Kuchita bwino kwa Tritace Plus kumadalira zotsatira za ramipril ndi hydrochlorothiazide. Zonsezi zimalepheretsa kusintha kwa angiotensin I kukhala mawonekedwe a angiotensin II, potero kukwaniritsa antihypertensive. Pankhaniyi, mankhwalawa samadziwika kawirikawiri mothandizidwa ndi monotherapy. Odwala amalandira othandizira ena monga gawo la zovuta zochizira matenda oopsa kuti akwaniritse kuthamanga kwa magazi.
Dzinalo Losayenerana
Hydrochlorothiazide + Ramipril.
ATX
C09BA05.
Kuchita bwino kwa Tritace Plus kumadalira zotsatira za ramipril ndi hydrochlorothiazide.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka piritsi. Piritsi limodzi la 1 limaphatikiza 2 yogwira mankhwala - ramipril ndi hydrochlorothiazide.
| Zogwira ntchito | Zotheka kuphatikiza, mg | |||
| Ramipril | 12,5 | 12,5 | 25 | 25 |
| Hydrochlorothiazide | 5 | 10 | 5 | 10 |
| Mapiritsi amtundu | pinki | lalanje | zoyera | pinki |
Kusintha magawo a pharmacokinetic, zosakaniza zina zimagwiritsidwa ntchito:
- sodium stearyl fumarate;
- iron oxide, yomwe imapatsa mapiritsiwo mtundu wa munthu kutengera kuchuluka kwa zigawo zikuluzikulu;
- gelatinized wowuma chimanga;
- ma cellcose a microcrystalline;
- hypromellose.
Mapiritsi a Oblong, okhala ndi mzere mbali zonse ziwiri.
Mankhwala nthawi zambiri samatchulidwa mu chipatala monga monotherapy.
Zotsatira za pharmacological
Tritace imaphatikizana ndi angiotensin potembenuza enzyme (ACE) inhibitor - ramipril, ndi thiazide diuretic hydrochlorothiazide. Kuphatikiza kwa zigawo zothandizira kumakhala ndi mphamvu ya antihypertensive. Blockbes ya ACE imalepheretsa kupangika kwa angiotensin II, komwe ndikofunikira kuti muchepetse minofu yosalala ya mtima endothelium.
Ramipril amaletsa kuchitika kwa vasoconstrictor zotsatira ndikuletsa kupasuka kwa bradykinin, chinthu chakukulitsa kwachilengedwe kwamitsempha yamagazi. Hydrochlorothiazide imakulitsa vasodilation, chifukwa chomwe zombo zimakulira zambiri. Ndikofunikira kuti magazi azikhala mozungulira pofuna kupewa kukula kwa bradycardia ndi ochepa hypotension.
Kwambiri achire zotsatira anati 3-6 maola pambuyo ntchito ndipo amalimbikira kwa tsiku limodzi. The diuretic zotsatira za thiazide okodzetsa amakhala kwa maola 6-12.
Pharmacokinetics
Ramipril ndi hydrochlorothiazide amatengeka mwachangu mu projimalum ya jejunum, pomwe amayamba kuyendetsa bwino. The bioavailability wa hydrochlorothiazide ndi 70%. M'magazi, mankhwala onse omwe amaphatikizidwa amafika pazowonjezera zambiri mkati mwa maola 2-4. Ramipril ali ndi digirii yambiri yomanga mapuloteni a plasma - 73%, pomwe 40% yokha ya hydrochlorothiazide amapanga zovuta ndi albumin.
Hafu ya moyo wa zonse ziwirizi imafika maola 5-6. Ramipril ndi 60% kuchotsedwa mu mkodzo ndi mkodzo. Hydrochlorothiazide imachoka m'thupi momwe idalili 95% kudzera mu impso mkati mwa maola 24.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amafunikira kuti muchepetse kuthamanga kwa magazi.
Mankhwala amafunikira kuti muchepetse kuthamanga kwa magazi.
Contraindication
Mankhwala omwe amaphatikizidwa ndi anthu omwe ali ndi:
- Hypersensitivity kwa hydrochlorothiazide, ramipril ndi zina mwa zinthu za Tritace;
- tsogolo la chitukuko cha Quincke edema;
- kukanika kwa aimpso;
- kusintha kwa ma electrolyte a plasma: potaziyamu, magnesium, calcium;
- matenda oopsa a chiwindi;
- kwambiri ochepa hypotension.
Ndi chisamaliro
M'pofunika kuwongolera thanzi lanu lonse munthawi yamankhwala omwe mumapezeka ndi zotsatirazi:
- kulephera kwamtima kwambiri;
- kusokonezeka kwa michere yamanzere, yodziwika ndi kusintha kwa hypertrophic;
- stenosis of the main, ubongo ziwiya, mitima kapena aimpso;
- chisokonezo cha madzi-electrolyte metabolism;
- ndi creatinine chilolezo cha 30-60 ml / min;
- kukonzanso nthawi pambuyo kumuika impso;
- matenda a chiwindi
- kuwonongeka kwa minofu yolumikizana - scleroderma, lupus erythematosus;
- kuponderezana kwa kufalikira kwamatumbo.
