Noliprel 0.625 amagwiritsidwa ntchito kutsitsa magazi. Mankhwala ndi a gulu la zophatikizika ndipo ali ndi zinthu zingapo zogwira ntchito. Chifukwa chamachitidwe osiyanasiyana a zinthuzi, zotsatira zabwino zimachitika mwachangu kwambiri.
Dzinalo Losayenerana
Perindopril + indapamide.
ATX
C09BA04.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa m'mapiritsi. Kuphatikiza kwa zinthu ziwiri zomwe zikugwira zikuwonetsa katundu wa antihypertensive:
- perindopril erbumin 2 mg;
- indapamide 0,625 mg.
Mankhwalawa amapezeka m'matumba okhala ndi mapiritsi 14 kapena 30.
Noliprel 0.625 amagwiritsidwa ntchito kutsitsa magazi.
Zotsatira za pharmacological
Mankhwala ndi a gulu la ACE zoletsa, komanso ali ndi okodzetsa, amenenso amathandizira kuthetsa zizindikilo za matenda oopsa. Chifukwa cha kuphatikiza, zinthu zomwe zimagwira ntchito zimathandizira kuchitirana. Thunthu perindopril linalake ndipo tikulephera kugwira ntchito kwa enzyme nawo kusintha kwa angiotensin I mu angiotensin II. Malinga ndi izi, chinthu ichi ndi cholepheretsa kusintha kwa eniotensin kapena ACE.
Angiotensin II amadziwika ndi kuthekera kochepetsa lumen ya mitsempha yamagazi. Chifukwa cha izi, kupanikizika kumawonjezeka. Ngati kutembenuka kwa ma angiotensins kuchepetsedwa, kufalikira kwa magazi kumapangidwa pang'onopang'ono, dongosolo la mtima limabwezeretseka. Kuphatikiza apo, puloteni ya angiotensin yotembenuza imayeneranso kuwonongeka kwa bradykinin, yomwe ntchito yake yayikulu ndikuwonjezera lumen ya mitsempha ndi mitsempha.
Izi zikutanthauza kuti zotsatira za ntchito ya ACE zimathandizira kubwezeretsa dongosolo lamtima. Kuphatikiza apo, kuthekera kwina kwa perindopril kwadziwika:
- imakhudza adrenal cortex, pomwe kukula kwa kupanga kwakukulu kwa mineralocorticosteroid, aldosterone, kumachepa;
- imakhala ndi vuto losagwirizana ndi dongosolo la renin-angiotensin, lomwe limathandizira kuthamanga kwa magazi, ndi chithandizo cha Noliprel, ntchito ya renin mu plasma yamagazi imawonjezeka;
- amachepetsa kukana kwamitsempha, komwe kumachitika chifukwa cha zotengera m'matumbo ofooka ndi impso.
Chifukwa cha zosakaniza zomwe zimagwira, Noliprel imachepetsa kupanikizika ndikuyenda bwino kwa CVS.
Mukamayendetsa Noliprel, kukula kwa mawonekedwe osawoneka sikumawonedwa, makamaka, mchere samakhalabe m'thupi, zomwe zikutanthauza kuti amadzimadzawo amadzimana msanga. Kuphatikiza apo, zotsatira za perindopril sizimayambitsa kukula kwa tachycardia. Chifukwa cha gawo ili, ntchito za myocardial zimabwezeretseka. Ichi ndi chifukwa cha kuchepa kwa magazi m'mitsempha yamagazi mkati mwa makulidwe amitsempha yamagazi. Komabe, pali kuwonjezeka kwa kutulutsa mtima.
Chothandizira china (indapamide) chofanana mu katundu ndi thiazide diuretics. Mothandizidwa ndi iye, kuchuluka kwa mafuta amchere a calcium kumachepa. Nthawi yomweyo, kukula kwa njira yochotsera potaziyamu ndi ma magnesium ion m'thupi kumawonjezeka. Komabe, uric acid imachotsedwa. Mothandizidwa ndi indapamide, njira yobwezeretsanso sodium ions imasokonekera. Zotsatira zake, kupendekera kwawo kumachepa. Kuphatikiza apo kumachotsera chlorine.
Njira izi zimathandizira kukulitsa kuchuluka kwa mkodzo. Nthawi yomweyo, madzi achilengedwe amachotsedwa mwamphamvu, kuthamanga kwa magazi kumachepa. Indapamide imatha kutengedwa pamiyeso yambiri, koma ngakhale pakali pano pali kuchepa kwa kuthamanga kwa magazi, komabe, Mlingo woterewu suthandizira kuwonetsa kwa diuretic action.
