Mapiritsi a Glibomet - malangizo ogwiritsira ntchito ndi contraindication

Mankhwala othandizira odwala matenda a shuga 2 samangokhala pa zakudya zapadera, komanso othandizira kudya zopangidwa zoyenera matendawa.

Ndizofunikira kukwaniritsa chikhalidwe chamtundu wa glycemia.

Mwa mankhwala ambiri omwe amaperekedwa ndi msika wogulitsa mankhwala, odwala nthawi zambiri amapatsidwa mapiritsi a Glibomet.

Zambiri pazamankhwala, mawonekedwe a mawonekedwe ndi mawonekedwe

Glibomet ndi m'gulu la mankhwala a hypoglycemic omwe amatengedwa pakamwa. Mankhwalawa amapangidwa ndi kampani yaku Germany ya BERLIN-CHEMIE / MENARINI. Kupatula Glibomet ku Russia, mankhwala opitilira 100 a kampaniyi adalembetsa, omwe amagwiritsidwa ntchito mochizira matenda ambiri ndipo akwanitsa kale kudalirika kwa odwala.

Mankhwala amagulitsidwa mwanjira ya mapiritsi ophimbidwa ndi chipolopolo choyera. Iliyonse mwa iyo ili ndi zigawo ziwiri zothandizira komanso kuchuluka kwa zinthu zothandizira.

Piritsi la mankhwalawa lili:

• Glibenclamide (2.5 mg) ndi Metformin Hydrochloride (400 mg) ndizofunikira kwambiri;
• wowuma chimanga (michere) - 57,5 ​​mg;
• mapadi (mbewu polysaccharide) - 65 mg;
• silicon dioxide (chakudya chowonjezera E551) - 20 mg;
• gelatin - 40 mg;
• Glycerol - 17,5 mg;
• talc (mchere) - 15 mg;
• Diethyl phthalate (0.5 mg) ndi 2 mg Acetylphthalyl cellulose - yomwe ili mgulu la mapiritsi.

Phukusili limatha kukhala mapiritsi 40, 60 kapena 100.

Pharmacology ndi pharmacokinetics

Chifukwa cha zomwe zimapangidwa pokonzekera, mankhwalawa amachepetsa chizindikiritso cha magazi m'magazi a wodwala.

Mankhwala Glibenclamide:

• imapangitsa secretion ya insulin, komanso imawonjezera kutulutsidwa kwa mahomoni;
• amathandizira kukulira chiwopsezo cha insulin yomwe ilipo mthupi;
• timapitiriza mphamvu ya insulin motsutsana shuga;
• Imachepetsa njira ya lipolysis.

Pharmacological zochita za Metformin:

• amathandizira kukulitsa chidwi cha insulin, komanso imathandizira zotsatira zake;
• amachepetsa mayamwidwe a shuga m'matumbo, bwino mayamwidwe ake ziwalo zina;
• amathandizira kuponderezana kwa gluconeogeneis;
• zimakhudza metabolidi ya lipid, zomwe zimabweretsa kuwonda.

Ndikotheka kukwaniritsa kuchepetsa kwa glycemia pambuyo piritsi patatha maola 2 ndikusungira kwa maola 12.

Kupanga kwamankhwala kumapangidwira amadziwika ndi mawonekedwe a mayamwidwe, kugawa, kagayidwe ndi kutulutsa kwa zigawo zikuluzikulu.

Glibenclamide:

1. Ntchito ndi kugawa. Pazitali kwambiri pazinthu zimafikiridwa maola awiri pambuyo pokhazikitsa. Gawo lake limatengeka mwachangu kuchokera kumimba yodyetsera (m'mimba). Kulumikizidwa kwa zinthu ndi mapuloteni a plasma kumafika pa 97%.
2. Metabolism imachitika pafupifupi m'chiwindi.
3. Kuswana. Kuongolera izi kumachitika ndi impso. Kukula kwa chinthu kumachitika limodzi ndi mkodzo ndi bile kudzera mkodzo. Kuchotsa theka moyo kumatenga maola 10.

Metformin:

1. The mayamwidwe ndi kufalitsa mu zimakhala za chigawocho chimachitika mwachangu komanso mosavuta.
2. Kukula kwa chinthu kuchokera m'thupi kumachitika mosasinthika kudzera mu impso ndi matumbo. Kuchotsa hafu ya moyo kumatenga maola 7.