Odwala omwe adatenga diuretics ayenera kuyang'anira mkhalidwe wamadzi amchere.
Momwe mungatenge Tritace Plus
Mankhwalawa sanatchulidwe ngati mankhwala oyamba a antihypertensive. Mapiritsiwo adapangira pakamwa. Kumwa mankhwala m'mawa ndikofunikira. Mlingowo umatsimikiziridwa ndi katswiri wa zamankhwala malinga ndi momwe magazi akuwonekera (BP) komanso kuopsa kwa matenda oopsa.
Mlingo wokhazikika kumayambiriro kwa mankhwala othandizira ndi 2,5 mg wa ramipril osakanikirana ndi 12.5 mg wa hydrochlorothiazide. Ndi kulolerana kwabwino, kuti muwonjezere zotsatira za hypotensive, mlingo ungathe kuwonjezeka pambuyo pa masabata awiri.
Ndi matenda ashuga
Mankhwala angayambitse hypoglycemia pogwiritsa ntchito mankhwala a hypoglycemic kapena insulin, motero, munthawi ya mankhwalawa ndimankhwala othandizira kuti muchepetse mankhwala. Odwala omwe ali ndi matenda ashuga ayenera kuyang'anitsitsa kuchuluka kwa shuga m'magazi awo.
Zotsatira zoyipa za Tritace Plus
Nthawi zambiri, kusapeza kwa Tritace kolakwika kumabweretsa kutopa kwakukuru ndi kutentha thupi.
Matumbo
Matumbo am'mimba amadziwika chifukwa cha kutukusira kwa mucous nembanemba, maonekedwe a gingivitis, kusanza kwa Refresh, komanso kudzimbidwa. Mwina chitukuko cha gastritis, kusapeza bwino pamimba.
Ndi matenda am'mimba, gastritis imatha kukhala ngati mavuto.
Hematopoietic ziwalo
Ndi kuchepa kwa mafuta a m'matumbo a hematopoiesis, kuchuluka kwa ma cell am'magazi kumatsika.
Pakati mantha dongosolo
Ndi kuchepa kwa chiwongolero cham'maganizo, wodwalayo amakhala ndi nkhawa, nkhawa, komanso amakhala ndi tulo. Potengera maziko a kukhumudwa kwa dongosolo lamanjenje, pamakhala kutayika kokhazikika m'malo, mutu, malingaliro oyaka, kutayika kapena kukoma kwakukwiya.
Kuchokera kwamikodzo
Mwina kuwonjezeka kwa mkodzo wotulutsidwa ndikukula kwa vuto la impso.
Kuchokera ku kupuma
Nthawi zambiri, chifukwa cha kuchuluka kwa bradykinin, kutsokomola kumatha kukhazikika, mwa odwala ena - kufinya kwammphuno ndi kutupa kwa zolakwazo.
Pa khungu
Pali chiopsezo chotenga angioedema, chomwe chingapangitse kuti asphyxia nthawi zina. Zizindikiro zokhala ngati Psoriasis, thukuta lomwe limachulukirachulukira, zotupa, kuyabwa ndi erythema yamaumboni osiyanasiyana ndizotheka.
Chifukwa chotenga mankhwalawa, erythema yamitundu yosiyanasiyana imatha kuyamba.
Kuchokera ku genitourinary system
Mwa amuna, kuchepa kwa mapangidwe ake ndi kuchuluka kwa zofunikira za mabere am'mimba ndizotheka.
Kuchokera pamtima
Mwina kutsika lakuthwa kwa kuthamanga kwa magazi, thrombosis chifukwa cha kuchepa kwa madzi m'thupi, stenosis yamitsempha yayikulu, kuletsa magazi, kutupa kwa khoma la mtima komanso a raynaud's syndrome.
Dongosolo la Endocrine
Ndizotheka kuonjezera kupanga ma antidiuretic mahomoni.
Pa mbali ya chiwindi ndi biliary thirakiti
Mwapadera, chiwopsezo cha cytolytic cha chiwindi chimayamba ndi zotsatira zakupha. Pali kuwonjezeka kwa mulingo wa bilirubin m'mwazi ndi kupezeka kwa cholecystitis yowerengeka.
Matupi omaliza
Zovuta zamatsenga zimadziwika ndi maonekedwe a khungu.
Zovuta zamatsenga zimadziwika ndi maonekedwe a khungu.
