Gentadueto ndi amodzi mwa mankhwala omwe amagwiritsidwa ntchito pochiza matenda ashuga. Imakhala ndi hypoglycemic yosatha ndipo imakupatsani mwayi wokhala ndi shuga wokwanira kwa nthawi yayitali.
Dzinalo Losayenerana
INN: Linagliptin + Metformil
Gentadueto ndi amodzi mwa mankhwala omwe amagwiritsidwa ntchito pochiza matenda ashuga.
ATX
A10BD11
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka mu mawonekedwe a mapiritsi okhala ndi filimu. Chofunikira chachikulu: linagliptin 2.5 mg ndi metformin hydrochloride mu Mlingo wa 500, 850 kapena 1000 mg. Zowonjezera zimaperekedwa: arginine, wowuma chimanga, Copovidone, silicon dioxide, magnesium stearate. Utoto wamtunduwu umapangidwa ndi titaniyidi dioxide, utoto wachikasu ndi wofiira wachitsulo, propylene glycol, hypromellose, talc.
Mapiritsi a 2,5 + 500 mg: biconvex, chowulungika, yokutidwa ndi filimu ya mtundu wachikaso. Pa dzanja limodzi pali zolemba za wopanga, ndipo kumbali inayo pali mawu akuti "D2 / 500".
Mapiritsi a 2,5 + 850 mg ndi ofanana, mitundu yokhayo yovala filimuyo ndi kuwala lalanje, ndipo mapiritsi a 2,5 + 1000 mg ali ndi mtundu wa pinki.
Zotsatira za pharmacological
Linagliptin ndi choletsa wa enzyme DPP-4. Inactivates ma insretins ndi glucose wodalira insulinotropic polypeptide. Ma insretins amakhudzidwa ndikukhalabe ndi shuga. Gawo lolimbikira limamangirira ma enzyme ndikuwonjezera kuchuluka kwa ma insretins. Kutupa kwa inshuwaransi kumadalira glucagon kumachulukitsa, ndipo katulutsidwe wa glucagon kamachepa, kamene kamapangitsa kukula kwa shuga.
Metformin ndi biguanide. Ili ndi mphamvu yosasintha ya hypoglycemic. Magazi a m'magazi a plasma amachepetsa. Pankhaniyi, kupanga insulin sikulimbikitsidwa, chifukwa chake hypoglycemia imangokhala nthawi zina. Kuphatikiza shuga kwa chiwindi kumachepetsedwa chifukwa chopinga glycogeneis ndi gluconeogeneis. Chifukwa cha kuchuluka kwa insulini pazinthu zolandilira, kugwiritsa ntchito bwino shuga kwa maselo kumachitika.
Metformin imathandizira kapangidwe ka glycogen mkati mwa maselo.
Metformin imathandizira kapangidwe ka glycogen mkati mwa maselo. Imakhala ndi phindu pa metabolidi ya lipid. Amachepetsa kuchuluka kwa cholesterol ndi triglycerides m'magazi. Kugwiritsira ntchito kwa linagliptin limodzi ndi zotumphukira za sulfonylurea ndi metformin kumachepetsa HbA1c (ndi 0,62% poyerekeza ndi placebo; HbA1c yoyambayo inali 8.14%).
Pharmacokinetics
Zinthu zomwe zimagwira mwachangu zimatengedwa msanga m'mimba. Ziwalo zimagawidwa mosiyanasiyana. Bioavailability ndi kuthekera kumangiriza ku zomanga mapuloteni ndizochepa kwambiri. Kuchuluka kumachitika pambuyo pa impso kusefedwa makamaka kosasinthika.
Zizindikiro zogwiritsidwa ntchito
Zowonetsa mwachindunji pakugwiritsa ntchito mankhwalawa ndi:
- mankhwalawa amtundu wa shuga 2 odwala omwe ali ndi vuto losakwanira glycemic ndi mlingo waukulu wa metformin;
- kuphatikiza ndi mankhwala ena ndi insulin mwa akuluakulu omwe ali ndi matenda ashuga, ngati kugwiritsa ntchito metformin komanso mankhwalawa sikupereka chiwonetsero chokwanira cha glycemic;
- mankhwala a anthu omwe kale ankamwa metformin ndi linagliptin payokha.
Chizindikiro chodziwika bwino chogwiritsira ntchito mankhwalawa ndi chithandizo cha matenda amtundu wa 2 wa odwala omwe ali ndi vuto losakwanira glycemic ndi mlingo waukulu wa metformin.
