Ntchito malangizo Glimeperid

Matenda a shuga amafunika kuwongolera shuga la wodwala.

Chifukwa cha izi, madokotala amagwiritsa ntchito mankhwala osiyanasiyana, malinga ndi chithunzi cha matendawa.

Pakati pa mankhwalawa, pali mankhwala omwe amatchedwa glimepiride.

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Mankhwala glimepiride ndi amodzi mwa mankhwala a hypoglycemic. Nthawi zambiri imagwiritsidwa ntchito kuwongolera shuga, ndiye kuti, ndi matenda a shuga.

Akatswiri salimbikitsa kumwa mankhwalawa popanda mankhwala a dokotala, chifukwa kuyenera kwake kwa mankhwalawo kumatengera mawonekedwe a matendawa.

Mankhwalawa amaperekedwa m'mapiritsi, mtundu wa chipolopolo chomwe chimatengera mtundu wa zomwe zimagwiritsidwa ntchito. Mankhwala amatengedwa pakamwa.

Chithandizo chophatikizika mu mankhwalawa ndi Glimepiride. Osangalala anawonjezerapo.

Glimepiride amapangidwa ndi miyala. Kutengera kuchuluka kwa ntchito, mitundu ingapo imasiyanitsidwa. Kuchuluka kwa mankhwala othandizira kungakhale 1, 2, 3, 4 kapena 6 mg pa gawo lililonse la mankhwala.

Mwa zina zothandizira zikuwonetsedwa:

• stesiate ya magnesium;
• povidone;
• wowuma glycolate;
• lactose monohydrate;
• cellulose;
• polysorbate 80.

Mankhwala okhala ndi mitundu yosiyanasiyana amasiyana ndi mtundu wa chipolopolo (cha pinki, chobiriwira, chachikaso kapena chamtambo), ndiye kuti mapiritsiwa amatha kukhala ndi utoto wa utoto wosiyanasiyana.

Pogulitsa mutha kupeza glimepiride muma contour cell a 10 ma PC. mu iliyonse (phukusi pamakhala maselo atatu kapena 6) kapena m'mabotolo a polymer omwe amakhala 30 kapena 60 ma unit.

Pharmacological kanthu ndi pharmacokinetics

Gawo lalikulu la mankhwalawo ndi kuchepa kwa kuchuluka kwa shuga m'magazi. Izi zimachitika chifukwa cha kuwonekera kwa maselo a beta a kapamba, omwe amayamba kupangira insulin yambiri. Mukamamwa Glimepiride, kuchuluka kwa maselo a beta kumawonjezereka, amakhudzidwa kwambiri ndi glucose, chifukwa chake kuyankha kwa insulin ku hyperglycemia kumakhala kothandiza kwambiri.

Komanso, mankhwalawa amadziwika ndi mphamvu ya extrapancreatic, yomwe imakhala ikukulitsa chidwi cha insulin m'malo ophatikizika. Mamolekyu omwe amatulutsa shuga ku minofu ndi minyewa ya adipose amapangidwa mokulira.

Ndi mankhwala oyenera, mbali yake yogwira imayamwa kwathunthu. Njirayi siyikhudzidwa ndi kuchuluka kwa chakudya. Chithandizo chogwira chimafikira kuchuluka kwake kwa maola 2.5 mutatha mapiritsi.

Mankhwalawa akamagwiritsidwa ntchito, mabatani okhazikika amapangidwa pakati pazigawo za mankhwala ndi mapuloteni a plasma (ndi 90% kapena kuposa). Pa oxidative biotransfform, kagayidwe kokwanira ka glimepiride kumachitika. Zotsatira zake, zotumphukira za carboxyl ndi cyclohexyl hydroxymethyl zimapangidwa.

Ma metabolites amuchotsa mkodzo (60%) ndi ndowe (40%). Izi zimachitika mkati mwa masiku 7. Hafu ya moyo imatenga pafupifupi maola 8.

Zizindikiro ndi contraindication

Pofuna kupewa zovuta ndi zovuta chifukwa chogwiritsa ntchito mankhwalawa, malangizo awo ayenera kuyang'aniridwa. Izi ndizowona makamaka kwa mankhwala opangidwa kwa odwala matenda ashuga.

Dokotala ayenera kuthana ndi mankhwala, ndipo izi ziyenera kuchitika pokhapokha ngati mwatsatanetsatane mayeso. Kugwiritsa ntchito mankhwala Glimepiride saloledwa popanda chifukwa.

Izi zimapangidwira odwala omwe ali ndi matenda ashuga a 2. Itha kugwiritsidwa ntchito yokha kapena kuphatikiza ndi mankhwala ena ochokera pagululi. Chithandizo cha glimepiride ndizofala kwambiri ndi mankhwala okhala ndi metformin.

