Wothandizira antidiabetesic kwa labeta ya Baeta ndi a gulu la agretists ndipo amathandizira kuyendetsa shuga mwa odwala omwe ali ndi mtundu II matenda a shuga.
Incretin ndi mahomoni opangidwa ndi mucosa wamatumbo poyankha kudya, kotsitsimutso wa insulin secretion.
Kupanga kwa Byet kumakupatsani mwayi wolimbana ndi matenda osokoneza bongo omwe samadalira insulin m'njira zingapo nthawi imodzi.- Amalepheretsa kubisalira kwa glucagon wa mahomoni, omwe amachititsa kuti shuga azikhala mthupi.
- Imalimbikitsa ma pancreatic β-cell kuti atulutse insulin mwachangu.
- Zimalepheretsa kutulutsa chakudya m'mimba, kupewa kutulutsa shuga m'magazi.
- Mwachindunji amawongolera malo osungirako satiety ndi njala, akuletsa chidwi.
Njira izi zimathandizira kuchepetsa kuchuluka kwa zakudya zomwe zimamwetsa, kulola wodwala matenda ashuga kuti achepetse thupi komanso kupewa kudumpha mumagazi a glucose, kuisunga pakulimbitsa thupi.
Pakadali pano, akatswiri akuwunika momwe ma incretin mimetics amathandizira ndi ma coronary system. Kafukufuku wazinyama adawonetsa kuti kugwiritsa ntchito mankhwala a kalasi ya insretin kumabweretsa kubwezeretsanso kwakanthawi kwa maselo owonongeka a pancreatic β-cell.
Opanga
Wopanga mankhwala a Beat ndi kampani ya Eli Lilly ndi Company drug, yomwe idakhazikitsidwa mu 1876 ku Indianapolis (USA, Indiana).Iyi ndi kampani yoyamba kupanga mankhwala ku insulin mu 1923.
Kampaniyo imapanga ndikupanga mankhwala kwa anthu omwe amagulitsidwa bwino m'maiko opitilira zana, ndipo m'maiko 13 muli mafakitale omwe amapanga.
Kuwongolera kwachiwiri kwa kampani ndikupanga mankhwala pazofunikira za mankhwala azowona zanyama.
Kupanga
Wothandizira yogwira mankhwalawo ndi ma 250 micrograms a exenatide.
Zowonjezera ndi sodium acetate trihydrate, glacial acetic acid, mannitol, metacresol ndi madzi a jakisoni.
Baeta imapezeka m'mapensulo otayidwa ndi jakisoni wosabala wa jekeseni pakhungu pakatha mphindi 60 asanadye m'mawa ndi madzulo.
Baeta - 5 mcg
Zizindikiro
Baeta akulimbikitsidwa pochiza matenda osokoneza bongo omwe amadalira shuga (mtundu II) kuti athandizire kuyendetsa glycemic:
- mu mawonekedwe a monotherapy - motsutsana ndi maziko a okhwima otsika carb zakudya ndi zotheka zolimbitsa thupi;
- kuphatikiza mankhwala:
- kuwonjezera pa mankhwala ochepetsa shuga (metformin, thiazolidinedione, zotumphukira za sulfonylurea);
- ntchito metformin ndi basal insulin.
Pankhaniyi, zochokera ku sulfonylurea zingafune kuchepetsedwa. Mukamagwiritsa ntchito Byeta, mutha kuchepetsa yomweyo pofika 20% ndikusintha moyang'aniridwa ndi glycemia.
Kwa mankhwala ena, njira yoyambira yoyendetsera singasinthidwe.
Boma, mankhwala ampretin kalasi amalimbikitsidwa kuti aphatikizidwe pamodzi ndi othandizira ena a hypoglycemic kuti athandizire kuchitapo kanthu komanso kuti achedwetse nthawi yoika insulin.
Kugwiritsa ntchito exenatide sikumawonetsedwa kwa:
- munthu atengeke kwambiri ndi zinthu zomwe mankhwala amakhala;
- insellinus wodwala matenda a shuga (mtundu I);
- decompensated aimpso kapena chiwindi kulephera;
- matenda am`mimba dongosolo, limodzi ndi paresis (yafupika contractility) m'mimba;
- mimba ndi mkaka wa m`mawere;
- pachimake kapena kapamba wam'mbuyomu.
