Zaltrap ndi mankhwala a antitumor omwe amagwiritsidwa ntchito pochiza khansa ya metastatic colorectal mwa akulu pamene chemotherapy sichimapereka zotsatira zochizira chifukwa chokana kwambiri chotupa kapena ngati chayambiranso.
Dzinalo Losayenerana
ZALTRAP.
Zaltrap ndi mankhwala a antitumor omwe amagwiritsidwa ntchito pochiza khansa ya metastatic colorectal akuluakulu.
ATX
L01XX - mankhwala ena a antitumor.
Kutulutsa mafomu ndi kapangidwe kake
Gwiritsani ntchito njira yothetsera kulowetsedwa. Mbale zokhala ndi kuchuluka kwa 4 ml ndi 8 ml. Kuchuluka kwazinthu zazikuluzikulu za aflibercept ndi 25 mg mu 1 ml. Njira yachiwiri ndi njira yokhazikika yopanda njira yotsekera makonzedwe amkati. Mtundu wa yankho ndi wowonekera kapena wowala wachikasu.
Chofunikira kwambiri ndi mapuloteni atlibercept. Omwe amathandizira: sodium phosphate, citric acid, hydrochloric acid, sucrose, sodium chloride, sodium hydroxide, madzi.
Zotsatira za pharmacological
Aflibercept imalepheretsa ntchito ya ma receptors, omwe amachititsa kuti mitsempha yatsopano ya magazi idyetse chotupacho ndikuthandizira kukula kwambiri. Kutsalira popanda magazi, neoplasm imayamba kuchepa kukula. Ndondomeko ya kukula ndikugawika kwa maselo ake atypical amasiya.
Aflibercept imalepheretsa zochitika za ma receptors, omwe amachititsa kuti magazi apangidwe.
Pharmacokinetics
Palibe deta pa kagayidwe kazakudya zomanga thupi. Zotheka kuti, monga mapuloteni ena onse, gawo lalikulu la mankhwalawo limagawika mu amino acid ndi peptides. Kuchotsa theka moyo mpaka 6 masiku. Mapuloteni samatulutsidwa kudzera mu impso ndi mkodzo.
Zizindikiro zogwiritsidwa ntchito
Amagwiritsidwa ntchito limodzi ndi folinic acid, Irinotecan ndi Fluorouracil kwa chemotherapy ya khansa ya metastatic colorectal komanso kukana kwakukulu kwa mankhwala ena a antitumor. Amalembera mankhwalawa.
Contraindication
Ndi zoletsedwa kugwiritsa ntchito mankhwalawa.
- magazi ambiri;
- matenda oopsa a ochepa mtundu, mankhwala atalephera;
- Gawo 3 ndi 4 la mtima wosalephera;
- wodwala ali ndi hypersensitivity pamagulu a mankhwala;
- kulephera kwambiri kwaimpso.
Kuletsa kwa zaka - odwala ochepera zaka 18.
Ndi chisamaliro
Kuwunikira nthawi zonse zaumoyo wa odwala omwe ali ndi vuto la impso, ochepa matenda oopsa, matenda a mtima, komanso magawo oyamba a kulephera kwa mtima kumafunika. Mosamala, mankhwalawa amaperekedwa kwa odwala okalamba komanso odwala omwe ali ndi vuto lathanzi, ngati mulingo wotsika sakhala wapamwamba kuposa 2 point.
Momwe mungatenge Zaltrap
Intravenous makonzedwe - kulowetsedwa kwa 1 ora. Mlingo wamba ndi 4 mg pa kilogalamu ya kulemera kwa thupi. Chithandizo chimasainidwa pamaziko a chemotherapeutic regimen:
- tsiku loyamba la mankhwala: kulowetsedwa kudzera mu mawonekedwe a Y-otupa wa Irinotecan 180 mg / m² kwa mphindi 90, calcium yatsala pang'ono kwa mphindi 120 pa mlingo wa 400 mg / m² ndi 400 mg / m² Fluorouracil;
- kulowetsedwa kosatha kumatenga maola 46 ndi mulingo wa Fluorouracil 2400 mg / m².
Intravenous makonzedwe - kulowetsedwa kwa 1 ora.
Amazungulira masiku 14 aliwonse.
Ndi matenda ashuga
Kusintha kwa Mlingo sikofunikira.
Zotsatira zoyipa za Zaltrap
Zochitika pafupipafupi za matenda otsegula m'mimba, proteinuritis, dysphonia, ndi matenda a kwamkodzo amadziwika. Mwa odwala ambiri, kusowa kwa chakudya kumachepa, kukha kwammphuno, kuchepa thupi kumachitika. Pali kutopa kochulukirapo, asthenia.
