Mapiritsi a Amaryl amagwiritsidwa ntchito pakusintha kuchuluka kwa shuga m'magazi. Pa mankhwala ndi wothandizirawa, zimachitika mwachindunji pa kapamba, chifukwa chake kupanga kwa insulin kumatheka.
Dzinalo Losayenerana
Glimepiride.
Mapiritsi a Amaryl amagwiritsidwa ntchito pakusintha kuchuluka kwa shuga m'magazi.
ATX
A10BB12
Kupanga
Yogwiritsa ntchito mankhwala ndi glimepiride. Zina mwazomwe zimapangidwira sizikuwonetsa ntchito za hypoglycemic ndipo zimangogwiritsidwa ntchito pokhapokha kuti mupeze kusasinthika kwa mankhwala:
- lactose monohydrate;
- povidone 25000;
- sodium carboxymethyl wowuma (mtundu A);
- magnesium wakuba;
- ma cellcose a microcrystalline;
- utoto;
- indigo carmine (E132).
Mlingo wa glimepiride piritsi 1 ikhoza kukhala yosiyana: 1, 2, 3, 4 mg. Mutha kugula malonda mumapaketi a 30 ndi 90 ma PC. Kuti mukhale yosavuta kusunga mapiritsi, matuza amaperekedwa (ma PC 15. Iliyonse).
Zotsatira za pharmacological
Amaryl amatanthauza othandizira a hypoglycemic omwe amapangidwira pakamwa. Mankhwala ndiwofala kwambiri pazomwe zimachokera ku sulfonylurea. Chida ichi ndi m'badwo wotsiriza, motero wopanda zovuta zingapo poyerekeza ndi analogu la 2 kapena 1 m'badwo. Mankhwalawa samakhudzana mwachindunji ndi glucose, koma amathandizira kuthetsa zomwe zimachitika chifukwa cha zomwe zili mumtunduwu pogwiritsa ntchito maselo a pancreatic.
Amaryl ikhoza kugulidwa m'matumba a 30 ndi 90 ma PC., Kuti ikhale yosavuta kusunga mapiritsi, matuza amaperekedwa.
Poterepa, njira yopangira insulin imayendetsedwa, chifukwa chomwe kuchuluka kwa glucose m'magazi kumakhala kosiyanasiyana. Mankhwala ena amathandizira chidwi cha zotumphukira pazokhudza kuperewera kwa insulin. Amawonjezera kuchuluka kwa kuyankha kwa thupi pakukula kwa glucose mu plasma.
Kupanga kwa insulin ndi kutenga nawo gawo kwa Amaril kutengera kutsekedwa kwa njira zotengera potaziyamu za ATP. Zotsatira zake, njira za calcium zimatsegulidwa. Zotsatira zake, kuchuluka kwa calcium m'maselo kumakulira kwambiri. Kuwonjezeka kwa kuchuluka kwa insulini kumachitika chifukwa cha kusinthasintha kwa kulumikizana kwa glimepiride ndi mapuloteni am'mimba a beta a kapamba ndi kufalikira kwake.
Amaryl imawonetsanso katundu wina: antioxidant, antiplatelet, amachepetsa kukana kwa insulin. Chifukwa cha izi, thupi limayankha ngakhale pang'ono milingo yaying'ono ya glimepiride. Mankhwala, njira yogwiritsira ntchito glucose pogwiritsa ntchito zotumphukira zake imayendetsedwa, pomwe chinthucho chimaperekedwa m'maselo a minofu ndi adipocytes (maselo amtundu wa adipose).
Mu shuga mellitus wamtundu wachiwiri, njirayi imachepetsedwa, chifukwa pali choletsa kuthamanga kwa kukhazikitsidwa kwake. Glimepiride imathandizira kuthamangitsa kugwiritsidwa ntchito kwa glucose, chifukwa chomwe chikhalidwe cha thupi chimakhazikika ndi hypoglycemia. Imodzi ndi njira zomwe zafotokozedwera, pang'onopang'ono pakupanga shuga m'magazi.
Hafu ya moyo wamankhwala Amaryl kuchokera mthupi limatenga maola 5 mpaka 8.
Komabe, glimepiride imadziwika ndi kusankha kosankha ndipo imakhudza ntchito ya cycloo oxygenase enzyme. Zotsatira zake, kuchuluka kwa kusintha kwa arachidonic acid kukhala thromboxane kumachepa. Chifukwa cha izi, kuchuluka kwa mapangidwe amwazi kumachepa, chifukwa mapulateleti samasungidwa mwachangu pamakoma amitsempha yamagazi. Nthawi yomweyo, kuchepa kwamphamvu kwa lipid oxidation kumadziwika, ndipo kutsimikizika kwawo kumapangidwanso.
