kwa cefazolin ndi mawonekedwe ake kumathandizanso pakagwiritsidwe ntchito ka kachilombo ka bacteria komwe kali pachiwopsezo cha moyo.
Prophylactic makonzedwe a Extentsef ayenera kusiyidwa chimodzimodzi tsiku limodzi pambuyo opareshoni. Pambuyo pa ma prosthetics a mtima komanso kulowererapo kwa mtima, mankhwalawa amaperekedwa kwa masiku 3-5.
Ndi zoletsedwa kusakaniza mankhwalawo ndi zinthu zina zomwe zimagwirizana mu syringe.
Ndi matenda ashuga
Mankhwalawa odwala matenda a shuga mellitus ayenera kuyang'anira glucometer nthawi zonse.
Mankhwalawa odwala matenda a shuga mellitus ayenera kuyang'anira glucometer nthawi zonse.
Zotsatira zoyipa za Extentsef
Kulandila kungakhale limodzi ndi zovuta izi.
- Kuchokera pamimba, kugaya nseru, kusanza, kutsegula m'mimba pang'ono, kusamva bwino m'mimba kumawonedwa. Nthawi zina odwala amakhala ndi colitis ndi dyspepsia.
- Mwina kuphwanya kwachilendo kwa kayendedwe ka mtima ndi mtima, kuwonekera mu kupweteka pachifuwa, vasodilation, kuchuluka kwa mtima.
- Zovuta zamkati mwa kupuma zimawonekera mu kupuma movutikira komanso kumverera kwa kusowa kwa mpweya. Nthawi zina kutsokomola mwamphamvu kumatha kuvutitsa wodwalayo.
- Kusintha kwa magwiridwe antchito amanjenje kumaonekera mu kupweteka mumutu, khosi, khosi, chizungulire, mavuto a kugona tulo usiku, kupweteka. Odwala ena amatha kuda nkhawa kwambiri.
- Mwa zina mwa mayankho omwe sagwirizana, omwe amakonda kwambiri ndi awa: kuyabwa, kuzizira, kutentha thupi, kusintha kwa anaphylactic.
- Zoyipa zomwe zingayambike pakubwera kwa magazi: leukopenia (kuchepa kwa maselo oyera amwazi m'magazi), kusapezeka kwa ma granulocytes m'magazi, ndi kuchepa kwa kupatsidwa magazi. Mwina kukula kwa mitundu yosiyanasiyana ya kuchepa magazi, kuchepa kwa hematocrit, kuchuluka kwa prothrombin nthawi. Ndi thrombocytopenia - chiopsezo chowonjezereka cha magazi.
- Cefazolin angayambitse kusokonezeka kwa impso. Imadziwonetsa yokha pakuwonjezeka kwa kuchuluka kwa nayitrogeni ndi urea wa magazi. Nthawi zina, odwala anayamba neuropathy, necrosis ya papillae a impso, impso.
- Pamalo a jakisoni pamakhala kupweteka komanso kuwonjezeka kwa kupsinjika kwa minofu yofewa. Ndi mtsempha wamkati, milandu ya phlebitis imawonedwa.
Zochitika zina zakuchitika:
- kufooka
- khungu pakhungu;
- kuchuluka kwa mtima;
- magazi
- vagidi candidiasis;
- kudzoza;
- vaginitis.
Kukwaniritsidwa kwamphamvu kumatheka kokha ngati munthu akugwiritsa ntchito mankhwala a cephalosporin nthawi yayitali.
Zokhudza mphamvu pakuwongolera njira
Popeza mankhwalawa amatha kuyambitsa chizungulire, ndizoletsedwa kuyendetsa galimoto ndikugwiritsa ntchito njira zovuta panthawi ya chithandizo.
