Matenda a shuga a mellitus, chifukwa cha kukula msanga komanso kuthekera kwakukulu kwa kufa, amabweretsa vuto lalikulu kwa anthu. Pazaka 20 zapitazi, matenda ashuga alowa m'malo atatu apamwamba omwe amafa. Ndizosadabwitsa kuti matendawa amaphatikizidwa pazolinga zingapo zoyambira madokotala padziko lonse lapansi.
Mtundu wa mankhwalawa
Mankhwala Metformin-richter okhala ndi njira yayikulu yogwiritsira ntchito metformin hydrochloride amapangidwa ndi wopanga wazinthu ziwiri: 500 mg kapena 850 mg aliyense. Kuphatikiza pazinthu zoyambira, palinso zokopa zomwe zimapangidwa: Opadry II, silicon dioxide, magnesium stearate, Copovidone, cellulose, polyvidone.
Mankhwalawa amatha kuzindikiridwa ndi mawonekedwe a mawonekedwe: ozungulira (500 mg) kapena chowulungika (850 mg) mapiritsi oyera oyera mu chipolopolo amakhala ndi zotumphukira m'maselo amtundu wa zidutswa 10. Mu bokosi mutha kupeza kuchokera 1 mpaka 6 ma mbale otere. Mutha kulandira mankhwalawa kokha mwa mankhwala.. Pa Metformin Richter, mtengo wa mapiritsi 60 a 500 mg kapena 850 mg ndi 200 kapena 250 rubles. motero. Wopanga anali atatsitsa masiku a kumaliza ntchito mkati mwa zaka zitatu.
Limagwirira a zochita za mankhwala
Metformin Richter ndi wa gulu la Biguanides. Zopangira zake zoyambirira, metformin, zimatsitsa glycemia popanda kusinthitsa kapamba, motero palibe hypoglycemia pakati pamavuto ake.
Metformin-richter ili ndi njira zopangira zitatu zotsutsana ndi matenda ashuga.
- Mankhwala omwe 30% amalepheretsa kupanga glucogen m'chiwindi poletsa glucogeneis ndi glycogenolysis.
- Mankhwalawa amalepheretsa kuyamwa kwa glucose pamakoma a matumbo, kotero mafuta pang'ono amalowa m'magazi. Kumwa mapiritsi sikuyenera kukhala chifukwa chokana zakudya zamafuta ochepa.
- Biguanide amachepetsa kukana kwa maselo ku glucose, imathandizira kugwiritsidwa ntchito kwake (kwakukulu m'misempha, mochepa pamafuta).
Mankhwalawa amathandizanso kupanga kwa lipid m'magazi: mwakufulumizitsa mawonekedwe a redox, amalepheretsa kupanga kwa triglycerol, komanso kwa onse komanso "oyipa" (otsika kachulukidwe) amitundu ya cholesterol, komanso amachepetsa insulini yolimbana ndi zolandilira.
Popeza ma β-cell a islet zida omwe amapanga ma insulin amkati samakhudzidwa ndi metformin, izi sizikuwadzetsa kuwonongeka kwawo msanga komanso necrosis.
Mosiyana ndi mankhwala ena a hypoglycemic, kugwiritsa ntchito mankhwalawa nthawi zonse kumalimbikitsa. Izi ndizofunikira kwa odwala matenda ashuga ambiri, chifukwa mtundu wachiwiri wa matenda ashuga nthawi zambiri umayendetsedwa ndi kunenepa kwambiri, komwe kumapangitsa kuti glycemia iwongolere kwambiri.
Ili ndi biguanide ndi fibrinolytic zotsatira, zomwe zimakhazikitsidwa ndi kuletsa kwa plasminogen minulin inhibitor.
Kuchokera m'matumbo am'mimba, wothandizira pakamwa amakhala odzipereka kwathunthu wofika 60%. Chiwongola dzanja chake chimawonekera patatha pafupifupi maola 2,5.
Zotsalira za metabolite zimathetsedwa ndi impso (70%) ndi matumbo (30%), kuphatikiza hafu ya moyo imasiyana maola 1.5 mpaka 4.5.
