Metformin ndi piritsi yochepetsera shuga yomwe imagwiritsidwa ntchito ndi mtundu 2 odwala matenda ashuga (2T). Mankhwalawa akhala akudziwika kwazaka zambiri.
Katundu wake wotsitsa shuga adapezeka mu 1929. Koma Metformin idagwiritsidwa ntchito kwambiri mu 1970, pomwe ma agogou ena adachotsedwa mu malonda.
Mankhwalawa amakhalanso ndi zofunikira zina, kuphatikizapo kuchepetsa kuchepa. Koma kodi ndizotheka kumwa Metformin ngati palibe shuga? Nkhaniyi iphunziridwa mwachangu ndi onse madokotala ndi odwala.
Kufotokozera kwa mankhwalawa
Ambiri amati za Metformin kuti imachulukitsa moyo. Ndipo izi zikunenedwa ndi asayansi omwe akuchita maphunziro osiyanasiyana azachipatala a mankhwalawa. Ngakhale kutsimikizika kwa mankhwalawa kumawonetsa kuti imangotengera shuga mellitus 2T, yomwe imatha kulemedwa ndi kunenepa kwambiri komanso kukana insulini.
Metformin 500 mg
Itha kugwiritsidwanso ntchito kwa odwala matenda a shuga 1T. Komano, Metformin imangowonjezera insulin. Kuchokera pazotsutsana ndikuwonekeratu kuti anthu omwe ali ndi vuto logaya mafuta osavomerezeka sayenera kugwiritsa ntchito mankhwalawa.
Chimachitika ndi chiani ngati mutatenga Metformin popanda matenda a shuga? Yankho limaperekedwa ndi asayansi omwe aphunzira momwe mankhwalawa amathandizira, kulepheretsa kukalamba kwa thupi, komanso kuchuluka kwa ma cell.
Mankhwala Metformin:
- kuthana ndi chitukuko cha matenda a Alzheimer's, momwe ma cell amitsempha omwe amachititsa kukumbukira kukumbukira amwalira;
- imalimbitsa maselo a tsinde, imathandizira kuti maselo atsopano a ubongo (ubongo ndi msana)
- amathandizira kubwezeretsa maselo am'mitsempha mu ubongo pambuyo pa sitiroko;
- amalepheretsa chitukuko cha multiple sclerosis.
Kuphatikiza pakuwongolera zinthu muubongo, Metformin imathandizira ntchito ya ziwalo zina ndi machitidwe a thupi:
- Amathandizira kupondereza kutupa kosagwirizana ndi kuchuluka kwa matenda ashuga a C osagwira;
- linalake ndipo tikulephera kukula kwa matenda, zomwe zimachititsa kukalamba kwa mtima, mitsempha ya magazi;
- imalepheretsa kuwerengetsa kwamitsempha yamagazi, kusokoneza ntchito ya mtima;
- amachepetsa chiopsezo chotenga khansa (Prostate, mapapu, chiwindi, kapamba). Nthawi zina amagwiritsidwa ntchito ndi chemotherapy yovuta;
- imalepheretsa matenda ashuga komanso mitundu yokhudzana ndi matendawa;
- imapangitsa kugonana kwa amuna akulu;
- amachitira mafupa am'matumbo ndi nyamakazi yokhudzana ndi chitukuko cha matenda a shuga;
- Amasintha ntchito ya chithokomiro;
- amathandiza impso ndi nephropathy;
- amalimbitsa chitetezo cha mthupi;
- Amathandizira kuteteza kupuma pamatenda.
Ntchito zotsutsa ukalamba za mankhwalawa zapezeka posachedwa. Izi zisanachitike, Metformin anali kugwiritsidwa ntchito kokha pothana ndi matenda a shuga. Koma zambiri zomwe zapezeka poyang'anira odwala omwe akuchiritsidwa ndi othandizidwawa adawonetsa kuti amakhala nthawi yayitali kuposa anthu opanda matenda awa.
Izi ndi zomwe zidapangitsa asayansi kuganiza zakuthana ndi kukalamba kwa Metformin. Koma malangizo owagwiritsa ntchito sawonetsa izi, chifukwa ukalamba si matenda, koma njira yachilengedwe yomaliza moyo.
Mchitidwe wokonzanso umakhala ndi:
- kuchotsera kwa cholesterol plaque mu zombo. Chiwopsezo cha thrombosis chimathetsedwa, kufalikira kwa magazi kumakhazikitsidwa, kuthamanga kwa magazi kumatheka;
- kukonza kagayidwe kachakudya njira. Kulakalaka kumachepa, komwe kumapangitsa kuti muchepetse kuchepa, kuchepa thupi komanso kuchepa thupi;
- kuchepa kwamatumbo a shuga m'matumbo. Kulumikizana kwa mamolekyulu a protein amapewedwa.
Metformin ndi ya m'badwo wachitatu biguanides. Zomwe zimagwirira ntchito ndi metformin hydrochloride, yomwe imathandizidwa ndi mankhwala ena.
Chiwembu chogwiritsira ntchito mankhwala motsutsana ndi matenda ashuga ndiwofatsa. Muli zoletsa njira ya gluconeogeneis, pomwe mukulimbikitsa glycolysis. Izi zimabweretsa kuyamwa bwino kwa shuga, pomwe kumachepetsa mayamwidwe ake m'matumbo. Metformin, posakhala othandizira pakupanga insulini, sikuti imayambitsa kutsika kwamphamvu kwa shuga.