Malangizo apadera
Kuchepetsa mwayi wa kukula kwa tizilombo toyambitsa matenda, mankhwala a cephalosporin ayenera kugwiritsidwa ntchito pokhapokha ngati causative wothandizila wa matenda atatsimikiziridwa panthawi ya bacanalysis. Ngati palibe chidziwitso chotere, ndiye kuti funso la kusintha maantibayotiki ndi njira yothandizira la mankhwala likusankhidwa.
Matenda am'mimba akapezeka, wodwala amayenera kutumizidwa kuti adziwe ngati ali ndi colitis. Potsimikizira matendawa, kukonza chithandizo kumachitika. Pokhapokha pakuchitika zochizira, wodwalayo sapatula kukula kwa megacolon, peritonitis, komanso ngakhale mantha.
M'badwo wa senile sichizindikiro chochepetsa kuchuluka kwa mankhwalawa, ndikofunikira kuwunika kuchuluka kwa magazi.
Pankhani ya kuperewera kapena matenda a mapangidwe a vitamini K (Vikasol), chizindikiro cha prothrombin chikuyenera kuyang'aniridwa nthawi zonse.
Gwiritsani ntchito mu ukalamba
Zaka za senile sichizindikiro chochepetsa kuchuluka kwa mankhwalawa. Ndikofunikira kuyang'anira kuwerengera magazi.
Kupatsa ana
Mankhwalawa amatha kuperekedwa kwa ana omwe ali ndi miyezi iwiri. Ndi mwana wolemera mpaka 40 makilogalamu, mlingo waukulu umafikira 50 mg pa 1 kg yolemera. Ndi matenda osavuta, amatha kuchepetsedwa.
Ndi kuwonongeka kwa ubongo wa meningococcal, kuphatikizidwa ndi matenda opatsirana am'mapapo thirakiti, tikulimbikitsidwa kuti mankhwalawa athandizidwe maola onse a 8.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa amaletsedwa mosaneneka panthawi yoyembekezera komanso kudya.
The ntchito aimpso kuwonongeka
Potha kuwonongeka kwa impso, milingo imachepetsedwa kotero kuti chithandizo chofanana chikuwonekera ndipo impso sizikhudzidwa. Ndi creatinine chilolezo pansipa 10 ml / mphindi, makonzedwe a 025 mpaka 1 g a Extentsef maola 24 aliwonse akusonyezedwa.
Pophwanya yachilendo magwiridwe antchito a impso, zizindikiro za nephrotoxicity zingachitike. Amawonetsedwa pakuwonjezeka kwakukulu kwa nayitrogeni mu mkodzo ndi creatinine. Ngati pali zizindikiro za nephrotoxicity, ndikofunikira kuchepetsa mlingo.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kuchepetsa mlingo wa mankhwalawo ndi chifukwa chomveka chokhudza matenda a chiwindi, matenda a chiwindi. Kusankhidwa sikuloledwa ndi chitukuko cha jaundice.
Mankhwala osokoneza bongo a Extentsef
Ndi i / m kapena iv yoyang'anira milingo yayikulu, mankhwalawa amayambitsa kulumikizana, kupweteka komanso kutopa kwa miyendo. Mwa anthu omwe ali ndi matenda oopsa a impso, osakhalitsa, ntchito yayitali imayambitsa cefazolin. Pamodzi ndi kukondoweza, zizindikiro zotsatirazi zimawonekera:
- palpitations
- kukokana
- kusanza
Ndikofunikira kusiya kumwa Extentsef ndi mawonekedwe a zomwe tafotokozazi. Muzoopsa, anticonvulsant mankhwala ndi desensitization amachitidwa. Woopsa bongo, kupuma, aimpso kuyenera kuyang'aniridwa nthawi zonse.
Mankhwalawa amachotsedwa ndi dialysis. Kuyeretsa kwa Peritoneal sikugwira ntchito bwino.
Kuchita ndi mankhwala ena
Sikulimbikitsidwa kupereka cefazolin wokhala ndi magazi ochepa, okodzetsa. Ngati mafuta opukusa malupu amagwiritsidwa ntchito nthawi yomweyo, ndiye kuti pali kuphwanya kuchotsedwa kwa nyengo ya kuphwanya kwa thupi.
