Momwe mungagwiritsire ntchito mankhwala Ofloxin 400?

Ofloxin 400 ndi mankhwala omwe ali mgulu la fluoroquinolone. Amakhala ndi antimicrobial effect.

Dzinalo Losayenerana

INN - Ofloxacin.

Ofloxin 400 ndi mankhwala omwe ali mgulu la fluoroquinolone.

Ath

J01MA01.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amapangidwa m'njira zosiyanasiyana: mapiritsi, mafuta, makapisozi, madontho ndi yankho. Zomwe zimagwiritsidwa ntchito m'mitundu yonse ndi ofloxacin, quinolone wa m'badwo wachiwiri.

Mapiritsi

Amatetezedwa ndi chipolopolo ndipo amakhala ndi zosakaniza ndi 400 mg ndi 200 mg. Zosakaniza zina:

• shuga mkaka;
• wowuma chimanga;
• talc;
• hypromellose 2910/5.

Atanyamula mapiritsi a 10 ma PC. m'matuza.

Madontho

Tulutsa mitundu iwiri ya madontho: diso ndi khutu. Mankhwala amaperekedwa mu mawonekedwe a yankho lomveka bwino, mu 1 ml yomwe muli:

• 3 mg ofloxacin;
• mchere njira;
• benzalkonium chloride;
• hydrogen chloride;
• madzi okonzedwa.

Mankhwalawa amadzimadzi amatsanulira m'mabotolo apulasitiki. Matanki ali ndi chopereka.

Tulutsa mitundu iwiri ya madontho: diso ndi khutu.

Ufa

Kutulutsidwa kwa ofloxacin kulibe.

Njira Zothetsera

Njira yothetsera vutoli ndi yothetsera kulowetsedwa. Imakhala ndi mtundu wachikasu wonyezimira. Mankhwala amathiridwa mu Mbale mu mulogalamu 100 ml. Kuphatikiza pazomwe zimagwira, pali zina zowonjezera:

• mchere njira;
• Trilon B;
• hydrogen chloride;
• madzi oyeretsedwa.

Makapisozi

Mankhwala amtunduwu amaperekedwa mu mawonekedwe a makapu a gelatin achikasu. Zopangidwa:

• ofloxacin - 200 mg;
• hypromellose;
• sodium lauryl sulfate;
• shuga mkaka;
• calcium phosphate bisubstituted anhydrous;
• talcum ufa.

Mankhwalawa amaperekedwanso monga mawonekedwe a makapu a gelatin achikasu.

Mafuta

Mankhwala amapangidwa ngati mafuta amitundu iwiri: zochizira mabala komanso zochizira matenda amaso. Ofloxacin, yomwe imagwiritsidwa ntchito pakhungu, imagulitsidwa m'matumba a 15 kapena 30 g ya mankhwala omwe ali ndi zinthu zotsatirazi:

• 1 mg ofloxacin;
• 30 mg ya lidocaine hydrochloride;
• propylene glycol;
• poloxamer;
• macrogol 400, 1500, 6000.

Mafuta amaso amapezeka m'matumba a 3 ndi 5 g.

• ofloxacin - 0,3 g;
• nipagin;
• nipazole;
• mafuta odzola.

Makandulo

Pansi pa mayina osiyanasiyana azamalonda, zowonjezera zamkati zimapangidwa.

Zotsatira za pharmacological

Mankhwalawa ali ndi ma bactericidal katundu omwe amayamba chifukwa cha kulepheretsa kwa DNA gyrase (awa ndi ma enzymes omwe amachititsa kuti michere ya DNA ipangike m'magazi a michere ndi kubereka kwawo, komanso amatenga nawo mbali pazinthu zofunika kwambiri: kupotoza kuzungulira ndi kutsimikiza kukhazikika kwake.

Mankhwalawa ali ndi ma bactericidal omwe ali chifukwa cha kuletsa kwa DNA-gyrase.

Fluoroquinolone amawononga chipolopolo cha pathogenic microflora, kotero kuti kuthekera kokukulira mitundu yolimbana ndi kochepa. Mankhwalawa amawonetsa ntchito yayitali kwambiri poyerekeza ndi mabakiteriya osagwiritsa ntchito gramu. Ofloxacin, poyerekeza ndi mankhwala a Ciprofloxacin a antiotic, amakhalabe akugwira ntchito akaphatikizidwa ndi mankhwala a RNA polymerase synthesis.