Ndani akuwonetsedwa mankhwalawo
Metformin-richter imayang'aniridwa kuti ayang'anire matenda a shuga a mtundu wa 2, onse ngati mankhwala oyambira ndi magawo ena a matendawa, ngati kusintha kwamachitidwe (zakudya zamagulu ochepa, kuwongolera zochitika zamthupi ndi zochitika zolimbitsa thupi) sikuperekanso kuwongolera kwathunthu kwa glycemic. Mankhwalawa ndi oyenera kuthandizira monotherapy, amagwiritsidwanso ntchito povuta.
Zitha kuvulaza mankhwala
Mapiritsi amatsutsana ndi anthu omwe ali ndi hypersensitivity pazomwe zimapangidwira. Kuphatikiza apo, Metformin Richter sichosankhidwa:
- Ndi decompensated aimpso ndi chiwindi dysfunctions;
- Anthu odwala matenda ashuga omwe ali ndi mtima woopsa komanso kulephera kupuma;
- Amayi oyembekezera komanso oyembekezera;
- Oledzera komanso ozunzidwa ndi poizoni wambiri;
- Odwala mu mkhalidwe wa lactic acidosis;
- Pa opaleshoni, chithandizo cha kuvulala, kuyaka;
- Pa nthawi ya maphunziro a radioisotope ndi radiopaque;
- Mu kukonzanso nthawi pambuyo myocardial infarction;
- Ndi hypocaloric zakudya komanso kuchita masewera olimbitsa thupi.
Malangizo ogwiritsira ntchito
Dokotala amatenga njira yothandizira aliyense wodwala matenda ashuga payekhapayekha, poganizira zidziwitso zasayansi, gawo la chitukuko cha matendawa, zovuta zina, zaka, momwe munthu amvera pa mankhwalawo.
Kwa Metformin Richter, malangizo ogwiritsidwira ntchito amalimbikitsa kuti muyambe maphunzirowa ndi mulingo wocheperako wa 500 mg mosakakamiza motsatana ndi masabata awiri aliwonse. Mulingo woyenera kwambiri wa mankhwalawa ndi 2.5 g / tsiku. Kwa odwala matenda ashuga okhwima, omwe nthawi zambiri amakhala ndi vuto la impso, mlingo waukulu ndi 1 g / tsiku.
Mukasinthira ku Metformin Richter kuchokera pamapiritsi ena ochepetsa shuga, muyezo woyambira ndi 500 mg / tsiku. Mukakonza chiwembu chatsopano, amathandizidwanso ndi kuchuluka kwa mankhwala am'mbuyomu.
Njira yamankhwala imatsimikiziridwa ndi dokotala, ndi mawonekedwe abwinobwino amthupi, odwala matenda ashuga amatenga moyo.
Kuunikira kwa mankhwalawa ndi madokotala ndi odwala matenda ashuga
About Metformin Richter, ndemanga zimasakanikirana. Madokotala ndi odwala matenda ashuga amawona kuchuluka kwa mankhwalawa: kumathandizira kuchepetsa shuga komanso kulakalaka kudya, palibe chosokoneza, zotsatira zoyipa zochepa, kupewa mtima wamtima ndi zovuta zina.
Anthu athanzi omwe amayesera mankhwalawa kuti achepetse thupi amatha kudandaula za zotsatira zosafunikira. Malangizo pakuwongolera chiwerengero cha odwala pano ayeneranso kupangidwa ndi akatswiri azakudya, osati othandizira pa intaneti.
Osangokhala ma endocrinologists okha omwe amagwira ntchito ndi metformin, komanso akatswiri a zamankhwala, othandizira, oncologists, gynecologists, ndipo kuwunika kotsatiraku ndikutsimikizanso kwina kwa izi.