Kugwiritsa ntchito Metformin, malinga ndi malangizo omwe aphatikizidwa ndi mankhwalawa, akuwonetsedwa:
- mawonetseredwe a insulin kukana kapena metabolic syndrome;
- kulolerana kwa shuga;
- kunenepa kwambiri kokhudzana ndi matenda a shuga;
- scleropolycystic ovary matenda;
- shuga mellitus 2T ndi zovuta chithandizo;
- shuga 1T ndi jakisoni wa insulin.
Kuchepetsa Ntchito
Kodi ndizotheka kumwa Metformin kuti muchepetse thupi, ngati shuga ndichabwinobwino? Kuwongolera uku pakukhudzana ndi mankhwala chifukwa cha kuthekera kwake kumenya nkhondo osati ma plaque m'mitsempha yamagazi, komanso ma deposits amafuta.
Kuchepetsa thupi mukamamwa mankhwala kumachitika chifukwa chotsatira:
- kuthamanga kwambiri oxidation;
- kutsika kwa kuchuluka kwa chakudya chamafuta;
- kuchuluka kwa shuga mwa minofu.
Nthawi yomweyo, kumverera kwa njala yosalekeza, komwe kumapangitsa kuti thupi lizikula kwambiri, kumachotsedwa. Koma muyenera kutentha mafuta mukudya.
Kuti muchepetse kunenepa, muyenera kusiya:
- maswiti, mchere;
- zopangidwa ndi ufa;
- mbatata.
Masewera olimbitsa thupi, monga masewera olimbitsa thupi olimbitsa thupi tsiku lililonse, amafunikanso. Ma regimen akumwa ayenera kuyang'aniridwa mosamala. Koma kumwa mowa ndikoletsedwa.
Ntchito yoletsa kukalamba (anti-okalamba)
Metformin imagwiritsidwanso ntchito kupeweratu kusintha komwe kumachitika mthupi.
Ngakhale mankhwalawa siwopanda chiyembekezo chaubwana wamuyaya, amakulolani:
- bwezeretsani kuperekera kwa ubongo mu kuchuluka kofunikira;
- kuchepetsa chiopsezo cha neoplasms yoyipa;
- limbitsani mtima minofu.
Vuto lalikulu la chiwalo chokalamba ndi atherosulinosis, yomwe imasokoneza kugwira ntchito kwa mtima ndi mitsempha yamagazi. Ndiye amene amayambitsa imfa zambiri zomwe zimachitika asanakwane.
Zomera za cholesterol zomwe zimatsogolera ku atherosulinosis zimachitika chifukwa:
- kuphwanya kakhalidwe koyenera kwa kapamba;
- Kulephera kwa chitetezo chamthupi;
- mavuto a metabolic.
Cholinga chake ndikukhalanso ndi moyo womwe anthu okalamba amatsogolera, pomwe amakhala ndi chakudya chambiri komanso zopatsa mphamvu, ndipo nthawi zina zimawonjezera.
Izi zimabweretsa kukokomeza magazi m'mitsempha ndikupanga ma cholesterol amana. Mankhwalawa amathandizira kuchepetsa mafuta m'thupi, kusintha kayendedwe ka magazi ndi kusintha ntchito ya ziwalo zonse ndi machitidwe. Ndiye kodi Metformin ingatengedwe ngati palibe shuga? Ndizotheka, koma pokhapokha ngati pali contraindication.
Zoyipa pa Metformin ndi:
- acidosis (pachimake kapena chovuta);
- nthawi ya pakati, kudyetsa;
- ziwengo ku mankhwalawa;
- chiwindi kapena kulephera mtima;
- myocardial infarction;
- Zizindikiro za hypoxia pomwa mankhwalawa;
- kufooka kwa thupi ndi matenda opatsirana;
- matenda am'mimba thirakiti (zilonda);
- kuchita zolimbitsa thupi kwambiri.
Lemberani Metformin kuti muchepetse thupi komanso kuti musinthe thupi ndikufunika kukumbukira zotsatirapo zoyipa:
- chiopsezo cha matenda a anorexia amachuluka;
- mseru, kusanza, kutsegula m'mimba kumachitika;
- Nthawi zina kukoma kwazitsulo kumawonekera;
- kuchepa magazi kumatha kuchitika;
- pali kuchepa kwa mavitamini a B, ndipo kukonzekera kowonjezerapo kofunikira kumafunikira;
- kugwiritsa ntchito kwambiri, hypoglycemia ingachitike;
- Kuchita zosafunikira kungayambitse mavuto amtundu wa khungu.
Makanema okhudzana nawo
Makhalidwe a pharmacological ndi malangizo ogwiritsira ntchito mankhwala Metformin:
Njira yogwiritsira ntchito Metformin osati pochiza matenda ashuga ndi yosatsata. Yambani kudzisankhira nokha ndikusankha mlingo woyenera nokha osakakumana ndi azaumoyo kuti akumane ndi zotsatila zoopsa zomwe sizingachitike. Ndipo ngakhale atayang'anitsitsa wodwala akamva, kutenga nawo gawo kwa dokotala pakuchepetsa / kuyambiranso mothandizidwa ndi Metformin ndikofunikira.
