Momwe mungagwiritsire ntchito mankhwala gabapentin 300?

Gabapentin 300 ndi mankhwala omwe ali ndi anticonvulsant. Katunduyo ndi gawo la mankhwalawa ndipo amamugulitsa pansi pa mayina wamba: Neurontin ndi Gabagamm. Chosakaniza chophatikizacho chimagwiritsidwa ntchito pochiza matenda a khunyu mwa ana kuyambira zaka zitatu ndikuchotsa kupweteka kwa neuropathic kwa odwala akuluakulu. Mankhwala saloledwa kugwiritsa ntchito jakisoni.

Dzinalo Losayenerana

Gabapentin.

Gabapentin 300 ndi mankhwala omwe ali ndi anticonvulsant.

ATX

N03AX12.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapezeka mu mawonekedwe a piritsi komanso mu kapisozi kapenanso pakamwa. Zopanda ma ampoules a jekeseni.

Mapiritsi

Phale loyera limakhala ndi mawonekedwe amodzi ndipo limakutidwa ndi filimu ya enteric. Pali zoopsa ndi zolemba za kampani yopanga mbali zonse ziwiri zamankhwala. Piritsi limodzi lili ndi 800 mg yogwira ntchito - gabapentin ndi zina zowonjezera, zomwe zimaphatikizapo:

• crospovidone;
• wowuma chimanga;
• magnesium wakuba;
• poloxamer 407.

Ulusi wamakanema womwe umakhala ndi candelila (mankhwala azitsamba), talc ndi hyprolose. Mapiritsi amadzaza zidutswa 10 m'matumba. Mtolo wa makatoni ukhoza kukhala ndi mapepala awiri amtundu wa 2, 5 kapena 10.

Makapisozi

Makapisozi adakutidwa ndi chipolopolo cholimba cha gelatin. Mkati mwa fomu ya mankhwalawa muli ufa woyera, womwe ndi msanganizo wa zotuluka ndi gulu logwira - 300 mg la gabapentin. Monga zina zomwe zimagwiritsidwa ntchito popanga:

• macrogol 6000;
• magnesium wakuba;
• wowuma mbatata;
• dihydrogenated calcium hydrogen phosphate.

Thupi la kapisozi limapangidwa ndi titanium dioxide ndi gelatin. Utoto wophatikizika: quinoline chikasu ndi indigo carmine imapereka mtundu wobiriwira ku chipolopolo.

Gabapentin amapezeka mu mawonekedwe a kapisozi.

Zotsatira za pharmacological

Gawo la gabapentin limabwereza mtundu wa morma-aminobutyric acid (GABA), womwe umakhala ngati neurotransmitter m'thupi. Pankhaniyi, chinthu chogwiritsidwa ntchito chimasiyana ndi neurotransmitter mu pharmacological kanthu. Gabapentin samanga ma barbiturates, GABA aminotransferase blockers, valproic acid ndi zotumphukira za γ-aminobutyric acid, potero sizikuwakhudza kubisala ndi kuwonongeka kwa GABA.

Mu maphunziro a zamankhwala, zidadziwika kuti chinthu chogwira ntchito chimapanga zovuta ndi alpha2-delta subunit ya njira zama calcium, zomwe zimathandizira pakupanga kupweteka kwa neuropathic. Chifukwa cha zomwe a Gabapentin akutulutsa, kutulutsidwa kwa calcium ion mu malo a interellular kumachepa, kubisala kwa gamma-aminobutyric acid kumawonjezeka, kufa kwa maselo amitsempha kuchokera pakulankhula kwa glutamic acid kumachepa, ndipo kufalikira kwa zotulutsa zama neurotransmitters a gulu la amine kumachitika. Zotsatira zake, ululu wa neuropathic samachitika.

