Glyclad mankhwala: malangizo ntchito

Gliclada ndi mankhwala ofunikira kuchiza matenda a shuga a 2 mwa odwala akulu. Wothandizirana ndi hypoglycemic amalembedwa pokhapokha mphamvu yochepa ya chakudya chapadera komanso zochita zolimbitsa thupi, zomwe sizingathandize kuchuluka kwa shuga m'magazi komanso kulemera kwa wodwalayo. Mankhwalawa sagwiritsidwa ntchito chifukwa cha matenda a shuga omwe amadalira insulin ndipo samalimbikitsidwa kuti agwiritse ntchito paubwana.

Dzinalo Losayenerana

Gliclazide.

Gliclada ndi mankhwala ofunikira kuchiza matenda a shuga a 2 mwa odwala akulu.

ATX

A10BB09.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amapezeka mu mawonekedwe a mapiritsi olimbikitsidwa amtundu wokhala ndi mawonekedwe a biconvex mawonekedwe ndi mtundu woyera. Gawo lokonzekera lili ndi 90 mg yogwira ntchito - glyclazide. Monga momwe othandizira amagwiritsidwa ntchito:

• hypromellose;
• shuga mkaka lactose;
• dehydrate silicon dioxide (colloidal);
• magnesium wakuba.

Mapiritsi ali m'matumba a chithuza cha mayunitsi 10. Pa mtolo wa makatoni pali matuza 3, 6 kapena 9.

Zotsatira za pharmacological

Mphamvu ya hypoglycemic yomwe imachokera ku m'badwo wachiwiri ndi chifukwa chosangalatsa cha glycazide motsutsana ndi maselo a pancreatic beta. Mankhwala omwe amagwira ntchito amakwiyitsa ndikusokoneza mabungwe a Langerhans kuti apange insulin. Poterepa, kuwonjezereka kwa chiwopsezo cha minyewa kupita ku timadzi timene timachitika.

Mapiritsi ali m'matumba a chithuza cha mayunitsi 10.

Kuzindikira kwamapangidwe amaselo kumawonjezeka chifukwa cha kuchuluka kwa ntchito ya minofu ya glycogen synthetase ndi ma enzyme ena mkati mwa cell. Pamene maselo a pancreatic sakwiya ndi gliclazide, nthawi kuyambira pakudya chakudya mpaka kuyamba kupanga kwa insulin imachepa. The hyperglycemic postprandial point amachepa, nsonga zoyambirira za mahisidwe a mahomoni amatulutsa.

Glyclazide amachepetsa kugundana komanso kukhazikika kwa mapulateleti m'makoma amitsempha, kuletsa mapangidwe a magazi chifukwa cha kuchuluka kwa fibrinolysis pabedi lamitsempha. Chifukwa cha zomwe zimagwira ntchitoyo, mafuta metabolism ndi capillary wall permeability adakhazikitsidwa. Mukamatenga Glyclades, kuchuluka kwa plasma ya cholesterol yathunthu komanso chiopsezo chokhala ndi malo ogwiritsira ntchito ma atherosrance.

Kufanana ndi hypoglycemic zotsatira, gliclazide ili ndi antioxidant katundu, poletsa kufalikira kwa zopitilira muyeso. Ma microcirculatory njira zimasintha ndipo chiwopsezo cha mtima cha adrenaline chimachepa. Amachepetsa proteinuria pamaso pa matenda ashuga nephropathy.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, mankhwalawa amalowetsedwa m'matumbo. Pamene gullazide yogwira ikulowera kayendedwe kazinthu, imafika m'magawo anayi a plasma mkati mwa maola 4. Chomwe chimagwira ntchito chimakhala ndi miyeso yambiri yomanga mapuloteni a plasma - pafupifupi 94-95%.

Pambuyo pakukonzekera pakamwa, mankhwalawa amalowetsedwa m'matumbo.

Mankhwala amapita kusintha kwa hepatocytes ndikupanga zinthu 8 zama metabolic zomwe zilibe katundu wa hypoglycemic. Hafu ya moyo ndi maola 12. Pulogalamu yamankhwala amapangidwa ndi 90-99% mu mawonekedwe a metabolites ndi mkodzo, ndi 1% yokha yomwe imachoka m'thupi mwa njira yake yoyambirira kudzera mu kwamikodzo.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amagwiritsidwa ntchito pochiza matenda a shuga a 2, ngati kudya moyenera, kuchita masewera olimbitsa thupi komanso njira zina zochepetsera thupi sizothandiza. Gliclazide munthawi yomweyo imalepheretsa kukula kwa zovuta zosadalira shuga zomwe zimadalira - - - -

Ndi mtundu 2 wa matenda ashuga, kodi ndizotheka kudya kirimu wowawasa? Werengani zambiri za izi munkhaniyi.