Pharmacokinetics
Momwe kuchuluka kwake kwa glimepiride kumafikira m'magazi zimatengera mlingo wa mankhwalawa komanso zomwe zili pazochitika zake. Chidacho chophatikizacho chimamwetsedwa mwachangu chikadyedwa pamimba yopanda kanthu komanso ndi chakudya. Ubwino wa mankhwalawo umakhala wokwanira kumapuloteni a plasma ndi mkulu bioavailability (100%).
Yogwira pophika imapukusidwa pamatumbo ndikuyenda pokodza. Hafu ya moyo wa mankhwalawa imatha maola 5 mpaka 8. Mukutenga kuchuluka kwa Amaril, njira yochotsera thupi imachedwa. Potengera maziko a matenda a impso, ndende ya wothandizirayi imachepa, chifukwa cha kuthamangitsidwa kwake kwachotsa theka la moyo.
Zisonyezo za mapiritsi a Amaryl
Mankhwalawa amagwira ntchito mankhwalawa mtundu wa matenda a shuga a 2, pomwe chiopsezo chokhala ndi mawonekedwe owoneka ndi zovuta ndizochepa. Amaryl imagwiritsidwa ntchito ngati njira yodziyimira payokha kapena pamodzi ndi njira zina.
Contraindication
Mankhwala omwe amafunsidwa sakhazikitsidwa pamikhalidwe yotere:
- tsankho ku chinthu chilichonse, ndi hypersensitivity kuti glimepiride nthawi zambiri yopanga;
- mtundu 1 matenda a shuga;
- kuphwanya kagayidwe kazakudya, kamene kamayendera limodzi ndi kuchepa kwa insulin;
- chikomokere, mtengo;
- uchidakwa wambiri, chifukwa pamenepa katundu pa chiwindi amawonjezeka;
- zosagwirizana ndi mankhwala alionse ochokera ku gulu la sulfonylurea.
Ndi chisamaliro
Chenjezo liyenera kuthandizidwa pazochitika zomwe zikusonyeza kufunika kosunthira wodwala kupita ku insulin: kuwonongeka kwa malo akulu pakhungu chifukwa cha kuyatsidwa, kuphatikizidwa kwa opaleshoni, kuperewera kwa chakudya ndi kuyamwa pang'onopang'ono kwa chakudya ndi mankhwala m'makoma am'mimba.
Momwe mungagwiritsire ntchito mankhwala Trulicity?
Metformin 1000 imakhazikitsidwa kuti muchepetse magazi. Werengani zambiri za mankhwalawa m'nkhaniyi.
Kugwiritsa ntchito Metformin Zentiva ndikulimbikitsidwa ndi madokotala.
Momwe mungatenge mapiritsi a Amaryl
Mankhwalawa amatengedwa musanadye kapena chakudya. Kutalika kwa chithandizo kumatsimikiziridwa malinga ndi momwe wodwalayo alili, kuchuluka kwa matendawo, koma nthawi zambiri njira yochizira ndi yayitali.
Ndi matenda ashuga
Kumayambiriro kwa mankhwalawa, osaposa 1 mg ayenera kumwedwa. Chithandizo: Mapiritsi amatengedwa 1 nthawi patsiku. Ngati ndi kotheka, tsiku ndi tsiku mlingo wa mankhwalawa umakulitsidwa, koma izi zimachitika m'magawo: 1 mg ya thunthu limawonjezeredwa, pamapeto - 6 mg. Ndi zoletsedwa kupitirira kuchuluka kwa mankhwalawo, chifukwa kuchuluka kwake tsiku lililonse ndi 6 mg.
Amaryl amatengedwa asanadye kapena asanadye.
Zotsatira zoyipa za mapiritsi a Amaryl
Pa mbali ya gawo la masomphenyawo
Zowonongeka zowonongeka chifukwa cha kufupika kwakanthawi kwa malensi. Chifukwa cha izi, mbali ya kukonzanso kusintha kwa kuwala.
Matumbo
Kusanza, kusanza, kupweteka pamimba, kusokonezeka kwa patumbu, zingapo za zikhalidwe za chiwindi.
Hematopoietic ziwalo
Zosintha pamagazi ndi kapangidwe kake, monga thrombocytopenia.
Kuchokera kumbali ya kagayidwe
Kuganiza za mankhwalawa nthawi zina kumayambitsa kutsika kwamphamvu kwa shuga. Pankhaniyi, zizindikiro zimayamba: mutu, nseru, kusanza, kufooka kwakukulu, kukwiya kumawonjezereka, chisokonezo chimasokonezeka, kuthamanga kwa chikumbumtima, kupsinjika, kusintha kwa kugunda kwa mtima, kugwedezeka kumadziwika, kuchuluka kwa kukakamizidwa kumachitika.
