Saroten Retard ndi m'gulu la antidepressants atatu. Mankhwalawa amagwiritsidwa ntchito pochita zachipatala kuti athetse nkhawa komanso nkhawa zomwe zimadza chifukwa chokhala ndi nkhawa. Akatswiri amatha kupaka mankhwala a mtundu wofooka wammbuyo komanso kukula kwa kukhumudwa ndi schizophrenia. Makapisozi sanapangidwe kuti mugwiritse ntchito muubwana ndipo sanalembedwe kwa amayi apakati.
Dzinalo Losayenerana
Amitriptyline.
ATX
N06AA09.
Saroten Retard ndi m'gulu la antidepressants atatu.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapangidwa mwa mawonekedwe a makapisozi okhala ndi mphamvu yayitali. Amitriptyline hydrochloride 50 mg amagwiritsidwa ntchito ngati chinthu chogwira ntchito pamagulu antidepressant. Zomwe zili m'mabotolo zimathandizidwa ndi mankhwala othandizira:
- magawo a shuga;
- povidone;
- stearic acid;
- chipolopolo.
Chipolopolo chakunja chimakhala ndi gelatin ndi titanium dioxide. Utoto wofiirira wofiyira m'makapuwo umapatsa utoto wa utoto wachitsulo.
Zotsatira za pharmacological
Mankhwalawa ndi a antidepressants omwe amakhala ndi mphamvu yayitali yogwira mtima pakhungu lamanjenje. The yogwira mankhwala amitriptyline nthawi imodzi amalepheretsa kutenga norepinephrine ndi serotonin asanalowe kuphatikiza. Chofunikira kwambiri cha amitriptyline metabolism (nortriptyline) ndizothandiza kwambiri pakuchiritsa. Chifukwa cha momwe mankhwalawa amathandizira, zochitika za H1-histamine receptors ndi M-cholinergic receptors zimachepa. Wodwala amatuluka kukhumudwa, nkhawa komanso nkhawa zimatha.
Chifukwa cha kusinkhira mphamvu, mankhwalawo amalepheretsa kugona kugona kwa REM, potero amawonjezera nthawi yayitali pang'onopang'ono gawo lake.
Pharmacokinetics
Pambuyo pakukonzekera pakamwa, chipolopolo cha gelatin chimasungunuka m'matumbo, amitriptyline imatulutsidwa ndipo imatengedwa ndi 60% ya yaying'ono yamatumbo. Kuchokera kukhoma la chiwalo, chinthu chogwira ntchito chimalowa m'magazi, momwe plasma ya ndende imakhala yamtengo wapatali mkati mwa maola 4-10. Amitriptyline amamanga mapuloteni a plasma ndi 95%.
Kagayidwe kake ka yogwira amapita m'chiwindi ndi hydroxylation ndi mapangidwe a nortriptyline. Hafu ya moyo wa mankhwalawa ndi maola 25-27. Zinthu zamankhwala zimasiya thupi ndi ndowe komanso kudzera mumkodzo.
Zizindikiro zogwiritsidwa ntchito
Mankhwala ndi mankhwala pamaso pa kukhumudwa boma ndi neurosis, makamaka mu milandu pamene kuphwanya kwamtundu woyenda limodzi ndi nkhawa, kugona tulo, kukhumudwa. Ma antidepressants atha kuphatikizidwa ndi mankhwala othandizira a schizophrenia.
Contraindication
Mankhwala ochepetsa nkhawa amaletsedwa kugwiritsidwa ntchito pamaso pa zinthu zomwe sizikupezeka mu zinthu zomwe zimapanga mlingo. Mankhwala sinafotokozeredwe anthu omwe ali ndi chibadwa cha fructose tsankho, malabsorption a glucose ndi galactose, omwe ali ndi vuto la isomaltase.
Ndi chisamaliro
Chisamaliro chikuyenera kuthandizidwa mukamamwa Saroten pazotsatirazi:
- zopweteka
- kuwonongeka kwambiri kwa chiwindi ndi mtima dongosolo;
- kuchuluka kwa chinsinsi cha chithokomiro cha chithokomiro;
- mphumu ya bronchial;
- mafupa a hematopoiesis chisokonezo;
- kuchuluka kwapakati pa intraocular;
- kusiya mowa matenda;
Chifukwa cha kupezeka kwa ziwalo za minofu yoyaka kugaya chakudya, mankhwalawa ali osavomerezeka.
Momwe mungatenge Saroten Retard?