Pharmacokinetics

Pakaperekedwa pakamwa, yogwira pophika imakwanira mu plasma mkati mwa maola 2-3. Bioavailability ndi 60%. Mapiritsi ndi makapisozi amataya michere yawo mkati mwa matumbo ang'onoang'ono mothandizidwa ndi ma enzymes apadera (esterases). Zinthu zomwe zimagwira zimaphatikizidwa m'makoma a matumbo, kuchokera pomwe zimasiyanirana m'matumbo.

Mankhwala samasintha mu chiwindi.

Zakudya zamafuta ambiri sizimachepetsa mayamwidwe ndi kuchuluka kwa mankhwalawa. Mu kama wamitsempha, osakwana 3% yaomwe amagwira amapanga mapuloteni a plasma. Mankhwala samasintha mu chiwindi. Kutha kwa theka moyo kumafika pafupifupi maola 5-7. Gabapentin amachoka m'thupi kudzera mu kwamikodzo m'njira yake yoyambirira.

Kodi chimagwiritsidwa ntchito ndi chiyani?

Mankhwalawa amagwiritsidwa ntchito ngati monotherapy mwa ana a zaka 12 mpaka 18 ndipo amaphatikizidwa ndi mankhwala othandizira akuluakulu. Mankhwalawa ngofunika kuti muchepetse kukomoka kwapadera pazomwe zili ndi khunyu. Odwala omwe ali ndi zaka zopitilira 12 amathandizidwa, mosasamala kanthu za kukhalapo kwa generalization kapena kusakhalapo. Nthawi zina, gabapentin ndi mankhwala okhazikika a khunyu odwala zaka zopitilira 3.

Mankhwala amaloledwa kugwiritsidwa ntchito poletsa ululu wa neuropathic odwala kuyambira azaka 18.

Contraindication

Ndi zoletsedwa kumwa mapiritsi ndi makapisozi pamaso poti chiwopsezo cha ziwalo za thupi chizigwira ntchito mothandizirana.

Ndi chisamaliro

Chenjezo liyenera kuchitidwa ngati vuto la impso.

Chenjezo liyenera kuchitidwa ngati vuto la impso.

Momwe mungagwiritsire gabapentin 300

Mitundu ya Mlingo imapangidwa pakamwa pakamwa popanda kutafuna. Kupukuta kwamakina kumayambitsa kuchepa kwa mayamwidwe. Mukasinthira ku mankhwala ena, simuyenera kusiya mwadzidzidzi kumwa Gabapentin. Kusinthanitsa kumachitika ndi kuchepetsa pang'onopang'ono Mlingo woposa masiku 7.

Kuti athetse njira ya pathological mu somatosensory neva system yomwe imayambitsa kupweteka kwa mitsempha, ndikofunikira kutenga 900 mg patsiku. Mlingo wa tsiku ndi tsiku umagawidwa pawiri. Ndi otsika achire kwenikweni, mulingo ungathe kuchuluka pang'onopang'ono mpaka pazovomerezeka - 3,6 g patsiku. Chithandizo cha mankhwala osokoneza bongo chimayamba ndi 900 mg / tsiku kapena njira ina yochiritsira. Potsiriza, mlingo wa tsiku ndi tsiku umakulitsidwa pang'onopang'ono mpaka 0,9 g pakufunika masiku atatu:

• 1 tsiku limodzi kamodzi 0,3 ga;
• kwa masiku 2, pafupipafupi kugwiritsa ntchito ndi 2 zina 300 mg;
• pa tsiku la 3, 900 mg amatengedwa, amagawidwa pawiri.

Kuti tikwaniritse antiepileptic zotsatira, odwala opitilira zaka 12 amafunika kumwa kuchokera 900 mpaka 3600 mg patsiku. Kutalika kwakukulu pakati Mlingo wa mapiritsi kapena makapisozi sayenera kupitirira maola 12 kuteteza kukula kwa khunyu.

Poyerekeza ndi kulephera kwa impso, dokotala amasintha mlingo wa tsiku ndi tsiku kutengera Cl (creatinine chilolezo).

