Galvus Met ndi njira yatsopano yothetsera matenda ashuga, zophatikizira zomwe zili mmenemo ndi vildagliptin ndi metformin. Mankhwala amatha kukonza glycemia: pagulu lolamulira chaka chothandizira, linathandiza kuchepetsa hemoglobin wa glycated ndi 1.5%. Kumwa mapiritsiwa kumapangitsa kuti mankhwalawa asungunuke kwambiri mwa kuchepetsa ma hypoglycemia nthawi 5.5. 95% ya odwala omwe adadwala adakhutira ndi mankhwalawo ndipo adaganiza zowatsatira.
Galvus ndi mtundu wina wa mankhwalawo, imangokhala ndi vildagliptin. Mapiritsi amatha kuphatikizidwa ndi metformin, zotumphukira za sulfonylurea, insulin.
Malangizo ogwiritsira ntchito
Machitidwe a Galvus amatengera zomwe zimachitika chifukwa cha ma impretins. Awa ndi mahomoni omwe amapangidwa m'thupi atatha kudya. Zimapangitsa secretion ndi kumasulidwa kwa insulin. Vildagliptin mu kapangidwe ka Galvus amachulukitsa zochita za imodzi mwazakudya - glucagon-peptide-1. Malinga ndi gulu la zamankhwala, mankhwalawo ndi a DPP-4 zoletsa.
Mankhwalawa amapangidwa ndi kampani yaku Swiss ya Novartis Pharma, kuzungulira kwazopanga konse ku Europe. Vildagliptin adalembetsa mu registry yama Russian mankhwala posachedwapa, mu 2008. Kwazaka khumi zapitazi, zopambana pakugwiritsa ntchito mankhwalawa zachuluka, zidaphatikizidwa m'ndandanda wazofunikira.
Mwachizolowezi, tsopano aliyense wodwala matenda ashuga a mtundu wa 2 atha kulandira ufulu. Mwakuchita izi, nthawi yoikidwiratu ndiyosowa, popeza mankhwalawa ndi okwera mtengo. Chithandizo chapakati cha Galvus chaka chilichonse ndi ma ruble 15,000. okwera mtengo kuposa muyezo.
Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale
- Matenda a shuga -95%
- Kuthetsa kwa mitsempha thrombosis - 70%
- Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
- Kuthana ndi kuthamanga kwa magazi - 92%
- Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%
| Machitidwe | Imayendetsa kagayidwe kazakudya kuchokera mbali zingapo: imasintha kaphatikizidwe ka insulin, imachepetsa katulutsidwe wa shuga, imachepetsa kudya kwamatumbo, imachepetsa chilimbikitso, imateteza kapamba, kuchedwetsa kufa kwa maselo a beta ndikulimbikitsa kukula kwatsopano. Metformin monga gawo la Galvus Meta imachepetsa kukana kwa insulini, imalepheretsa kaphatikizidwe ka shuga m'chiwindi ndi kulowa kwake kuchokera m'mimba. Galvus amatha kukonza mawonekedwe a lipid pamwazi, kuphatikiza ndi metformin, izi zimathandizidwa kwambiri. The bioavailability wa mankhwalawa ukufika 85%, sasintha kutengera nthawi yakudya. Malinga ndi malangizo ogwiritsira ntchito, kuchuluka kwambiri kwa chinthu m'magazi kumachitika pambuyo pa mphindi 105, ngati mapiritsiwo adatengedwa pamimba yopanda kanthu, ndipo pambuyo pa mphindi 150, ngati ndi chakudya. Vildagliptin yambiri imachotsedwamo mkodzo, pafupifupi 15% kudzera m'matumbo am'mimba, metformin imachotsedwa kwathunthu ndi impso. |
| Zizindikiro | Type 2 shuga. Chithandizo cha Galvus sichimaletsa kudya komanso maphunziro akuthupi. Itha kugwiritsidwa ntchito ngati gawo la zovuta mankhwala, sagwiritsidwa ntchito mtundu wa 1 shuga ndi ketoacidosis. |
