Mankhwala Diapiride: malangizo ntchito

Diapiride ndi mankhwala omwe amakhala ndi mphamvu yayitali. Mankhwalawa ndi amodzi mwa omwe amapezeka mu sulfonylurea.

Dzinalo Losayenerana

Ndalama za INN - Glimepiride.

Diapiride ndi mankhwala omwe amakhala ndi mphamvu yayitali.

ATX

Nambala ya ATX: A10VB12.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amapangidwa mwanjira ya mapiritsi okhala ndi mitundu yosiyanasiyana ya yogwira ntchito. Pakhadikhodi phukusi pali miyala 30 m'matumba. Piritsi 1 ili ndi 2, 3 kapena 4 mg ya glimepiride (yogwira mankhwala). Mapiritsi okhala ndi Mlingo wa 2 mg ndiwobiliwira, 3 mg ndi kuwala achikasu, 4 mg ndi kuwala kwamtambo.

Zomwe mapiritsiwo akuphatikizira:

• lactose monohydrate;
• ma cellcose a microcrystalline;
• sodium wowuma glycolate;
• povidone;
• oxide wachikasu;
• magnesium wakuba;
• indigo carmine.

Glimepiride imakhala ndi hypoglycemic polimbikitsa kutulutsa kwa insulin.

Zotsatira za pharmacological

Glimepiride imakhala ndi hypoglycemic polimbikitsa kutulutsa kwa insulin. Thunthu limagwira zimagwira michere ya β-cell ya kapamba, kutseka njira za potaziyamu. Zotsatira zake, maselowa amayamba kukonda kwambiri kuchuluka kwa shuga m'thupi, ndipo insulin imamasulidwa mosavuta komanso mwachangu.

Palinso kuwonjezeka kwa chidwi cha maselo kuti apange insulin, ndipo kugwiritsa ntchito kwake kwa chiwindi kumachepetsedwa. Nthawi yomweyo, gluconeogenesis imalepheretsa. Lipid ndi minofu yam'mimba imalowetsa mamolekyulu a glucose mwachangu chifukwa cha kuchuluka kwa mapuloteni onyamula.

Chithandizo chogwira chimachepetsa kukula kwa kuphatikiza kwa oxidative polimbikitsa kupanga kwa α-tocopherol ndikupititsa patsogolo michere ya antioxidant enzymes.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, glimepiride imalowetsedwa m'matumbo ndikuyamba kulowa m'magazi. Kudya sikuchepetsa kuyamwa kwa mankhwalawa. Izi zimafika pachimake kwambiri m'madzi am'madzi mkati mwa 2-2,5 maola.

Pambuyo pakukonzekera pakamwa, glimepiride imalowetsedwa m'matumbo ndikuyamba kulowa m'magazi.

Glimepiride imadziwika ndi zomangira zabwino zama protein (99%). Kagayidwe ka mankhwala kumachitika chiwindi. Zomwe zimayambira metabolites zimachotsedwa impso ndi matumbo. Mankhwalawa amachotsedwa m'thupi pakatha maola 10-16. Ngakhale mukutenga Diapiride, kudzikundikira kwa zinthu m'thupi sikumawonedwa (ngakhale ndikugwiritsa ntchito nthawi yayitali).

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amagwiritsidwa ntchito pochiza odwala omwe ali ndi mtundu II matenda a shuga. Mapiritsi amalembedwa pamene sizingatheke kusintha shuga m'magazi pogwiritsa ntchito zakudya zoyenera komanso masewera olimbitsa thupi.

Contraindication

Sizoletsedwa kumwa mankhwala ngati pali zotsatirazi zotsutsana:

1. Kusalolera payekha kwa sulfonamides.
2. Hypersensitivity kumagawo.
3. Coma
4. Ketoacidosis.
5. Mitundu ikuluikulu ya chiwindi kapena matenda a impso.
6. Mtundu woyamba wa shuga.
7. Nthawi ya pakati ndi kuyamwa.
8. Zaka za ana.

Ndi chisamaliro

Moyang'aniridwa ndi dokotala, mankhwalawa amagwiritsidwa ntchito kuchitira ntchito mwachangu, kuledzera, kutentha thupi, matenda a chithokomiro, kuchepa kwa adrenal komanso matenda oopsa.

