Momwe mungagwiritsire ntchito mankhwala Biosulin P?

Biosulin P ndi glycemic wothandizira potengera zochita za insulin ya anthu. Zotsirizirazi zimapangidwa chifukwa cha ukadaulo wamtundu wa majini. Chifukwa cha kapangidwe kofanana ndi maholide achilengedwe a kapamba, Biosulin ikhoza kugwiritsidwa ntchito pa mtundu 1 ndi matenda ashuga 2. Gawo lothandizirali silidutsa placenta, chifukwa chake, mankhwalawa amaloledwa kuyendetsedwa pa nthawi yapakati.

Dzinalo Losayenerana

Insulin yamunthu Mu Latin - insulin munthu.

Biosulin P ndi glycemic wothandizira potengera zochita za insulin ya anthu.

ATX

A10AB01.

Kutulutsa mafomu ndi kapangidwe kake

Yankho la jakisoni limaperekedwa ngati madzi osapaka utoto. Monga pawiri yogwira, 1 ml ya kuyimitsidwa imakhala ndi 100 IU ya insulin yaumunthu. Kusintha pH yamadzi ndikuwonjezera bioavailability, chophatikiza chophatikizidwa chimaphatikizidwa ndi izi:

• metacresol;
• madzi osalala;
• 10% caustic koloko yankho;
• yankho la hydrochloric acid 10% ya ndende.

Biosulin imapezeka m'mabotolo agalasi kapena makatoni okhala ndi 3 ml, omwe amapangidwa kuti agwiritsidwe ntchito ndi cholembera cha cholembera cha Biomatic cholembera. Bolodi yokhala ndi makatoni okhala ndi zotengera 5 mumalongedzero azinthu.

Zotsatira za pharmacological

Insulin imatsata kapangidwe ka timadzi ta pancreatic ya munthu kudzera pakubwezeretsanso kwa DNA. Mphamvu ya hypoglycemic imachitika chifukwa chomanga chinthu chogwira ntchito mpaka zolowa kunja kwa membrane wa khungu. Chifukwa cha phatikizoli, maselo okhala ndi insulin amapangidwa, omwe amathandizira ntchito ya enzymatic ya hexose-6-phosphotransferase, kaphatikizidwe ka chiwindi cha glycogen ndi kupasuka kwa shuga. Zotsatira zake, kuchepa kwa magazi m'magazi a seramu kumawonedwa.

Biosulin P imawonjezera mapangidwe a glycogen ndi mafuta achilengedwe kuchokera ku glucose, amachepetsa njira ya gluconeogenesis m'chiwindi.

The achire zotsatira zimatheka mwa kuwonjezera mayamwidwe a shuga ndi minofu. Kuyendetsa kwake mkati mwa maselo kumakulitsidwa. Mapangidwe a glycogen ndi mafuta achilengedwe kuchokera ku shuga amawonjezereka, ndipo njira ya gluconeogenesis m'chiwindi imachepa.

Kutalika kwa zotsatira za hypoglycemic amawerengedwa potengera kuchuluka kwa kukakamira, komwe, zimatengera malowa ndi njira yoyendetsera insulin, mikhalidwe ya munthu wodwala matenda ashuga. Pambuyo pa subcutaneous makonzedwe, achire zotsatira zimawonedwa pambuyo theka la ola ndikufika mphamvu yake yayitali pakati pa maola atatu ndi 4 mutatha kugwiritsa ntchito cartridge. Zotsatira za hypoglycemic zimatha kwa maola 6-8.

Pharmacokinetics

Bioavailability ndi isanayambike achire zotsatira zimadalira zotsatirazi:

• njira ntchito - subcutaneous kapena mu mnofu jekeseni amaloledwa;
• kuchuluka kwa mahomoni omwe amaperekedwa;
• tsamba la jakisoni (rectus abdominis, ntchafu ya kunja, gluteus maximus);
• insulin ndende.