Zizindikiro ndi contraindication kuti mugwiritse ntchito

Mankhwala tikulimbikitsidwa kuti mugwiritse ntchito ndi matenda a shuga a 2, mukamadya zakudya komanso kugwiritsa ntchito mankhwala ena osathandiza.

Zoyipa:

• Hypersensitivity ku zilizonse za mankhwala;
• mtundu 1 shuga;
• mawonekedwe a shuga;
• lactic acidosis;
• ketoacidosis;
• chikomokere (hypoglycemic kapena hyperglycemic);
• kwambiri aimpso kuwonongeka;
• matenda a chiwindi, impso;
• wandewu
• kukhalapo kwa matenda opatsirana;
• kuchitapo kanthu kwa opaleshoni, limodzi ndi kuchepa kwakukulu kwa magazi;
• kuvulala kapena kuwotcha;
• Mulingo uliwonse wofuna kugwiritsa ntchito mankhwala a insulin;
• leukopenia;
• porphyria;
• masinthidwe a dystrophic;
• kuledzera;
• nthawi yoyamwitsa;
• ana, achinyamata osakwana zaka 18;
• mimba

Malangizo ogwiritsira ntchito ndi malangizo apadera

Mapiritsi amatengedwa pakamwa ndi zakudya. Mlingo wa mankhwalawa ayenera kusankhidwa ndi adokotala, poganizira momwe kagayidwe kazinthu kamene kamayambira ndi glycemia wodwala.

Kumwa mankhwala nthawi zambiri kumayamba ndi piritsi limodzi. Kutengera ndi zotsatira za mankhwala, mankhwalawa amatha kusiyanasiyana. Chiwerengero chokwanira cha mapiritsi ololedwa patsiku ndi 6, chifukwa ndiwowopsa kumwa nawo. Kuchita bwino kwa mitundu yosankhidwa ya mankhwala kumatsimikiziridwa ndi phindu la glucose.

Ndikofunika kuti odwala azitsatira malangizo a dokotala pazakudya, njira yoyendetsera ndi kumwa mankhwala. Ndi shuga wowola, kufa ndi njala, kuledzera, chiwindi chokwanira, komanso chiwonetsero chilichonse cha hypoxia, mapiritsi ayenera kumwedwa mosamala chifukwa cha ngozi yomwe ilipo ya lactic acidosis. Izi zimachitika chifukwa cha kuchuluka kwa metformin, chifukwa chomwe lactate imapezeka m'magazi.

Kulandila ndalama kumakhudzanso kuyesedwa kwa mayesedwe a magazi a creatinine:

• Kamodzi pachaka panthawi yachilendo ntchito ya impso (odwala matenda a shuga);
• zopitilira 2 pachaka mwa anthu omwe ali ndi HBV (kobadwa nako adrenal hyperplasia) kapena odwala okalamba.

Malangizo apadera:

• gwiritsani ntchito mosamala ndi okodzetsa;
• Musamamwe mankhwalawa masiku awiri musanayambe kupimidwa X-ray kapena opaleshoni pogwiritsa ntchito mankhwala oletsa kupweteka, m'malo mwake ndi insulin kapena mankhwala ena;
• pitilizani mankhwala pokhapokha maola 48 kuchokera pa nthawi yomwe opaleshoni iliyonse ingachitike kapena mutha kugwira ntchito yofanana ndi impso;
• musamwe mowa limodzi ndi mankhwalawo kuti mupewe hypoglycemia kapena kupezeka kosiyanasiyana komwe kumachitika motsatila zakumwa zoledzeretsa;
• Mankhwala amachepetsa kuchuluka kwa ma psychomotor, omwe angayambitse kuyendetsa galimoto molakwika.

Matenda a shuga nthawi zambiri amakhala amodzi mwa matenda omwe wodwala amakhala nawo. Pamaso pa pathologies ena, ndikofunikira kumwa mankhwalawa mosamala kwambiri.

Gulu lapadera la odwala ndi:

• amayi oyembekezera kapena oyembekezera (mankhwalawa akuphwanya);
• Odwala omwe ali ndi vuto la chiwindi (mankhwalawo amaletsedwa kugwiritsa ntchito);
• anthu omwe ali ndi mavuto a impso (okhala ndi creatinine ochokera ku 135 mmol / l mwa amuna ndipo opitilira 100 mmol / l mwa akazi, mankhwala othandizira amaletsedwa).