Zomwe zimagwiritsidwa ntchito ndi mankhwalawa zimawononga kulumikizana pakati pa ziwiya za DNA, chifukwa chomwe khungu la ma microorganism limafa. Chifukwa cha izi mankhwalawa, amagwiritsidwa ntchito kuthana ndi mitundu ingapo ya mabakiteriya omwe amalimbana ndi mitundu ina ya maantibayotiki ndi sulfonamides.

Pharmacokinetics

Mankhwalawa amatha msanga m'matumbo, kuchuluka kwa Ofloxacin m'madzi am'magazi kumaonedwa pambuyo pa maola 1-3. Kutha kwa theka-moyo ndi maola 5-10, chifukwa chomwe mankhwalawa amatha kutumikiridwa 1-2 pa tsiku. Pafupifupi 75-90% ya mankhwalawa amachoka m'thupi ndi mkodzo.

Zizindikiro zogwiritsidwa ntchito

Ofloxacin amagwiritsidwa ntchito pofuna kuchiza matenda:

• kwamikodzo dongosolo;
• wamkazi kapena wamwamuna;
• STI
• matumbo;
• pamimba ndi m'mimba thirakiti;
• dongosolo la biliary;
• nosocomial ndi postoperative;
• kupuma thirakiti;
• septicemia ndi bacteremia;
• Pakati mantha dongosolo;
• chifuwa chachikulu, khate.

Mafuta amasonyezedwa pochiza khungu, mano ndi mano mabala.

Ofloxacin amagwiritsidwa ntchito pochiza matenda a kwamikodzo.

Ofloxacin amagwiritsidwa ntchito pofuna kuchiza matenda amtundu wa wamkazi ndi wamkazi.

Ofloxacin amagwiritsidwa ntchito pochiza matenda opatsirana pogonana.

Ofloxacin amagwiritsidwa ntchito pofuna kuchiza matenda am'matumbo.

Ofloxacin amagwiritsidwa ntchito pochiza matenda opumira.

Ofloxacin amagwiritsidwa ntchito pofuna kuchiza matenda a biliary system.

Ofloxacin amagwiritsidwa ntchito pochiza matenda a CNS.

Contraindication

Mankhwalawa ali ndi zotsutsana zotsatirazi:

• kuchuluka kwa zigawo zikuluzikulu;
• mimba ndi hepatitis B;
• ana ochepera zaka 18;
• khunyu ndi kugwidwa matenda (pambuyo pa kuvulala kwa craniocerebral)
• zambiri za urea;
• kuwonongeka kwa tendons komwe kunachitika mukutenga fluoroquinolones;
• kusowa kwa cytosolic enzyme (G6FD).

Ndi chisamaliro

Malangizo ogwiritsira ntchito akuwonetsa kuti popereka mankhwala, ayenera kusamala ndi odwala omwe ali ndi zotsatirazi:

• matenda amitsempha yamagazi;
• kuzungulira kwa ubongo;
• aimpso kuwonongeka (ndi creatinine chilolezo cha 50-20 ml / min);
• zodabwitsika chitukuko ndi chikhalidwe cha chapakati mantha dongosolo;
• kulephera kwa mtima ndi nthawi yayitali ya QT.

Amakanizidwa kwa amayi apakati.

Mankhwala ali zotsatirazi contraindication - khunyu ndi kugwidwa m'magazi.

Mankhwalawa ali ndi zotsutsana zotsatirazi - kuwonongeka kwa tendons zomwe zimachitika pomwa fluoroquinolones.

Musamale ndi anthu omwe ali ndi vuto la ubongo.

Musamale ndi anthu omwe ali ndi vuto la impso.

Gwiritsani ntchito mosamala kwa anthu omwe ali ndi vuto la mtima.

Samalani anthu omwe ali ndi vuto la ubongo.

