Momwe mungagwiritsire ntchito mankhwala Amitriptyline Nycomed?

Amitriptyline Nycomed ndi membala wa gulu la ma tridclic antidepressant. Mankhwalawa ndi gulu lotsika mtengo, ndizofunikira, chifukwa nthawi zambiri mankhwalawa amakhala milungu ingapo kapena miyezi ingapo.

Dzinalo Losayenerana

Amitriptyline.

Amitriptyline Nycomed ndi membala wa gulu la ma tridclic antidepressant.

ATX

N06AA09.

Kutulutsa mafomu ndi kapangidwe kake

Malondawa ali ngati mapiritsi. Ichi ndi gawo limodzi lokonzekera, lili ndi 1 yogwira mankhwala - amitriptyline. Mapiritsiwo ali ndi chipolopolo, chifukwa chomwe mphamvu yaukali wa mankhwalawa imafupika. The kuchuluka kwa yogwira: 10 kapena 25 mg (piritsi 1). Ma antidepressant ali ndi zinthu zingapo zosagwira ntchito zomwe zimagwiritsidwa ntchito kuti mupeze kusasinthika kwa mankhwala:

• magnesium wakuba;
• ma cellcose a microcrystalline;
• silika;
• talc;
• lactose monohydrate.
• kukhuthala.

Amitriptyline amapangidwa mwa mawonekedwe a mapiritsi okhala ndi mphamvu, chifukwa chomwe kuchuluka kwaukali kwa mankhwalawa pa mucous nembanemba wam'mimba kumachepetsedwa.

Chigoba choteteza chipangacho chimapangidwanso zambiri:

• macrogol;
• dimethicone;
• propylene glycol;
• titanium dioxide;
• hypromellose;
• talcum ufa.

Mapiritsiwo amapezeka m'mabotolo omwe amakhala ndi ma PC 50.

Zotsatira za pharmacological

Mfundo yakuchitikira kwa ma tridclic antidepressants imakhazikitsidwa ndi choletsa kugwidwa kwa monoamines, yomwe imayimiriridwa ndi norepinephrine, dopamine ndi serotonin. Zinthu izi ndizomwe zimayambitsa chisangalalo.

Mankhwalawa, monga njira zina za gulu la mankhwala onunkhira okondwerera, ali ndi vuto lalikulu - zovuta zingapo zomwe zimachitika nthawi ya chithandizo. Izi ndichifukwa chachikhalidwe chosasankha. Zotsatira zake, mankhwalawa samangokhudza kugwidwa kwa monoamines, komanso amalepheretsa zochitika zina zamitundu mitundu.

Amitriptyline nthawi yomweyo amachita ntchito zingapo. Chuma chake chachikulu ndichipondacho. Kuphatikiza apo, mankhwalawa amapereka chothandiza, kusokoneza, kupusa mtima. Izi zikutanthauza kuti mukamalandira chithandizo sikuti thanzi la wodwalayo limakhazikika, komanso kugona kumabwezeretsedwa, nkhawa zimatha.

Amitriptyline imapereka sedative hypnotic athari, chifukwa chomwe wodwalayo amabwezeretsa kugona.

Chifukwa cha kulepheretsa kubwezeretsanso kwa ma monoamines, kuwonjezeka kwawo kwa kuphatikizika kwa khungu kwapakati kumadziwika. Kuphatikiza apo, gawo logwira ntchito la Amitriptyline Nycomed limatseka M1- ndi M2-muscarinic cholinergic receptors, histamine receptors, ndipo nthawi yomweyo, alpha1-adrenergic receptors. Zotsatira zabwino za mankhwala omwe ali ndi antidepressant izi zimadziwika chifukwa cha kulumikizana komwe kulipo pakati pa ma neurotransmitters omwe amapezeka mu synapses ya ubongo ndi mkhalidwe wamalingaliro.

Mbali ina ya mankhwalawa ndimayendedwe ochepetsera. Zotsatira zabwino sizimachitika mwachangu, koma pambuyo pakuphatikizidwa kwazomwe zimagwira m'magazi zimafikira pazofanana. Kuphatikiza apo, ikafika pamlingo wina (zimasiyanasiyana kutengera mlingo), mphamvu yolimbitsa thupi imawonekeranso. Komabe, zotsatira zake nthawi zonse zimatsimikiziridwa motsutsana ndi kumbuyo kwa kuchuluka kwa metabolite yayikulu ya amitriptyline - nortriptyline.

