Kuti achulukitse kuchuluka kwa shuga m'magazi, mumagwiritsidwa ntchito mankhwala osiyanasiyana, kuphatikizapo Merifatin. Mankhwala a Hypoglycemic ali ndi contraindication ndi zotsatira zoyipa, kotero musanayambe chithandizo, muyenera kukaonana ndi katswiri ndikuphunzira malangizowo.
Dzinalo Losayenerana
Metformin.
Kuti achulukitse kuchuluka kwa shuga m'magazi, mumagwiritsidwa ntchito mankhwala osiyanasiyana, kuphatikizapo Merifatin.
ATX
A10BA02.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka mu mawonekedwe a mapiritsi a 500 mg, 850 mg ndi filimu ya 1000 mg. Amayikidwa mu zidutswa 10. mu chithuza. Mtolo wa makatoni ukhoza kukhala ndi matuza 1, 2, 3, 4, 5, 6, 8, 9 kapena 10. Mapiritsi amatha kuikidwa mumtsuko wa polymer wa ma 15 ma PC, ma 30 ma PC., Ma 60 ma PC. 100 ma PC. kapena ma PC 120. Chosakaniza chophatikizacho ndi metformin hydrochloride. Zothandiza monga povidone, hypromellose ndi sodium stearyl fumarate. Kanema wamadzi wosungunuka wamadzi amakhala ndi polyethylene glycol, titanium dioxide, hypromellose ndi polysorbate 80.
Zotsatira za pharmacological
Mankhwalawa ndi mankhwala amkamwa a hypoglycemic okhudzana ndi biguanides. Chosakaniza chophatikizika chimathandizira kuponderezera gluconeogenesis, mapangidwe a mafuta achilengedwe omasuka ndi oxidation wamafuta. Chifukwa cha makonzedwe a mankhwalawa, zotumphukira zake zimakhudzidwa kwambiri ndi insulini ndikugwiritsanso ntchito kwa glucose m'maselo. Kuchuluka kwa insulini m'magazi sikusintha, koma kuchuluka kwa insulin ndi insulin yaulere kumachepera ndipo chiwopsezo cha insulin ndi proinsulin chikuwonjezeka.
Mukadziwika ndi glycogen synthetase, metformin imasintha kapangidwe ka glycogen. Kuchita kwake ndikufuna kuwonjezera kuthekera kwamayendedwe amitundu yonse yamtundu wama glucose omwe amayenda ndi nembanemba. Katunduyu amachepetsa kuyamwa kwa glucose m'matumbo am'mimba, amachepetsa kuchuluka kwa LDL, triglycerides ndi VLDL, komanso kumatha kusintha kwa magazi a fibrinolytic, kutsekereza minofu ya plasminogen activator inhibitor. Panthawi ya chithandizo cha metformine, kulemera kwa wodwalayo kumakhazikika kapena pang'onopang'ono kumacheperachepera pakakhala kunenepa kwambiri.
Ndi kugwiritsa ntchito nthawi yomweyo chakudya, kuyamwa kwa mankhwalawo kumacheperachepera.
Pharmacokinetics
Mutatha kumwa piritsi, kuyamwa kwake pang'onopang'ono komanso kosakwanira m'mimba kumachitika. Kuchuluka kwazinthu zambiri m'madzi a m'magazi kumachitika pambuyo pa maola 2,5. Ndi kugwiritsa ntchito nthawi yomweyo chakudya, kuyamwa kwa mankhwalawo kumacheperachepera. Chidacho chopanga chimalowa m'matumbo onse a thupi la munthu, popanda kumanga mapuloteni a plasma.
Amadziunjikira impso, chiwindi ndi mavu gasi. Kutha kwa theka-moyo wa metformin kudzatenga 2 mpaka 6 maola. Mankhwalawa amamuchotsa mkodzo m'njira zosasinthika. Kuchulukitsa kwa gawo lothandizika kumatha kuchitika ndi zovuta ndi impso.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amaperekedwa kwa odwala omwe ali ndi matenda a shuga 2, makamaka onenepa kwambiri, pomwe zakudya ndi zolimbitsa thupi sizinathandize. Zochizira odwala akulu, zitha kugwiritsidwa ntchito ngati monotherapy kapena kuphatikiza ndi insulin kapena othandizira ena a hypoglycemic.