Makapisozi kapena zomwe zili m'matumba (pellets) ndikulimbikitsidwa kuti mumwe madzi ambiri osafuna kutafuna. Pazovuta, kuphatikiza pamtunda wa schizophrenia, ndikofunikira kutenga kapisozi imodzi patsiku kwa maola 3-4 musanagone, ndikuwonjezereka kwa sabata iliyonse mpaka 100-150 mg. Mankhwala okhazikika akapezeka, mlingo wa tsiku ndi tsiku umachepetsedwa mpaka 50-100 mg.
Mphamvu yotsutsana imayamba kutchulidwa pakatha milungu iwiri. Mankhwala ayenera kupitilizidwa, chifukwa mankhwalawa ndiwothandiza kwambiri panthawi yomwe dokotala wakupangira. Popewa kuyambiranso, tikulimbikitsidwa kupitiliza kulandira chithandizo kwa miyezi 6. Pakukhumudwa kwawopanda, antidepressant amatengedwa zaka zingapo ngati chithandizo chokonzanso kuti asayambenso.
Ndi matenda ashuga
Anthu omwe ali ndi matenda ashuga amayenera kutenga makapisozi mosamala, chifukwa amitriptyline imatha kusintha magwiridwe antchito a insulin kukhala plasma ndende yamagazi m'magazi. Ndi kusintha kwa shuga, ndikofunikira kusintha mlingo wa insulin ndi othandizira a hypoglycemic.
Zotsatira zoyipa za Saroten retard
Nthawi zina, zotsatira zoyipa (chizungulire, kutsika kwa kufooka, kugwedezeka, kuchepa kwa metabolism, kupweteka kwa mutu) zimatha kukhala zizindikiro za kukhumudwa.
Matumbo
Kulakalaka kumachepa kapena kumawonjezeka, kumverera kwa nseru komanso kuwuma pamlomo wamkamwa kumawoneka, kukula kwa zothetsera zamkaka kumawonjezeka, ntchito ya hepatocytic transaminases imakulanso.
Pakati mantha dongosolo
Zotsatira zoyipa za kupsinjika kwa CNS zimawonetsedwa ngati:
- kugona
- kugwedezeka kwamiyendo;
- kusokonezeka kwa kukoma, ma tactile ndi olodoory receptors;
- kusowa tulo
- chisokonezo, nkhawa komanso zoopsa;
- chizungulire ndi chisokonezo;
- vuto la chidwi;
- malingaliro ofuna kudzipha;
- machitidwe a manic;
- kuyerekezera komwe kumayambira maziko a kukhumudwa.
Kusintha kwa kukoma ndi chimodzi mwazotsatira zamankhwala.
Odwala omwe ali ndi khunyu, amakomoka pafupipafupi.
Kuchokera kwamikodzo
Kusungika kwamtchire ndikotheka.
Pa khungu
Ndi kuphwanya kwamanja-electrolyte bwino chifukwa chotenga Saroten, kukula kwa khungu la khungu, alopecia ndikotheka.
Kuchokera ku genitourinary system
Kusokonekera kwa njira yolerera kumawonedwa mwa amuna okha, kuwonetseredwa mawonekedwe a kusokonekera kwa erectile komanso kutukusira kwa tiziwalo ta mammary.
Kuchokera pamtima
Ndi kukula kwa zoyipa, wodwalayo akhoza kumva kugunda kwa mtima, kupanikizika kumachepa, tachycardia imawoneka. Chiwopsezo cha atrioventricular blockade, kusokonezeka kwazosokonezeka mu mtolo wa kuchuluka Kwake. Ndi chopinga wa hematopoietic dongosolo, agranulocytosis ndi leukopenia.
Matupi omaliza
Mwa odwala odziwikiratu, kusintha kwa khungu, urticaria, kuyabwa, erythema kumatha kuchitika. Nthawi zina, Quincke edema ndi chidwi chothandizira kukulira.
Zokhudza mphamvu pakuwongolera njira
Ngati agwiritsidwa ntchito molakwika, mankhwalawa amatha kubweretsa kugona komanso kusokonezeka kwa mitsempha, motero mukamalandira chithandizo chamankhwala mumalimbikitsidwa kuti musayendetse galimoto, gwiritsani ntchito zida zovuta komanso muchite zinthu zina zomwe zimafuna kuthamanga kwambiri kwa ma psychomotor.
Malangizo apadera
Wodwalayo adziwitsidwe kuti pali kuthekera kwa zovuta kuchokera ku mtima.