Momwe mungatenge Ofloxin 400

Kwa odwala akuluakulu, Mlingo wa mankhwalawa ndi 200-600 mg. Kulandila kutsogolera mkati mwa masiku 7-10. Mankhwala mu 400 mg akhoza kumwa kamodzi. Mapiritsiwo sangathe kutafuna, ayenera kuwameza athunthu, kutsukidwa ndi kuchuluka kwa madzi. Pankhani ya matenda akulu komanso kunenepa kwambiri, mlingo umakwera mpaka 800 mg tsiku lililonse.

Mankhwalawa yotupa pathologies a m'munsi mwa kwamikodzo dongosolo losavuta mawonekedwe, iwo amatengedwa 200 mg kamodzi patsiku, maphunzirowa kumatha masiku 3-5. Mankhwala a chinzonono, mankhwalawa amamwa kamodzi pa 400 mg.

Mukadumpha mlingo

Ngati pazifukwa zina wodwalayo sanathe kumwa mankhwalawo, ndiye kuti mutha kumwa iwo akangokumbukira izi.

Ndi matenda ashuga

Odwala odwala matenda ashuga nthawi ya mankhwala ndi Ofloxin ayenera kuwunika kuchuluka kwa shuga m'magazi, chifukwa Co-makonzedwe a mankhwala ndi shuga-kuchepetsa mankhwala, insulin ndi fluoroquinolones kungayambitse kukula kwa hypo- kapena hyperglycemia.

Odwala odwala matenda ashuga nthawi ya mankhwala ndi Ofloxin ayenera kuwunika kuchuluka kwa shuga m'magazi.

Zotsatira zoyipa zaloxine 400

Ndipo ngakhale zovuta sizimachitika kawirikawiri, ngati zapezeka, wodwalayo ayenera kufunsa dokotala.

Matumbo

Zizindikiro zotsatirazi zimachitika:

• kupweteka ndi kusamva bwino m'mimba;
• mavuto a dyspeptic;
• gastralgia;
• dysbiosis;
• chilala;
• chiwindi.

Hematopoietic ziwalo

Zowonekera:

• kuchepa magazi
• leukopenia;
• pancytopenia;
• zotupa za malo;
• thrombocytopenia.

Zotsatira zoyipa zaloxine 400 - matenda osokoneza bongo.

Zotsatira zoyipa zaloxine 400 gastralgia.

Zotsatira zoyipa zaloloin 400 - dysbiosis.

Zotsatira zoyipa zaloloine 400 - hepatitis.

Zotsatira zoyipa zaloxine 400 - magazi m'thupi.

Zotsatira zoyipa za heloxine 400-point hemorrhage.

Zotsatira zoyipa zaloxine 400 - thrombocytopenia.

Pakati mantha dongosolo

Zizindikiro zoyipa zomwe zili ndi vuto lamkati la neva:

• Chizungulire
• migraine
• Kuda nkhawa
• chisokonezo cha kugona;
• psychosis ndi phobias;
• kuchuluka kwachuma chamkati;
• kuyerekezera;
• mkhalidwe wopsinjika.

Kuchokera ku minculoskeletal system

Zowonekera:

• tendonitis;
• kusweka kwa minofu;
• yotupa njira mu ogwirizana-ligamentous zida;
• kufooka kwa minofu ndi kuwawa.

Kuchokera ku kupuma

Sapezeka.

Pa khungu

Kuyang'ana: petychia, zidzolo, ndi khungu.

Zotsatira zoyipa zaloloin 400 - chizungulire.

Zotsatira zoyipa zaloloine 400 - migraine.

Zotsatira zoyipa zaloxine 400 - psychosis ndi phobias.

Zotsatira zoyipa za Ofloxin 400 - kusokonezeka kwa tulo.

Zotsatira zoyipa zaloloin 400 - tendonitis.

Zotsatira zoyipa zaloloine 400 - njira yotupa m'matimu ogwirizana

Zotsatira zoyipa za Ofloxin 400 zimawonedwa: petichia, zotupa ndi dermatitis.

Kuchokera ku genitourinary system

Zotsatira zoyipa zotere sizimachitika kawirikawiri:

• hypercreatininemia;
• yade;
• kuchuluka kwa urea.