Pambuyo pochita opaleshoni yayikulu, kuvulala, kuwotcha, odwala amalangizidwa kuti asinthane ndi insulin.

Kodi kutenga diapiride?

Mankhwala amatengedwa pakamwa ndi madzi pang'ono. Ndikofunika kuphatikiza kumwa mapiritsi ndi chakudya popewa matenda am'mimba.

Sizoletsedwa kumwa mankhwala osokoneza bongo.

Ndi zoletsedwa kumwa mankhwala pamaso pa ketoacidosis.

Ndi zoletsedwa kumwa mankhwala pamaso pa mitundu yayikulu ya chiwindi ndi matenda a impso.

Sizoletsedwa kumwa mankhwala pamaso pa matenda ashuga a mtundu woyamba.

Sizoletsedwa kumwa mankhwala panthawi yoyembekezera.

Kutenga mankhwala ndi koletsedwa pa mkaka wa m`mawere.

Sizoletsedwa kumwa mankhwala ali mwana.

Ndi matenda ashuga

Ngati mankhwalawa amachokera ku mtundu wachiwiri wa shuga wa II-insulin, mankhwalawa amatengedwa katatu patsiku. Kumayambiriro kwa mlingo, mlingo ndi 1 mg malinga ndi glimepiride. Ngati zili zokwanira kutulutsa shuga m'magazi, ndiye kuti mlingowo sukuwonjezeka.

Ndi osakwanira kwenikweni, mlingo umakulitsidwa pang'onopang'ono mpaka 2, 3 kapena 4 mg. Nthawi yocheperako pakati pa kusintha kwa mlingo uyenera kukhala wosachepera masiku 7. Nthawi zina odwala amalamula 6 mg wa glimepiride patsiku (pazovomerezeka tsiku lililonse mlingo).

Madokotala atha kuperekera mankhwala othandizira pamodzi ndi metformin kapena insulin kuti akwaniritse kwambiri. Kumwa mankhwalawa kungapangitse kuti insulin ichuluke. Pankhaniyi, mlingo umachepetsedwa kapena kuthetsedwa kwathunthu.

Zotsatira zoyipa za Diapyrid

Pa mbali ya gawo la masomphenyawo

Pa chithandizo, kusokonezeka kwakanthawi kwakanthawi (kuwonongeka kwakanthawi) kumatha kuchitika. Zomwe zimayambitsa izi ndizosintha m'magazi.

Ngati mankhwalawa amachokera ku mtundu wachiwiri wa shuga wa II-insulin, mankhwalawa amatengedwa katatu patsiku.

Matumbo

Zokhudza chimbudzi:

• kusanza ndi kusanza
• kutsegula m'mimba
• kupweteka m'mimba;
• matenda a chiwindi (chiwindi, kulephera kwa chiwindi, ndi zina).

Hematopoietic ziwalo

Zotsatira zoyipa kuchokera ku hematopoietic system:

• thrombocytopenia;
• leukopenia;
• kuchepa magazi
• granulocytopenia;
• erythrocytopenia;
• agranulocytosis;
• pancytopenia.

Munthawi ya kumwa mankhwalawa, mseru ungayambike.

Nthawi yakumwa mankhwalawa, kusanza kumatha kuoneka.

Munthawi ya kumwa mankhwalawa, kutsekula m'mimba kumatha kuonekera.

Munthawi yakumwa mankhwalawa, kupweteka m'mimba kumatha kuoneka.

Munthawi ya kumwa mankhwalawa, chiwindi chimatha kuoneka.

Munthawi yakumwa mankhwalawa, vuto la chiwindi limatha kuoneka.

Nthawi yomwe mumamwa mankhwalawa, kuchepa kwa magazi kumatha kuonekera.

Pakati mantha dongosolo

Kuchokera kumbali yamanjenje yapakati imawonedwa:

• mutu
• Chizungulire
• chisokonezo cha chikumbumtima;
• kusowa tulo
• kutopa;
• mayiko achisoni;
• kutsika kwa ma psychomotor
• kusokonekera kwa mawu;
• kugwedezeka kwamiyendo;
• kukokana.

