Mildronate adapangira kuti athane ndi matenda a mtima komanso othandizira thupi pazinthu zovuta komanso zolimbitsa thupi kwambiri. Zomwe zimapangidwira ndi meldonium dihydrate - analogue yopanga ya gamma-butyrobetaine. Njira yotulutsira yomwe imagwiritsidwa ntchito pakamwa pakamwa ndi makapisozi apadera, ngakhale kuti mitundu yosapezeka ya kumasulidwa, monga mapiritsi ndi Mildronate 500, imakonda kutchulidwa pamaneti.
Mitundu yomwe ilipo ndi kapangidwe kake
Pa tsamba lovomerezeka la wopanga, mitundu yotsatirayi yamankhwala imalengezedwa:
- makapisozi okhala ndi 250 mg a meldonium;
- makapisozi okhala ndi 500 mg a meldonium;
- yankho lomwe lili ndi 500 mg ya meldonium mu 1 ampoule.
Mitundu yonseyi ya mankhwalawa imawonetsedwa m'mafakisi aku Russia ndipo imapezeka kuti mugule. Kupeza zogulitsa mankhwalawa mu mawonekedwe a madzi omwe ali ndi 5 ml ya 250 mg ya meldonium ndikosatheka, ngakhale kuli kambiri kukunena za mtunduwu wamasulidwe muzowunika.
Dzinalo Losayenerana
Meldonium
ATX
S01EV
Mildronate adapangira kuti athane ndi matenda a mtima komanso othandizira thupi.
Zotsatira za pharmacological
Gawo logwira ntchito la Mildronate, ndikamwetsa, limachepetsa njira zotsatirazi:
- ntchito ya gamma butyrobetaine hydroxy kinase;
- kupanga kwa carnitine;
- unyolo wautali transmembrane mafuta kusamutsa asidi;
- kuchuluka kwa cell cytoplasm wa adamulowetsa mitundu ya unoxidized mafuta zidulo.
Kuphatikiza pazomwe tafotokozazi, meldonium imatha:
- kukonza njira yoperekera minofu ndi mpweya;
- tsitsani glycolysis;
- zimakhudza kagayidwe ka minofu ya mtima ndi contractility;
- kusintha magazi kulowa mu ubongo;
- zimakhudza ziwiya za retina ndi fundus;
- khalani ndi chidwi pamphamvu yamanjenje.
Pharmacokinetics
The bioavailability wa mankhwalawa 80%. Amadziwika ndi kulowererapo mwachangu, zomwe zili mumapulasitiki ambiri zimafika ola limodzi pambuyo povomerezeka. Thupi lomwe limayang'anira kagayidwe kameneka ndi chiwindi. Zovunda zimachotsedwa impso. Hafu ya moyo imatsimikiziridwa ndi mlingo ndipo umasiyana mkati mwa maola 3-6.
Kodi Mildronate 500 ndi chiyani?
Zisonyezo zogwiritsa ntchito mankhwalawa ndi:
- Kuchepetsa magwiridwe;
- kuchuluka kwa thupi;
- kupsinjika ndi kusokonezeka kwa malingaliro;
- achire syndrome.
Mildronate akulimbikitsidwa kuti aphatikizidwe ndi zovuta kuchiza kwa matenda monga:
- matenda a mtima;
- kulephera kwa mtima;
- dishormonal mtima;
- ngozi ya cerebrovascular (aakulu ndi pachimake gawo).
Ntchito zamasewera
Mankhwalawa akuwonetsedwa kuti alipira zolimbitsa thupi zolimbitsa thupi, chifukwa amathandizira kubwezeretsa thupi, kuchepetsa zizindikiro za kuchuluka kwa thupi, komanso amatha kukhala ndi mphamvu yoteteza myocardium. Komabe, mu 2016, meldonium idaphatikizidwa mndandanda wazinthu zomwe zikuyenda, kotero sizivomerezedwa kuti zigwiritsidwe ntchito ndi akatswiri othamanga panthawi ya mpikisano.
Contraindication
Kukhazikitsidwa kwa Mildronate sikuloledwa pamaso pa zinthu izi:
- kukhudzidwa kwazomwe zimagwiritsidwa ntchito;
- zotupa za intracranial kapena zosokoneza mu venous outflow zomwe zimatsogolera kuwonjezeka kwa kuthamanga kwa intracranial;
- zaka zosakwana 18;
- mimba, yoyamwitsa.