Ndi kuwonjezeka ndi kuchepa kwa mulingo, mphamvu za mankhwalawa zimasintha pang'ono. Chifukwa chake, pakufika pamlingo wina, zochitika za nortriptyline zimachepa, mphamvu ya amitriptyline imawonjezeka. Komabe, kuchepa kwa zotsatira zamavuto ena nthawi zina kumadziwika. Pachifukwa ichi, simungathe kumwa mankhwalawo nokha, chifukwa ndikofunikira kusankha njira yoyenera yolingana ndi mawonekedwe a thupi. Tiyenera kudziwa kuti kumwa mankhwala ochepa sikungakuthandizeni.

Ndi amitriptyline, mutha kuwongolera kugunda kwa mtima wanu. Ichi ndi chifukwa cha antiarrhythmic mphamvu ya mankhwala.

Mankhwala omwe amafunsidwawo ndi othandizanso kutsutsana ndi ntchito ya CCC. Mwachitsanzo, itha kugwiritsidwa ntchito kuwongolera kugunda kwa mtima. Ichi ndi chifukwa cha antiarrhythmic mphamvu ya mankhwala. Mukamapereka mankhwala muyezo Mlingo wambiri, kuchepa kwa mphamvu ya mapangidwe amkati amadziwika.

Pharmacokinetics

Amitriptyline amadziwika ndi kuyamwa mwachangu. Pambuyo pa maola 2-6, nsonga za chinthu ichi zimafikiridwa. Amasiyanitsidwa ndi pafupifupi bioavailability (50%). Koma zomwe zimamangidwa ndi mapuloteni a seramu ndizokwera - 95%. Popeza kuti mankhwalawa amapereka zotsatira zoyenera pambuyo pakufika pa kufanana kwa thupi yogwira ntchito mthupi, zotsatira zoyenera siziyenera kuyembekezedwa kale kuposa sabata 1 pambuyo pake. Izi ndichifukwa choti nthawi yayitali ngati imeneyi imafunikira kuti ikwaniritse zomwe zikuluzikulu za matenda zimayamba kutha.

Zinthu zomwe zimapangidwa zimapangidwira m'chiwindi. Choyamba, phata lalikulu, nortriptyline, limamasulidwa. Kenako, onse amitriptyline ndi metabolite yake yogwira amakhala hydroxylated, ndikutsatira ndikumasulidwa kwa zinthu zopanda mphamvu. Hafu ya moyo wa mankhwalawa imasinthana ndi maola 9 mpaka 46, omwe amakhudzidwa ndi boma la thupi, kupezeka kwa ma pathologies ena.

Ndikofunika kugwiritsa ntchito mankhwalawa kupsinjika kwamitundu yosiyanasiyana, limodzi ndi kusokonezeka kwa tulo.

Amitriptyline amalembera mavuto a chikhodzodzo (enuresis omwe amawonetsedwa usiku).

Amitriptyline amasonyezedwa bulimia.

Zomwe zimayikidwa

Ndikofunika kugwiritsa ntchito mankhwalawa pamavuto ambiri amisala, makamaka:

• mitundu yosiyanasiyana ya kukhumudwa, limodzi ndi chisokonezo cha kugona, kuda nkhawa, pomwe mankhwalawo amagwiritsidwa ntchito ngati njira yayikulu yothandizira;
• Monga gawo la zovuta mankhwala, antidepressant amalembedwa zingapo: kakhalidwe, phobic, kusokonezeka kwamalingaliro, kukanika kwa chikhodzodzo (enuresis yokhala ndi mawonekedwe usiku), anorexia, bulimia.

Contraindication

Pali zoletsa zambiri pakugwiritsa ntchito mankhwalawa:

• kusasamala kwazinthu zilizonse pazomwe zimapangidwa (zogwira ntchito komanso zopanda ntchito);
• myocardial infaration, kuphatikizapo mbiri ya;
• pachimake ethanol poyizoni;
• Matenda a m'matumbo ochitika pamodzi ndi khungu;
• poyizoni ndi mankhwala osokoneza bongo (antidepressants, psychotropic kapena hypnotics);
• arrhythmia;
• kutsekeka kotsekera glaucoma;
• kuphwanya intraventricular, atrioventricular conduction;
• Matenda amtundu wokhudzana ndi kuchepa kwa lactase, tsankho lactose, glucose-galactose malabsorption syndrome;
• kuchuluka kwa maselo mu minyewa ya prostate, komwe kumayambitsa kuchepetsedwa kwa lumen ya urethra;
• kufooka matumbo;
• kutsika kwa potaziyamu;
• bradycardia.