Ma synthetenti opanga ma cell amagawidwa mosiyanasiyana mthupi. Pulogalamu yogwira imawonongeka mu hepatocytes ndi impso. Hafu ya moyo ndi mphindi 5-10. Zomwe zimagwira zimachoka m'thupi ndi 30-80% ndi mkodzo.

Mwachidule kapena kutalika

Insulin ili ndi vuto lalifupi.

Kutalika kwa zotsatira za hypoglycemic amawerengedwa potengera kuchuluka kwa kukondoweza.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa atha kuperekedwa mwa zotsatirazi:

• shuga wodalira insulin;
• shuga osadalira insulini kumbuyo kwa mphamvu yochepa yochepetsera mankhwala, zochitika zolimbitsa thupi ndi njira zina zochepetsera kunenepa;
• zinthu zadzidzidzi kwa odwala matenda a shuga, omwe amadziwika ndi kuwonongeka kwa saccharide metabolism.

Contraindication

Ndi zoletsedwa kugwiritsa ntchito mankhwalawa kwa hypoglycemia ndi tsankho la munthu pazigawo zothandizira komanso zothandizira.

Ndi chisamaliro

Ndikofunikira kuwunika pafupipafupi kuchuluka kwa shuga ndikuwonana ndi dokotala pazinthu zotsatirazi:

• kulephera kwambiri kwa aimpso chifukwa kuchepa kwa kufunika kwa insulin motsutsana ndi maziko a kagayidwe kake;
• ukalamba, popeza kwa zaka zambiri ntchito za impso zimachepa;
• kulephera kwa mtima;
• matenda kapena kulephera kwa chiwindi komwe kumatsogolera kuchepa kwa gluconeogeneis;
• stenosis yayikulu yam'mimba ndi mitsempha ya m'magazi;
• Kugonjetsedwa ndi prinifosic retinopathy popanda chithandizo chothandizira ndi Photocoagulation, matendawa ndi kukula kwa hypoglycemia kumawonjezera mwayi wakhungu;
• matenda oyamba omwe amasokoneza njira ya shuga ndikuwonjezera kufunika kwa insulin.

Kulephera kwambiri kwa aimpso, mankhwalawa ayenera kumwedwa mosamala.

Kulephera kwamtima kosatha ndi chifukwa chogwiritsa ntchito mosamala mankhwalawa Rinsulin R.

Kwa matenda kapena kulephera kwa chiwindi, Rinsulin P imatengedwa mosamala.

Rinsulin P imatengedwa mosamala ngati wodwala ali ndi vuto la m'mitsempha yamagazi ndi chithokomiro.

Rinsulin P iyenera kumwedwa mosamala mukalamba.

Momwe mungatengere Biosulin P

Mlingo wa insulin umatsimikiziridwa ndi katswiri wazachipatala payekhapayekha, kutengera ndi zomwe zimadziwika ndi shuga. Biosulin imaloledwa kuthandizidwa mosasamala, m'malo okhala ndi minofu yambiri. Pakati pazakudya zomwe munthu wamkulu amadyetsa tsiku lililonse ndi 0,5-1 IU pa 1 kg ya kulemera kwake (pafupifupi 30-30 maunits).

Akatswiri azachipatala amalangiza kuperekera mankhwalawa mphindi 30 asanayambitse zakudya zomwe zimakhala ndi chakudya. Pankhaniyi, kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kofanana ndi kutentha kozungulira. Ndi monotherapy yokhala ndi Biosulin, wothandizirana ndi hypoglycemic amaperekedwa katatu patsiku, pakudya zazakudya pakati pa chakudya, pafupipafupi jakisoni amawonjezeka mpaka 5-6 patsiku. Ngati mulingo woposa 0,6 IU pa 1 kg ya kulemera kwa thupi, ndikofunikira kupanga majakisoni awiri m'magawo osiyanasiyana amthupi osati m'dera limodzi lokha.

