Insulin glargine ndi analogue ya human pancreatic hormone, yomwe imapezeka mwa kubwezeretsanso mabakiteriya a DNA amtundu winawake.
Amadziwika ndi kusungunuka pang'ono m'malo osaloledwa. Ichi ndiye chinthu chachikulu cha mankhwala otchedwa Lantus.
Mankhwalawa ali ndi mphamvu ya hypoglycemic ndipo amagwiritsidwa ntchito kuwongolera kagayidwe ka shuga. Nkhani yotsatirayi ili ndi chidziwitso chokwanira chokhudza mankhwalawa Lantus, fanizo lomwe limapezekanso pano.
Kufotokozera kwa mankhwalawa
Amagwiritsidwa ntchito ngati wodwala ali ndi matenda a shuga, omwe amayenera kuthandizidwa ndi insulin. Makamaka, mankhwalawa amalembera achikulire, achinyamata ndi ana opitilira zaka ziwiri. Wothandizira wa hypoglycemic palokha amawoneka ngati madzi owoneka bwino komanso opanda khungu.
Insulin lantus
Pambuyo pakulowetsedwa pansi pa khungu, acidic reaction yothetsera vutoli sinatheretu, zomwe zimapangitsa kuti ma microprecipitate, omwe magawo ochepa a insulin glargine amasulidwe. Zomwe zimagwira zimasinthidwa kukhala ma metabolites awiri ogwira ntchito M1 ndi M2.
Pakadali pano, kugwiritsa ntchito bwino mankhwalawa kwatsimikiziridwa. Mu makanda opitirira zaka ziwiri ndi matenda amtundu 1, kukhala bwino bwino kumatha bwino pambuyo pa kuwongolera.
Contraindication
Mankhwala osavomerezeka kuti agwiritsidwe ntchito ndi:
- kukhudzika kwakukulu pazogwira mankhwala;
- ana ochepera zaka ziwiri;
- ndi chenjezo kwa akazi mu magawo onse a mimba.
Zotsatira zoyipa
Chimodzi mwazotsatira zoyipa kwambiri zogwiritsa ntchito mankhwalawa ndi hypoglycemia.
Zimayimira zomwe zimachitika kawirikawiri mthupi ku insulin. Izi ndizotheka poyerekeza ndi momwe kuchuluka kwa timadzi timeneti kumakhala kwakukulu kwambiri poyerekeza ndi zosowa zathupi.
Zizindikiro za matendawa zimawonekera mwadzidzidzi. Koma, kawirikawiri zovuta za neuropsychiatric motsutsana ndi maziko a mitsempha ya neuroglycopenia zimayambitsidwa ndi zizindikiro za adrenergic counterregulation.
Momwe mungalowere?
Mankhwalawa amadziwika ndi nthawi yayitali, motero, ndikofunikira kuyisankha kuposa, mwachitsanzo, ena a Lantus insulin analogues. Amalandira odwala omwe amadwala matenda a shuga omwe amadalira insulin, ndipo pankhaniyi tikulankhula osati za mtundu woyamba wa matenda.
Ma analogu ofala kwambiri omwe amalowa m'malo mwa insulin Lantus ndi Novorapid, Humalog, ndi Apidra.
Lantus, monga fanizo lina la insulin, limayendetsedwa ndi jekeseni wa subcutaneous. Cholinga sichinapangidwe kuti athandizidwe kukonzekera mtsempha.
Mukanyalanyaza lamuloli ndikulidziwitsa, mutha kupangitsa kuti kuchitika kwa hypoglycemia. Iyenera kuyambitsidwa ndi mafuta m'mimba, mapewa kapena matako.Ndikofunika kuti musaiwale kuti simungabaye jakisoni wa insulin pamalo omwewo, chifukwa izi ndizodzala ndi mapangidwe a hematomas.
Ma analogi a Lantus, ngati iyemwini, siwoyimitsidwa, koma yankho loonekeratu.
Ndikofunika kufunsa dokotala wanu za kugwiritsa ntchito mankhwalawo osagwiritsa ntchito mankhwalawo, koma mawonekedwe ake otchuka, omwe ali ndi zotsatira zofanana.
Analogi
Pofuna kuthana ndi chiwonetsero choyipa cha matenda ashuga, akatswiri amapereka mankhwala a Lantus ndi mawonekedwe ake otchuka. Kwazitali kwambiri, mankhwalawa mwapang'onopang'ono adadziwika ndipo pakadali pano amadziwika kuti ali oyamba pakulimbana ndi kuphwanya kwa dongosolo la endocrine.
Maubwino angapo a mahomoni opanga ma pancreatic:
- Ndiwothandiza kwambiri ndipo amatha kuchepetsa chiwonetsero cha matenda ashuga;
- ili ndi mbiri yabwino kwambiri yachitetezo;
- yosavuta kugwiritsa ntchito;
- mutha kulunzanitsa jakisoni wa mankhwala ndi chinsinsi chake cha mahomoni.
Mankhwala a mankhwalawa amasintha nthawi yowonetsedwa ndi mahomoni amunthu a kapamba kuti apatse munthu njira yothandizira matupi awo komanso chithandizo chokwanira kwa wodwala yemwe ali ndi vuto la endocrine.
Mankhwalawa amathandizira kukwaniritsa muyeso wolondola pakati pa zoopsa za kutsika kwa shuga wamagazi ndikukwaniritsa gawo la glycemic.
Mankhwala Humalog
Pakadali pano, pali mitundu ingapo yamomwe imafanana ndi mahomoni amunthu pancreatic:
- ultrashort (Humalog, Apidra, Novorapid Penfill);
- nthawi yayitali (Lantus, Levemir Penfill).