Mankhwalawa sanatchulidwe bradycardia.

Mankhwala contraindicated mu myocardial infarction, kuphatikizapo mbiri.

Mosamala, amitriptyline amalembera kuthamanga kwa magazi.

Ndikakhudzidwa, mankhwalawa amayikidwa mosamala.

Bipolar matenda ndi zotsutsana kupezeka kwa amitriptyline.

Mochenjera, mankhwalawa amathandizidwa kuti apewe matenda a m'magazi, limodzi ndi kusintha kwa kapangidwe kake ndimagazi ake.

Ndi chisamaliro

Zotsutsana:

• kuthamanga kwa magazi;
• pathological zinthu limodzi ndi kusintha kapangidwe ndi magazi;
• kuchuluka kwachulukidwe ka magazi ndi matenda ena a ziwalo zamasomphenya;
• chilichonse matenda limodzi ndi kwamikodzo posungira;
• kukokana
• schizophrenia
• khunyu
• kupsinjika;
• kuphwanya chithokomiro (chithokomiro).

Momwe mungatenge Amitriptyline Nycomed

Kusankhidwa kwa njira yochizira kumachitika poganizira mtundu wa matenda. Ganizirani zaka, kukula kwa kagayidwe ka matenda, kupezeka kwa zoletsa kugwiritsa ntchito Amitriptyline Nycomed. Mapiritsi sayenera kutafuna. Fotokozerani mankhwala mukatha kudya.

Dosing dongosolo la akulu

Kuchiza kuyenera kuyamba ndi mlingo wa 50-75 mg. Kenako imachulukitsa, ngati pangafunike, ndi 25-50 mg. Kuchuluka kumeneku kumatengedwa kamodzi asanagone kapena kugawidwa pawiri. Komabe, simungathe kupitilira mlingo wa 200 mg. Kutalika kwa maphunziro - miyezi 6.

Amitriptyline Nycom wokhala mosamala amalembedwa kuti aphwanya chithokomiro.

Fotokozerani mankhwala mukatha kudya, mapiritsi sangathe kutafunidwa.

Kutalika kwa mankhwala ndi amitriptyline ndi miyezi 6.

Amitriptyline Nycomed regimen ya ana

Perekani ndi enuresis: 25 mg kamodzi kwa odwala azaka 7 mpaka 12, wopitilira zaka 12 - 50 mg. Ndikofunika kuti mutenge ndalama musanagone.

Kumwa mankhwala a shuga

Mankhwala omwe amafunsidwa amakhudza zotsatira za insulin, komanso amathanso kusintha kuchuluka kwa shuga. Pazifukwa izi, nthawi zambiri, kusintha kwa mlingo kumafunika. Kuchuluka kwa mankhwalawa kumayikidwa payekha.

Zambiri ndizovomerezeka

Chogwiritsidwacho chimapereka zotsatira mu masabata angapo. Imayamba kugwira ntchito nthawi yoyamba maola atayamba. Zotsatira zake zimakhala masiku awiri.

Momwe mungalembetse Amitriptyline Nycomed molondola

Popewa kudzipatula, tikulimbikitsidwa kuti muchepetse pang'onopang'ono mlingo.

Zotsatira zoyipa

Tiyenera kukumbukira kuti mankhwalawa omwe akufunsidwa amathandizira kuwoneka kosiyanasiyana.

Matumbo

Kuchepetsa mphuno, ziwalo zam'mimba zowuma, kusintha kwa chopondapo kapangidwe (kudzimbidwa). Kuchokera m'mimba, chizimba zotsatirazi nthawi zambiri chimachitika: kusapeza bwino mkamwa, kutupa, caries. Pafupipafupi, kutsegula m'mimba, kusanza, kutulutsa lilime, chiwindi, jaundice, matumbo.

Kugwiritsa ntchito amitriptyline kungakhale limodzi ndi boma.

Pa mankhwala, kupezeka kwa zoyipa monga kugwedezeka kwamadera kumadziwika.