Ndizofunikanso popereka mankhwala kuti agwirizane ndi contraindication. Ndi chifukwa cha iwo kuti m'malo motukuka, zovuta zimatha kubuka.

Kugwiritsa ntchito glimepiride ndizoletsedwa pamilandu monga:

• tsankho kwa zigawo zikuluzikulu;
• matenda ashuga ketoacidosis;
• mtundu 1 matenda a shuga;
• kwambiri aimpso kuwonongeka;
• matenda apamwamba a chiwindi;
• matenda a shuga (kapena precoma);
• zaka za ana;
• nthawi yapakati;
• yoyamwitsa.

Izi zophwanya malamulo ndizokhwima. Ngati alipo, mankhwalawa ayenera kusinthidwa ndi wothandizira wina.

Mosamala, glimepiride amalembera:

• chiwopsezo cha kukhala ndi hypoglycemia;
• matenda am'mimba (matumbo kutsekereza);
• Kusintha kwakukhudzidwa kwa moyo wa wodwalayo (kuchuluka / kuchepa kwa zochitika zolimbitsa thupi, kukana zizolowezi zoipa, kusintha kwa zakudya).

Muzochitika izi, dokotala amayang'anira kuwongolera kwa chithandizo. Wodwala mwiniyo akuyenera kudziwitsa katswiri wazinthu zonse zomwe zimasokoneza, chifukwa zimatha kuwonetsa zovuta zomwe zimachitika chifukwa cha mankhwalawo.

Malangizo ogwiritsira ntchito

Kugwiritsa ntchito bwino kwa matenda ashuga ndi chida ichi kumatengera momwe mlingo umasankhidwa. Katswiri ayenera kuchita izi posanthula mawonekedwe a moyo wa wodwalayo. Koma choyimira chachikulu ndi shuga.

Kumayambiriro kwa mankhwala ndi glimepiride, tikulimbikitsidwa kumwa 1 mg patsiku. Muyenera kuchita izi musanadye chakudya cham'mawa kapena nthawi ya chakudya. Piritsi amayenera kuti azimwa. Pokhapokha poti pakhale zovuta, muyezo ungathe kuchuluka. Kuchuluka kwazomwe zimagwira ntchito sikuyenera kupitirira 6 mg pa tsiku.

Kuchulukitsa mlingo kuyenera kuchitika pang'onopang'ono, kuyang'ana zotsatira za kuyesedwa kwa magazi. Mutha kuwonjezera 1 mg pa sabata (kapena ngakhale awiri). Ngati zotsatira zoyipa zapezeka, kugwiritsa ntchito mankhwalawa kuyenera kutayidwa.

Malangizo apadera

Mankhwala amafunika kusamalidwa pokhudzana ndi odwala ena:

1. Amayi pa nthawi yoyembekezera. Glimepiride imatha kusokoneza mayendedwe am'mimba ndikukhazikika kwa mwana wosabadwayo, chifukwa chake, panthawiyi, wodwala akulimbikitsidwa kulandira chithandizo cha insulin.
2. Amayi oyamwitsa. Kufufuza m'derali kwachitika pang'ono, koma pali umboni wa kuthekera kwa kulowa kwa chinthucho mkaka wa m'mawere. Izi zimabweretsa chiwopsezo kwa mwana, chifukwa chake, pakubala, shuga iyenera kulamulidwa ndi njira zina.
3. Ana. Muubwana ndi unyamata, mankhwalawa amatsutsana. Kugwiritsa ntchito kololedwa kokha kuyambira wazaka 18.

Izi zimatha kugwiritsa ntchito mankhwalawa mosamala, kusasamala kungayambitse zovuta.

Matenda onga amakhalanso chifukwa chokana kugwiritsa ntchito glimepiride.

Mankhwalawa angayambitse kupita patsogolo kwa mitundu inayake ya matenda, monga:

• matenda oopsa a chiwindi;
• zoopsa kwambiri mu ntchito ya impso;
• zosokoneza mu endocrine system;
• kuvulala
• magwiridwe;
• matenda omwe amayambitsa matendawa.

Ndi kupatuka koteroko, adokotala ayenera kusankha chida china chothandizira kuti shuga asakhale bwino.

Zotsatira zoyipa ndi bongo

Glimepiride imatha kuyambitsa zovuta zina.

Mwa iwo amatchulidwa:

• zotupa pakhungu;
• urticaria;
• kuphwanya kwam'mimba;
• nseru
• kupuma movutikira
• kuchepetsa kupsinjika;
• jaundice
• thupi lawo siligwirizana;
• masomphenya osalala.

Ngati atapezeka, wodwalayo ayenera kufunsa dokotala. Ndi mawonekedwe owopsa kwambiri, mankhwalawa amachotsedwa. Nthawi zina, amaloledwa kupitiliza chithandizo - ngati zovuta zake zimakhala zopanda pake komanso zopanda ntchito.