Kwa ana atatha zaka 10, mankhwalawa amatha kugwiritsidwa ntchito pawokha kapena kuphatikiza ndi insulin. Kuphatikiza apo, mapiritsi amagwiritsidwa ntchito popewa matenda pamaso pa matenda am'mbuyomu komanso matenda ena omwe ali pachiwopsezo cha kukula kwa matenda amtundu wa 2, pomwe kuwongolera kwamphamvu kwa glucose sikungatheke ndi kusintha kwa moyo.
Mankhwalawa amaperekedwa kwa odwala omwe ali ndi matenda a shuga 2, makamaka onenepa kwambiri, pomwe zakudya ndi zolimbitsa thupi sizinathandize.
Contraindication
M'pofunika kukana chithandizo chamankhwala ngati:
- Hypersensitivity zigawo zikuluzikulu;
- matenda ashuga ketoacidosis;
- matenda a shuga kapena chikomokere;
- kulephera kwa impso kapena chiwindi;
- kusowa kwamadzi;
- matenda opatsirana opatsirana;
- matenda mu pachimake kapena matenda mawonekedwe, kumabweretsa minofu hypoxia.
Ndi chisamaliro
Amatenga mankhwalawa mosamala kwambiri pakuchita opaleshoni yayikulu ndikuvulaza ngati pakufunika kutenga insulin, pakati, uchidakwa wambiri kapena poyizoni waukali, kutsatira zakudya zochepa zama calorie, lactic acidosis, komanso ngati isanachitike kapena itatha kuunika kwa radioisotope kapena x-ray, panthawi yomwe wothandizira wokhala ndi ayodini amaperekedwa. .
Pa nthawi yoyembekezera, Merifatin iyenera kumwedwa mosamala kwambiri.
Momwe mungatenge Merifatin?
Chochita chake chimapangidwira kuti azigwiritsa ntchito pakamwa. Mlingo woyambirira panthawi ya monotherapy mwa odwala akuluakulu ndi 500 mg katatu patsiku. Mlingo umatha kusinthidwa kukhala 850 mg 1-2 pa tsiku. Ngati pali chosowa, ndiye kuti muyezo wa mankhwalawo umakulitsidwa mpaka 3000 mg kwa masiku 7.
Ana opitirira zaka 10 amaloledwa kutenga 500 mg kapena 850 mg kamodzi patsiku kapena 500 mg kawiri pa tsiku. Mlingo utha kuwonjezeredwa mu sabata mpaka 2 g patsiku la 2-3. Pambuyo masiku 14, adokotala amasintha kuchuluka kwa mankhwalawa, poganizira kuchuluka kwa shuga.
Akaphatikizidwa ndi insulin, mlingo wa Merifatin ndi 500-850 mg katatu patsiku.
Ndi matenda ashuga
Pamaso pa matenda a shuga, metformin imatengedwa molingana ndi chiwembu chomwe dokotala amapanga, poganizira zomwe wodwalayo ali ndi zotsatira zake zoyesedwa kwathunthu.
Zotsatira zoyipa za Merifatin
Nthawi zina, kusachita bwino kumaonekera. Kukhazikika kwa mapiritsi munthawi ya zovuta kumayimitsidwa ndipo adokotala amayendera.
Matumbo
Kuchokera pagawo logaya chakudya, kusanza, kusanza, kutsegula m'mimba, kupweteka kwam'mimba komanso kusowa kwa chakudya kumawonedwa. Zizindikiro zosasangalatsa zimachitika koyamba pa chithandizo ndikupita mtsogolo. Kuti musayanjane nawo, ndikofunikira kuti muyambe ndi kuchuluka kochepa ndikuwonjezera pang'onopang'ono.
Hematopoietic ziwalo
Nthawi zina, pali kuphwanya mayamwidwe a vitamini B12.
Kuchokera kumbali ya kagayidwe
Nthawi zina mankhwala amayambitsa kukula kwa lactic acidosis.
Matupi omaliza
Thupi lawo siligwirizana limapezeka mu kuyabwa, zotupa ndi erythema.
Zokhudza mphamvu pakuwongolera njira
Ndi monotherapy, mankhwalawa samakhudza kasamalidwe ka mayendedwe ndi kuperekedwa kwa zinthu zomwe zimafunikira kuti anthu azikhala ndi chidwi komanso azigwire mwachangu ma psychomotor. Ngakhale izi, wodwala ayenera kudziwa zizindikiro za hypoglycemia ndipo ayenera kusamala.
Malangizo apadera
Pa chithandizo, ndikofunikira kuwunika kuchuluka kwa shuga m'magazi.
