Metformin Canon ndi mankhwala osokoneza bongo opangidwa kuchokera ku gulu la Biguanide. Amagwiritsidwa ntchito pochiza matenda ashuga komanso kunenepa kwambiri chifukwa cha kuperewera kwa lipid ndi carbohydrate metabolism.
Dzinalo Losayenerana
Metformin.
Dzinali m'Chilatini ndi Metformin.
Metformin Canon imagwiritsidwa ntchito pochiza matenda osokoneza bongo komanso kunenepa kwambiri chifukwa cha kuperewera kwa lipid ndi carbohydrate metabolism.
ATX
A10BA02.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka mu mawonekedwe a mapiritsi okhala ndi filimu. Pali mapiritsi okhala ndi 500 mg, 850 mg ndi 1000 mg ya metformin.
Mapiritsi okhala ndi Mlingo wa 500 mg ndi ozungulira, ndipo mapiritsi okhala ndi 850 mg ndi 1000 mg (Metformin kutalika) amakhala owulungika.
Mankhwala amapezeka mu mawonekedwe a mapiritsi okhala ndi filimu.
Mapale:
- Metformin hydrochloride.
- Polyethylene glycol (macrogol).
- Povidone.
- Talc.
- Sodium stearyl fumarate.
- Wowuma wa sodium carboxymethyl.
- Wowuma pregelatinized.
- Opadry II woyera (wopanga kuyimitsidwa).
- Titanium dioxide.
- Mowa wa Polyvinyl.
Zotsatira za pharmacological
Metformin imalepheretsa gluconeogeneis, kaphatikizidwe wamafuta acids aulere, komanso njira ya lipolysis (kusweka kwamafuta) ndi oxidation wamafuta. Nthawi yomweyo, kumwa kwa glucose mthupi kumayambitsidwa ndikuwonjezera chidwi cha maselo kuti apange insulin.
Mankhwala amateteza zomwe zili ndi triglycerides ndi cholesterol m'magazi. Pali kuchepetsa pang'onopang'ono kwa odwala onenepa kwambiri.
Mankhwala tikulimbikitsidwa pamaso pa thrombosis, chifukwa ali ndi fibrinolytic. Metformin imathandiza kuthetsa ziwalo zamagazi m'mitsempha yamagazi.
Mankhwala tikulimbikitsidwa pamaso pa thrombosis, chifukwa ali ndi fibrinolytic.
Pharmacokinetics
Mukamamwa pakamwa, mankhwalawo amayamba kutengeka pang'onopang'ono kuchokera m'mimba. Kulowetsedwa kwa Metformin ndi 50%. Bioavailability sichidutsa 60%. Zinthu zimafika poizika kwambiri m'madzi am'madzi mkati mwa 2-2,5 maola.
Metformin imangokhala yofooka mpaka kumagazi a albin, koma imalowetsedwa mwachangu zamadzimadzi achilengedwe. Amadzipatula m'thupi ndi impso makamaka zosasinthika. Nthawi ya excretion ndi maola 8-12.
Kodi limayikidwa kuti?
Mankhwalawa amalembera achikulire ndi ana a zaka zopitilira 10 kuchokera ku kunenepa kwambiri ndi mtundu wa 2 wodwala mellitus (osagwirizana ndi insulin). Mankhwalawa angagwiritsidwe ntchito m'njira zoyambira komanso zachiwiri (kuphatikiza ndi insulin).
Zizindikiro zina zogwiritsidwa ntchito ndi:
- Mafuta hepatosis (chiwindi dystrophy). Matenda omwe hepatocytes (maselo a chiwindi) amasinthidwa kukhala minofu ya lipid.
- Polycystic ovary. Izi matenda nthawi zambiri limodzi ndi kuchuluka insulin kukana. Pali kupangika kwakukulu kwa mahomoni awa ndikuwonjezereka kwa kuchuluka kwa shuga m'magazi.
- Hyperlipidemia. Matendawa amadziwika ndi nkhani zambiri za lipids ndi lipoprotein m'magazi.
Chizindikiro chogwiritsidwa ntchito ndi mafuta a hepatosis.
Contraindication
Mankhwala contraindised otsatirawa milandu:
- kusalolera payekha kwa metformin kapena oyimira;
- matenda a shuga;
- matenda ashuga;
- matenda akulu a chiwindi;
- aimpso kuwonongeka;
- kutsegula m'mimba kwambiri kapena kusanza;
- matenda opatsirana opatsirana;
- hypoxia;
- malungo;
- sepsis
- anaphylactic mantha;
- myocardial infarction;
- kupuma kapena kulephera kwa mtima;
- uchidakwa;
- lactic acidosis;
- kuchepa kwa kalori;
- ana ochepera zaka 10.