Mukamwa mankhwalawa, mumayamba kupweteka mutu, chomwe ndi chizindikiro cha zotsatira zoyipa.

Poyerekeza ndi momwe ntchito ikugwiritsidwira, chizungulire chitha kuoneka.

Amitriptyline ikhoza kuyambitsa kusintha kwa chimbudzi (kudzimbidwa).

Zochitika pafupipafupi mutatha kumwa mapiritsi zimawerengedwa kuti ndizosasangalatsa mkamwa, kutupa, caries.

Hematopoietic ziwalo

Kusokonekera kwa mafupa ntchito, angapo a m'mikhalidwe momwe kusintha kwa kapangidwe ndi magazi.

Pakati mantha dongosolo

Kufooka, kugona, kugwedezeka miyendo, mutu ndi chizungulire, kusokonezeka chidwi, kuyankhula, kulawa.

Kuchokera kumbali ya kagayidwe

Sinthani pakudya: kuchuluka, kuchepa. Zotsatira zake, kulemera kwa thupi kumachuluka kapena kuchepa.

Matupi omaliza

Vasculitis, urticaria, yomwe imawonetsedwa ndi kuyabwa, zotupa.

Zokhudza mphamvu pakuwongolera njira

Pa chithandizo, muyenera kukana kuyendetsa magalimoto, chifukwa mankhwalawo amathandizira kuti thupi lizisokonezeka, zimakhudza ziwalo za m'maso komanso kumva, komanso zimayambitsa matenda amisala.

Malangizo apadera

Chithandizo chimayamba ndikuwongolera kuthamanga kwa magazi.

Posintha mawonekedwe a thupi, chisamaliro chikuyenera kuchitika;

Thupi lawo siligwirizana ndi mankhwalawa limasonyezedwa ndi urticaria, kuyabwa, zotupa.

Pa chithandizo, muyenera kukana kuyendetsa magalimoto, chifukwa mankhwalawa amathandizira kuti thupi lizitha kugwira ntchito, limakhudza ziwalo zamawonedwe ndi kumva.

Mwa achinyamata (mpaka zaka 24), chiopsezo chodzipha ndi mankhwala a Amitriptyline Nycomed chikuwonjezeka.

Odwala azaka zopitilira 50 ali ndi chiopsezo chowonjezeka cha mafupa.

Nthawi zina pangafunikire kuwongolera kuchuluka kwa magazi.

Zochitika zodzipha zimakhalabe mpaka pomwe gawo lomwe limathandizira limathandizira kuchepetsa kufooka kwamisala.

Mwa achinyamata (mpaka zaka 24), chiopsezo chodzipha ndi mankhwala a Amitriptyline Nycomed chikuwonjezeka.

Musanagwire ntchito yayitali, njira zamano, muyenera kusiya kumwa mankhwalawa.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Sanapatsidwe.

Gwiritsani ntchito mu ukalamba

Ndizovomerezeka kugwiritsa ntchito mankhwala oletsa kupanikizika pakufunsidwa, koma muyenera kusamala. Muyenera kuyamba maphunziro a mankhwalawa ndi 25-30 mg (kamodzi patsiku). Kuchulukitsa kuchuluka kwa mankhwalawa kuyenera kukhala nthawi 1 masiku awiri aliwonse. Mlingo wapamwamba tsiku lililonse ndi 100 mg.

The ntchito aimpso kuwonongeka

Odwala omwe ali ndi matenda amtunduwu, kupukusira kwa metabolites yogwira ya Amitriptyline Nycomed kuchokera ku thupi kumachepetsedwa. Palibe malamulo oletsa kumwa mankhwalawo.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Amaloledwa kugwiritsa ntchito mosamala. Ndi osakwanira chiwindi ntchito, mlingo umachepetsedwa.

Ngati chiwindi chayamba kugwira ntchito, amitriptyline amaloledwa kugwiritsidwa ntchito mosamala.

Odwala omwe ali ndi matenda a impso, palibe malamulo okhwima ogwiritsira ntchito mankhwalawa.

Pa nthawi yoyembekezera komanso mkaka wa m`mawere, amitriptyline sinafotokozeke.

Mukakalamba ndizovomerezeka kugwiritsa ntchito amitriptyline, koma muyenera kusamala.