Kodi zotsatira za kuyesedwa kwa magazi kwa prothrombin ndi fibrinogen zikuwonetsa chiyani ndipo chifukwa chiyani ndikofunikira kwa wodwala matenda ashuga?

Contraindication

Mankhwala ndi oletsedwa kugwiritsidwa ntchito motere:

• ndi mtundu wa 1 wodwala matenda a shuga;
• mkhalidwe wodwala matenda ashuga;
• kuphwanya kwambiri kugwira ntchito kwa impso, chiwindi;
• Hypersensitivity pamagulu a glycases ndi sulfonamides;
• Pa mankhwala ndi imidazole.

Mankhwalawa amadziwikiratu odwala omwe ali ndi ketoacidosis.

Mankhwalawa amadziwikiratu odwala omwe ali ndi ketoacidosis.

Momwe mungatenge Gliclada

Mankhwalawa amapangidwira pakamwa. Ndikulimbikitsidwa kumwa m'mawa m'mimba yopanda kanthu, osafuna kutafuna. Chakudya ndi makina akupukutira zimachepetsa kuthamanga ndi kutsirizika kwa mayamwa a gliclazide m'matumbo ang'ono. Mlingo watsiku ndi tsiku ndi 30-120 mg wa ntchito imodzi. Ngati wodwalayo walephera kumwa mankhwalawo, muyezo sayenera kuwonjezeka tsiku lotsatira.

Mlingo komanso kuchuluka kwa tsiku ndi tsiku kumatha kusinthidwa ndi dokotala kutengera chithunzi cha munthu wazachipatala komanso kagayidwe kazakudwala.

Pa gawo loyambirira la mankhwalawa, tikulimbikitsidwa kumwa kamodzi patsiku 30 mg. Mankhwala akakwaniritsidwa, sibwino kusiya kumwa mankhwalawo. Mapiritsi amapitirirabe kuledzera ngati njira yolepheretsera. Ngati mankhwalawa palibe, ndiye kuti mlingo umawonjezeka pang'onopang'ono motsogozedwa ndi plasma ndende ya glucose. Masabata onse a 2-4, tsiku lililonse limawonjezeka ndi 30 mg. Mlingo wololedwa wambiri umafika pa 120 mg patsiku.

Mankhwalawa akhoza kuphatikizidwa ndi biguanides, alpha-glucosidase blockers, insulin.

Ndi matenda ashuga

Kuvomerezedwa ndikololedwa kwa mtundu wachiwiri wa shuga pogwiritsa ntchito mtundu wanthawi zonse wa mankhwala.

Zotsatira zoyipa Glycades

Matumbo

Chifukwa cha zomwe mankhwalawa amapezeka m'matumbo a pancreatic, zimachitika zovuta kugaya chakudya:

• kupweteka m'dera la epigastric, limodzi ndi kusanza;
• kulakalaka, njala;
• kutsegula m'mimba, kudzimbidwa ndi matenda osokoneza bongo.

Chifukwa cha zochita za mankhwala pama cell a pancreatic, ululu wammbuyo mu epigastric ungawoneke.

Chifukwa cha momwe mankhwalawa amathandizira pama cell a pancreatic, kuwonjezeka kwa chilimbikitso kungaoneke.

Chifukwa cha momwe mankhwalawa amathandizira pama cell a pancreatic, kumatha kumva njala.

Chifukwa cha zochita za mankhwala pama cell a pancreatic, kutsegula m'mimba kumatha kuonekera.

Chifukwa cha zochita za mankhwala pama cell a pancreatic, kudzimbidwa kumatha kuoneka.

Chifukwa cha zochita za mankhwala pama cell a pancreatic, dyspepsia imatha kuoneka.

Nthawi zina, pali kuchuluka kwa aminotransferases mu chiwindi maselo, kusayenda kwa bile ndi kutupa chiwindi. Ndi kothekera kuwonjezera plasma ndende ya bilirubin, pomwe cholestatic jaundice imayamba.