Zomwe zimagwiritsidwa ntchito sizikhudzana ndi magwiridwe antchito a zisumbu za Langerhans za kapamba.

Odwala a hemodialysis tikulimbikitsidwa kuti atenge 300-400 mg patsiku loyamba la mankhwalawa, Mlingo wotsatira ukhale 0,2-0.3 g maola 4 asanachitike.

Ndi matenda ashuga

The yogwira mankhwala sizikhudzana magwiridwe antchito a islets a Langerhans a kapamba ndipo samatulutsa glycemic kwambiri pa plasma ndende ya glucose m'magazi. Chifukwa chake, odwala matenda a shuga safuna kusintha kwa mlingo woyenera.

Zotsatira zoyipa

Zotsatira zoyipa zimachitika ndi mlingo woyenera wa mankhwalawa. Pankhani yovuta ya gabapentin, ndikofunikira kusiya kumwa mankhwalawo ndikupita kuchipatala.

Matumbo

Zosintha pammimba zakudya zimayendera limodzi ndi maulemu, kupweteka kwa epigastric, kutsekula m'mimba. Poyerekeza ndi vuto la kugaya chakudya, matenda a anorexia kapena chilimbikitso chowonjezereka chimayamba. Nthawi zina, kusinthasintha kwa enamel ya mano kumawonedwa, pakamwa pouma kumawonekera, kapamba ndi chiwindi zimayaka, mulingo wa bilirubin komanso ntchito ya hepatocyte aminotransferases imakwera.

Hematopoietic ziwalo

Supombocytopenic purpura, leukocytopenia ndi kuperewera kwa mapasulo ndizotheka.

Pakati mantha dongosolo

Kuponderezedwa kwamanjenje kumawonetsedwa muzizindikiro monga:

• Chizungulire
• kusowa kwa Reflex mu tendons;
• kusokonezeka kwa chidwi;
• kutaya mtima kwamphamvu (kupsinjika, kuda nkhawa);
• kuyerekezera;
• kugona
• kugwedezeka kwamiyendo;
• kufooka wamba.

Nthawi zina, ataxia, nystagmus, choreoathetosis amapezeka.

Matenda okhumudwa amatha kuchitika chifukwa chogwiritsa ntchito mankhwalawa Gabapentin.

Gabapentin angayambitse matenda am'mimba.

Gabapentin angayambitse kuyabwa.

Gabapentin amayambitsa kugona.

Gabapentin amayambitsa chizungulire.

Gabapentin angayambitse matenda a anorexia.

Kuchokera ku kupuma

Ndi kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, kutsokomola kouma, kufupika, kupuma, ndi matenda a kupuma kumawonekeranso.

Pa khungu

Kutulutsa khungu: ziphuphu, kutupa, totupa, pruritus, ndi matenda a Stevens-Johnson.

Kuchokera pamtima

Minofu yosalala ya khoma la mtima imapumulanso, kuthamanga kwa magazi kumakwera ndipo kuthamanga kwa mtima kumawonjezeka.

Matupi omaliza

Ngati wodwalayo ali ndi vuto la chiwonetsero cha thupi lawo siligwirizana, kukhazikika kwa khungu la pakhosi ndi larynx, bronchospasm ndi anaphylactic. Ndi chifuwa chofatsa kuti chikhale zolimba, kusintha kwa khungu ndi kutupa kwa nkhope ndikotheka.

Malangizo apadera

Pakafukufuku wamankhwala. Kutsika pang'ono pang'onopang'ono kwa mankhwalawa ndikofunikira kuti muchepetse kuopsa kwa khunyu ndi kugwidwa pamene mankhwala a antiepileptic atathetsedwa.

Mankhwala sinafotokozeredwe kwa khunyu ndi paroxysms wopweteka.