Kuchokera kumbali ya kagayidwe

Zotsatira zoyipa zama metabolism zimawonetsedwa ndi hypoglycemia.

Matupi omaliza

Panthawi ya makonzedwe, thupi limakhala limachititsa:

• Khungu;
• urticaria;
• zotupa
• Matupi a vasculitis.
  

  Kwa nthawi ya mankhwalawa pogwiritsa ntchito mankhwalawa, mutu umatha kuonekera.

  

  Kwa nthawi ya mankhwalawa ndi mankhwalawa ku Central system, chizungulire chitha kuoneka.

  

  Kwa nthawi ya mankhwalawa ndi mankhwalawa kuchokera ku mbali ya chapakati yamanjenje, chisokonezo chitha kuoneka.

  

  Kwa nthawi ya mankhwalawa pogwiritsa ntchito mankhwalawa kuchokera ku dongosolo lalikulu lamanjenje, kusowa tulo kumatha kuoneka.

  

  Kwa nthawi ya mankhwalawa ndi mankhwalawa kuchokera ku dongosolo lalikulu lamitsempha, kutopa kumawonekera.

  

  Munthawi ya chithandizo ndi mankhwalawa kuchokera ku dongosolo lalikulu lamanjenje, zovuta zitha kuwoneka.

  

  Kwa nthawi ya mankhwalawa ndi mankhwalawa kuchokera ku dongosolo lalikulu lamitsempha, kukomoka kumatha kuonekera.

Zokhudza mphamvu pakuwongolera njira

Mankhwala amatha kuchepetsa kuthamanga kwa zochitika zama psychomotor ndikupangitsa chizungulire. Kumayambiriro kwa chithandizo cha mankhwalawa, komanso kusintha maselo, sikulimbikitsidwa kuyendetsa magalimoto ndikuchita ntchito ina yomwe imafuna chidwi chachikulu.

Malangizo apadera

Ngati mulingo wa shuga m'magazi utachepa kuchoka pa mlingo wochepa kwambiri wa tsiku ndi tsiku (1 mg ya glimepiride), tikulimbikitsidwa kusiya pang'onopang'ono kugwiritsa ntchito mankhwalawa. Zotsatira za hypoglycemic pamenepa zimatheka pogwiritsa ntchito njira yochizira (popanda kugwiritsa ntchito mankhwala).

Pochiritsira, muyenera kuyang'anira shuga, magazi, komanso chiwindi, maselo oyera am'magazi komanso mapulateleti m'magazi.

Gwiritsani ntchito mu ukalamba

Chidacho chimaloledwa kugwiritsidwa ntchito kwa odwala azaka zosiyanasiyana, kupatula ana. Koma anthu achikulire ogwiritsa ntchito mapiritsi nthawi yayitali amatha kuyamba kukhala ndi hypoglycemia. Popewa matenda amenewa, madokotala amapatsa odwala okalamba zakudya zapadera komanso kuchuluka kwa mankhwalawa (ngati zingatheke).

Kupatsa ana

Mankhwalawa amaloledwa kugwiritsidwa ntchito patatha zaka 18.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Pa mimba ndi mkaka wa m`mawere, kumwa mankhwalawa contraindicated.

Ngati mulingo wa shuga m'magazi utachepa kuchoka pa mlingo wochepa kwambiri wa tsiku ndi tsiku (1 mg ya glimepiride), tikulimbikitsidwa kusiya pang'onopang'ono kugwiritsa ntchito mankhwalawa.

The ntchito aimpso kuwonongeka

Mu matenda owopsa a impso, palibe mankhwala omwe amapatsidwa. Odwala otere amapatsidwa insulin. Pa gawo loyambirira la kulephera kwa impso, kugwiritsa ntchito mapiritsi ndikotheka kuyang'aniridwa ndi dokotala.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Zambiri ziwindi matenda ndi contraindication kugwiritsa ntchito mankhwala. Mu matenda ofatsa kapena olimbitsa mwamphamvu, ake makonzedwe otsika Mlingo ndiotheka. Therapy iyenera limodzi ndi kuwunika kwa chiwindi.