Ndi bongo wa mankhwala, hypoglycemia imayamba.

Zimaphatikizidwa ndi zizindikiro monga:

• kugona
• kukokana
• mavuto ndi mgwirizano wamagulu;
• kugwedezeka
• nseru

Zikatero, ndikofunikira kutsuka m'mimba ndikugwiritsa ntchito adsorbents. Woopsa, chithandizo cha kuchipatala chingafunike.

Kuyanjana Ndi Mankhwala Ndi Analogi

Chofunikira kwambiri pakugwiritsa ntchito mankhwala aliwonse ndi kuphatikiza kwake koyenera ndi mankhwala ena.

Mukamagwiritsa ntchito glimepiride, ndikofunikira kumvetsetsa kuti magulu ena a mankhwalawa amatha kuwonjezera kapena kufooketsa mphamvu yake. Izi zikutanthauza kuti mukamamwa mankhwalawa, muyenera kusintha mlingo wake.

Kuchepetsa kuchepetsa kwa glimepiride ndikofunikira mukamagwiritsidwa ntchito limodzi ndi magulu monga:

• ATP zoletsa;
• othandizira a hypoglycemic;
• insulin;
• yaitali akuchita sulfonamides;
• Mao zoletsa;
• salicylates;
• anabolic steroids etc.

Magulu ena a mankhwala amachepetsa mphamvu ya mankhwalawa, chifukwa cha iwo muyenera kuwonjezera kuchuluka kwake.

Izi zikuphatikiza:

• glucagon;
• barbiturates;
• glucocorticosteroids;
• mankhwala othandizira;
• nicotinic acid;
• estrogens;
• okodzetsa.

Simungasinthe mlingo wa mankhwalawo. Izi zikuyenera kuchitika ndi katswiri, chifukwa ndi iye yekha yemwe angayang'anire zofunikira zonse.

Popanda kulekerera glimepiride, wodwala amatha kutha ndi mankhwala ena omwe ali ndi vuto lofananalo:

1. Glimax. Mankhwalawa ali ndi mawonekedwe ofanana ndi zomwe zikuchitika.
2. Dimaril. Maziko a mankhwalawa ndi glimepiride.
3. Glidiab. Chithandizo chogwira mankhwalawa ndi Gliclazide. Zimakhudzanso matupi a odwala chimodzimodzi.

Mukasinthana ndi mankhwala ena, kusamala ndikofunikira, popeza zochita zotere zimatha kusokoneza thanzi lanu. Popanda kukaonana ndi katswiri, izi ndizoletsedwa.

Kanema wokhudza matenda a shuga, mitundu yake, zizindikiro ndi chithandizo:

Maganizo a odwala

Kuchokera pa ndemanga za odwala omwe akutenga Glimepiride, titha kunena kuti mankhwalawa amachepetsa shuga komanso mtengo wake umakhala wotsika kwambiri kuposa mankhwala ambiri a analog, komabe, zovuta zake ndizofala mokwanira, motero ndikofunika kumwa mankhwalawo moyang'aniridwa ndi katswiri.

Adotolo adandiuza Glimepiride pamodzi ndi Metformin. Izi zathandiza kuti matendawa azikhala shuga. Kuchulukitsa ndikungotsutsana ndi kadyedwe. Zikatero, ndimawonjezera mlingo wa Glimepiride kuchokera 2 mpaka 3 mg, ndiye kuti zonse zili mu dongosolo. Chithandizo ichi chimandiyenerera, sindinawonepo zoyipa zilizonse. Mwa zabwino - ndachepa thupi, pachithunzicho kusiyana maonekedwe ndikodabwitsa.

Marina, wazaka 39

Ndinkakonda kutenga Amaril, ndiye idasinthidwa ndi Glimepiride yotsika mtengo. Pa mlingo womwewo, zotsatira zake zinali zopanda mphamvu - shuga sanachepe. Dokotala amayenera kuwonjezera mlingo mpaka 6 mg. Ndibwino, koma zimandivutitsa kuti ndiyenera kumwa mankhwala ochuluka. Koma sindingakwanitse kugula Amaril.

Lyudmila, wazaka 48

Mankhwalawa ndi abwino, ngakhale sizinali zophweka kuti ndizizolowere. Chifukwa cha zovuta zina, adotolo adaganiza kuti ndimamwa zoposa zofunika. Koma kenako mavuto onse amachoka, mkhalidwewo umakhala wolimba, palibenso ma glucose enanso. Kutenga glimepiride ndinazindikira kuti kutsatira malangizowa ndikofunikira kwambiri.

Eugene, wazaka 56

Mtengo wa mankhwalawa umatengera kuchuluka kwa zomwe zimagwiritsidwa ntchito pamapiritsi. Imatha kukhala ma ruble 160 mpaka 450.