Invokana adapangira zochizira matenda amitundu iwiri matenda ashuga. Imaperekedwa pakamwa. Mankhwalawa sichilowa m'malo mwa insulin, koma amathandizira kuti glycemia ikhale yachilendo.
Dzinalo Losayenerana
INN - Kanagliflozin.
Invokana adapangira zochizira matenda amitundu iwiri matenda ashuga.
ATX
A10BX11
Kutulutsa mafomu ndi kapangidwe kake
Kuphatikizika kwa mapiritsiwa kumaphatikiza canagliflozin hemihydrate mu gawo lofanana ndi 100-300 mg wa canagliflozin. Zomwe zimapangidwira zimathandizira kuphatikiza zinthu zomwe zimapangitsa kapangidwe ka piritsi ndikuthandizira kufalikira kwa zinthu zogwira ntchito mthupi.
Amapezeka mu mapiritsi a 100 kapena 300 mg, filimu yokutidwa ndi tint yachikasu. Piritsi lililonse lili ndi chiopsezo chosinthana ndi kusweka.
Zotsatira za pharmacological
Ili ndi vuto la hypoglycemic. Kanagliflosin ndi mtundu 2 wa sodium glucose cotransporter inhibitor. Pakangotha mlingo umodzi, mankhwalawa amathandizira kuphipha kwa glucose ndi impso, zomwe zimathandiza kuchepetsa kuchepa kwake m'magazi. Mankhwalawa ndi othandizika pochiza matenda osokoneza bongo omwe amadalira insulin. Siziwonjezera katemera wa insulin.
Mankhwalawa ndi othandizika pochiza matenda osokoneza bongo omwe amadalira insulin.
Kuchulukitsa diuresis, komwe kumapangitsanso kuchepa kwa ndende yamagazi. Kafukufuku wachipatala akuwonetsa kuti kugwiritsa ntchito mankhwalawa tsiku lililonse kumachepetsa mphamvu ya shuga komanso kupangitsa kuti ikhale yokhazikika. Kugwiritsira ntchito kukonzekera kwa canagliflozin kumachepetsa glycemia atatha kudya. Imathandizira kuchotsedwa kwa glucose m'matumbo.
M'maphunziro, zidatsimikizika kuti kugwiritsa ntchito Singokana ngati monotherapy kapena ngati adjunct pochiza ndi mankhwala ena a hypoglycemic, poyerekeza ndi placebo, kumathandizira kuchepetsa glycemia musanadye ndi 1.9-2.4 mmol pa lita.
Kugwiritsa ntchito mankhwalawa kumathandizira kuchepetsa glycemia pambuyo poyesa kulekerera kapena kadzutsa. Kugwiritsa ntchito canagliflozin kumachepetsa shuga ndi 2.1-3.5 mmol pa lita. Potere, mankhwalawa amathandizira kusintha magawo a beta cell mu kapamba ndikuwonjezera chiwerengero chawo.
Pharmacokinetics
Pambuyo pakukonzekera pakamwa, chinthu chogwira ntchito chimalowa mu magazi kuchokera m'mimba. Kuchuluka kwazomwe zimagwira mu plasma kumachitika pambuyo pa maola 1-2. Nthawi yomwe mankhwalawa amachotsedwa m'magazi ndi maola 10 mpaka 13. Kuyanʻanila kwa yogwira mankhwala m'magazi kumafikira masiku 4 pambuyo poyambira chithandizo.
Pambuyo pakukonzekera pakamwa, chinthu chogwira ntchito chimalowa mu magazi kuchokera m'mimba.
The bioavailability wa Invokany ndi 65%. Kudya zakudya zamafuta sikukhudza motsutsana ndi pharmacokinetics ya canagliflozin. Chifukwa chake, mankhwalawo amaloledwa kumwa onse akudya, ndikatha. Kuti mukwaniritse kuyamwa kwambiri kwa glucose, ndikulimbikitsidwa kumwa mapiritsi awa musanadye chakudya cham'mawa.
Chogulitsacho chimagawidwa m'misempha yonse. Pafupifupi timatenga mapuloteni a plasma. Komanso, ubalewu sudalira mlingo ndipo sukumana ndi vuto laimpso kapena chiwindi.
Metabolism imachitika ndi glucuronidation. Izi zimachitika chifukwa cha ntchito ya michere ya chiwindi. Ma metabolabolites amapezeka ndowe, mkodzo. Gawo laling'ono la mankhwalawa limachotsedwa m'thupi ndi impso yake osasinthika.
Kuwonongeka kwa impso sikukhudza plasma ndende ya mankhwalawa. Kusokonezeka kwa ntchito ya chiwindi komanso zaka za odwala sikukhudzana ndikugawika kwa zinthu zomwe zimagwira komanso kagayidwe kake.
Kafukufuku wa pharmacokinetics mwa anthu osakwana zaka 18 sanachitike.