Irina, wazaka 27, St. Petersburg. Pamabwalo azisangalalo, Metformin Richter amakambirana zambiri ndi anthu odwala matenda ashuga kapena othamanga, ndipo ndinamwa kuti ndimve. Ndakhala ndikuchiza ovary yanga yotchedwa polycystic ovary, yomwe madokotala amatcha kuti imayambitsa matenda osabereka, kwa zaka pafupifupi 5. Pulogalamu ya Progesterone (jakisoni) kapena mapiritsi a mahomoni sanathandizire kuthana ndi vutoli, adaperekanso laparoscopy kuti ayambitsa thumba losunga mazira. Ndikukonzekera kuyesa ndikuchiritsa mphumu yanga - cholepheretsa pakuchita opareshoni, dokotala wina wazachipembedzo wanzeru adandiuza kuti ndiyese Metformin Richter. Pang'onopang'ono, mayendedwe adayamba kuyambiranso, ndipo miyezi isanu ndi umodzi pambuyo pake panali zizindikiro za kutenga pakati, sindinakhulupirire mayeso kapena madokotala! Ndikukhulupirira kuti mapiritsiwa adandipulumutsa, ndikulakalaka ndikukulangizani kuti muyese, ingovomerezani ndi dokotala wazamankhwala pazakudya zomwe mungadye.
Mankhwala osokoneza bongo ambiri komanso zoyipa
Kuchulukanso kakhumi pamiyeso ya metformin yomwe odzipereka adalandira muzipatala sizinayambitse hypoglycemia. M'malo mwake, lactic acidosis idayamba. Mutha kuzindikira kuti ndiwowopsa chifukwa cha kupweteka kwa minyewa ndi ma spasms, kutsitsa kutentha kwa thupi, kusokonezeka kwa magazi, kuchepa kwa mgwirizano, thupi kukomoka.
Wovutitsidwayo amafunikira kuchipatala mwachangu. Mu chipatala, zotsalira za metabolite zimachotsedwa ndi hemodialysis, ndipo chidziwitso chothandizira chimachitika ndikuwunika ntchito za ziwalo zonse zofunika.
Gawo logwira ntchito la metformin hydrochloride lili ndi umboni wolimba wa chitetezo. Koma izi zikugwira ntchito, choyambirira, kwa Glucophage yoyambirira. Zojambula zamtundu wina ndizosiyana mosiyanasiyana, maphunziro akulu pazomwe amachita bwino sanachitidwe, chifukwa chake zotsatira zake zingatchulidwe.
Pafupifupi theka la odwala matenda ashuga amadandaula za matenda a dyspeptic, makamaka panthawi yosinthira. Mukasintha mlingo pang'onopang'ono, mumwani mankhwalawo pakudya, nseru, kulumikizana ndi zitsulo ndi zopunthwitsa zomwe zingakhumudwe zimatha kupewedwa. Kuphatikizidwa kwa chakudya kumathandizanso pakugwira ntchito: mawonekedwe a metformin komanso thupi ndizabwinobwino pazinthu zopanga mapuloteni (nyama, nsomba, mkaka, mazira, bowa, masamba osaphika).
Ndingasinthe bwanji Metformin-richter
Mankhwala Metformin Richter, ma analogu amatha kukhala mapiritsi okhala ndi gawo limodzi la metformin hydrochloride, kapena mankhwala ena a hypoglycemic omwe ali ndi zotsatira zomwezo:
- Glucophage;
- Glyformin;
- Metfogamm;
- NovoFormin;
- Metformin-Teva;
- Bagomet;
- Diaformin OD;
- Metformin Zentiva;
- Forom Pliva;
- Metformin-Canon;
- Glyminfor;
- Siofor;
- Methadiene.
Kuphatikiza pa kufanana ndi kutulutsidwa mwachangu, pali mapiritsi okhala ndi mphamvu yayitali, komanso kuphatikiza kwa zinthu zingapo zogwira ntchito mumapangidwe amodzi. Kusankha kwakukulu kwa mankhwala, ngakhale kwa madokotala, sikukukulolani kuti musankhe molondola komanso mulingo woyenera, ndikuyesera thanzi lanu palokha ndi pulogalamu yodzivulaza nokha.
Ntchito ya odwala matenda ashuga ndikuthandizira kuti ntchito ya mankhwalawa ikhale yabwino kwambiri, chifukwa popanda kusintha mawonekedwe, malingaliro onse amataya mphamvu.
Upangiri wa Pulofesa E. Malysheva kwa onse omwe adotolo adamuuza metformin, pa odzigudubuza