Kuchokera musculoskeletal system ndi minofu yolumikizana
Munthu amatha kumva kupweteka komanso kufooka minofu.
Kuchokera kumbali ya kagayidwe
Mwapadera, pali kuchepa kwa kulekerera kwa minofu kwa glucose, chifukwa chomwe shuga m'magazi amakwera. Posemphana ndi kagayidwe kake ka zinthu zambiri, zomwe mumapanga mu urea zomwe zimagwera m'magazi zimachulukana, gout imachulukitsa ndipo matenda a anorexia amakula. Nthawi zina, hypokalemia ndi metabolic acidosis amakula.
Kuchokera ku chitetezo chamthupi
Mwina chitukuko cha anaphylactic zimachitika chifukwa cha kuwonjezeka kwa titer ya antinuclear antibodies. Kulandila Tritace kumatha kupweteka kwa nkhope ya angioedema, matumbo ang'ono, miyendo ndi lilime.
Zokhudza mphamvu pakuwongolera njira
Chifukwa cha kuchepa kwa kuthupi kowoneka ndi kuwonongeka kwa chikumbumtima, wodwalayo ayenera kusamala poyendetsa zida zovuta kapena magalimoto omwe amafunikira kuthamanga kwa ma psychomotor komanso kuwonjezereka.
Chifukwa cha kuchepa kwa kuthupi kowoneka ndi kuwonongeka kwa chikumbumtima, wodwala ayenera kusamala poyendetsa zida zovuta kapena magalimoto.
Malangizo apadera
Pamaso pokonzekera kuchitidwa opaleshoni, ndikofunikira kuchenjeza opaleshoni yochita opaleshoni ndi mankhwala oletsa kupweteka omwe ali pantchito yokhudzana ndi mankhwalawa ndi ACE zoletsa. Izi ndizofunikira kuti muchepetse kugwa kwa magazi pakuchita opareshoni.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Chifukwa cha zotheka za teratogenic ndi fetotoxic, mankhwalawa saikidwa kwa amayi apakati. Pali chiopsezo cha kubisala kwa intrauterine mu fetus.
Pa mankhwala, muyenera kusiya kuyamwitsa.
Kukhazikitsa Tritace Plus kwa ana
Chifukwa cha kusowa kwa chidziwitso cha Tritace pathupi la munthu panthawi yopitilira, mankhwalawa amadziwikiridwa kwa ana osakwana zaka 18.
Gwiritsani ntchito mu ukalamba
Akuluakulu safunika kusintha njira yochizira.
Akuluakulu safunika kusintha njira yochizira.
The ntchito aimpso kuwonongeka
Odwala omwe ali ndi matenda ofiira a impso ochepetsetsa ayenera kuwonetsetsa ntchito za ziwalo zamankhwala pakumwa.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwala amaletsedwa kugwiritsidwa ntchito ndi anthu omwe ali ndi vuto la chiwindi.
Mankhwala opitilira muyeso a Tritace Plus
Chithunzi chachipatala cha bongo wambiri chimadziwonetsa povutitsidwa ndi wogwiritsa ntchito hypotensive ndipo amadziwika ndi mawonekedwe otsatirawa:
- polyuria, amene odwala chosaopsa Prostatic adenoma kapena mkodzo mkodzo kutuluka amakwiya kukula kwa kusakhazikika kwamikodzo ndi kuyamwa kwa chikhodzodzo;
- bradycardia, arrhythmia;
- zotumphukira vasodilation;
- kuphwanya kagayidwe ka madzi;
- chisokonezo ndi kutayika kwa chikumbumtima ndi chitukuko chakumaso;
- minofu kukokana;
- matumbo kusalala minofu kukanika.
Ngati mphindi zosakwana 30-90 zadutsa piritsi litatengedwa, ndikofunikira kuti wolakwiridwayo ayambe kusanza ndikutsuka m'mimba. Pambuyo pa njirayi, wodwala ayenera kutenga adsorbent kuti achepetse kuyamwa kwa zinthu zomwe zimagwira. Ndi bradycardia yayikulu, ndikofunikira kuyambitsa intravenly 1-2 mg wa adrenaline kapena kukhazikitsa pacemaker kwakanthawi. Pankhani ya bongo wambiri, ndikofunikira kuwongolera kuchuluka kwa seramu creatinine komanso kuthamanga kwa magazi panthawi ya chithandizo.
Ndi mankhwala osokoneza bongo ambiri, minyewa yam'mimba imatha kuwoneka.
Kuchita ndi mankhwala ena
Ndi munthawi yomweyo ya Tritace ndi thiazides, kuchuluka kwa mafuta m'thupi seramu akhoza kuchuluka.