Ndi chisamaliro
Pazaka zopitilira 60, pamakhala chiopsezo chachikulu chotenga lactic acidosis. Chifukwa chake, odwala okalamba amapatsidwa mankhwala mosamala.
Momwe mungatenge Metformin Canon?
Mankhwalawa adapangira pakamwa.
Asanadye kapena pambuyo chakudya?
Kuti muchepetse mavuto obwera chifukwa cha metformin pamimba, mapiritsi amalimbikitsidwa kuti amwe ndi chakudya kapena pambuyo pake.
Kumwa mankhwala a shuga
Malinga ndi malangizo, achikulire omwe ali ndi monotherapy amakhazikitsidwa 1000-1500 mg wa mankhwala patsiku. Ngati ndi kotheka, tsiku lililonse mlingo umakulitsidwa pang'onopang'ono mpaka 2000 mg. Mlingo wapamwamba tsiku lililonse ndi 3000 mg wa metformin. Mlingo wa tsiku ndi tsiku utha kugawidwa mu Mlingo wa 2-3.
Akaphatikizidwa ndi insulin, mlingo wa Metformin ndi 1000-1500 mg patsiku. Pa mankhwala, kusintha kwa insulin kungafunike.
Kodi mungatani kuti muchepetse kunenepa?
Zochizira kunenepa, zomwe zimapangitsa kuti insulin ikane, mankhwalawa ndi mankhwala 500 mg kamodzi. Mlingo ukuwonjezeka 2000 mg pa tsiku, kuwonjezera 500 mg sabata lililonse.
Metformin imathandizira kuchepetsa kulemera pophatikizidwa ndi zakudya zoyenera.
Metformin imathandizira kuchepetsa kulemera pophatikizidwa ndi zakudya zoyenera. Koma kudya mosamalitsa sikungalandiridwe chifukwa choopsa cha hypoglycemia.
Zotsatira zoyipa za Metformin Canon
Mukumwa mankhwalawa, zoyipa za ziwalo zosiyanasiyana zimawonedwa, koma nthawi zambiri, m'mimba mumakhala zovuta.
Matumbo
Kuchokera m'mimba momwe timayang'aniridwa:
- kusanza ndi kusanza
- kulawa kwazitsulo mkamwa;
- kusadya bwino;
- matenda a anorexia;
- kupweteka m'mimba ndi matumbo;
- kutsegula m'mimba
- kuchuluka kwa mpweya.
Kuchokera kumbali ya kagayidwe
Zokhudza kagayidwe:
- lactic acidosis;
- Kuperewera kwa B12 (kuperewera kwa mavitamini).
Pa khungu
Khungu limapangika pakhungu, kuyabwa, ndi zinthu zina zam'deralo zomwe zimachitika.
Dongosolo la Endocrine
Zotsatira zoyipa zimawonetsedwa ndi shuga wochepa kwambiri m'magazi - hypoglycemia.
Matupi omaliza
Ndi tsankho la munthu pazinthu zomwe zikuchitika, pali:
- zotupa
- Khungu;
- urticaria;
- redness la pakhungu.
Zokhudza mphamvu pakuwongolera njira
Zosagwirizana ndi kuzunzidwa. Komabe, chifukwa cha chiwopsezo cha kukhala ndi hypoglycemia, kusamala kuyenera kuchitidwa poyendetsa.
Malangizo apadera
Pamaso ntchito ndi mayeso ntchito radiopaque zinthu, mankhwala anathetsa. Kuchotsa mankhwala kumachitika masiku awiri asanafike mayeso ndipo amayambiranso pambuyo masiku awiri.
Pamaso pa opareshoni, mankhwala amatsitsidwa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Popeza zinthu zomwe zimadutsa zimadutsa placenta, amayi apakati saloledwa kumwa mankhwalawa. Maphunziro odalirika a teratogenic zotsatira za metformin sanachitike. Nthawi zina madokotala amapereka mankhwala kwa amayi apakati ngati pakufunika.
Kuyamwitsa panthawi ya chithandizo ndikulimbikitsidwa kuti uyime.
Kupangira Metformin Canon kwa Ana
Mankhwalawa amaloledwa kupita kwa ana opitirira zaka 10 moyang'aniridwa ndi dokotala.
Gwiritsani ntchito mu ukalamba
Mankhwalawa osavomerezeka kwa anthu okalamba (pambuyo pa zaka 60) chifukwa cha chiwopsezo chachikulu cha lactic acidosis.
The ntchito aimpso kuwonongeka
Zotsimikizika.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Sizoletsedwa kuvomera.