Zizindikiro zoyipa za kupuma kwamkati: dyspnea ya kusiyanasiyana, rhinorrhea, kutuluka kwa magazi kuchokera m'matumbo kumachitika nthawi zambiri.
Kuchokera minofu ndi mafupa
Odwala ena amakhala ndi nsagwada ya fupa.
Matumbo
Kutsegula m'mimba, kupweteka kwam'mimba kosiyanasiyana, kukula kwa zotupa, mapangidwe a fistulas mu anus, chikhodzodzo, matumbo ochepa. Kupweteka kwameno, kupweteka kwam'mimba, kupweteka kwa rectum, nyini. Fistulas m'mimba yogaya ndi kukonza makoma sizichitika kawirikawiri, zomwe zingayambitse kuti wodwalayo afe.
Zizindikiro zoyipa za kupuma: dyspnea nthawi zambiri imachitika.
Hematopoietic ziwalo
Nthawi zambiri pamakhala leukopenia ndi neutropenia wamisala yosiyanasiyana.
Pakati mantha dongosolo
Pafupifupi nthawi zonse pamakhala mutu wosiyanasiyana, wolumikizika pafupipafupi.
Kuchokera kwamikodzo
Nthawi zambiri - proteinuria, kawirikawiri - kukula kwa nephrotic syndrome.
Pa khungu
Kuyenda, redness ndi zidzolo, urticaria.
Kuchokera ku genitourinary system
Matenda, kuphwanya chonde mwa amuna ndi akazi.
Odwala ambiri, kutenga Zaltrap kumatha kuyambitsa thromboembolism.
Kuchokera pamtima
Amalumphira kuthamanga kwa magazi, kutulutsa magazi mkati. Odwala ambiri: thromboembolism, ischemic attack, angina pectoris, chiwopsezo chachikulu cha kulowerera myocardial. Pafupipafupi: kutsegula kwa magazi m'mimba, kukhetsa magazi, kutulutsa magazi m'matumbo am'mimba, omwe akupha.
Pa mbali ya chiwindi ndi biliary thirakiti
Kukula kwa chiwindi kulephera.
Kuchokera kumbali ya kagayidwe
Nthawi zambiri, pamakhala kusowa kwa chakudya, nthawi zambiri - kuchepa kwa madzi m'thupi (kuyambira wofatsa mpaka wamphamvu).
Matupi omaliza
Mkulu Hypersensitivity anachita: bronchospasm, kupuma movutikira, anaphylactic mantha.
Zokhudza mphamvu pakuwongolera njira
Palibe zambiri pa kafukufuku wazomwe zimachitika chifukwa cha mankhwalawa. Ndikulimbikitsidwa kuti musayendetse magalimoto ndikugwiritsa ntchito mwaukadaulo wodwala ngati wodwala ali ndi zovuta kuchokera ku dongosolo lamkati lamanjenje, matenda a psychomotor.
Pamasamba azithandizo zatsopano (masiku 14 aliwonse), kuyezetsa magazi kuyenera kuchitidwa.
Malangizo apadera
Pamasamba azithandizo zatsopano (masiku 14 aliwonse), kuyezetsa magazi kuyenera kuchitidwa. Mankhwala chikuyendetsedwera mu chipatala kukhazikitsidwa munthawi yochepa zizindikiro za kuchepa magazi, mafuta a makoma am'mimba thirakiti.
Odwala omwe ali ndi index yaumoyo wamba ya 2 point kapena kuposa ali ndi chiopsezo cha zotsatila. Amafuna kuyang'aniridwa ndi achipatala pafupipafupi kuti azindikire kuwonongeka kwakanthawi paumoyo.
Kapangidwe ka fistulas mosasamala kanthu komwe akukhala ndi chizindikiro cha kutha kwa chithandizo. Sizoletsedwa kugwiritsa ntchito mankhwalawa pochiza odwala omwe adachitidwa opaleshoni yayikulu (mpaka mabala amachira kwathunthu).
Amuna ndi akazi a msinkhu wobereka ayenera kugwiritsa ntchito njira zosiyanasiyana zakulera asanakwanitse miyezi isanu ndi umodzi (osachepera) atatha kumwa kwa Zaltrap. mimba ya mwana siyenera kupatula.
Zaltrap yankho ndi hyperosmotic. Kapangidwe kake sikumagwiritsa ntchito mankhwalawa intraocular space. Sizoletsedwa kuyambitsa yankho mu thupi la vitreous.
Gwiritsani ntchito mu ukalamba
Pali chiopsezo chachikulu chotenga matenda otsegula m'mimba, chizungulire, kuchepa thupi komanso kuchepa madzi m'thupi mwa odwala omwe ali ndi zaka 65 ndi akulu. Mankhwala a Saltrap ayenera kuchitika pokhapokha poyang'aniridwa ndi ogwira ntchito kuchipatala. Poyamba chizindikiro cha kutsegula m'mimba kapena kusowa kwamadzi, chithandizo chamankhwala chofunikira chimafunikira.