Ndi mankhwala a Noliprel, zotsatira zabwino zimapitilira kwa maola 24 otsatira. Komabe, kusintha kwamphamvu kwa wodwala wokhala ndi matenda oopsa kumawonekera patatha milungu ingapo. Ubwino wa Noliprel ndi kusapezeka kwa zizindikiro zakuchoka kumapeto kwa mankhwala.
Zimadziwika kuti kuphatikiza kwa indapamide ndi perindopril kumapereka zotsatira zabwinoko (kuchepetsa komanso kuthamanga kwambiri pamagazi) kuposa mukamagwiritsa ntchito chinthu chilichonse padera. Noliprel sichikuwakhudza. Kuphatikiza apo, mankhwala omwe amafunsidwawa ndi othandizira matenda oopsa oopsa. Izi zimathandizidwa makamaka ndi kupezeka kwa perindopril pakuphatikizika.
Pharmacokinetics
Ndi kuphatikiza kwa zinthu ziwiri zogwira ntchito, ma pharmacokinetics awo sasintha. Chifukwa chake, perindopril imalowa mwachangu. Pambuyo pa mphindi 60, nsonga ya ntchito ya chinthu ichi chinafikiridwa, popeza kuchuluka kwa ndende kumafika pamwambamwamba. Perindopril imapukusidwa. Komabe, pawiri imodzi yokha imagwira ntchito limodzi ndi gawo lalikulu la mankhwalawo.
Pa chakudya, mayamwidwe a perindopril amayamba kuchepa. Impso ndizomwe zimayambitsa kuphipha kwake. Pakasokonekera chiwalochi, chomwe chimagwira chimasungidwa m'thupi, zomwe zimapangitsa kuti chiwonjezere.
Indapamide imafanana mu pharmacokinetic katundu kwa perindopril. Amadziwikanso mwachangu. Pambuyo mphindi 60, pazinthu zambiri pazomwe zimachitika. Hafu ya moyo wa indapamide imasiyanasiyana 14 mpaka 24 maola. Poyerekeza, perindopril amachotsedwa m'thupi mkati mwa maola 17, koma boma lofanana silifikirako kuposa masiku 4 pambuyo pake.
Ngati aimpso ntchito, ophatikizika mankhwala amasonkhana m'thupi.
Zizindikiro zogwiritsidwa ntchito
Matenda oopsa kwambiri.
Contraindication
Zoletsa kusankhidwa kwa Noliprel:
- tsankho la munthu aliyense wa kapangidwe kake, koma nthawi zambiri zotsatira zoyipa zomwe zimagwiritsidwa ntchito zimawonetsedwa, kuwonjezera apo, mankhwalawa sagwiritsidwa ntchito kwa hypersensitivity ku mankhwala ena a gulu la sulfonamide gulu (okodzetsa), ACE zoletsa;
- Kulephera kwamtima kwakatikati pamlingo wobwezera;
- chizolowezi cha laryngeal edema;
- hypokalemia;
- kuchepa kwa lactase, shuga-galactose malabsorption syndrome, galactosemia.
Momwe mungatenge Noliprel 0.625?
Popewa zovuta komanso kupewa zoyipa, komanso kukwaniritsa zotheka munthawi yochepa kwambiri, mankhwalawa adayikidwa m'mawa. Ndi bwino kumwa mankhwalawa pamimba yopanda kanthu. Mlingo womwe umalimbikitsa ndi piritsi limodzi patsiku. Njira ya mankhwala koyambira kumatenga mwezi umodzi.
Ngati kumapeto kwa nthawi imeneyi zotsatira zabwino (kuchepetsa kukakamiza) sizikwaniritsidwa, Mlingo wa zomwe mukugulitsazo ukuunikidwanso. Pankhaniyi, Noliprel Forte angafotokozeredwe kukhala ndi zigawo zothandizika zomwe zimapangidwanso kawiri nthawi ya Noliprel.
Kodi kuchitira matenda a shuga a 2?
Chofunikira kwambiri pakuchizira odwala m'gululi ndikumwa kumwa ochepa sabata yoyamba. Chifukwa chake, mutha kuyambitsa maphunziro ndi piritsi limodzi la Noliprel. Pang'onopang'ono, ngati pakufunika, mlingo wa mankhwalawo umakulanso. Komabe, pankhaniyi, zizindikiritso zazikulu za magazi, chiwindi, ndi impso zimayang'aniridwa nthawi zonse kupewa mavuto.
Zotsatira zoyipa za Noliprel 0.625
Zochitika mu ziwalo za masomphenyawo, kumva, kusabala, hyperhidrosis. Pa mbali ya mtima dongosolo, angina pectoris akuwonetsedwa, kawirikawiri: myocardial infarction, kuchepa kwambiri kwa magazi.