Kugwiritsa ntchito kwa phenenecid kumachepetsa kuchulukitsidwa kwa cefazolin m'magazi ndipo kumawonjezera zotsatira zoyipa zamankhwala.
Kuphatikiza ndi aminoglycosides nthawi zina kumagwiritsidwa ntchito kupititsa patsogolo synergism. Ndi zovuta za impso, kuphatikiza uku sikungakhale kosayenera. Sipayenera kuphatikizidwa ndi metronidazole, vancomycin, ndi gentamicin.
Kugwiritsa ntchito kwa phenenecid kumachepetsa kuchulukitsidwa kwa cefazolin m'magazi ndipo kumawonjezera zotsatira zoyipa zamankhwala.
Mankhwalawa sakugwirizana ndi:
- Amikacin;
- sodium amobarbital;
- Bleomycin;
- calcium gluceptate kapena gluconate;
- Cimetidine;
- Colistimetate;
- Pentobarbital;
- Polymyxin;
- Tetracycline.
Mankhwala amatha kuchepetsa mphamvu ya BCG, katemera wa typhoid. Katemera amachitika pokhapokha atachotsa maantibayotiki.
Kuyenderana ndi mowa
Cefazolin sigwirizana ndi mowa. Odwala ena amakhala ndi vuto lodana ndi thupi. Zoterezi zimathandizira kuti pakhale gawo lokhumudwitsa.
Mankhwala extentsef sagwirizana ndi mowa.
Analogi
Zofanizira za mankhwalawa ndi:
- Efipim;
- Megapim;
- Sebopimu;
- Europim;
- Kefpim;
- Kefsepim;
- Posineg;
- Ceficad
- Abipim;
- Akpim;
- Dimipra.
Kupita kwina mankhwala
Mankhwalawo amagulitsidwa ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
M'mafakisoni angapo, wodwala amatha kugula mankhwala osagwirizana ndi mankhwala. Pankhaniyi, amakhala pachiwopsezo cha kupha poizoni kapena kuchulukitsa kwa njira ya matenda yomwe ilipo.
Efipim imatha kukhala ngati analogue ya mankhwala a Extentsef.
Mtengo wa Extentsef
Mtengo wa botolo ndi ma ruble 450-550.
Zosungidwa zamankhwala
Mankhwalawa amasungidwa m'malo opanda dzuwa pakatentha osaposa 25ºº.
Tsiku lotha ntchito
Ufa ndi woyenera kugwiritsidwa ntchito kwa miyezi 36. Osagwiritsa ntchito nthawi imeneyi ikatha.
Wopanga
Mankhwalawa amapangidwa ku Samrudh Pharmaceuticals Pvt. Ltd kapena Astral steritech Private Limited, India.
Makamaka a Extentsef
Irina, wazaka 40, Syzran: "Atakhala ozizira komanso wokonzekera" adalandira "chibayo champhamvu. Dotoloyo, atafika kunyumba, adapereka chipatala .. Chipatala chidatumiza Extentsef kawiri patsiku m'njira yokhala ngati wakomoka. pofikira masiku atatu: Khunyu lidatsika ndi masiku 5. kale, masiku 10 adathandizidwa. "
Svetlana, wazaka 39, ku Moscow: "Extentsef adatha kuchiza matenda oopsa a bacteria. kugwiritsa ntchito yankho la lidocaine. "
Igor, wazaka 35, Ryazan: "Dokotala adalemba jakisoni wa Extentsef zochizira matenda am'mimba. Poyamba ndinkaopa kubayitsa jakisoniyo, chifukwa ndikudziwa kuti zimapweteka komanso zimayambitsa kutupa kwambiri. kupweteka. Jakisoni amaperekedwa nthawi ziwiri patsiku. Prostatitis yovuta kwambiri idachira patatha sabata limodzi. "