Hematopoietic ziwalo

Poyerekeza ndi zakumayambiriro kwa mankhwala osokoneza bongo, kuwonongeka kwa mapangidwe ofiira ndikotheka, chifukwa chomwe kuchuluka kwa mawonekedwe amwazi amachepetsa, agranulocytosis ndi pancytopenia.

Dongosolo la Endocrine

Pali chiopsezo chotenga hypoglycemia kapena hyperglycemia.

Matupi omaliza

Ngati pakumveka kukhudzika kwa minofu ya thupi kupita ku zigawo zikuluzikulu, zotupa pakhungu, kuyabwa, urticaria ndi redness zimawonekera. Nthawi zina, odwala omwe amakonda anaphylactoid zimachitikira amakhala edema (Quincke's edema), anaphylactic mantha, vasculitis ndi erythema.

Zokhudza mphamvu pakuwongolera njira

Chenjezo limalangizidwa mukamachita zinthu zomwe zimafuna kuyankhidwa mwachangu ndi kusamaliridwa.

Chenjezo limalangizidwa mukamachita zinthu zomwe zimafuna kuyankhidwa mwachangu ndi kusamaliridwa.

Malangizo apadera

Gulu lamavuto omwe ali ndi chiwopsezo chachikulu cha kukhala ndi hypoglycemia limaphatikizapo anthu omwe ali ndi:

• chakudya chopanda malire;
• kuchuluka zolimbitsa thupi tsiku ndi tsiku;
• aimpso kuwonongeka;
• matenda oopsa a endocrine dongosolo;
• kusiya kwaposachedwa kwamphamvu kwa mankhwala a corticosteroid;
• matenda oopsa a mtima (matenda a coronary, kuwonongeka kwa mitsempha ya carotid).

Odwala oterewa amalimbikitsidwa kuti azimwa mankhwala 30 mg okha patsiku. Pankhaniyi, mankhwalawa amatchulidwa kuti azikhala ndi zakudya zokhazikika, chifukwa ndi matenda a shuga ndikofunikira kudya zakudya zopatsa mphamvu.

Pa chithandizo ndi Gliclada, ndikofunikira kuyang'anira kuchuluka kwa shuga ndi glycated hemoglobin pamimba yopanda kanthu. Ndikosavuta kuyang'ana momwe zinthu ziliri pakakhala kuvulala kwamakina, malungo, matenda opatsirana, komanso munthawi yokonzanso opereshoni.

Nthawi zina, njira yothandizira achire ya Glyclades imatha kuchepa kwakanthawi, chifukwa cha kupita patsogolo kwa njira ya pathological komanso kuchepa kwa mayankho a minyewa. Mikhalidwe yotereyi imatchedwa yachiwiri kukana mankhwala.

Pa chithandizo ndi Gliclada, ndikofunikira kuyang'anira kuchuluka kwa shuga ndi glycated hemoglobin pamimba yopanda kanthu.

Mankhwalawa ali ndi lactose, chifukwa chake, anthu omwe ali ndi chibadwa chololera mkaka wa shuga, malabsorption a monosaccharides, komanso kuperewera kwa mapiritsi a lactase Glyclades osavomerezeka kuti agwiritsidwe ntchito.

Kusintha kwa mapiritsi a Glyclazide a 80 mg ndikutulutsidwa mwachangu pakulandila Gliklada wa 90 mg wa nthawi yayitali ndikuloledwa.

Gwiritsani ntchito mu ukalamba

Anthu azaka zopitilira 65 azisowa kusintha njira.

Kupatsa ana

Mphamvu ya gliclazide pakukula ndi kukula kwa thupi muubwana ndi unyamata sizinaphunzire, chifukwa chake, kumwa mankhwalawa sikulimbikitsidwa mpaka zaka 18.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Chifukwa chosowa maphunziro azachipatala, kuthekera kwa gliclazide kudutsa placenta sikulimbikitsidwa kwa amayi apakati. Pa mankhwala ndi Glyclad, yoyamwitsa iyenera kuyimitsidwa.

Pa mankhwala ndi Glyclad, yoyamwitsa iyenera kuyimitsidwa.