Matumbo
Kusungunula, mseru, kupweteka pamimba, kusintha kwa kukoma, kuvuta kutulutsa ndowe, kulakalaka kwa wodwalayo kusowa, chimbudzi chimasokonekera, kutsegula m'mimba. Nthawi zina zotupa zimayamba (chotupa m'matumbo). Pafupipafupi, kapamba amadziwika ndi Noliprel.
Hematopoietic ziwalo
Zomwe zimapangidwazo, ndipo nthawi yomweyo, mawonekedwe a magazi akusintha. Mwachitsanzo, kuchepa magazi, thrombocytopenia, ndi zina.
Pakati mantha dongosolo
Wodwala nthawi zambiri amasintha momwe akumvera. Pali mavuto ndi tulo, chizungulire, kupweteka mutu, kumva kukasokonezeka. Chomwe chofala ndikusintha kwa chikumbumtima.
Kuchokera kwamikodzo
Zowopsa zaimpso.
Kuchokera ku kupuma
Kupuma pang'ono, bronchospasm, chifuwa (makamaka chouma), rhinitis, chibayo cha eosinophilic.
Matupi omaliza
Vasculitis, yokhala ndi hemorrhage, urticaria, edincke.
Zokhudza mphamvu pakuwongolera njira
Chenjezo liyenera kuchitidwa poyendetsa magalimoto panthawi ya mankhwala a Noliprel. Kufunika uku kumachitika chifukwa chakuti mothandizidwa ndi magawo omwe amagwira ntchito, zosokoneza zowoneka zimatha kukula. Pokhapokha aliyense atakumana ndi zovuta zomwe zakhudzidwa ndi mankhwalawo, ndizovomerezeka kuchita nawo mtundu uliwonse wa zochitika zomwe zimafuna chidwi chochulukirapo.
Chenjezo liyenera kuchitidwa poyendetsa magalimoto panthawi ya mankhwala a Noliprel.
Malangizo apadera
Mkhalidwe wodabwitsawu monga idiosyncrasy nthawi zambiri umakula.
Nthawi zambiri, mankhwalawa samatchulidwa ngati kulephera kwaimpso chifukwa cha kukula kwa aimpso. Zovuta zamtunduwu zimachitika kawirikawiri chifukwa cha matenda a mtima. Izi zimathandiziridwa ndi ma pathologies a impso omwe alipo.
Ndi ochepa hypotension, palibe chifukwa chosiya kumwa mankhwalawa. Potere, kupanikizika kumakhala koyenera pobweretsa yankho la sodium chloride.
Pamafunika kuwunika pafupipafupi mulingo wa potaziyamu m'madzi a m'magazi.
Kuchepa kwa neutropenia kumawonjezeka kwa odwala omwe ali ndi matenda ena, mwachitsanzo, osakwanira aimpso ntchito, matenda amitsempha.
Kutenga Noliprel ndi desensitizing mankhwala (tizilombo toyambitsa matenda) kumawonjezera chiopsezo cha anaphylactic.
Poyerekeza ndi maziko a opaleshoni yodziwika bwino, kuchepa kwakukulu kwa zovuta kumatha kuchitika ngati wodwala watenga mankhwalawo.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala sanatchulidwe. Izi ndichifukwa choti poyamwitsa, limodzi ndi mkaka wa amayi, ziwalo zomwe zimagwira ntchito zimalowa m'thupi la wakhanda. Kuphatikiza apo, panthawi yomwe ali ndi pakati, ndizotheka kuti mwana wosabadwayo apange ma pathologies.
Gwiritsani ntchito mu ukalamba
Njira yochotsa zigawo zogwira ntchito imachepetsedwa. Mlingo wowerengera ungafunikire.
Kukhazikitsidwa kwa ana a Noliprel 0.625
Sikugwiritsidwa ntchito osakwanitsa zaka 18.
The ntchito aimpso kuwonongeka
Potengera maziko akuwonongeka kwakukulu kwa chiwalo ichi, Noliprel sichomwe adalemba. Kuchepetsa mphamvu zaimpso si chifukwa chobwerera mankhwala. Poterepa, palibe chifukwa chokwaniritsanso mlingo.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Pofatsa pang'ono komanso moyenera zamankhwala, mankhwalawa angagwiritsidwe ntchito. Kuwerenga kuchuluka kwa mankhwalawa sikuchitika. Poyerekeza ndi maziko azovuta za ntchito ya chiwindi, mankhwalawa sagwiritsidwa ntchito.
Ndi mankhwala osokoneza bongo, zizindikiro za hypotension zimawonekera: kugona, chizungulire, etc.
Mankhwala ochulukirapo a Noliprel 0.625
Chizindikiro chachikulu ndicho hypotension. Poyerekeza ndi maziko a kuchepa kwakanthawi, zizindikiro zotsatirazi zimachitika: kupweteka, nseru, chizungulire, kugona, kusanza. Mwina kuphwanya kwa chikumbumtima, kusintha kwa zinthu za sodium ndi potaziyamu m'thupi: kuchepa, kuchuluka.