Kukhumudwa kumathandizira kukulitsa chizolowezi chofuna kudzipha. Malingaliro akudzipha atha kupitirirabe mpaka thanzi lonse lipitirire, kotero kuyang'anitsitsa wodwala omwe amamwa mankhwalawa ndikofunikira panthawi ya chithandizo. Izi ndizofunikira pachigawo choyambirira cha mankhwala, ngati kuwonongeka kwakanthawi kwa vutoli kungatheke, ndikukula kwa malingaliro ofuna kudzipha motsutsana nawo. Muzochitika zotere, ndikofunikira kuchepetsa kugwiritsa ntchito mankhwalawa.
Khalidwe la manic likawoneka, chithandizo chachipatala chimatha.
Mankhwala amayimitsidwa asanapangidwe opareshoni. Ngati pakufunika kuchitidwa opaleshoni mwachangu, wothandizira opaleshoni ayenera kuchenjezedwa za kutenga mankhwala oletsa kuponderezana. Kuchita opaleshoni kumayambitsa hypotension.
Ndi kutha koopsa kwa kutenga Saroten kumbuyo kwa chithandizo cha nthawi yayitali, nthawi zina, matendawa amayamba. Kuti muchepetse vuto lochitapo kanthu, ndikofunikira kuchepetsa pang'onopang'ono kuchuluka kwa mankhwalawa pakadutsa masabata 4-5.
Mankhwala saloledwa kugwiritsidwa ntchito mwa ana osakwana zaka 18.
Gwiritsani ntchito mu ukalamba
Anthu opitilira 65 azitenga 1 kapisozi 50 mg yamadzulo.
Kukhazikitsidwa kwa Sarotin Retard kwa ana
Mankhwala saloledwa kugwiritsidwa ntchito mwa ana osakwana zaka 18.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Ma antidepressants amaletsedwa azimayi panthawi yoyembekezera, chifukwa amitriptyline imatha kusokoneza kuyika kwa ziwalo zazikuluzikulu ndi machitidwe pakukonzekera kwa embryonic, makamaka mu trimester yachitatu.
Mukamamwa mankhwala oletsa kuponderezana m'mimba, kuyamwa sikuchotsedwa ngati pakufunika kutero. Panthawi yamankhwala, kuwunika momwe mwana wakhanda amakhalira m'mwezi woyamba wa moyo wake amafunikira.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Odwala omwe ali ndi vuto la chiwindi ayenera kusamala ndipo ngati kuli kotheka, azilamulira ndende ya amitriptyline mu seramu.
Mukamamwa mankhwala oletsa kuponderezana m'mimba, kuyamwa sikuchotsedwa ngati pakufunika kutero.
Mankhwala ochulukirapo a Saroten retard
Ndi gawo limodzi la mankhwala okwanira ola limodzi, mungamve:
- kugona
- kuyerekezera;
- wokongola
- zotupa za ana;
- kamwa yowuma
- kukhumudwa ndi kukhumudwa kwa chapakati mantha dongosolo;
- dziko lokongola, chisokonezo, chikomokere;
- metabolic acidosis, yafupika potaziyamu ndende;
- kukoka kwamtima;
- Zizindikiro za mtima: kugwa kwa magazi, kugunda kwa mtima, kugunda kwa mtima.
Wovutitsidwayo amafunikira kuchipatala mwachangu. M'malo okhazikika, ndikofunikira kutsuka m'mimba ndikupereka adsorbent kuti muchepetse kuyamwa kwa mankhwalawa.
Kuchiza kumathandizira kubwezeretsa kupuma ndi mtima ntchito, pochotsa zizindikiro za bongo. Kuwunikira zochitika pamtima ndikofunikira mkati mwa masiku 3-5.
Kuchita ndi mankhwala ena
Kugwiritsanso ntchito kwa amitriptyline ndi mankhwala ena kumapereka njira zotsatirazi:
- Kuphatikiza ndi monoamine oxidase inhibitors, serotonin syndrome imachitika, yodziwika ndi chisokonezo, myoclonus, malungo, kunjenjemera kwa malekezero. Kuti achepetse kuledzera kwa mankhwala, Saroten amalembedwera pambuyo pa masabata awiri kuchokera kumapeto kwa chithandizo chamankhwala osasintha a Mao kapena maola 24 atatha kugwiritsa ntchito mankhwala obwezeretsanso a monoamine oxidase blockers.
- The achire zotsatira za barbiturates limatheka.
- Kuchulukitsa kwa matumbo kutsekeka chifukwa cha chopinga cha minyewa yosalala ya matumbo mukamamwa antipsychotic kapena anticholinergics. Ndi hyperthermia, matumbo kukanika limodzi ndi hyperpyrexia. Mukamamwa ma antipsychotic, njira yotsatsira okonzekera kutsika imachepa.