Ngati muyeso wa amitriptyline udakwaniritsidwa, m'mimba muyenera kutsukidwa kuti muchepetse kuwopsa kwa mankhwalawa.

Zakumwa zomwe zimakhala ndi mowa komanso amitriptyline siziphatikizidwa.

Bongo

Kuchuluka kwa amitriptyline kungayambitse kwambiri intraventricular blockade. Zotsatira zina zoyipa zimakulitsidwa. Chithandizo: m'mimba mumatsukidwa kuti muchepetse kuchuluka kwa mankhwalawo, mankhwalawa amayikidwa, ngati ndi kotheka, ma inhibitors a cholinesterase amaperekedwa, kukakamiza kwa kayendetsedwe kake kumafunikira, ndikuwonetsetsa moyenera pakasungidwe ka madzi.

Kuchita ndi mankhwala ena

Kuletsa kwa chapakati mantha dongosolo kumatheka ndi kuphatikiza kwa mankhwala omwe amafunsidwa ndi ma antipsychotic, kusintha, ma hypnotics, mankhwala oletsa kupindika, a narcotic analgesics.

Pamodzi ndi Amitriptyline, MaO inhibitors sagwiritsidwa ntchito. Sizingatheke kuphatikiza ndi Adrenaline, Ephedrine, Dopamine, Noradrenaline, Phenylephedrine.

Kuyenderana ndi mowa

Zakumwa zokhala ndi zakumwa zoledzeretsa komanso zoponderezera pamafunso siziphatikizidwa.

Analogi

Mankhwala othandiza wogwiritsidwa ntchito m'malo mwa Amitriptyline Nycomed:

• Anafranil;
• Melipramine;
• Ladisan;
• Doxepin ndi ena

Ngati njira ina, mutha kusankha doxepin.

Mutha kusintha mankhwalawa ndi mankhwala monga doxepin.

Ngati ndi kotheka, mankhwalawa atha kubwezeredwa ndi Melipramin.

Kodi pali kusiyana kotani pakati pa Amitriptyline ndi Amitriptyline Nycomed

Mankhwala omwe ali ndi dzina loti Nycomed m'dzina sakupangidwa monga yankho. Itha kugulidwa kokha pamapiritsi. Amitriptyline imapezeka m'mitundu yosiyanasiyana: yolimba, yamadzimadzi (jekeseni). Kukonzekera kwa magulu awa kuli mgulu lomweli. Zitha kusiyanasiyana pazomwe zimagwira.

Miyezo ya tchuthi Amitriptyline Nycom kuchokera ku pharmacy

Mankhwala ndi mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Ayi.

Mtengo wa Amitriptyline Nycomed

Mtengo wapakati ndi ma ruble 60.

Zosungidwa zamankhwala

Ana amafunika kutseka malonda. Malo osungidwa osungidwa: + 15 ... + 25 ° С.

Tsiku lotha ntchito

Mankhwalawa amasungabe katundu wake kwa zaka 5 kuchokera tsiku lotulutsidwa.

Wopanga Amitriptyline Nycomed

Takeda Pharma A / S, Denmark.

Ndemanga za Amitriptyline Nycomed

Akatswiri azamisala

Chukhrov V.V., wazamisala, wazaka 49, Chelyabinsk

Mankhwala achikale, ma analogu atsopano tsopano akuwoneka omwe ali ndi zotsatira zochepa zoyipa pamankhwala.

Kochev V.O., Psychiatrist, wazaka 34, Stavropol

Kuletsa antidepressant wogwira, kuwonjezera pamenepo kumachotsa mutu ndi psychosomatics. Zitha kupangitsa kuti kuchepetsedwa pokonzekera kukodza.

Odwala

Larisa, wazaka 34, Barnaul

Ndidatenga mapiritsi 10 mg. Zotsatira zakuchiritsazo zinachitika pambuyo pa masabata atatu, omwe amakhala nthawi yayitali. Koma, pamapeto pake, kukhumudwa kudagonjetsedwa.

Marina, wazaka 41, Moscow

Adatenga mankhwalawa. Pangopita nthawi yayitali sindimatha kupirira. Choyamba, adokotala anachenjeza kuti zotsatira zabwino zimachitika mkati mwa mwezi woyamba atayamba maphunziro. Kachiwiri, zoyipa za mankhwalawa sizinalole chithandizo china.