Kuchita mkodzo pafupipafupi kumatha kuwonetsa kuti palibe vuto la proteinuria. Kuti mupewe kuyesedwa mobwerezabwereza kuti mupeze mapuloteni mu mkodzo, ndikofunikira kuchenjeza ogwira ntchito Laborator kuti atenge Gabapentin. Akatswiri azichita kafukufuku pogwiritsa ntchito sulfosalicylic acid.

Kuchita mkodzo pafupipafupi kumatha kuwonetsa kukhudzika kwa proteinuria mwa odwala omwe akutenga gabapentin.

Gwiritsani ntchito mu ukalamba

Anthu opitilira zaka zopitilira 65 safunika kusintha njira zina.

Kulembera Gabapentin kwa ana 300

Kwa ana opitirira zaka 12, muyezo wa 900 mg tsiku lililonse amathandizidwa kuti azigwiritsa ntchito pang'ono.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Kumwa mankhwalawa panthawi yapakati sikulimbikitsidwa. Maphunziro okwanira azachipatala okhudzana ndi kutha kwa Gabapentin kudutsa chotchinga sichinachitike, chifukwa chake pamakhala chiwopsezo cha kutukuka kwa minofu pakukula kwa mankhwalawa pakumwa mankhwala.

Pa mankhwala a gabapentin, kuyamwitsa kuyenera kuyimitsidwa.

Bongo

Ndi nkhanza ya mankhwala, chitukuko cha:

• Chizungulire
• kugona
• kusokonezeka kwa ntchito yolankhula;
• ulesi;
• diplopia.

Wovutitsidwayo amayenera kutsuka m'mimba ndikupereka adsorbent. Kuthana ndi zizindikiro za bongo, chithandizo chamankhwala chimachitika.

Vuto la mankhwala osokoneza bongo, wogwirirayo ayenera kutsuka m'mimba.

Kuchita ndi mankhwala ena

Momwe amagwiritsidwa ntchito mofanananso ndi gabapentin ndi mankhwala ena, zotsatirazi zimawonedwa:

1. Chithandizo chogwira sichikhudzanso magawo a pharmacokinetic a njira zakulera zamkamwa zomwe zimakhala ndi mahomoni ogonana achikazi kapena ethinyl estradiol.
2. Morphine amatengedwa maola awiri musanagwiritse ntchito Gabapentin, chifukwa mankhwala onse atamwa nthawi yomweyo, AUC ya gabapentin imachulukitsidwa ndi 43%. Malowa a ululu adakulitsidwa. Makhalidwe a theka la moyo komanso kukwaniritsidwa kwa kuchuluka kwa plasma ya Morphine sizinasinthe, chifukwa chake, machitidwe azachipatala, izi sizinakhudze thanzi la wodwalayo.
3. Phenobarbital, Mexicoidol, Valproic acid ndi mankhwala ena antiepileptic sizikhudza magawo a mankhwala a Gabapentin.
4. Ndi kufanana kwa ma antacid ndi othandizira okhala ndi mchere wa aluminium ndi magnesium, kuchepa kwa bioavailability wa Gabapentin ndi 22% kunalembedwa. Zotsatira zake, anticonvulsant imatengedwa maola 2 mutatha maantacid.
5. Probenecid sichikhudzanso kuvomerezeka kwa aimpso a Gabapentin.

Munthawi ya chithandizo ndi Gabapentin, ndizoletsedwa kumwa mowa. Mowa wa Ethyl umawonjezera mwayi wa kukhumudwa kwa chapakati chamanjenje ndipo umawonjezera zochitika zoyipa. Poyerekeza ndi zoyipa zoyipa za ethanol pa kayendetsedwe kazinthu zozungulira, kufooka kwa zochizira zotsatira za Gilapentin kumawonedwa.