Mankhwala a Saltrap ayenera kuchitika pokhapokha poyang'aniridwa ndi ogwira ntchito kuchipatala.
Kupatsa ana
Chitetezo cha Zaltrap mwa ana sichinakhazikitsidwe.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Zambiri pakugwiritsa ntchito Zaltrap mwa amayi apakati komanso oyamwitsa sapezeka. Popeza kuopsa kwa zotsatira zoyipa kwa mwana, mankhwala a antitumor sanalembedwe m'magulu a odwala. Palibe chidziwitso kuti ngati gawo logwiritsidwira la mankhwala limayamwa mkaka wa m'mawere. Ngati ndi kotheka, ntchito mankhwala mankhwalawa khansa kwa mayi woyamwitsa, mkaka wa m`mawere ayenera anathetsedwa.
The ntchito aimpso kuwonongeka
Kugwiritsa ntchito kwa Zaltrap odwala omwe ali ndi vuto lochepa kwambiri komanso lolimbitsa thupi amaloledwa. Palibe chidziwitso pakugwiritsa ntchito mankhwalawa odwala omwe ali ndi vuto laimpso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Palibe zambiri pakugwiritsa ntchito mankhwalawa odwala omwe ali ndi chiwindi cha hepatic. Chithandizo cha odwala omwe ali ndi vuto lalikulu la chiwindi, koma mosamala kwambiri komanso moyang'aniridwa ndi dokotala, amaloledwa.
Chithandizo cha odwala omwe ali ndi vuto lalikulu la chiwindi amaloledwa.
Mankhwala ochulukirapo a Zaltrap
Palibe chilichonse chokhudza momwe mankhwalawa amapitilira 7 mg / kg kamodzi pakatha masiku 14 kapena 9 mg / kg kamodzi pakatha masiku 21 aliwonse.
Mankhwala osokoneza bongo amatha kuwonetsedwa ndi kuwonjezeka kwa kukula kwa zizindikiro zammbali. Chithandizo - kukonza, kuyang'anira kuthamanga kwa magazi. Palibe mankhwala.
Kuchita ndi mankhwala ena
Kuchita maphunziro a pharmacokinetic ndi kuwunika koyerekeza sizinawonetse kuyanjana kwa pharmacokinetic kwa Zaltrap ndi mankhwala ena.
Kuyenderana ndi mowa
Kumwa mowa panthawi yamankhwala ndizoletsedwa.
Analogi
Kukonzekera ndi mawonekedwe ofanana: Agrelide, Bortezovista, Vizirin, Irinotecan, Namibor, Ertikan.
Irinotecan ndi mankhwala okhala ndi mawonekedwe ofanana.
Kupita kwina mankhwala
Kungopereka mankhwala kuchokera kwa dokotala.
Kodi ndingagule popanda kulandira mankhwala?
Zogulitsa za OTC sizikuphatikizidwa.
Mtengo
Kuyambira 8500 rub. pa botolo.
Zosungidwa zamankhwala
Pa kutentha + kuyambira +2 mpaka + 8 ° C.
Tsiku lotha ntchito
Zaka zitatu Kugwiritsanso ntchito mankhwalawa kumachotsedwa.
Wopanga
Sanofi-Aventis Deutschland GmbH, Germany.
Ndemanga
Ksenia, wazaka 55, ku Moscow: "Njira ya ku Zaltrap idalangizidwa kwa bambo anga kuti amupatse mankhwala a khansa. Mankhwalawa ndi abwino, ogwira ntchito koma owopsa. Pali zovuta zina zilizonse. Ndi bwino kuti amathandizidwa kamodzi pakatha masabata awiri, chifukwa pambuyo pa chemotherapy makolo amakhala osakhalitsa "Chulukirachulukira, koma kuwunikira kunawonetsa njira yabwino yochepetsera kupanikizika."
Eugene, wazaka 38, Astana: "Ndinakumana ndi mavuto ambiri kuchokera ku Zaltrap. Ndinali pamavuto akulu: nseru, kusanza, kupweteka mutu pafupipafupi, kufooka kwakukulu. Koma mankhwalawa amagwira ntchito pamatumbo mwachangu. kupulumuka chizunzo chonsechi. "
Alina, wazaka 49, Kemerovo: "Awa ndi mankhwala okwera mtengo, ndipo sindimva ngati ndingakhale ndi iye pambuyo pa mankhwala amphamvu. kuchuluka. Zaltrap isanachitike, mankhwala ena anali ogwiritsidwa ntchito, koma matendawo anali osakhalitsa, ndipo nditatha zaka zitatu ndakhala ndikupanda matenda. "