Mankhwala osavomerezeka kuti agwiritsidwe ntchito ndi odwala azaka zopitilira 60, chifukwa akamagwira ntchito zolimbitsa thupi, amatha kukhala ndi lactic acidosis.

Zotsatira zoyipa ndi bongo

Kumwa mankhwalawa kumatha kuyambitsa zotsatirazi:

• mokhudzana ndi chimbudzi;
• Kuchokera kuzungulira kwa magazi - leukopenia, komanso magazi m'thupi ndi pancytopenia;
• mogwirizana ndi mitsempha, mutu;
• kuyabwa, urticaria, erythema;
• hypoglycemia kapena lactic acidosis;
• zokonda mtima.

Ndi mankhwala osokoneza bongo ambiri, thanzi la wodwalayo limakulirakulira, hypoglycemia imayamba. Pankhaniyi, muyenera kudya michere. Kupita patsogolo kwa hypoglycemia kungayambitse kulephera kudziletsa komanso kuzindikira. Munthawi imeneyi, wodwalayo sangathenso kudya, motero shuga wamagazi ndi othandizira amafunikira.

Kuchita ndi mankhwala ena ndi analogi

Hypoglycemic zotsatira za mankhwala zimatheka mothandizidwa ndi othandizira monga:

• Zotumphukira za Coumarin;
• Salicylates;
• Mao zoletsa;
• phenylbutazone zotumphukira;
• Sulfonamides;
• Miconazole;
• Feniramidol;
• Ethanoli

Kuti muchepetse kugwiritsidwa ntchito kwa mankhwalawa zimakhudza:

• Glucocorticoids;
• Thiazide okodzetsa;
• kulera (pakamwa);
• mahomoni kuti azisamalira chithokomiro;
• Adrenaline.

Ngati Glibomet pazifukwa zina sizili bwino, pali zambiri zake, zomwe zimasiyana pakapangidwe kake komanso mtengo wake.

Zofanizira zazikulu:

• Galvus Met;
• Glimecomb;
• Avandaglim;
• Janumet;
• Avandamet;
• Combogliz.

Ndikofunikira kumvetsetsa kuti adokotala okha ndi omwe ayenera kupanga chisankho chokhudza kusintha kwa Glibomet ndi mankhwala ena.

Kanema pazanjira zisanu ndi ziwiri zochepetsera shuga kunyumba:

Maganizo a odwala komanso mitengo ya mankhwala

Kuchokera pakuwunika kwa odwala, titha kunena kuti mankhwalawa amayenera kumwedwa mosamala, popeza ali ndi zovuta zambiri, ndikofunikira kufunsa katswiri musanamwe mankhwalawo.

Ndinayamba kumwa mankhwalawo monga adanenera dokotala. Patsiku loyamba la chithandizo, adamva kawiri Zizindikiro za hypoglycemia, ngakhale kuti zakudya sizinasinthe. Sindinathe kupita kwa dokotala nthawi yomweyo, kotero ndinasankha ndekha kuti ndisayesenso ndipo ndinabwereranso kumwa mapiritsi akale.

Svetlana, wazaka 33

Ndimakondwera kwambiri ndi Glibomet. Ndi chithandizo chake, zinali zotheka kusinthitsa shuga. Atawerenga malangizowo, poyamba anali ndi mantha ndi mndandanda waukulu wazotsatira zoyipa, koma adaganiza zokhulupirira dokotala. Zotsatira zake zidakondwera.

Egor, wazaka 46

Chaka chatha ndidamwa mapiritsi awa. Mankhwalawa sanandigwirizire, chifukwa kulawa kwazitsulo mkamwa mwanga kunalipo nthawi zonse ndipo nthawi zina ndimakhala wosangalala.

Nikita Alexandrovich, wa zaka 65

Chidacho chimachepetsa shuga bwino, koma pakudya kwake simungathe kudumphanso ngakhale osakudya, osati monga zakudya zazikulu. Glybomet imafuna kudya pafupipafupi kuti pasakhale hypoglycemia.

Irina, wazaka 48

Mtengo wa mankhwalawa ndi pafupifupi ma ruble 350 pamapiritsi 40.