Meldonium imawonedwa ngati mankhwala a antiarrhythmic, ndi njira yokhazikitsira kagayidwe. Mankhwala okhala ndi chinthu choterechi ali ndi mitundu yosiyanasiyana yamasulidwe ndipo amadziwika kwambiri pochiza matenda monga mtima wamatumbo komanso matenda amkati mu ubongo. Amasungidwanso m'malo mwakuthupi komanso mwamalingaliro.
Meldonius anali wotchuka pakati pa othamanga. Koma mu 2016 adazindikiridwa ngati dope ndipo tsopano aletsedwa kuti azigwiritsidwa ntchito ndi iwo omwe amachita nawo mipikisano.
Katunduyu adapezeka mu theka lachiwiri la zaka za zana la 20 ndipo poyambilira adagwiritsidwa ntchito paulimi monga othandizira pakukula kwa mbewu ndi zoweta.
Dzinalo Losayenerana
Meldonium (Meldonium).
ATX
C01EV22 - Mankhwala ena ochizira mtima.
Meldonium imawonedwa ngati mankhwala a antiarrhythmic, ndi njira yokhazikitsira kagayidwe.
Kutulutsa mafomu ndi kapangidwe kake
Meldonium 500 imapezeka mu mawonekedwe a makapisozi, omwe amaphatikizapo 500 mg ya chinthu chomwechi. Amakutidwa ndi matuza 10 zidutswa. Mankhwalawa amagulitsidwa m'makatoni, omwe ali ndi matuza atatu kapena 6.
Mlingo wofananawo uli mgulu lomwe limakhala ndi 5 ml ya jakisoni. Ma Ampoules amadzaza mapepala apulasitiki amtundu wa 5 kapena 10 ndipo amagulitsidwa m'makatoni ama 5, 10, 20, 50, 75 kapena 100 ampoules.
Zotsatira za pharmacological
Meldonium ndi analogue ya gamma-butyrobetaine. Imatha kukhutiritsa kufunikira kwama cell kwa kayendedwe ka okosijeni ndi kuchotsedwa kwa zinthu za metabolic zomwe zimatuluka chifukwa chonyamula katundu. Chifukwa cha izi, imakhala ndi chitetezo pamtima wamatenda, imalepheretsa kuukira kwa angina, komanso imakhala ndi antihypoxic katundu.
Thupi limalepheretsa kaphatikizidwe ka carnitine, limayambitsa glycolysis. Kutha kupereka zotsatirazi achire zotsatira:
- Ndi vuto la mtima - chepetsani mapangidwe a necrotic zone.
- Ndi mtima kulephera - kusintha myocardial contractility ndi masewera olimbitsa thupi.
- Ndi ubongo ischemia, sinthani kayendedwe ka magazi m'dera lomwe lakhudzidwa.
- Ndi uchidakwa wambiri, chotsani zovuta zamagulu amanjenje.
Meldonium - kugwiritsa ntchito moyenera pamaseweraMeldonium: Katswiri Wamphamvu Wamphamvu
Pharmacokinetics
Mankhwala amadziwika ndi kuyamwa mwachangu kuchokera m'mimba. Ku bioavailability wake kumakhala pafupifupi 78%. Patatha maola awiri makonzedwe a plasma, pazotheka anthu ambiri. Hafu ya moyo imadalira mlingo womwe umatengedwa ndipo umatha kufika maola 6. Vutoli limagawika mu ma metabolites awiri ndipo limatulutsidwa mkodzo.
Zizindikiro zogwiritsidwa ntchito
Mankhwala okhala ndi meldonium monga chinthu chogwira amakhala ndi gawo lalikulu. Kusankhidwa kukuwonetsedwa ku:
- matenda a mtima;
- mikwingwirima
- kuchepa kwa magazi
- kuchepa kwa magwiridwe antchito;
- kupsinjika kwakuthupi;
- kudziletsa matenda;
- kukonzanso nthawi pambuyo pa ntchito;
- asthenic zinthu, aakulu kutopa syndrome.
Mankhwala amagwiritsidwa ntchito yaying'ono Mlingo ndi ophthalmology kwa parabulbar makonzedwe vuto la kuzungulira kwa retina osiyanasiyana etiologies.