Amagwiritsidwa ntchito ngati chowonjezera pakudya ndi masewera olimbitsa thupi kuti athandize kuwongolera glycemic mwa anthu omwe ali ndi mtundu wa 2 matenda.
Contraindication
Ndi zoletsedwa kugwiritsa ntchito mankhwalawa motere:
- mtundu 1 matenda a shuga;
- Hypersensitivity ku zigawo zikuluzikulu;
- matenda ashuga ketoacidosis;
- lactic acidosis;
- mkhalidwe wodwala matenda ashuga;
- kulephera kwambiri kwaimpso;
- matenda omwe amachititsa minofu hypoxia: kuwonongeka kwa minofu ya mtima, kuchepa kwa mpweya, kugunda kwamtima kwaposachedwa;
- kulephera kwa chiwindi;
- kuledzera.
Ndi chisamaliro
Kusamalidwa makamaka kuyenera kuthandizidwa ndi odwala omwe ali ndi zaka zopitilira 80.
Momwe mungatenge Gentadueto?
Mankhwalawa amapangidwira pakamwa. Kuti muchepetse kuwoneka ngati mavuto osafunikira, mapiritsi amalimbikitsidwa kuti amwe ndi zakudya.
Chithandizo cha matenda ashuga
Mlingo watsiku ndi tsiku ndi 2.5 mg + 500 mg, 2,5 mg + 850 mg kapena 2,5 mg + 1000 mg. Imwani mapiritsi kawiri tsiku lililonse. Mlingo amasankhidwa poganizira zovuta za matenda matenda ndi chiwopsezo cha zinthu yogwira thupi. Mlingo wambiri watsiku ndi tsiku sayenera kupitirira 5 mg + 2000 mg.
Zotsatira zoyipa Gentadueto
Nthawi zambiri, pogwiritsa ntchito metformin ndi linagliptin, kutsegula m'mimba kumachitika. Mukamamwa linagliptin ndi metformin osakanikirana ndi mankhwala a sulfonylurea, hypoglycemia imakonda kuchitika. Amakhalanso mutatenga linagliptin, metformin yokhala ndi insulini.
Zizindikiro zodziwika bwino za zovuta:
- nasopharyngitis;
- kutsokomola;
- kuchepa kwa chakudya;
- kutsegula m'mimba
- nseru
- zotupa pakhungu limodzi ndi kuyabwa;
- kuchuluka kwamasewera a lipase;
- hypoglycemia;
- kudzimbidwa
- chiwindi ntchito;
- lactic acidosis;
- kulakwira;
- kupweteka kwam'mimba.
Zokhudza mphamvu pakuwongolera njira
Zosakhudzidwa.
Malangizo apadera
Malinga ndi kafukufuku, ngati muphatikiza mankhwalawa ndi mankhwala a sulfonylurea, mphamvu ya hypoglycemic imachitika mofulumira kuposa zomwe zimachitika ndi placebo. Mankhwala palokha samayambitsa hypoglycemia. Ngati agwiritsidwa ntchito molakwika, lactic acidosis imatha kuchitika, yomwe imabweretsa chiwopsezo m'miyoyo ya anthu.
Mobwerezabwereza makonzedwe a metformin pakumwa zakumwa zoledzeretsa angayambitse kukulira kwa lactic acidosis, makamaka ndi njala, kuperewera kwa zakudya m'thupi, kapena kulephera kwa chiwindi.
Gwiritsani ntchito mu ukalamba
Mankhwalawa ndiolandiridwa kuti apereke kwa anthu azaka 65 zakubadwa. Koma nthawi yomweyo, muyenera kuyang'anira ntchito za impso, chifukwa paukalamba, zoopsa zomwe zimapangitsa kuti matenda a impso akhale okwanira, ndizomwe zimagwiritsidwa ntchito ngati metformin.
Kupatsa ana
Mankhwalawa sagwiritsidwa ntchito pochita ana.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Simungathe kumwa mapiritsi panthawi yachisangalalo. Kuti mupewe chiwopsezo cha kubisala kwa intrauterine, muyenera kusinthira ku insulin yokhazikika momwe mungathere.
Palibe kafukufuku wokwanira momwe mankhwala omwe amapangidwira amapitilira mkaka wa m'mawere, koma pamakhala chiwopsezo kwa akhanda. Chifukwa chake, kwazaka zamankhwala otere, ndi bwino kusiya kuyamwitsa.
The ntchito aimpso kuwonongeka
Ndi chilolezo chachikulu cha creatinine, mankhwalawa amatsutsana. Izi zimagwiranso ntchito pakulephera kwa impso mosalephera.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mukusowa kwambiri, mankhwalawa saloledwa, chifukwa mukamamwa mankhwalawo kuchokera ku hepatobiliary system, chiwindi cha hepatitis ndi chiwindi kukanika.