Pa chithandizo, ndikofunikira kuwunika kuchuluka kwa shuga m'magazi.
Gwiritsani ntchito mu ukalamba
Odwala atatha zaka 60, pali chiopsezo cha kupangika kwa lactic acidosis, choncho mankhwalawa sayenera kumwa mu gulu la odwala.
Kupatsa ana
Mankhwalawa sanatchulidwe kwa ana osakwana zaka 10.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Sitikulimbikitsidwa kumwa mapiritsi mukanyamula mwana ndikuyamwitsa, popeza chinthu chogwira chimalowa mu placenta ndikuyamwa mkaka wa m'mawere. Mankhwalawa amatha kuthandizidwa ngati phindu la mankhwalawa limaposa zoopsa zomwe zimabweretsa mwa mwana.
The ntchito aimpso kuwonongeka
Ndi koletsedwa kugwiritsa ntchito mankhwalawa ngati mukulakwitsa thupi.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Amakanizidwa kuti achite mankhwalawa ndi Merifatin chifukwa cha vuto la chiwindi.
Amakanizidwa kuti achite mankhwalawa ndi Merifatin chifukwa cha vuto la chiwindi.
Mankhwala osokoneza bongo a Merifatin
Ngati mumagwiritsa ntchito mankhwalawa kuchuluka kwa mankhwala, mankhwala osokoneza bongo amatha kuchitika, akuwonetseredwa ngati lactic acidosis. Amasiya kumwa mankhwalawo ndipo amafunsira katswiri yemwe akuwapatsa mankhwala a matenda a hemodialysis.
Kuchita ndi mankhwala ena
Sizoletsedwa kuphatikiza metformin ndi mankhwala okhala ndi ayodini omwe amakhala ndi radiopaque. Mosamala, akutenga Merifatin ndi Danazole, Chlorpromazine, glucocorticosteroids, diuretics, jekeseni wa beta2-adrenergic agonists ndi othandizira antihypertensive, kupatula ngati zoletsa za agiotensin kutembenuza enzyme.
Kuwonjezeka kwa ndende ya metformin m'magazi kumawonedwa panthawi yolumikizana ndi mankhwala a cationic, omwe amiloride. Kuchulukitsidwa kwa metformin kumachitika pakaphatikizidwa ndi nifedipine. Kulera kwa mahomoni kumachepetsa mphamvu ya hypoglycemic ya mankhwala.
Kuyenderana ndi mowa
Mankhwala, amaletsedwa kumwa zakumwa zoledzeretsa ndi zinthu zomwe zimakhala ndi ethanol, chifukwa cha chiwopsezo chachikulu cha lactic acidosis.
Analogi
Ngati ndi kotheka gwiritsani ntchito mankhwalawa:
- Bagomet;
- Glycon;
- Glucophage;
- Langerine;
- Siafor;
- Fomu.
Katswiri amasankha analogue, poganizira kuopsa kwa matendawa.
Kupita kwina mankhwala
Kuti mugule mankhwala kuchipatala, mufunika kupatsidwa mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala sangathe kugulidwa popanda mankhwala kuchokera kwa dokotala.
Mtengo wa Merifatin
Mtengo wa mankhwalawa umatengera ndondomeko yamitengo yamapiritsi ndi ma 169 rubles.
Zosungidwa zamankhwala
Phukusi lokhala ndi mapiritsi limayikidwa m'malo amdima, owuma komanso osafikira ana omwe ali ndi kutentha kosaposa + 25 ° C.
Tsiku lotha ntchito
Mankhwalawa amasunga katundu wake kwa zaka zitatu kuyambira tsiku lomwe adapanga, malinga ndi malamulo osungira. Tsiku lotha litatha, mankhwalawo amatayidwa.
Wopanga
Pharmasintez-Tyumen LLC akuchita nawo ntchito yopanga mankhwala ku Russia.
Pa mankhwala, amaletsedwa kumwa mowa.
Ndemanga za Merifatin
Konstantin, wazaka 31, Irkutsk: "Ndimagwiritsa ntchito mankhwalawa nthawi zonse. Panalibe zotsatirapo zake. Mtengo wama suti. Ndikupangira."
Lilia, wazaka 43, ku Moscow: "M'masiku oyamba a chithandizo cha Merifatin, nseru ndi chizungulire zinachitika. Ndinapita kwa dotolo. Anasintha mlingo. Amva bwino."