The ntchito aimpso kuwonongeka

Ndiwofatsa pang'ono komanso pang'ono pamlingo wowonongeka wa impso, mulingo wambiri umaloledwa, moyang'aniridwa ndi achipatala.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Mankhwala osavomerezeka kuti agwiritsidwe ntchito ndi anthu omwe akuvutika kwambiri ndi chiwindi.

Mankhwala ochulukirapo a Glyclades

Ndi gawo limodzi lokha la mlingo waukulu, hypoglycemia yamatenda osiyanasiyana amakula. Woopsa milandu, zinthu zimachitika limodzi ndi kupezeka kwa minofu kukokana ndi mitsempha. Kuti muchepetse vuto la kuperewera kwa m'magazi, ndikofunikira kupereka zakudya zopatsa mphamvu. Wodwala yemwe watenga mlingo waukulu ayenera kuyang'aniridwa ndi achipatala mpaka matenda atakhazikika.

Ngati vuto la mitsempha limakayikiridwa, glucagon kapena njira yokhazikika ya 10% shuga iyenera kuperekedwa. Izi zikuthandizira kukwaniritsa kuchuluka kwa shuga kwa plasma. Hemodialysis ya mankhwala osokoneza bongo siothandiza.

Kuchita ndi mankhwala ena

Synergism imawonedwa mukatenga Pyrazoline, caffeine, Theophylline, salicylates.

Ndi gawo limodzi lokha la mlingo waukulu, hypoglycemia yamatenda osiyanasiyana amakula.

Kukhazikitsa munthawi yomweyo kwa Glyclades ndi mankhwala ena ophatikizika kungalimbikitse mkhalidwe wa hypoglycemic kapena kungayambitse hyperglycemia.

Kuyenderana ndi mowa

Kugwiritsa ntchito mowa pa mankhwala osokoneza bongo ndizoletsedwa. Mowa wa Ethyl umawonjezera chiopsezo cha mavuto komanso umalimbitsa kuletsa kwamitsempha yamagetsi (CNS). Ethanol amathandizira kukulitsa kukomoka kwa hypoglycemic.

Analogi

Zoyimira m'malo mwa Glyclades:

• Diabeteson MV;
• Glioral;
• Gliclazide;
• Glidiab;
• Diabefarm MV.

Musanasinthane ndi mankhwala ena, muyenera kufunsa katswiri.

Kupita kwina mankhwala

Mankhwala amagulitsidwa ndi mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Kugulitsa kwaulere kwa mankhwala kumakhala kochepa chifukwa cha chiwopsezo chowonjezereka chochokera ku kapamba pomwe mukutenga popanda zowonetsa zachipatala mwachindunji.

Mtengo wa Gliclada

Mtengo wapakati wa mankhwalawo ndi ma ruble 290.

Zosungidwa zamankhwala

Ndikulimbikitsidwa kusunga mankhwalawo pamalo otetezedwa ku chinyezi ndi kuwala kwa dzuwa, kutentha kwa + 30 ° C.

Tsiku lotha ntchito

Zaka zitatu

Mankhwala amagulitsidwa ndi mankhwala.

Wopanga

KRKA, d.d., Slovenia.

Ndemanga za Gliclad

Dina Rybalovskaya, wazaka 38, Orenburg

Mwamuna wanga ali ndi shuga wambiri.Zinali zofunika kupeza mankhwala omwe sangachepetsa shuga, komanso kuti mulibe oyenera. Potsatira kufunsa, adokotala adalimbikitsa kutenga Gliclada kwa mwezi umodzi. Ngati palibe chochita, ndiye kuti kunali kofunikira kuti mudzabwere pazokambirana zachiwiri. Pakatha milungu itatu, shuga adabweranso mwakale. Tsopano mwamuna wake ali ndi 8,2 mm, zomwe ndi zabwino kuposa 15-16 mm zomwe zidalipo kale.

Diana Zolotaya, wazaka 27, Veliky Novgorod

Amamwa kumwa piritsi la Gliclazide 60 mg 1 nthawi patsiku. Shuga sanachepetse. M'mawa ndi masana, 10-13 mm adatsalira. Pambuyo pothandizidwa, adokotala adakulitsa mlingo mpaka 90 mg. Pokhapokha panali pofunika kutenga Gliclada, kuti asatenge mapiritsi 1.5. Tsopano shuga m'mawa ndi 6. Nthawi yomweyo, muyenera kudya zakudya ndikuchita masewera olimbitsa thupi kuti mukwaniritse izi.