Analogi

Mankhwala omwe angalowe m'malo mwa Gabapentin ndi makina amachitidwe ndi kapangidwe kazinthu monga:

• Katena
• Convalis;
• Neurontin;
• Tebantin;
• Gabagamm

Kusinthira ku mankhwala ena kumachitika moyang'aniridwa ndi achipatala chifukwa chakuwopsezedwa pang'ono.

Zinthu za tchuthi Gabapentina 300 kuchokera ku pharmacy

Mankhwalawa sanagulitsidwe popanda mankhwala aku Latin.

Kodi ndingagule popanda kulandira mankhwala?

Mankhwala anticonvulsant sangathe kugulidwa popanda upangiri wachipatala mwachindunji, chifukwa ngati mutatenga molakwika Gabapentin, mutha kuona kuchepa kwa ntchito yogwira mtima, kuwonekera kwa ululu wamitsempha ndi zotsatira zoyipa.

Zambiri bwanji ndi gabapentin 300

Mtengo wapakati wa mankhwala umasiyana kuchokera pa 349 mpaka 464 rubles.

Zosungidwa zamankhwala

Ndikulimbikitsidwa kuti mapiritsi ndi makapisozi a Gabapentin 300 azisungidwa m'malo omwe amakhala ndi chinyezi chochepa komanso kutentha mpaka + 25 ° C.

Tsiku lotha ntchito

Zaka zitatu

Wopanga Gabapentin 300

CJSC Canonfarm Production, Russia.

Katena amatengedwa ngati chithunzi cha mankhwala a Gabapentin.

Convalis amatengedwa ngati chithunzi cha mankhwala a Gabapentin.

Neurontin ndi analogue of gabapentin.

Tebantin nthawi zina amapatsidwa mankhwala m'malo mwa Gabapentin.

Gabagamm amadziwika kuti ndi analogue wa mankhwala a Gabapentin.

Ndemanga pa Gabapentin 300

Pamabungwe azachipatala pamakhala ndemanga zabwino kuchokera kwa odwala zokhudzana ndi mankhwalawa komanso malingaliro a akatswiri a mitsempha.

Madokotala

Ramil Dzhumabaev, wamisala, wazaka 44, Omsk

The achire zotsatira zimatheka mofulumira. Ndikuganiza kuti Gabapentin ndi amodzi mwa mankhwala otsika mtengo kwambiri othandizira kupweteka kwa neuropathic ndikwaniritsa zotsatira za anticonvulsant. Koma nthawi zambiri, ndimazindikira zotsatira zoyipa: myalgia, ululu wammbuyo, fractures, milandu yayikulu, amnesia imayamba.

Ivan Tikhonov, wamisala, wazaka 51, Krasnoyarsk

Gabapentin bwino amachepetsa ululu wa neuropathic wamatenda osiyanasiyana, omwe sangathe kulepheretsa mankhwala omwe si a antiidal. Pogwiritsa ntchito nthawi yayitali, muyenera kusamala. Odwala amafotokoza kusokonezedwa ndi kukhumudwa. Mlingo ndi pafupipafupi wa makonzedwe uyenera kukhazikitsidwa ndi adokotala okha.

Odwala

Anastasia Koshkina, wazaka 34, Moscow

Ndimatenga gabapentin ndikudziwitsa za matenda am'mimba a shuga. Mukamatenga, pali mphamvu ya analgesic, koma imakhala yofooka. Nditamwa mapiritsi, ndimamva chizungulire, ndimalephera kuyenda, ndimatopa. Ndikupangira kugona pambuyo pamapiritsi kwa ola limodzi.

Lilia Alekseeva, wazaka 42, Tomsk

Mankhwala amathandiza kwambiri ndi khunyu. Ndimavomereza molingana ndi malangizo. Ili ndi mphamvu yofatsa anticonvulsant. Panalibe kuchitika mutamwa mankhwalawa. Nditapuma, adayambiranso kubwereza. Zotsatira zoyipa, nditha kutsindika chizungulire, chomwe chikukula m'mawa.