Kugwiritsa ntchito meldonium pamasewera
Kuchita kwa Meldonium cholinga chake ndikuchepetsa njira zopangira mphamvu, pogwiritsa ntchito mafuta acids monga gwero lake ndikubweretsa kukwezedwa kwa nyimbo ya mtima. Izi zimathandiza thupi kutsitsa katundu pa myocardium posintha njira yopezera mphamvu kuchokera ku glucose ndi oxygen.
Kwa anthu omwe amatenga nawo mbali pamasewera, meldonium iyi ndi yofunika monga:
- kutsegula kwa kusinthika njira mu minofu pambuyo kuchita masewera olimbitsa thupi;
- zabwino pamlingo wosintha;
- kuthekera kwakuwongolera zochita za thupi pakugwira ntchito mopitirira muyeso.
Makhalidwewa amagwira ntchito pamasewera aliwonse, koma zotsatira zake zimawonekera bwino nthawi yayitali yochita masewera olimbitsa thupi. Ngakhale kuti chinthuchi chimatengedwa ngati chopanda, sichikuthandizira pakuphatikiza minofu ndi kusintha kwa zizindikiro zamphamvu.
Madokotala omwe akuthandiza pa zamankhwala am'madzi anazindikira kuti kumwa Meldonium sikungaphatikizidwe ndi mafuta komanso zakudya zopanda mafuta ambiri.
Contraindication
Meldonium sangadziwike ndi kuwonjezeka kwa kuthamanga kwa intracranial komwe kumachitika chifukwa cha ma neoplasms osiyanasiyana komanso kuphwanya kwa venous kubuda.
Komanso, contraindication kumwa mankhwala ndi awa:
- tsankho kwa Meldonium;
- mimba
- kuyamwa.
Simalimbikitsidwa kuti azigwiritsidwa ntchito ndi anthu ochepera zaka 18.
Momwe mungatenge Meldonium 500
Mlingo umodzi, kuchuluka kwa Mlingo patsiku komanso nthawi yayitali ya mankhwala amathandizidwa ndi wodwala aliyense payekhapayekha ndi dokotala. Zimangodalira kungodziwa wodwalayo, komanso mkhalidwe wakuthupi wake. Wopanga malangizo a mankhwalawa amalimbikitsa magawo a kumwa Meldonium mu mulingo wa 500 mg:
- Ngati mwayamba kudwala matenda a mtima: 1 kapisozi kapena jakisoni tsiku lililonse. Kutalika kwa jakisoni ndi masiku 10, kutalika kwa pakamwa kumatenga masabata atatu.
- Kulephera kwa mtima kosatha: choyamba, kudzera m'mitsempha kapena mu mnofu, mpaka 1000 mg ya mankhwala patsiku kwa masabata awiri. Kenako - pa kapisozi kanayi / tsiku. Njira yamankhwala imatha kufikira milungu 6.
- Ndi Cardialgia: kudzera m'mitsempha 1 kapena tsiku kwa masabata awiri. Kenako ikanikeni kapisozi ndi muyezo wotsikirapo.
- Ndi zizindikiro zodziletsa: kapisozi kanayi / tsiku osaposa masiku 10. Ngati ndi kotheka, kulowetsedwa kwa mankhwala osokoneza bongo sikungapangidwe osaposa 1 g / tsiku.
- Ndi katundu wambiri: pa kapisozi 2 kawiri / tsiku, kutalika kwa maphunzirowo ndi masiku 10 mpaka 14.
Mlingo umodzi, kuchuluka kwa Mlingo patsiku komanso nthawi yayitali ya mankhwala amathandizidwa ndi wodwala aliyense payekhapayekha ndi dokotala.
Musanadye kapena musanadye
Malangizo okhudzana ndi momwe Meldonium ayenera kumwedwa asanadye kapena asanadyepo malangizo omwe akupanga. Komabe, kafukufuku wasonyeza kuti kugona pamimba yonse kumachepetsa kukhudzana kwa mankhwalawa, ngakhale kuti sikukhudza kugwira ntchito kwake. Ngati mungathe kukhala ndi vuto la kukomoka, mutha kumwa makapisozi kwa mphindi 30 mutatha kudya. Popanga mankhwala ophatikiza, mphindi 15 pakati pakumwa Meldonium ndi mankhwala ena ziyenera kuonedwa.