Kuphatikiza kophatikizidwa
Kusagwirizana kwa mankhwala kumawonedwa limodzi ndi kugwiritsidwa ntchito kwa aliskiren ndi angiotensin II receptor antagonists. Potsirizira pake, makonzedwe amakhudzana ndi odwala omwe ali ndi matenda ashuga polyneuropathy. Aliskiren sinafotokozeredwe kuti azikhala wochepa kwambiri komanso wolephera.
Osavomerezeka kuphatikiza
Wophatikiza antihypertgency wophatikiza ndi mapiritsi ogona, mchere wa lithiamu, tacrolimus wokhala ndi sulfamethoxazole sayenera kutumikiridwa.
Kuphatikiza komwe kumafunikira kusamala
Ndikofunika kuyang'ananso chitetezo pamanthawi yomweyo:
- ma tridclic antidepressants;
- mankhwala ena a antihypertensive;
- barbituric acid zotumphukira;
- ndalama zothandizira opaleshoni;
- sodium mankhwala enaake;
- mankhwala okodzetsa;
- vasopressor sympathomimetics;
- allopurinol, immunomodulatory agents, glucocorticosteroids, cytostatics;
- estramustine, heparin, vildagliptin;
- wothandizira wa hypoglycemic.
Munthawi ya mankhwalawa, mankhwala okonza a ethanol ndi zinthu za mowa sayenera kugwiritsidwa ntchito.
Ndikofunikira kusiya kumwa Mowa.
Kuyenderana ndi mowa
Munthawi ya mankhwalawa, mankhwala okonza a ethanol ndi zinthu za mowa sayenera kugwiritsidwa ntchito. Mukatenga Tritace yokhala ndi ethanol palimodzi, pamakhala chiwopsezo cha kugwa.
Analogi
Kusintha kwa mankhwala ena a antihypertgency kumachitika moyang'aniridwa ndi dokotala, yemwe angakupatseni imodzi mwazomwezi mankhwala ngati chithandizo chamankhwala:
- Hartil-D;
- Amprilan NL;
- Amprilan ND;
- Wazolong H;
- Ramazid H.
Ma Analogs amapezeka mosavuta pamitundu yamtengo - 210-358 rubles.
Kupita kwina mankhwala
Kugulitsidwa pazamankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala angayambitse hypotension ya orthostatic ngati itagwiritsidwa ntchito molakwika. Poteteza odwala ku malo ogulitsa mankhwala, mankhwala amatha kugula kokha ndi mankhwala.
Mtengo pa Tritac Plus
Mtengo wapakati wa mapiritsi a 5 mg ndi ma ruble 954-1212, ndi mlingo wa 10 mg - 1537 rubles.
Zosungidwa zamankhwala
Mapiritsi amaloledwa kuti asungidwe kutentha kwa + 8 ... + 30 ° C m'malo osiyanitsidwa ndi dzuwa.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Sanofi Aventis, Italy.
Ndemanga za Tritac Plus
Ndemanga zabwino za mankhwalawa zimawonetsa kuti mankhwalawa adzipanga okha pamsika wamankhwala.
Madokotala
Svetlana Gorbacheva, katswiri wamtima, Ryazan
Ndiwothandizira wothandizira wa hydrochlorothiazide. Mankhwala amathandizira antihypertensive kwenikweni. Ndimapereka mankhwala kwa odwala anga omwe ali ndi ochepa ochepa kwa tsiku limodzi patsiku. Kutalika kwa mankhwalawa ndi kwa wodwala aliyense. Palibe mavuto omwe adawonedwa. Anthu omwe ali ndi vuto la impso samaloledwa kumwa mankhwalawa.
Odwala
Alexey Lebedev, wazaka 30, Yaroslavl
Mayiyo anayamba kuwonetsa matenda oopsa ndi zaka. Chifukwa cha kuthamanga kwa magazi, mankhwala a antihypertensive amayenera kumwa tsiku lililonse. M'masiku angapo apitawa, Tritace wakhala thandizo lalitali. Mapiritsiwo amateteza magazi kuundana ndipo samayambitsa mavuto. Pogwiritsa ntchito nthawi yayitali, muyenera kupuma kapena kuwonjezera kuchuluka kwake, chifukwa thupi limasiya kuzindikira mphamvu ya mapiritsi. Chobwereza chokha ndicho kukoma kowawa.
Elena Shashkina, wazaka 42, Vladivostok
Tritace adamuthamangitsira mayi ake pambuyo poti adwala chifukwa cha kuthamanga kwa magazi. Mankhwalawa adathandizira - amayi akumva bwino, kusinthasintha kwamphamvu kwamphamvu kwasiya. Amayi amatenga pamlingo wochepera kuti mankhwalawa amatha nthawi yayitali. Malinga ndi malingaliro a adotolo, atatha mwezi wovomerezeka pafupipafupi, amasiya kugwiritsa ntchito milungu iwiri. Izi ndizofunikira kuti pasakhale zovuta komanso zovuta.