Kuti muchepetse mawonekedwe owonetsa, muyenera kutsuka m'mimba, chifukwa cha izi, mankhwala owonjezera amachotsedwa m'thupi. Komabe, izi zidzapereka zotsatira zofunikira pokhapokha ngati Noliprel adalandiridwa posachedwa. Kuphatikiza apo, sorbent imayikidwa, mankhwala othandizira amakonzedwa ndikulinga kuti abwezeretse mulingo wa electrolyte.
Kuchita ndi mankhwala ena
Ndi chisamaliro
Chisamaliro chofunikira chimafunikira mkhalidwe wamthupi pamene mukumwa Noliprel ndi zina zotero:
- Baclofen;
- NSAIDs;
- antidepressants ndi antipsychotic;
- GCS;
- mankhwala ena omwe machitidwe awo akufuna kutsitsa magazi;
- mankhwala a hypoglycemic;
- Allopurinol;
- zopatsa zina;
- Metformin;
- mchere wamchere;
- Cyclosporin;
- Zinthu zokhala ndi ayodini zomwe zimagwiritsidwa ntchito popanga maphunziro a Hardware pogwiritsa ntchito njira yosiyaniranayi.
Noliprel satengedwa nthawi yomweyo ndi zakumwa zokhala ndi zakumwa zoledzeretsa.
Kuphatikiza sikofunikira
Noliprel sagwiritsidwa ntchito nthawi imodzi ndi zokonzekera zomwe zimakhala ndi lithiamu. Osatipatsa mankhwala omwe amakulitsa kukula kwa arrhythmias, hypokalemia, mtima glycosides.
Kuyenderana ndi mowa
Noliprel satengedwa nthawi yomweyo ndi zakumwa zoledzeretsa, chifukwa mu vuto ili la hypotension limayamba, ndipo katundu pa chiwindi nawonso umakulanso.
Analogi
M'malo a Noliprel:
- Perindopril kuphatikiza indapamide;
- Noliprel A;
- Indapamide / Perindopril-Teva;
- Ko-perineva.
Kupita kwina mankhwala
Mankhwala omwe mumalandira.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Mtengo Noliprel 0.625
Mtengo wapakati ndi ma ruble 600-700.
Zosungidwa zamankhwala
Palibe malingaliro aliwonse osungira Noliprel. Komabe, mapiritsi amayenera kugwiritsidwa ntchito pakatha miyezi iwiri kuchokera pakukhulupirika kwa ma sachet.
Tsiku lotha ntchito
Mankhwala amasunga katundu kwa zaka zitatu.
Wopanga
Mtumiki, France.
Ndemanga pa Noliprel 0.625
Omvera zamtima
Zhikhareva O. A., Samara
Mankhwala ndi othandiza. Kuphatikiza apo, kusintha kwabwino kumaonekera mwa odwala poyambira matenda oopsa, komanso mwa mitundu ikuluikulu. Ndimaona ngati vuto ndikutenga nthawi yayitali, koma ngati pangafunike, mutha kukulitsa mlingo, koma ndizambiri.
Zafiraki V.K., Tula
Mankhwala amathandizanso kuti wodwalayo akhale ndi matenda oopsa, komanso amalepheretsa kukula kwa matenda a mtima. Mtengo ndi wapakati, phukusi limakhala ndi kuchuluka kwa mapiritsi ofanana ndi maphunziro a mwezi uliwonse, omwe ndi osavuta komanso amakupatsani ndalama.
Odwala
Veronica, wazaka 49, Penza
Ndidatenga Noliprel nthawi yayitali (pafupipafupi), chifukwa kupanikizika kwanga kumakhala kukwera, ndipo pamene zizindikiro zakufalikira, magazi anga akadali pamlingo wapamwamba kwambiri. Monga momwe ndimalandirira, ndidazindikira kuti kukhosomola kudawonekera motsutsana ndi kusapezeka kwa zizindikiro zina za chimfine. Pambuyo pa kufufuza, kunapezeka kuti umu ndi momwe mankhwalawo amagwirira ntchito, ndinayenera kusiya kumwa ndikupeza m'malo mwake.
Eugenia, wazaka 29, Vladimir
Noliprel adatengedwa ndi amayi. Adayesa mankhwala osiyanasiyana, koma nthawi zambiri pamakhala zovuta, makamaka zoyipa zakumbuyo. Mutatenga Noliprel, mkhalidwewo umakhala pang'onopang'ono, kupanikizika sikukula. Kuphatikiza apo, mankhwalawa samatsuka calcium, yofunikira pakukalamba.