Mankhwala ochulukirapo a Metformin Canon
Mukamamwa mankhwala kwambiri Mlingo,
- kusanza ndi kusanza
- kutsegula m'mimba
- kutentha pang'ono kwa thupi;
- kupweteka m'mimba;
- Chizungulire
- kukomoka
- chikomokere
Kuchita ndi mankhwala ena
Mankhwala amatengedwa mosamala ndi mankhwala otsatirawa:
- Danazole (wothandizira hyperglycemic).
- Chlorpromazine.
- Ma antipsychotic.
- Zochokera ku sulfonylureas.
- NSAIDs.
- Oxytetracycline.
- ACE ndi Mao zoletsa.
- Clofibates.
- Mankhwala a Hormonal (kuphatikiza kulera kwa pakamwa).
- Ma diuretics (ochokera pagulu la thiazide kapena loop diuretics).
- Amachokera ku nicotinic acid ndi phenothiazine.
- Glucagon.
- Cimetidine.
Ngati kuphatikiza koteroko ndikofunikira, adokotala amasintha muyeso wa mankhwalawo ndikuwongolera kuchuluka kwa shuga ndi lactic acid m'magazi.
Kuyenderana ndi mowa
Izi sizigwirizana ndi mowa. Mowa umawonjezera chiopsezo cha minofu hypoxia, lactic acidosis ndi zovuta zina.
Analogi
Ma fanizo odziwika bwino pankhaniyi akuphatikiza Glucophage (Merck Sante, France), Formmetin (Pharmstandard, Russia), Siofor (Berlin-Chemie, France). Mankhwalawa ali ndi chinthu chofanana - metformin hydrochloride.
Mankhwala monga Metformin Teva ndi Metformin Richter ndi ma genetic. Ndizofanana ndi Metformin Canon pamapangidwe ndi zochita, koma amapangidwa ndi ena opanga.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Mankhwalawa ndi a mndandanda B ndipo amaperekedwa mosamalitsa ndi mankhwala.
Mtengo wa Metformin Canon
Mtengo wa mankhwalawa ku Russia ndi ma ruble a 130-200. mapiritsi 30.
Glucophage ndi amodzi mwa fanizo lotchuka lazinthu izi.
Zosungidwa zamankhwala
Sungani mankhwalawo pa kutentha osaposa 25 ° C.
Tsiku lotha ntchito
Mankhwalawa ndi oyenera kwa zaka zitatu.
Wopanga
Wopanga chida ichi ndi CJSC Kanofarma Production, NPO FarmVilar (Russia).
Ndemanga pa Metformin Canon
Madokotala
Konstantin, wazaka 42, St. Petersburg
Ndakhala ndikugwira ntchito ya endocrinologist kwazaka 10. Mankhwalawa amalembedwa kwa odwala matenda a shuga komanso kunenepa kwambiri. Zimathandizira kuteteza kagayidwe kazigawo ndi glucose. Sindimawona zotsatira zoyipa machitidwe anga.
Irina, wazaka 35, Krasnodar
Metformin ndiwothandiza pa matenda a shuga 2. Odwala anga amalekerera bwino mapiritsi awa. Pakatha mwezi umodzi amatenga magazi madontho. Popewa kupweteka m'mimba, ndikulimbikitsa kuti musamwe mankhwalawa pamimba yopanda kanthu.
Odwala
Valentin, wazaka 56, Belorechensk
Ndinaphunzira zamankhwala monga Metformin, Siofor, Glucofage kuchokera kwa endocrinologist. Adawalimbikitsa kuti alimbane ndi matenda ashuga. Ubwino wa Metformin poyerekeza ma analogu ndi mtengo wotsika. Mankhwalawa adathandizira ndipo sanayambitse zoyipa.
Alexander, wazaka 43, Volgograd
Ndimamwa mankhwalawa pofuna kupewa matenda ashuga. Shuga wamagazi adayamba kukwera, ndipo adotolo adatcha Metformin. Sindinapeze zoyipa zilizonse panthawi yamankhwala.
Kuchepetsa thupi
Ekaterina, wazaka 27, Moscow
Nditabereka, ndinayamba kuchira msanga. Sindingathe kutsatira zakudya zosafunikira kwa nthawi yayitali, choncho ndidaganiza zoyesa Metformin kuti muchepetse chilakolako cha kudya. Mankhwalawa adathandizira kuchotsa makilogalamu asanu pamwezi. Njala inachepetsa, ndipo sinditha kudya kwambiri.
Arina, wazaka 33, Irkutsk
Ndinayamba kumwa mapiritsiwa motsimikiza kwa dokotala. Mankhwalawa amachepetsa chilakolako chofuna kusangalatsa maswiti. Mwezi wovomerezeka, kulemera kwanga kunachepa ndi 4 kg, zomwe ndine wokondwa. Panalibe mavuto.