Ndikofunikira kupaka jekeseni wamankhwala pakhungu pa minofu ya rectus abdominis, kutsatira njira ya algorithm yochita:

1. Patsamba lamayendedwe ofunsidwawo, muyenera kusonkhanitsa khungu lanu pogwiritsira ntchito chala chamanthu. Singano ya syringe iyenera kuyikika pakhungu la pakhungu la 45 ° ndipo piston imatsitsidwa.
2. Pambuyo pakuyambitsa insulin, muyenera kusiya singano pansi pa khungu kwa masekondi 6 kapena kuposerapo kuti muwonetsetse kuti mankhwalawo amaperekedwa kwathunthu.
3. Pambuyo pochotsa singano, magazi amatha kutuluka pamalo opaka jekeseni. Dera lomwe lakhudzidwalo liyenera kukanikizidwa ndi chala kapena ubweya wa thonje wothira mowa.

Komanso, jakisoni aliyense amayenera kuchitika mkati mwa malire a anatomical, ndikusintha jakisoni. Izi ndizofunikira kuti muchepetse mwayi wa lipodystrophy. Kubayidwa mu mnofu ndi jekeseni wamitsempha kumachitika kokha ndi akatswiri azachipatala. Insulin yogwira ntchito mwachidule imaphatikizidwa ndi mtundu wina wa insulini womwe umathandizanso kuti ukhale wotalikirapo.

Ndi monotherapy ndi Biosulin, wothandizira wa hypoglycemic amaperekedwa katatu patsiku.

Zotsatira zoyipa za Biosulin P

Maonekedwe a zoyipa zimachitika chifukwa cha momwe thupi limayendera pochita zinthu, mulingo woyenera kapena kuyambitsa jakisoni.

Kuchokera kumbali ya kagayidwe

Hypoglycemic syndrome yodziwika ndi:

• cyanosis;
• thukuta;
• tachycardia;
• kunjenjemera;
• njala;
• kuchuluka kwambiri;
• kulawa paresthesia;
• mutu;
• hypoglycemic chikomokere.

Matupi omaliza

Odwala ndi minofu hypersensitivity kwa kapangidwe kazinthu mankhwala, angioedema pakhosi ndi khungu zimachitika. Nthawi zina, kugundana kwa anaphylactic kumatha kuchitika.

Kuthetsa thukuta kwambiri ndi zotsatira za mankhwala Rinsulin R.

Rinsulin P imatha kuyambitsa tachycardia.

Nthawi zina Rinsulin P imayambitsa mutu.

Hypoglycemic coma imadziwika ndi hypoglycemic syndrome yomwe imachitika mutatenga Rinsulin R.

Nthawi zina, kugwedezeka kwa anaphylactic kumatha kuchitika chifukwa chotenga Rinsulin P.

Zokhudza mphamvu pakuwongolera njira

Mankhwalawa sasokoneza kuthekera kowongolera njira zovuta. Chifukwa chake, pa chithandizo cha glycemic, kuyendetsa kapena kugwira ntchito ndi zida zamagetsi sikuletsedwa.

Malangizo apadera

Simungathe kulowa yankho lamtambo, mankhwala omwe asintha mtundu kapena okhala ndi matupi okhazikika. Pa chithandizo cha insulin, ndikofunikira kuwongolera kuchuluka kwa shuga m'magazi.

Kuopsa kwa vuto la hypoglycemic kumawonjezeka motere:

• kusinthana ndi othandizira ena a hypoglycemic kapena mtundu wina wa insulin;
• kudula chakudya;
• kusowa kwamadzi chifukwa cha kusanza ndi kutsegula m'mimba;
• kuchuluka zolimbitsa thupi;
• matenda wamba;
• kuchepa kwa katulutsidwe katulutsidwe katemera ka adrenal cortex;
• kusintha m'dera loyang'anira;
• mogwirizana ndi mankhwala ena.

Ngati chithandizo choyenera sichikuchitika, hyperglycemia imatha kupangitsa kuti matenda ashuga a ketoacidosis.

Njira zophatikizana ndi pathological, makamaka za matenda opatsirana, kapena mikhalidwe yodziwika ndi kukula kwa malungo, zimakulitsa kufunikira kwa insulin. Njira yochotsa matenda a Biosulin ndi mtundu wina wa insulin yaumunthu iyenera kuchitika mothandizidwa ndi shuga ya magazi a seramu.