Kuchokera pamtima

Odwala atha:

• kusokonezeka kwa mtima;
• kutsika kwa kuthamanga kwa magazi;
• tachycardia;
• zotupa zam'mimba;
• kugwa chitukuko.

Dongosolo la Endocrine

Sapezeka.

Matupi omaliza

Zotsatira zoyipa zimasonyezedwa ndi zizindikiro zotsatirazi:

• zotupa;
• kuyabwa
• kupuma movutikira
• Matupi nephritis;
• kutupa pa nkhope ndi khosi;
• matupi awo sagwirizana pneumonitis;
• Edema ya Quincke;
• anaphylactic mantha.

Ndi osowa kwambiri mukamamwa mankhwala omwe nephritis imayamba.

Mukamamwa mankhwalawa, kuthamanga kwa magazi kumatha kuchepa.

Kuwonetsera kwa thupi lawo siligwirizana mu mawonekedwe a zidzolo ndi kuyabwa ndikotheka.

The thupi lawo siligwirizana mu mawonekedwe a kupuma movutikira n`zotheka.

Mukamamwa mankhwalawa, edema ya Quincke imatha kukulira.

Zokhudza mphamvu pakuwongolera njira

Panthawi ya chithandizo ndi Ofloxin, ndizoletsedwa kuyendetsa galimoto ndi njira zovuta.

Malangizo apadera

Mankhwalawa satha kugwira ntchito pachipatala, zomwe zimayambitsidwa ndi chibayo kapena mycoplasmas: mawonekedwe a bronchitis ndi chibayo.

Pankhani ya mapangidwe ziwengo, zotsatira zoyipa za chapakati mantha dongosolo, ndikofunikira kusiya mankhwala.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Mankhwala amaletsedwa kuti azigwiritsidwa ntchito ndi amayi munthawi ya kubereka mwana komanso mkaka wa m'mawere chifukwa cha kukula kwa matenda a mafupa ndi minyewa mwa mwana.

Mankhwala aloxine wa ana 400

Odwala osakwana zaka 18 salembetsa mankhwala, chifukwa muyenera kuyembekezera kumaliza kukula ndi mapangidwe a minofu ndi mafupa. Koma ngati ndi kotheka, ndikuyang'aniridwa ndi dokotala, Ofloxacin itha kutumikiridwa pa mlingo wa 7.5 mg pa 1 kg ya kulemera. Mulingo wovomerezeka ndi 15 mg / kg.

Odwala osakwana zaka 18 salembetsa mankhwala, chifukwa muyenera kuyembekezera kumaliza kukula ndi mapangidwe a minofu ndi mafupa.

Gwiritsani ntchito mu ukalamba

Gwiritsani ntchito maantibayotiki mosamala chifukwa cha kusintha kwokhudzana ndi zaka komanso chiopsezo chotsatira.

The ntchito aimpso kuwonongeka

Kusintha kwa mlingo kuyenera, ndipo chithandizo chikuchitika moyang'aniridwa ndi dokotala.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Mankhwalawa amagwiritsidwa ntchito pokhapokha ngati wodwalayo azidzayang'anira kuchuluka kwa biliburin, ndipo ngati pigment ya bile ikuwonjezeka, ndiye kuti mlingo umasintha kapena kuti mankhwala amalephera kwathunthu.

Ofloxin 400 Overdose

Zizindikiro zotsatirazi za kuledzera zingakhale:

• mavuto a dyspeptic;
• matenda oopsa
• chisokonezo.

Ngati mankhwala osokoneza bongo apezeka, mankhwalawo amasiya, wodwalayo amasambitsidwa m'mimba kuchipatala. Ngati waledzera kwambiri, hemodialysis akhoza zotchulidwa.

Mankhwala osokoneza bongo a Ofloxin 400 amawonetsedwa mu mawonekedwe a matenda a dyspeptic.

Mankhwala osokoneza bongo a Ofloxin 400 amawonetsedwa mwa matenda oopsa.

Mankhwala osokoneza bongo a Ofloxin 400 amawonetsedwa mwanjira yachisokonezo.

Kuchita ndi mankhwala ena

Mankhwala amakhudzana mosiyanasiyana ndi mankhwala ena.