Ndi mtsempha wa intravenous kapena intramuscular, palibe mgwirizano ndi chakudya chomwe wapezeka.
Mlingo wa matenda ashuga
Meldonium imavomerezeka kuti izigwiritsidwa ntchito mu matenda a shuga, ngakhale atakhala amtundu wanji. Ichi ndichifukwa chake amatha kuchepetsa shuga m'magazi ndikuyambitsa metabolism. Ndikofunikira kumwa makapisozi a 1-2 patsiku. Kubwereza mankhwala kangapo pachaka ndikulimbikitsidwa. Kuwerengera kwa nthawi yomwe mankhwalawa amagwiritsidwa ntchito komanso kupuma pakati pa maphunziro kumatsimikiziridwa ndi dokotala.
Ndi kukula kwa vuto la dyspeptic, mutha kumwa makapisozi mphindi 30 mutatha kudya.
Zotsatira zoyipa za Meldonium 500
Zotsatira zoyipa mukamamwa Meldonium ndizosowa. Odwala anena zoyipa za mankhwala ndi mankhwala monga:
- tachycardia;
- kudumpha mu kuthamanga kwa magazi;
- psychomotor mukubwadamuka;
- dyspepsia, mawonetseredwe omwe angakhale ofanana ndi zizindikiro zamatenda am'mimba;
- mawonekedwe owoneka osiyanasiyana.
Zokhudza mphamvu pakuwongolera njira
Meldonium sikuchepetsa kuthekera kwambiri, sikuchepetsa chidwi komanso sikuchititsa kugona. Chifukwa chake, chikalandilidwa, palibe chifukwa chochepetsera ntchitoyo m'njira zovuta.
Psychomotor mukubwadamuka kumatha kukhala ngati mavuto.
Malangizo apadera
Chifukwa chakuti mankhwalawa ali ndi zosangalatsa, ndikofunikira kumwa m'mawa. Mu milandu yomwe Mlingo wambiri akuwonetsedwa patsiku, kapisoti yomaliza iyenera kuledzera asanafike 1700. Malangizowo akukhudza jakisoni.
Mukamwa Meldonium, muyenera kusamala pochita matenda a chiwindi ndi impso. Ndi maphunziro atali, kuyang'aniridwa kwa achipatala ndikuwunika magawo a labotale ndikofunikira.
Gwiritsani ntchito mu ukalamba
Anthu achikulire nthawi zambiri amamwa mankhwala ambiri osiyanasiyana. Chifukwa chakuti Meldonium ali ndi kuthekera koonjezera mankhwalawa komanso zotsatira zoyipa za mankhwalawa, asanayambe kugwiritsa ntchito, munthu wokalamba ayenera kufunsa katswiri yemwe amatha kuyesa kuyenderana kwa mankhwalawa ndi ena komanso chitetezo chamtundu wa wodwalayo.
Kulembera Meldonium kwa ana 500
Palibe deta pa zamankhwala zomwe zimachitika pa Meldonium pa thupi la ana. Chifukwa chake, mankhwalawa saikidwa kwa odwala osakwana zaka 18.
Okalamba amalangizidwa kuti azikambirana ndi dokotala musanagwiritse ntchito meldonium.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa amaletsedwa kuti azigwiritsidwa ntchito ndi amayi omwe ali ndi pakati komanso oyembekezera.
Mankhwala ochulukirapo a Meldonium 500
Nkhani za bongo wa Meldonium sizinalembedwe.
Kuchita ndi mankhwala ena
Meldonium imatha kupititsa patsogolo zotsatira za mankhwala angapo:
- adapangidwa kuti athane ndi kupanikizika kozungulira;
- mankhwalawa angina pectoris;
- mankhwala azitsamba omwe amatha kupereka antiarrhythmic athari (mtima glycosides).
Kuphatikizidwa ndi mankhwala othana ndi matenda oopsa komanso zinthu zomwe zimakhudza lumen ya zotumphukira zingapangitse kukula kwa tachycardia ndi kuponya kwakuthwa pakukakamiza.
Kumwa zakumwa zoledzeretsa panthawi ya mankhwala ndi Meldonium kumatsutsana.