Osamawalembera ana mpaka atakula.
Pafupipafupi zochitika zoyipa mukamagwiritsa ntchito Byet ndi 10 mpaka 40%, zimawonetsedwa makamaka kusanza komanso kusanza koyambira. Nthawi zina zimachitika mdera lanu.
Mitu ya mankhwalawa
Funso lolowetsa Bayet ndi mankhwala ena, monga lamulo, lingabuke potsatira zotsatirazi:
- mankhwalawa samachepetsa shuga;
- zoyipa zimawonekera kwambiri;
- Mtengo ndiwokwera kwambiri.
Mankhwala a Baeta opanga - mankhwala omwe amatsimikiziridwa achire komanso kufanana kwachilengedwe - satero.
Zofananira zake zonse pansi pa layisensi yochokera ku Lilly ndi Company zimapangidwa ndi Bristol-Myers squibb Co (BMS) ndi AstraZeneca.
Mayiko ena amagulitsa Byetu pansi pa chida cha mankhwala a Bydureon.
Baeta Long ndi wothandizirana ndi hypoglycemic yemwe ali ndi zomwezi (exenatide), zotenga nthawi yayitali. Mtheradi wokwanira wa Baeta. Njira yogwiritsira ntchito - jekeseni imodzi yamavuto masiku 7 aliwonse.
Gulu la mankhwala ochepetsa mphamvu ya intretin limaphatikizanso Victoza (Denmark) - mankhwala ochepetsa shuga, chogwira ntchito ndi liraglutide. Mwa achire katundu, zikuwonetsa ndi contraindication, ndizofanana ndi Baete.
Agonists a Incretin ali ndi mtundu umodzi wokha wa mankhwala - jakisoni.
Gulu lachiwiri la gulu la mankhwala ampretin limayimiriridwa ndi mankhwala omwe amaletsa kupanga kwa enzyme dipeptidyl peptidase (DPP-4). Amakhala ndi ma molekyu osiyanasiyana.
Zoletsa za DPP-4 zimaphatikizapo Januvia (Netherlands), Galvus (Switzerland), Transgenta (Germany), Ongliza (USA).
Monga Baeta ndi Victoza, amawonjezera insulin pakukulitsa nthawi ya ma protein, akuletsa kupanga kwa glucagon ndikuthandizanso kubwezeretsanso maselo a pancreatic.
Basi musakhudze kuchuluka kwa kumasulidwa kwam'mimba ndipo musathandizire kuwonda.
Chizindikiro chogwiritsidwa ntchito ndi gulu la mankhwalawa komanso omwe samadalira shuga-wodwala matenda a shuga (mtundu II) mwanjira ya monotherapy kapena molumikizana ndi mankhwala ena ochepetsa shuga.
Chimodzi mwazabwino ndi mtundu wawo wa mankhwala mwanjira ya mapiritsi amkamwa, omwe amakupatsani mwayi kuti mulowe mankhwalawo popanda kulowa jakisoni.
Baeta kapena Victoza: kuli bwino?
Mankhwala onsewa ndi a gulu limodzi - kaphatikizidwe kamapangidwe a incretin, ali ndi zotsatira zofanana zochizira.Koma Victoza ali ndi tanthauzo lotchuka lomwe limathandiza kuchepetsa kunenepa kwa odwala onenepa kwambiri omwe ali ndi matenda amtundu II.
Victoza ali ndi mphamvu yayitali, ndipo tikulimbikitsidwa kuti jakisoni wothandizila amapatsidwa kamodzi patsiku komanso mosasamala za kudya, pomwe Bayetu amayenera kuperekedwa kawiri patsiku ola limodzi asanadye.
Mtengo wogulitsa wa Viktoza m'mafakisi ndiwokwera.
Dokotala wothandizapo amapanga chisankho pa mankhwalawa, poganizira momwe wodwalayo alili, zovuta zake zoyipa ndikuwunika kuchuluka kwa matenda ake.