Kuphatikiza kophatikizidwa

The munthawi yomweyo mankhwala antimicrobial wothandizila ndi zotsatirazi mankhwala oletsedwa:

• NSAIDs - njira yolanda matenda aubongo itha kuchepa;
• quinolones ndi mankhwala okhala ndi aimpso metabolite - mulingo wa ofloxin umakwera ndipo nthawi yake ya chimbudzi imakhala yayitali;
• antihypertensive mankhwala, barbiturates - kuthamanga kwa magazi kumatha kuchuluka kwambiri;
• glucocorticoids - chiwopsezo chowonjezereka cha tendonitis;
• anthocyanins - digestibility ya mankhwala yafupika.

Osavomerezeka kuphatikiza

Kuphatikizana kwa Ofloxacin ndi mankhwala otsatirawa ndizoletsedwa:

• mavitamini a vitamini K - kuwundana kwa magazi kumatha kuchuluka;
• Glibenkamid - mulingo wa seramu Glibenkamide uwonjezeke;
• panthawi yodziwikirayi, chifukwa cha maantibayotiki, pamakhala zotsatira zoyipa za opiates ndi porphyrins mkodzo.

Kuphatikiza komwe kumafunikira kusamala

Ndi kuphatikiza kwa Ofloxacin wophatikizira pakamwa, kuwonjezeka kwa ntchito yotsiriza ndikotheka.

Ndi kuphatikiza kwa maantibayotiki omwe ali ndi mankhwala omwe amaphwanya mtundu wa sinus, ndikofunikira kuti azilamulira ECG.

Kuyenderana ndi mowa

Mankhwalawa sagwiritsidwa ntchito ndi mowa.

Analogi

Ofloxacin ali ndi izi:

• Ofaxin;
• Oflo;
• Phloxane;
• Oftagel;
• Ofor.

Mmalo mwa mankhwalawa ndi Oflo.

M'malo mwa mankhwalawa ndi Phloxan.

M'malo mwa mankhwalawa ndi Oftagel.

M'malo mwa mankhwalawa ndi a Ofor.

Kupita kwina mankhwala

Ndi mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Ayi.

Mtengo wa Ofloxin 400

Mutha kugula mankhwala ku Ukraine pamtengo wa 133.38-188 UAH., Ndipo ku Russia - 160-180 rubles.

Zosungidwa zamankhwala

Sungani mankhwalawa pamalo owuma komanso amdima osatheka ndi ana. Kutentha sikuyenera kupitirira 25 ° C.

Tsiku lotha ntchito

Osapitilira zaka zitatu.

Wopanga

Republic Czech.

Ndemanga ya Ofloxin 400

Madokotala

Maxim, Moscow: "Muzochita zanga zachipatala, ndimagwiritsa ntchito fluoroquinolones kuchiza odwala. Ofloxacin, ndimaiganiza kuti ndi mankhwala othandiza. Imapereka zotsatira zake mwachangu, popanda zotsatirapo zake."

Galina, St. Petersburg: "Ndakhala ndikugwira ntchito ya gynecology kwa zaka 10. Kutupa kwa ziwalo za urogenital, ndikuwapatsa amayi a Ofloxacin. Mwa zabwino zake, mawonekedwe osavuta otulutsira, kuthekera kwa kuwongolera ndi kusamalira mlingo wake ndikokwanira. Ndikokwanira kumwa mankhwalawa katatu patsiku."

Mukamwa mankhwalawa, kutupa kwamitsempha kumayamba.

Odwala

Anna, wazaka 38, Omsk: "Mankhwalawa anathandizira kuchiritsa kwambiri cystitis. Patatha masiku awiri awiri, zinthu zinasintha, chifukwa chakuti matendawa anali atatha.

Yuri, wazaka 29, Krasnodar: "Chaka chapitachi ndidazizira kwambiri kuntchito, zomwe zidabweretsa mavuto pokodza.Dotolo adandiuza mankhwala omwe ndidatenga sabata limodzi. "

Tatyana, wazaka 45, Voronezh: "Dotolo atatha kuyesa mayeso adandipeza ndimatenda obisika. Ofloxacin adalembedwa, omwe ndidawatenga kwa masiku 10. Pambuyo pa mayeso achiwiri, zotsatira zake zidakhala zopanda pake."