Chiwopsezo cha mkhalidwe wa hypoglycemic imachulukitsidwa makamaka mukamayanjana ndi mankhwala ena.

Mlingo wa mankhwalawa uyenera kusinthidwa mosamala pazinthu zotsatirazi:

• utachepa magwiridwe antchito a chithokomiro;
• chiwindi kapena matenda a impso;
• Matenda a Addison;
• zaka zopitilira 60;
• kuchuluka kwa zolimbitsa thupi kapena kusintha kadyedwe.

Mankhwala amachepetsa kulekerera kwa minofu pazovuta za ethanol.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Insulin yopangidwa ndi chibadwa sichimadutsa chotchinga, chomwe sichingawononge kukula kwa chibadwa. Chifukwa chake, chithandizo cha insulin sichimaletsedwa panthawi yomwe muli ndi pakati. Mankhwalawa samalowa m'matumbo a mammary ndipo samatulutsidwa mkaka wa m'mawere, zomwe zimapangitsa amayi otupa kulowa Biosulin mopanda mantha.

Gwiritsani ntchito mu ukalamba

Okalamba chifukwa chazaka zokhudzana ndi kuchepa kwa ntchito ya impso nthawi zambiri amafunika kuwongolera kuchuluka kwa shuga m'magazi.

Kupangira Biosulin P kwa ana

Muubwana, kukhazikitsidwa kwa magawo 8 a mankhwalawa kumalimbikitsidwa.

Mankhwala osokoneza bongo a Biosulin P

Pogwiritsa ntchito limodzi mlingo waukulu wa insulin, hypoglycemia imatha kuchitika. Kutsika pang'ono kwa glucose kumatha kutha nokha pakudya shuga kapena zakudya zopatsa mphamvu. Chifukwa cha izi, odwala omwe ali ndi matenda a shuga a 2 amalangizidwa kuti azinyamula ufa kapena mankhwala a confectionery, misuzi ya zipatso, ndi shuga.

Ngati wodwala ataya chikumbumtima, ndiye kuti pali kuchuluka kwakukulu kwa hypoglycemia. Pankhaniyi, kutumikiridwa msanga kwa 40% shuga kapena dextrose solution, 1-2 mg ya glucagon kudzera m'mitsempha, kudzera m'mitsempha kapena intramuscularly ndikofunikira. Mukayambanso kuzindikira, ndikofunikira kuti chakudya chikhale chokwanira kwa odwala omwe akhudzidwa ndi zakudya kuti muchepetse kuyambiranso.

Ngati wodwala ataya chikumbumtima, ndiye kuti pali kuchuluka kwakukulu kwa hypoglycemia.

Kuchita ndi mankhwala ena

Kuyenderana ndi mowa

Mowa wa Ethyl umakhudza gawo lamagazi ndi magwiridwe antchito a chiwindi ndi impso. Zotsatira zake, kagayidwe ka insulin kamasokonekera, komwe kungayambitse kutayika kwa glycemic control. Mwayi wopanga hypoglycemia ukuwonjezeka. Chifukwa chake, munthawi ya chithandizo ndi mankhwalawa, ndizoletsedwa kumwa zakumwa zoledzeretsa.

Analogi

Mankhwalawa akhoza kusintha mitundu yotsatirayi ya insulin:

• Insuman Rapid GT;
• Actrapid NM Penfill;
• Gensulin P;
• Humulin Wokhazikika.

Kupita kwina mankhwala

Mankhwalawa atha kugulidwa ndi mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Mlingo wosalondola ungayambitse kukula kwa hypoglycemia mpaka kumayambiriro kwa matenda a shuga, chifukwa chake, mankhwalawa amagulitsidwa pazifukwa zachipatala mwachindunji.

Mtengo wa Biosulin P

Mtengo wapakati wokumangira ndi mabotolo ndi ma ruble a 1034.

Zosungidwa zamankhwala

Ndikulimbikitsidwa kusunga ma cartridge ndi ma ampoules okhala ndi insulini pamtunda wa + 2 ... + 8 ° C pamalo osiyanitsidwa ndi kuwala ndi chinyezi chochepa kwambiri.