Mankhwala okhathamira omwe adakhalapo Lantus Solostar, nawonso - Tciousba amadziwika kuti ndiodziwika kwambiri.
Lantus kapena Tresiba: zili bwino?
Poyamba, muyenera kuganizira za aliyense payekhapayekha. Mankhwala othandizira omwe amapezeka Tresiba ndi insulin degludec. Monga Lantus, ndi analogue of the pancreatic homoni. Chifukwa cha ntchito yopweteka kwambiri ya asayansi, mankhwalawa adalandiranso zinthu zina zapadera.
Kuti apange, ma biotechnologies apadera a DNA omwe adapangidwanso adagwiritsidwa ntchito ndikuphatikizira gawo la Saccharomyces cerevisiae, ndipo mawonekedwe a maselo a insulin a anthu adasinthidwa.
Mankhwala a Tresiba
Pakadali pano, mankhwalawa amatha kugwiritsidwa ntchito ndi odwala, omwe ndi oyamba komanso achiwiri a shuga. Ndikofunikira kudziwa kuti ili ndiubwino wina poyerekeza ndi ma insulin ena, omwe alipo ambiri.
Malinga ndi malonjezo opanga, palibe hypoglycemia iyenera kuchitika pogwiritsa ntchito mankhwala a Tresib.Palinso mwayi wina wa mankhwalawa: kusinthika kocheperako pamlingo wa glycemia masana. Mwanjira ina, pamankhwala ochiritsira omwe mumagwiritsidwa ntchito ndi mankhwala a Tciousba, m'magazi a shuga mumakhala maola makumi awiri ndi anayi.
Uwu ndi mwayi wamtengo wapatali kwambiri, chifukwa kugwiritsa ntchito analogi iyi ya Lantus kumakupatsani mwayi woti musaganize za insulin osati masana, komanso usiku.
Koma chida ichi chili ndi phindu limodzi: sizikulimbikitsidwa kuti zigwiritsidwe ntchito ndi anthu azaka zosaposa khumi ndi zisanu ndi zitatu, amayi apakati komanso oyembekezera. Sizingathe kutumikiridwa ndi jakisoni wamkati. Kugwiritsa ntchito kwapansipansi kokha ndi kololedwa.
Ponena za Lantus, zabwino zake zonse zafotokozedwa pamwambapa. Koma ngati titha kufanana pakati pa ma insulin, titha kunena kuti kuchuluka kwa hemoglobin kumatsika kwakukulu ndikugwiritsa ntchito mankhwala a Tresib kuposa Lantus. Ndiye chifukwa chake kufanana kwa zinthu zomaliziraku nkothandiza kwambiri.
Lantus analogues ku Russia
Pakadali pano, mdziko lathu ma fanizo odziwika kwambiri a insulin iyi omwe amapanga anthu insulin ndi Tresiba ndi Detemir (Levemir).
Mankhwala Levemir
Popeza zabwino za Tresiba zafotokozedwa pamwambapa, mawu ochepa ayenera kunena za Levemir. Amadziwika kuti ndi analogue yopanda pake ya insulin yaumunthu ya nthawi yayitali, yomwe imayendetsedwa kamodzi kapena kawiri patsiku.
Pakadali pano, Levmir amagwiritsidwa ntchito poyambitsa matenda a insulin a 2 matenda a shuga. Imatha kupereka ndikusungitsa kuchuluka kwa insulin m'magazi. Izi zimakuthandizani kuti muzilamulira glycemia.Mwa zabwino za analogue iyi ndikuti imatsimikizira chiopsezo chochepa cha shuga m'magazi mwa anthu.
Kuphatikiza apo, ponena za phindu lake usiku, poyerekeza ndi mankhwala ena, zimakupatsani mwayi wosankha mlingo wokwanira kuti mupeze ndende ya plasma yomwe mukufuna. Kuphatikiza apo, samakwiyitsa makilogalamu owonjezera.
Za nthawi ya chithandizo, zimatengera mlingo. Choyamba, muyenera kugwiritsa ntchito Levemir kamodzi patsiku. Mlingo woyambirira wa odwala omwe sanalandire insulin m'mbuyomu ali ndi magawo 9 kapena mayunitsi a 0,1-0.2 / kg okhala ndi thupi labwinobwino.
Makanema okhudzana nawo
Kufotokozera mwatsatanetsatane ndi malingaliro pakugwiritsira ntchito insulin Lantus mu kanema:
Opanga Lantus sakhala mdziko limodzi, koma awiri - Germany ndi Russia. Itha kugulidwa ku malo ena ogulitsa, koma posachedwapa ma analogi ake kapena chophatikizika chokha chimagwiritsidwa ntchito nthawi zambiri. Izi ndichifukwa choti posachedwapa mankhwalawo akhala ovuta kwambiri kupeza. Ku Lantus, njira yachilatini nthawi zambiri imawoneka motere: "Lantus 100 ME / ml - 10 ml".
Kuchiza kwambiri pogwiritsa ntchito mankhwalawa kumatha kupititsa patsogolo thanzi labwino ndikuwongolera glycemia mwa anthu omwe ali ndi mitundu yonse ya matenda a shuga. Ndikofunikira kuyandikira phwando mosamala kuti pasakhale zovuta zina. Onetsetsani kuti mukutsatira mlingo womwe dokotala wakupatsani kuti mupewe zovuta zosiyanasiyana komanso zovuta zomwe mungagwiritse ntchito.