Matupi omaliza
Pafupipafupi mu Amaril chithandizo ndi urticaria, limodzi ndi zidzolo, kuyabwa. Pafupipafupi, pamakhala vuto, vasculitis, dyspnea.
Zokhudza mphamvu pakuwongolera njira
Pali chiopsezo cha hypo- ndi hyperglycemia, chomwe chingapangitse chidwi cha anthu, kusintha kwa chikumbumtima, komanso kuipiraipira kwama psychomotor. Chenjezo liyenera kuchitidwa poyendetsa galimoto.
Malangizo apadera
Ndi kuphatikiza mankhwala ndi Metformin, kusintha kwa kagayidwe kachakudya kumadziwika.
M'malo mwa Metformin, insulin ikhoza kutumikiridwa. Nthawi yomweyo, njira yowongolera kagayidwe kameneka imapangidwanso mosavuta.
Wodwalayo akayamba kukhudzana ndi mankhwalawa omwe amwetsedwa muyezo wochepa (1 mg), ndikokwanira kutsatira kadyedwe kuti akhalebe ndi shuga wokwanira.
Kuchiza ndi mankhwalawa kumafunikira kupenda pafupipafupi: kuwunika magawo a chiwindi ndi magazi. Udindo wofunikira mu izi umaseweredwa ndi leukocytes ndi mapulateleti.
Gwiritsani ntchito mu ukalamba
Njira zochizira komanso mankhwalawa zimawunikanso, chifukwa nthawi zambiri mwa odwala a gululi, ntchito yaimpso imalephera.
Kupatsa ana
Popeza palibe chidziwitso chokhudza chitetezo cha mankhwalawa chomwe chikufunsidwa mwa odwala omwe ali ndi zaka 18, sangathe kugwiritsidwa ntchito.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Amaryl sinafotokozeredwe kwa azimayi pakubala ndi poyamwitsa.
The ntchito aimpso kuwonongeka
Chida sichikugwiritsidwa ntchito.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Zowonongeka zamtunduwu ndizophatikizira kugwiritsa ntchito Amaril. Ngati kulephera kwa chiwindi kumayamba, chiopsezo cha zovuta zimachuluka.
Bongo
Hypoglycemia imawonekera. Zizindikiro za matendawa zimapitilira masiku 1-3. Mutha kuthana ndi matendawa pomwa mankhwala a calcium. Kubwezeretsa kuchuluka kwa glucose mwachangu, tikulimbikitsidwa kuti muzisanza ndikumwa madzi ambiri.
Kuchita ndi mankhwala ena
Pali mwayi wotsika kwa glucose ngati, pamodzi ndi Amaril, insulin kapena othandizira pakamwa.
Zotsatira zotsutsana zimatheka ndikuphatikizidwa kwa Amaril ndi barbiturates, GCS, okodzetsa a gulu la thiazide, Epinephrine.
Ntchito za zotumphukira za coumarin zimatha kuchepa ndikuwonjezeka ngati mankhwalawa amaperekedwa pamodzi ndi mankhwala omwe akufunsidwa.
Kuyenderana ndi mowa
Ndikosatheka kumwa zakumwa zokhala ndi mowa nthawi imodzi ngati Amaril, chifukwa zotsatira zake kuphatikiza kwa zinthu izi sizikulosera: zotsatira za hypoglycemic zitha kukulira komanso kufooka.
Analogi
Ngati wodwalayo wapanga hypersensitivity ku yogwira mankhwala omwe amafunsidwa, mankhwala ena amagwiritsidwa ntchito m'malo mwake:
- Maninil;
- Gliclazide;
- Diabetes;
- Glidiab.
Kupita kwina mankhwala
Mankhwalawa ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Zikwana ndalama zingati?
Mtengo wapakati: 360-3000 rub. Mtengo umadalira kuchuluka kwa glimepiride ndi kuchuluka kwa mapiritsi.
Zosungidwa zamankhwala
Ulamuliro wolimbikitsa kutentha: osapitirira + 25 ° ะก. Kufikira kwa ana ku malowa kuyenera kutsekedwa.
Tsiku lotha ntchito
Mankhwala amakhalabe ndi zaka zitatu.
Wopanga
Aventis Pharma Deutschland GmbH, Germany.
Ndemanga
Anna, wazaka 32, Novomoskovsk
Mankhwala ndi othandizira, amachotsa mwachangu zizindikiro za hypoglycemia. Koma munthawi yamankhwala, kuchuluka kwa shuga kunatsika kangapo.
Elena, wazaka 39, Nizhny Novgorod
Mankhwalawa sanakwane. Amadziwika kuti ndiothandiza kwambiri m'gulu lake, koma ndimayamba kusanza ndikayamba kumwa mapiritsi. Ndipo mtengo wake ndi wokwera.