- Amitriptyline imawonjezera mtima wa opaleshoni, ma decongestants, ephedrine ndi phenylpropanolamine. Chifukwa cha kuwonongeka kwa mtima wamtima, mankhwalawa satchulidwa ngati mankhwala ophatikiza.
- Zomwe zimagwira ntchito za Saroten zimachepetsa mphamvu ya Methyldopa, Guanethidine, Reserpine ndi mankhwala ena a antihypertensive. Ndi munthawi yomweyo amitriptyline, muyenera kusintha mulingo wa mankhwala omwe amachepetsa kuthamanga kwa magazi.
- Mapiritsi othandizira kubereka komanso mankhwala okhala ndi mahomoni ogonana achikazi amathandizira bioavailability ya amitriptyline, yomwe imafuna kuchepetsa kuchuluka kwa onse a mankhwalawa. Ngati ndi kotheka, kuchotsedwa kwa Saroten kungafunike.
Kuphatikiza ndi acetaldehydrogenase inhibitors, mwayi wokhala ndi zovuta za psychotic, chisokonezo ndikuwonongeka kwa chikumbumtima kumawonjezeka.
Munthawi yamankhwala osokoneza bongo, ndikofunikira kusiya kumwa zakumwa zoledzeretsa.
Kuyenderana ndi mowa
Munthawi yamankhwala osokoneza bongo, ndikofunikira kusiya kumwa zakumwa zoledzeretsa. Mowa wa Ethyl umatha kuchepetsa mphamvu ya mankhwala oletsa kupanikizika, ungakulitse kapena kuchulukitsa zomwe zingachitike poyipa. Makamaka mokhudzana ndi dongosolo lamanjenje, chifukwa Mowa umadzetsa nkhawa m'magazi amanjenje.
Analogi
Zalozera za Saroten zimaphatikizira othandizira omwe amabwereza kuphatikizidwa kwa mankhwala a antidepressant ndi pharmacological:
- Amitriptyline;
- Clofranil;
- Doxepin;
- Khalidal.
M'malo mankhwalawa ikuchitika pokhapokha pakalibe phindu, pambuyo pothandizidwa ndi madokotala.
Kupita kwina mankhwala
Makapisozi amagulitsidwa ndi mankhwala.
Clofranil ndi analogue ya Saroten.
Kodi ndingagule popanda kulandira mankhwala?
Ma antidepressants ali m'gulu la mankhwala a psychotropic, ngati atagwiritsidwa ntchito molakwika, amatha kuyambitsa kuvutika kwamitsempha yama neva. Chifukwa cha izi, kugulitsa kwaulere ndizochepa.
Mtengo Wobwezera wa Sarotin
Mtengo wapakati wa makapisozi ndi ma ruble 590. Ku Belarus - 18 ma ruble.
Zosungidwa zamankhwala
Makapisozi amayenera kusungidwa m'malo okhala ndi chinyezi chochepa, otetezedwa ndi dzuwa, pamtunda wosaposa + 25 ° C.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
H. Lundbeck AO, Denmark.
Ndemanga za Saroten retard
Taras Evdokimov, wazaka 39, Saransk.
Kukumana ndi kupsinjika kwa nthawi yayitali. Sindinathe kudzipulumutsa ndekhandekha, motero ndinatembenukira kwa sing'anga wamisala kuti andithandize. Dokotala adamuuza Saroten. Ndimaona kuti mankhwalawa ndi othandiza, amathana bwino ndikakhala ndi nkhawa komanso amathandizira kuthetsa tulo. Makapisozi amayenera kumwedwa masana ndi mlingo wa 50 mg komanso pogona, 100 mg. Pakatha sabata, ndi mlingo wausiku wokhawo womwe ungagwiritsidwe ntchito. Sindinazindikire zovuta zilizonse, ngati si kugona. Koma amafunika kuthana ndi vuto la kugona.
Angelica Nikiforova, wazaka 41, St. Petersburg.
The psychotherapist adalemba ma kapisozi a Saroten okhudzana ndi nkhawa. Ikagwiritsidwa ntchito moyenera, mosamalitsa malinga ndi malangizo, imakhala ndi mphamvu. Ndikupangira kumwa mapiritsi omaliza mpaka 20:00. Ngati izi sizinachitike, ine, kusisita kwamanjenje ndi kusowa tulo zinayamba. Ngati tachycardia adawoneka, ndikuyamba kugona, ndiye kuti amachepetsa, ndipo zizindikirizo zimatha.Munalandira mphamvu yokhazikika mukamatenga 50 mg 2 kawiri pa tsiku ndi zina 50 mg usiku. Ndikofunikira kusankha mulingo woyenera pokambirana ndi dokotala.