Zizindikiro zogwiritsidwa ntchito
Amawonetsedwa pochiza matenda osokoneza bongo omwe amadalira shuga. Mapiritsi amaphatikizidwa ndi zakudya zama carb ochepa komanso masewera olimbitsa thupi. Imagwiritsidwanso ntchito ngati gawo la mankhwala ophatikiza odwala omwe adalandira insulin.
Contraindication
Sizingatengedwe ndi:
- Hypersensitivity kwa yogwira chigawo;
- mtundu 1 shuga;
- ketoacidosis ya odwala matenda ashuga;
- kwambiri aimpso kapena kwa chiwindi kusakwanira;
- nthawi ya phwando;
- wosakwana zaka 18.
Ndi chisamaliro
Gwiritsani ntchito mosamala mwa anthu omwe ali ndi vuto laimpso.
Wodwala akaphonya mlingo, ndiye kuti ayenera kumwa piritsi mwachangu. Sikoyenera kulipiritsa mlingo womwe wasowa ndikuwonjezera kawiri mlingo (pofuna kupewa chitukuko cha hypoglycemia).
Kodi kutenga Invocana?
Ndi matenda ashuga
Kwa matenda a shuga a 2, imwani piritsi limodzi musanadye chakudya cham'mawa. Mulingo woyenera ndi 0.1 kapena 0,3 g.
Kodi zimayamba kuthamanga motani?
Maola 1-2 atatha kumwa.
Zotsatira zoyipa
Pogwiritsa ntchito insulin, hypoglycemia imayamba. Nthawi zina, odwala amatha kuwonjezera kuchuluka kwa potaziyamu mu seramu yamagazi. Izi ndizosakhalitsa ndipo sizifunikira chithandizo chowonjezera.
Pogwiritsa ntchito insulin, hypoglycemia imayamba.
Nthawi zina pali kuwonjezeka kwa kuchuluka kwa kachulukidwe kolesterol. Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumafuna kuwongolera cholesterolemia.
Mukamagwiritsa ntchito Invokana muyezo waukulu wa mankhwalawa, kuchuluka kwa hemoglobin m'magazi kumawonedwa. Zodabwitsazi ndizakanthawi kochepa ndipo sizitsogolera kuzinthu zoipa.
Matumbo
Kumwa mankhwalawa kumayambitsa kusokonezeka kwa ntchito yokhudza chakudya cham'mimba. Odwala amamva ludzu kwambiri, pakamwa lowuma ndipo akuvutika ndi kudzimbidwa.
Kuchokera kwamikodzo
Mwinanso kuphwanya kwa magwiridwe antchito a impso mwa njira yokoka pafupipafupi komanso kutulutsa madzi ambiri. Zakumwa zomwe wodwalayo amamwa zimasintha, ndipo amayamba kumwa madzi ambiri. Zilimbikitso zosayenera zitha kuchitika, bola ngati mkodzo mulibe.
Mwinanso kuphwanya kwa magwiridwe antchito a impso mwa njira yokoka pafupipafupi komanso kutulutsa madzi ambiri.
Kuchokera ku genitourinary system
Mwa amuna, balanitis ndi balanoposthitis amatha. Amayi nthawi zambiri amakhala ndi matenda amkati komanso ziwonetsero zam'mimba za vulvovaginal candidiasis (thrush), matenda amkazi.
Kuchokera pamtima
Pokhudzana ndi kuchepa kwa magazi, chizungulire, kutsika kwa magazi ndikusintha kwa malo amthupi, zotupa pakhungu ndi urticaria ndizotheka. Kumwa mankhwalawa kumayambitsa kusowa kwamadzi.
Pa mbali ya chiwindi ndi biliary thirakiti
Sichimayambitsa kuwonongeka kwa chiwindi komanso kusintha kwa ntchito ya ma enzymes a chiwindi.
Matupi omaliza
Nthawi zina, zimathandizira kuti thupi lanu lizipweteka ngati liziwongola khungu kapena edema.
Nthawi zina, zimathandizira kuti thupi lizigwirizana chifukwa cha chotupa cha pakhungu.
Zokhudza mphamvu pakuwongolera njira
Chifukwa cha chiwopsezo cha hypoglycemia, kuyendetsa pamodzi munthawi yomweyo kapena kugwiritsa ntchito njira zovuta sikulimbikitsidwa.
Malangizo apadera
Kugwiritsa ntchito kwa mankhwalawa kwa matenda amtundu wa 1 sikunaphunzire. Zambiri pazotsatira zamankhwala sizimawona mutagenic ndi carcinogenic zotsatira za thupi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Cholinga cha mankhwalawa panthawi ya gestation ndi yoyamwitsa sichimachitika. Ngakhale maphunziro azinyama sanawonetse vuto la mwana pa mwana wosabadwayo, akatswiri azachipatala ndi othandizira salimbikitsa kugwiritsa ntchito mapiritsi atatenga mwana.