Kuyenderana ndi mowa
Kumwa zakumwa zoledzeretsa panthawi ya mankhwala ndi Meldonium kumatsutsana. Kuphatikiza kumeneku sikungochepetsa kuthandizira kwa mankhwalawa, komanso kumathandizira mwayi wazotsatira zoyipa. Iyenera kusiyidwa osati kuchokera ku vodika ndi zakumwa zina zamkaka, komanso kwa mowa ndi mowa wambiri.
Analogi
Ma Analogs a Meldonium ndi mankhwala onse omwe ali ndi zinthu zomwezi. Amatha kukhala ndi mawonekedwe omwewo a kutulutsidwa kapena kukhala madzi, mapiritsi, njira zovomerezeka kapena makapisozi amtundu wina.
Mankhwala otchuka kwambiri amalembedwe awa:
- Mildronate;
- Idrinol;
- Angiocardyl;
- Maluwa;
- Midrocard N.
Kupita kwina mankhwala
Ndizovuta kupeza mankhwala m'mafakitale omwe ali ndi dzina la malonda Meldonium ndikupanga mawonekedwe a makapisozi a 500 mg, ngakhale atakhala kuti yemwe ali ndi chikalata chovomerezeka ndi kampani ya ku Russia Pharmstandard-Leksredstva OAO. Ma network ambiri amapereka kugula ma analogi ake. Mankhwala omwewo mu ampoules amatha kugulidwa popanda kufufuza kwakutali.
Kodi ndingagule popanda kulandira mankhwala?
Malangizo a mankhwalawa omwe ali ndi 500 mg a Meldonium, opanga amawonetsa kuti mankhwalawa amayenera kuperekedwa pokhapokha atapereka mankhwala. Kufunika kwatsatanetsatane wa lamuloli mumapulogalamu ena kumadalira ndondomeko ya bungwe. Zochita zimawonetsa kuti akatswiri azamankhwala amapita kwa makasitomala.
Mildronate ndi analogue ya Meldonium.
Mtengo wa Meldonium 500
Munthu amene akufuna kugula mankhwala okhala ndi 500 mg ya meldonium mu kapisozi, nthawi zambiri amafunsidwa kuti asankhe Mildronate. Mtengo wa mankhwalawa m'masitolo apulogalamu ya pa intaneti umayambira ku ma ruble 514.
Mtengo wa phukusi la ma ampoules 10 a Meldonium mwanjira yothetsera jakisoni wopangidwa ndi JSC "Biochemist" ndi ma ruble 240. Mankhwala omwewo opangidwa ndi LLC Grotex atenga ndalama zokwana 187 rubles.
Zosungidwa zamankhwala
Meldonium iyenera kusungidwa kutentha mpaka + 25 ° C. Makapisozi ndi ma ampoules sayenera kuzizira. Sizoletsedwa kusiya mankhwalawa pamalo omwe ana akhoza kupezeka.
Tsiku lotha ntchito
Makapisozi amatha kusungidwa kwa zaka 3, yankho - zaka 4.
500 mg ya meldonium imakhala yovuta kwambiri kupeza mumafakisi, kotero nthawi zambiri imasinthidwa ndi analogues.
Wopanga
Mankhwala okhala ndi dzina la malonda a Meldonium ndi zomwe zimagwiranso ntchito m'mabotolo amatha kupangidwa ndi Pharmstandard-Leksredstva OJSC.
Ma Ampoules okhala ndi yankho la jakisoni amapangidwa ndi makampani a Biochemist JSC ndi Grotex LLC.
Ndemanga za Meldonia 500
Ndemanga zambiri za anthu omwe amatenga Meldonium ndi zabwino.
Omvera zamtima
Svetlana, Moscow: "Nthawi zonse ndimapereka mankhwalawa kwa angina pectoris. Odwala anga amauza kuchepa kwa pafupipafupi. Chimodzi mwamaubwino apakati pa mankhwalawa ndi kuthekera kwake kuchepetsa kufunika kwa nitroglycerin."
Odwala
Andrey, wazaka 48, Nizhny Novgorod: "Ndinapita kwa dotolo chifukwa cha kutaya mphamvu. Nditamaliza maphunziro ake ndi Meldonium, ndikutha kuwona kuti ntchito yake ndiyabwino. Ndikumva bwino tsiku lonse."