Gentadueto Overdose
Palibe deta pa bongo. M'mayesero azachipatala, mankhwala osokoneza bongo a linagliptin sanawonedwe. Ndi mtundu umodzi wa metformin, hypoglycemia sunawonedwe, koma panali milandu ya lactic acidosis. Lactic acidosis ndimalo ovuta omwe amafunikira kuchipatala. Metformin imathandizidwa ndi hemodialysis.
Kuchita ndi mankhwala ena
Mobwerezabwereza makonzedwe a mankhwalawo kapena magawo ake omwe amagwira ntchito mosiyana samasintha ma pharmacokinetics a mankhwalawa. Mutha kugwiritsa ntchito mankhwalawa molumikizana ndi Glibenclamide, Warfarin, Digoxin ndi mankhwala ena oletsa kubereka.
Kuphatikiza kophatikizidwa
Simungagwiritse ntchito mankhwalawa molumikizana ndi ritonavir, rifampicin ndi njira zakulera zamkamwa.
Simungagwiritse ntchito mankhwalawa molumikizana ndi ritonavir.
Osavomerezeka kuphatikiza
Sitikulimbikitsidwa kuphatikiza kutenga mapiritsi ndi thiazolidinediones ndi ena ochokera ku sulfonylurea, chifukwa amathandizira kuchepa kwambiri kwa glucose ndikuyambitsa glycemia.
Kuphatikiza komwe kumafunikira kusamala
Gwiritsani ntchito mankhwala a cationic yogwira, mwachitsanzo, cimetidine. Zikatero, ndikofunikira kuyang'anira ntchito ya aimpso tubular kayendedwe ndikuwunika kuchuluka kwa shuga m'magazi am'magazi.
Kuyenderana ndi mowa
Simungathe kuphatikiza kumwa mapiritsi ndi mowa, chifukwa achire zotsatira yafupika, ndipo zotsatira za mankhwalawa pamitsempha yamafuta ndi m'mimba zimachulukirachulukira.
Simungathe kuphatikiza kumwa mapiritsi ndi mowa, chifukwa achire zotsatira yafupika.
Analogi
Mankhwalawa ali ndi ma fanizo ambiri ofanana nawo mu chinthu chimodzi kapena zingapo zogwira ntchito:
- Avandamet;
- Amaryl;
- Douglimax;
- Velmetia;
- Janumet;
- Vokanamet;
- Galvusmet;
- Glibomet;
- Glybophor;
- Glucovans;
- Duotrol;
- Dianorm-M;
- Dibizid-M;
- Casano;
- Comboglize;
- Sinjardi;
- Tripride.
Kupita kwina mankhwala
Pamafunika mankhwala kuti mugule.
Kodi ndingagule popanda kulandira mankhwala?
Kupatula.
Mtengo wa Gentadueto
Zambiri zamtengo sizikupezeka, monga Tsopano mankhwalawo akumupatsanso ziphaso.
Zosungidwa zamankhwala
Ndikofunikira kuti mupeze malo owuma komanso amdima, pamtunda wopanda kutentha + 25 ° C.
Ndikofunikira kuti mupeze malo owuma komanso amdima, pamtunda wa kutentha kuposa + 25 ° C.
Tsiku lotha ntchito
Osapitilira zaka zitatu kuchokera tsiku lomwe limatulutsidwa pazomwe zidakhazikitsidwa koyambirira. Osagwiritsa ntchito nthawi imeneyi.
Wopanga
Kampani yopanga: Beringer Ingelheim Pharma GmbH & Co KG, Germany.
Ndemanga za Gentadueto
Irina, wazaka 37, Ivanovo
Mankhwala abwino omwe amathandiza kuti shuga azikhala bwino kwa maola 12. Ndizomvetsa chisoni kuti tsopano ndizosatheka kuchipeza m'mafakitore, ndikofunikira kusankha mankhwalawa pogwiritsa ntchito zomwezi.
Vladimir, wazaka 64, Murmansk
Ndidamwa mankhwalawa kwa zaka zingapo mpaka pomwe adagulitsa. Shuga anapitilirabe, palibe mavuto, anali osavuta kuyambitsa. Tsopano ndimayenera kuyang'ana choloweza.
Yaroslav, wazaka 57, Chelyabinsk
Ntchito mankhwalawa limodzi ndi insulin. Kutsegula m'mimba kunali kovuta. Ndinaisintha ndi mankhwala ena.