Mankhwala osokoneza bongo a Diapiride

Mankhwala osokoneza bongo amatsogolera ku mawonekedwe a hypoglycemic (kutsika kwamphamvu kwa shuga). Potere, wodwalayo amamva kutopa, kugona, chizungulire. Kuwonongeka kotheka. Kuti athetse vuto la bongo, amayamba kugwiritsa ntchito mankhwalawa.

Mankhwala osokoneza bongo amatsogolera ku mawonekedwe a hypoglycemic (kutsika kwamphamvu kwa shuga).

Kuchita ndi mankhwala ena

Mankhwala ayenera kumwedwa mosamala molumikizana ndi mankhwala monga:

1. Fluconazole
2. Phenylbutazone
3. Azapropazone.
4. Sulfinpyrazone.
5. Oxyphenbutazone.
6. Pentoxifylline.
7. Tritokvalin.
8. Kutulutsa mawu.
9. Fenfluramine.
10. Khalid.
11. Maanticoagulants ochokera ku gulu la coumarin.
12. Salicylates.
13. Ma antidepressants ena (Mao inhibitors).
14. Fibates.
15. Fluoxetine.
16. Cyclophosphamide.
17. Feniramidol.
18. Ifosfamide.
19. Miconazole
20. Tetracycline ndi mankhwala a quinolone.
21. Mankhwala ena a hypoglycemic.
22. Ma -abolic mankhwala.
23. ACE zoletsa.
24. PASK (para-aminosalicylic acid).

Kutsika kwa mphamvu ya mankhwalawa kumawonedwa tikamayikidwa limodzi ndi Phenothiazine ndi zotumphukira zake.

Pogwiritsa ntchito nthawi imodzi ndalamazi, mphamvu ya Diogiride imatheka. Kutsika kwa mphamvu ya mankhwalawa kumawonedwa tikamayikidwa limodzi ndi Phenothiazine ndi zotumphukira zake, ma estrogens ndi progestogens, glucagon, nicotinic acid, corticosteroids, barbiturates, Phenytoin, Acetazolamide, diuretics ndi mankhwala ochizira chithokomiro.

Kuyenderana ndi mowa

Mankhwalawa sagwirizana kwenikweni ndi Mowa. Zakumwa zoledzeretsa zimatha kuwonjezera ndikuchepetsa kuchiritsa kwa Diapiride.

Analogi

Pali zotengera za mankhwala:

1. Gliclazide.
2. Maninil.
3. Diabetes.
4. Glidiab.
5. Ziphuphu.

Kupita kwina mankhwala

Kodi ndingagule popanda kulandira mankhwala?

Mankhwala amaperekedwa ndi mankhwala.

Mtengo

Mtengo wa Diapiride pama pharmacies amachokera ku ma ruble 110 mpaka 270, kutengera mlingo wa chinthu chomwe chikugwira.

Zosungidwa zamankhwala

Sungani mapiritsi m'malo owuma komanso amdima osawonekera kwa ana, kutentha mpaka + 25 ° C.

Tsiku lotha ntchito

Moyo wa alumali ndi zaka 2.

Wopanga

Wopanga PJSC "Farmak" (Ukraine).

Ndemanga

Lyudmila, wazaka 44, Izhevsk.

Ndinayamba kugwiritsa ntchito mankhwalawa monga momwe adanenera dokotala kuti muchepetse magazi. Mankhwalawa ndi okwera mtengo komanso othandiza. Zimathandizira kukhala ndi shuga.

Alexey, wazaka 56, Moscow.

Ndakhala ndikudwala matenda ashuga a 2 kwa zaka zoposa 5. Ndimamwa mapiritsi awa mu kuchuluka kochepa. Ndi kugwiritsa ntchito pafupipafupi, kuchuluka kwa shuga m'magazi kumakhazikika. Zotsatira zoyipa sizimachitika. Koma ndimayesetsa kuphatikiza mankhwala ndi chakudya kuti ndipewe shuga.

Anna, wazaka 39, Voronezh.

Dokotala wa endocrinologist adalimbikitsa kumwa mankhwalawa. Ndimalola mankhwalawa mosavuta, sindimva zoyipa zilizonse. Mtengo wake ukundikwanira. Mwazi wa m'magazi ulibe malire. Ndikupangira!