Kuphatikiza apo, ndi kuphwanya komwe kumadziwika mu chiwindi kapena impso, mankhwalawa ayenera kuikidwa mosamala.
Momwe mungatenge Mildronate 500
Mlingo, wosakwatiwa komanso watsiku ndi tsiku, komanso nthawi yonse ya njira yochizira imatengera matendawa ndipo amatsimikiza ndi dokotala. Zomwe zimaperekedwa mu malangizo ogwiritsira ntchito ndialangizidwe mwachilengedwe ndipo muziwonjezera zotsatirazi:
- IHD komanso kulephera kwa mtima kosatha - kuyambira 0,5 mpaka 2 g / tsiku, mpaka masabata 6;
- dishormonal mtima - 0,5 g / tsiku kwa masiku 12;
- Zotsatira za stroko, kuperewera kwa magazi m'thupi - 0.5-1 g / tsiku, mpaka masabata 6, mankhwala a kapisozi amayamba pokhapokha jakisoni;
- ngozi ya matenda okomoka - 0.5 g / tsiku, mpaka masabata 6;
- utachepa magwiridwe, kuchuluka kutopa - 0,5 g 2 pa tsiku, mpaka masiku 14;
- achire matenda - 0,5 ga 4 pa tsiku, mpaka 10 masiku.
Sitikulimbikitsidwa kuti mutenge makapisozi pambuyo pa 17.00. Izi zimatha kudzetsa nkhawa kwambiri komanso kugona.
Njira yothetsera mulingo wofanana wa mankhwala omwe ali mu 1 ampoule angagwiritsidwe ntchito:
- intramuscular and intravenous jakisoni pakuchiza matenda a mtima ndi matenda a mtima m'mitsempha yomweyo monga makapisozi;
- kwa parabulbar makonzedwe a retinopathy kapena matenda a mtima wa 0,5 ml kwa masiku 10.
Musanadye kapena musanadye
Mildronate amamuledzera pamimba yopanda kanthu. Izi ndizofunikira popewa kuchepa kwa kukhudzika kwa zinthu zomwe zikugwira. Pankhani ya matenda am'mimba, kuti muchepetse katundu pazakudya zam'mimba, n`zotheka kumwa mankhwalawa theka la ola mutatha kudya.
Mankhwala makamaka amatengedwa pamimba yopanda kanthu.
Mlingo wa matenda ashuga
Kukhazikitsidwa kwa Mildronate mu matenda ashuga ndi chifukwa chakuwongolera kagayidwe. Pachifukwa ichi, mankhwalawa angagwiritsidwe ntchito kuchuluka kwa 500-1000 mg patsiku.
Zotsatira zoyipa za Mildronate 500
Mankhwala othandizira Mildonate amaloledwa mosavuta ndi thupi. Zotsatira zoyipa mukamazitenga ndizosowa. Malinga ndi zomwe wopanga adapanga, zinthu zotsatirazi zidadziwika:
- ziwengo zosiyanasiyana mawonekedwe;
- kupukusa m'mimba ndi mawonekedwe a dyspeptic;
- tachycardia;
- kusintha kwa kuthamanga kwa magazi;
- kukondwerera kwakukulu;
- kufooka
- kuchuluka kwa eosinophils m'magazi.
Malangizo apadera
Odwala omwe ali ndi vuto la chiwindi kapena impso samasonyezedwa kugwiritsa ntchito mankhwalawa kwa nthawi yayitali. Ngati pali zofunika kuti mugwiritse ntchito kwa mwezi wopitilira, muyenera kuwunika momwe wodwalayo alili.
Zotsatira zoyipa za kumwa mankhwala zitha kukhala zofooka.
Kupatsa ana
Chitetezo pakulembera makapisozi a Mildronate kwa ana 500 sichinatsimikizidwe, chifukwa chake, sichinapangidwe mpaka zaka 18.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Zotsatira za mwana wosabadwayo komanso momwe zimapangidwira kukonzanso kwa meldonium sizinaphunziridwe, chitetezo cha chiwonetsero chotere sichinatsimikizidwe, chifukwa chake mankhwalawa sanalembedwe kwa amayi apakati. Ngati ndi kotheka, chithandizo mukamadyetsa mwana panthawiyi chimasinthidwa kukhala zosakaniza za chakudya.