Mankhwala osokoneza bongo amaletsedwanso panthawi ya mkaka wa m'mawere, chifukwa mapiritsi omwe amatha kugwira ntchito amatha kulowa mkaka wa m'mawere ndikuchita thupi la wakhanda.
Mankhwala osokoneza bongo amaletsedwanso panthawi ya mkaka wa m'mawere, chifukwa mapiritsi omwe amatha kugwira ntchito amatha kulowa mkaka wa m'mawere ndikuchita thupi la wakhanda. Mphamvu ya mankhwalawa pachonde sichinaphunzire.
Kusankhidwa Kukhazikitsa ana
Kugwiritsa ntchito mankhwalawa ndizoletsedwa kwa odwala osakwana zaka 18.
Gwiritsani ntchito mu ukalamba
Zololedwa. Sizitengera kusintha kwa muyezo kapena mtundu wa mankhwala.
Bongo
Palibe milandu ya bongo ya Invocana yomwe idapezeka. Odwala onse analekerera kukonzanso kwa kawiri Mlingo wa mankhwala. Mlingo umodzi wa mapiritsi 5 muyezo wa 300 mg sizinadzetse vuto mthupi.
Pankhani ya bongo, mankhwala othandizira amafunikira. Kuchotsa zotsalira za mankhwalawa zomwe sizimamwa, mapiritsi am'mimba amachitika kapena mankhwala ofewetsa tuwisi wokhazikika. Kutsegula m'mimba sikothandiza.
Kuchita ndi mankhwala ena
Mankhwalawa amasintha pang'ono kuchuluka kwa digoxin m'madzi a m'magazi. Anthu omwe amamwa mankhwalawa amayenera kukhala osamala kwambiri ndikusintha kuchuluka kwake pa nthawi.
Tisinthe pang'ono mayamwidwe ndi kagayidwe ka Levonorgestrel, Glibenclamide, Hydrochlorothiazide, Metformin, Paracetamol.
Kuyenderana ndi mowa
Ndikusowa.
Analogi
Zotsatira za Invokany zimaphatikizapo:
- Forsyga;
- Baeta;
- Victoza;
- Guarem;
- Novonorm.
Mankhwala atchuthi Mankhwala atchuthi
Mankhwalawa amathandizidwa kuchokera kwa mankhwala atatha kupereka mankhwala kuchokera kwa dokotala.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala pawokha atha kugulitsa mankhwalawa osafunikira mankhwala. Pogula mankhwala, odwala amakhala pachiwopsezo chifukwa chothekera kotukula miyoyo yowopsa.
Mtengo wa Invocana
Mtengo wa mapiritsi 30 a 0,5 g - pafupifupi rubles 3,000. Mtengo wa mapiritsi 30 a Invokana 0,3 g - pafupifupi 13.5,000 ma ruble.
Zosungidwa zamankhwala
Sungani m'malo amdima komanso ozizira, kutali ndi ana.
Tsiku lotha ntchito
Yoyenera kugwiritsidwa ntchito mkati mwa zaka ziwiri kuyambira tsiku lopanga. Osagwiritsa ntchito mapiritsi atatha nthawi ino.
Wopanga Wondokany
Imapangidwa m'mabizinesi a Janssen-Ortho LLC, 00778, State Road, 933 km. 0.1 Maimi Ward, Gurabo, Puerto Rico.
Pakati pazofanizira zamankhwala, Forsigu amakhala payokha.
Ndemanga za Invocane
Madokotala ambiri komanso odwala amawona kuti mankhwalawa ndi othandizira pochizira matenda amishuga a 2.
Madokotala
Ivan Gorin, wazaka 48, wothandizira matenda a endocrinologist, Novosibirsk: "Ndikupangira Winokan kuti agwiritse ntchito odwala omwe ali ndi matenda osokoneza bongo omwe amadalira shuga."
Svetlana Usacheva, wazaka 50, wodwala matenda am'madzi, Samara: "Mankhwalawa amalimbana ndi matenda a hyperglycemia ndipo amalepheretsa zovuta za matenda ashuga.
Odwala
Matvey, wazaka 45, ku Moscow: "Mapiritsi a Attokana amathandizira kuchepetsa matenda a shuga komanso kupewa ziwonetserozo za matenda a m'magazi (hyperglycemia). Ndimapilira. Sindinawone zotsatira zoyipa za mankhwalawa."
Elena, wazaka 35, Tambov: "Zakudya za Advokana ndizabwino kuposa mankhwala ena kuti muchepetse vuto la glycemic. Pogwiritsa ntchito zakudya, ndizotheka kuti zizikhala ndi malire ake - osapitirira 7.8 mmol kwa lita."
Olga, wazaka 47, wa ku St. Petersburg: "Mothandizidwa ndi Attokana, ndimayendetsa matenda ashuga komanso ndimalepheretsa hypoglycemia kapena hyperglycemia. Nditayamba maphunziro awa ndi mankhwalawa, ndidazindikira kuti momwe ndakhalira ndikuyenda bwino."