Tsiku lotha ntchito

Miyezi 24. Mukatsegula ampoule mutha kusungidwa kwa masiku 42, ma cartridge - masiku 28 pa kutentha kwa + 15 ... + 25 ° C.

Wopanga

Marvel LifeSines, India.

Ndemanga za Biosulin P

Mankhwalawa adakhazikika pamsika wamankhwala chifukwa chakuyankha kwabwino kuchokera kwa madokotala ndi odwala.

Analog ya Rinsulin P imawerengedwa kuti Insuman Rapid GT.

Humulin Wokhazikika analogue wa mankhwala Rinsulin R.

Actrapid NM Penfill amadziwika ngati analogue ya mankhwala Gensulin R.

Gensulin R - analogue ya mankhwala Rinsulin R.

Madokotala

Elena Kabluchkova, endocrinologist, Nizhny Novgorod

Njira yothandiza yochokera ku insulin yomwe imathandizira odwala matenda a shuga mwadzidzidzi. Cholembera cha syringe ndichabwino kwa odwala omwe ali ndi ndandanda yosinthika ya moyo ndi ntchito. Kuchita kochepa kumathandiza kuthana ndi shuga wambiri. Pokwaniritsa mwachangu zotsatira zochizira, mutha kugwiritsa ntchito cartridge musanadye. Biosulin imaloledwa kugwiritsidwa ntchito ndi mankhwala ena potengera insulin. Odwala atha kulandira mankhwala kuchotsera.

Olga Atamanchenko, endocrinologist, Yaroslavl

Muzochita zamankhwala, ndakhala ndikukulemberani mankhwalawa kuyambira Marichi 2015. Kubwera kwa mtundu wa insulini mu matenda ashuga, moyo umakhala bwino, mwayi wa hyperglycemia ndi hypoglycemia umachepa. Amaloledwa kugwiritsidwa ntchito mwa ana ndi amayi apakati. Chifukwa cha insulin yochepa, wodwalayo amatha kupereka mankhwalawa panthawi yadzidzidzi (yokhala ndi shuga yambiri). Ndikuganiza kuti Biosulin ndiwothandiza mwachangu, komanso wathanzi.

Anthu odwala matenda ashuga

Stanislav Kornilov, wazaka 53, Lipetsk

Kugwiritsa ntchito bwino insulin. Ndidagwiritsa ntchito Gensulin ndi Farmasulin, koma nditha kukwaniritsa kutsika kwamphamvu kwa glucose kokha chifukwa cha Biosulin. Mankhwala adziwonetsa okha kuphatikiza Insuman Bazal - insulin yayitali. Chifukwa cha kuthamanga kwake, ndinatha kukulitsa kudya kwa zipatso. Ndinaona kuti kuchokera kumankhwala am'mbuyomu mutu wanga umandipweteka, koma zotsatirapo zake sizimawonedwa. Ndine wokhutira ndi zotsatira zake, koma chinthu chachikulu ndikutsatira malangizo ogwiritsa ntchito komanso zakudya zomwe mwapatsidwa.

Oksana Rozhkova, wazaka 37, Vladivostok

Zaka 5 zapitazo, anali mu chisamaliro chachikulu chokhudzana ndi kufalikira kwa matenda a shuga, omwe sanadziwe za izi.Atakwanitsa kuyang'anira glycemic, adotolo adalankhula za matendawa ndikuyambitsa Biosulin mosalekeza. Anatinso ndizosavuta kugwiritsa ntchito cholembera. Pomwe mankhwalawo anali atabayidwa, mitengo ya shuga idakhalabe yochepa. Koma insulin yamtunduwu imagwiranso ntchito kwakanthawi, ndipo kunali kofunikira kusankha mitundu inanso yotalikirapo. Ndinkawopa kuti mankhwalawa angagwirizane, koma kukayikira sikunatsimikizike. Ndibwino kuphatikiza ndi mtundu wina wa insulin.