Kuyenderana ndi mowa
Mukamamwa Mildronate, simuyenera kumwa mowa. Ethanol imachepetsa mphamvu yake yothandizirana ndipo imathandizira kuti mawonekedwe asiyane ndi mthupi amuyambe.
Zokhudza mphamvu pakuwongolera njira
Kulandila kwa Mildronate sikupangitsa kuti masinthidwe osintha kayendetsedwe ka zinthu, sikubweretsa kugona ndipo sikubweretsa chidwi chokwanira.
Bongo
Mankhwala a Mildronate ali ndi poizoni wochepa kwambiri ndipo sipanakhalepo ndi vuto la kumwa mopitirira muyeso mukamamwa. Zikachitika, chithandizo chamankhwala chimalimbikitsidwa.
Mukamamwa Mildronate, simuyenera kumwa mowa.
Kuchita ndi mankhwala ena
Kukhazikitsidwa kuti Mildronate amathandizira kuchitapo kanthu:
- nitroglycerin;
- alpha adrenergic blockers;
- mtima glycosides;
- zotumphukira zotumphukira.
Mankhwala atha kuphatikizidwa momasuka ndi zinthu monga:
- okodzetsa;
- bronchodilators;
- anticoagulants;
- antiarrhythmic mankhwala;
- mankhwala a antianginal.
Osavomerezeka kuti azigwiritsidwa ntchito limodzi ndi mankhwala okhala ndi zakumwa zoledzeretsa.
Analogi
Mankhwala aliwonse omwe amakhala ndi meldonium azichita chimodzimodzi ndi Mildronate. Mwachitsanzo ndi mankhwala monga:
- Cardionate;
- Melfort;
- Medatern.
Cardionate ndi amodzi mwa fanizo la mankhwala.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Malinga ndi malangizo omwe ali m'malangizo, mankhwalawa ndi amodzi mwa mankhwala omwe mumalandira. Koma kuchita kumawonetsa kuti m'mafakitala ambiri, akakwaniritsidwa, safuna chitsimikizo kuti kugwiritsa ntchito mankhwalawa ndikulimbikitsidwa ndi adokotala.
Mtengo
500 mg makapisozi a Mildronate amagulitsidwa m'matumba 60. Mtengo wa paketi imodzi yogula pa intaneti ukuyambira pa ma ruble 545. Mtengo uwu ungasiyane kutengera dera la dzikolo, komanso mtengo wamankhwala.
Zosungidwa zamankhwala
Phukusi lomwe lili ndi makapisozi a mankhwalawa likuyenera kuti lisungidwe mumdima, kutentha mpaka 25 ° C. Kuthekera kwa kugwera m'manja mwa ana kuyenera kupatula.
Tsiku lotha ntchito
Zaka 4 kuyambira tsiku lopangidwa
Wopanga
JSC "Grindeks"
Ndemanga
Mildronate adziyambitsa ngati chida chothandiza komanso chotetezeka. Izi zikuwonetsedwa ndi kuwunika kwa madotolo ndi odwala onse. Mankhwalawa adapeza kutchuka kwambiri monga wothandizira pantchito yovuta komanso kupsinjika.
Omvera zamtima
Victor, wazaka 40, Kaluga: "Ndidziwa opaleshoni yamtima kwambiri, ndikupereka Mildronate mwachangu kwa odwala onse omwe amachitidwa opaleshoni yamtima, mankhwalawa amathandizira kuti matendawa azigwira bwino ntchito, amakhudza bwino matupi athu."
Chikondi, wazaka 58, Perm: "M'mayendedwe anga, ndimapereka mankhwala kwa a Mildronate. Ndikhulupirira kuti chinthuchi chitha kukulitsa kulolerana kochita masewera olimbitsa thupi ndikusintha moyo wa wodwalayo."
Odwala
Oleg, wazaka 35, Rostov-on-Don: "Adotolo adandiwuza kuti nditenge makapu amtundu wa Mildronate chifukwa chodandaula za kutopa. Patatha sabata limodzi ndidamva mphamvu zambiri."
Svetlana, wazaka 53, Salavat: "Ndamwa Mildronate nthawi yoyamba. Nditalandira chithandizo, ndimazindikira kusintha kosatha, kuwukira kwa angina kumayima kwa miyezi ingapo."