| Contraindication | Contraindication mtheradi ndi sayanjana zimachitika zigawo zikuluzikulu za mankhwala. Kuphatikizika kwa mapiritsi kumaphatikizapo lactose, chifukwa chake samalimbikitsidwa chifukwa cha kuchepa kwa lactase. Galvus siikuperekedwa kwa ana, chifukwa momwe zimakhudzira thupi la ana sizinaphunzire. Kwa opaleshoni yokhazikika, Galvus iyenera kupukusidwa munthawi yake ndikuchotsedwa m'thupi. Musanayambe kumwa mapiritsi, odwala matenda a shuga omwe ali ndi vuto la chiwindi ndi impso ayenera kukayang'anidwanso. Kulandila Galvus Meta amaletsedwanso chifukwa chosowa madzi m'thupi, hypoxia, matenda oyambitsidwa ndi matenda osokoneza bongo, matenda ashuga, uchidakwa. Mapiritsi amathetsedwa kwakanthawi panthawi yopangira opaleshoni, kuledzera, kuyambitsa zinthu za radiopaque. |
| Kuwongolera zaumoyo | Chifukwa chakuti Galvus ikhoza kukhudza ntchito ya chiwindi, malangizo ogwiritsira ntchito amalimbikitsa kuti pakukonzekera, mulimbikitse chitetezo chamthupi. Musanamwe mapiritsi, ndibwino kuti muyesedwe kuyesa kwa chiwindi: kuyezetsa magazi kwa AcAt ndi AlAt. Maphunziro amabwerezedwa katatu pachaka choyamba chovomerezedwa. Ngati zotsatira za kuyesa kwa chiwindi ndizokwera katatu kuposa zabwinobwino, Galvus iyenera kuletsedwa. Galvus Met imawonjezera chiopsezo cha lactic acidosis. Vutoli limaphatikizidwa ndi kupuma movutikira, kupweteka m'misempha ndi m'mimba, kutsika kwa kutentha. Odwala omwe ali ndi lactic acidosis amafuna kuchipatala mwachangu. |
| Sankhani | Piritsi lililonse la Galvus lili ndi 50 mg ya vildagliptin. Imwani mapiritsi 1 kapena 2 patsiku. Mlingo umatengera kuopsa kwa matenda ashuga. Galvus Met silivomerezedwanso mapiritsi awiri. Kufikira 1000 mg ya metformin imawonjezeredwa piritsi lililonse. Mwachitsanzo, mu Galvus Met 50 + 1000 mg: vildagliptin 50, metformin 1000 mg. Mlingo wa metformin umasankhidwa molingana ndi glycemia. |
| Bongo | Kuchulukitsa kwakanayi pamlingo wololedwa kwambiri kumayambitsa edema, kutentha thupi, kupweteka kwa minofu, komanso kusamva bwino. Mankhwala osokoneza bongo osokoneza bongo asanu ndi limodzi amawonda ndikuwonjezeka kwa michere ndi mapuloteni m'magazi. Mankhwala osokoneza bongo a Galvus Meta ndi owopsa kwa lactic acidosis. Mukamatenga oposa 50 g a metformin, kusinthika kumachitika 32% ya odwala. Mankhwala osokoneza bongo amathandizidwa mosiyanasiyana, ngati ndi kotheka, mankhwalawa amachotsedwa m'magazi pogwiritsa ntchito hemodialysis. |
| Zotsatira zoyipa | Galvus imayambitsa zovuta zingapo. Zotsatira zoyipa zambiri zimakhala zofatsa komanso zosakhalitsa, chifukwa chake, sizifunikira kuthetseratu mapiritsi. Mavuto omwe angakhalepo: <10% ya odwala - chizungulire, <1% - kupweteka m'mutu, kudzimbidwa, kutupira, "0% - chiwindi cholakwika. Zotsatira za zoyipa za Galvus Meta, kuwonjezera pa kuphwanya pamwambapa, zimaphatikizanso zovuta zosakhudzidwa ndi metformin:> 10% - nseru kapena zovuta zina zam'mimba, <0.01% - zimachitika pakhungu, lactic acidosis, kuchepa magazi m'thupi. |
| Mimba ndi GV | Zoyesa zoyambirira zikuwonetsa kuti Galvus siyimasokoneza chitukuko chabwinobwino cha mwana wosabadwayo, koma chidziwitso chokwanira chogwiritsa ntchito mankhwalawa sichinadzipikebe. Kafukufuku wokhuza kutayika kwa vildagliptin mkaka sanachitike. Chifukwa chosowa chidziwitso Malangizo amaletsa kugwiritsa ntchito Galvus pa nthawi yoyembekezera komanso kudya. |
| Kuyanjana kwa mankhwala osokoneza bongo | Panalibe milandu yokhudzana ndi vildagliptin ndi mankhwala ena. Metformin imatha kusintha magwiridwe antchito akamatenga ndi mahomoni, mapiritsi opsinjika ndi mankhwala ena otchuka (mndandanda wathunthu umapezeka mumalangizo). |
| The mapiritsi | Vildagliptin kapena vildagliptin + metformin, lactose, cellulose, magnesium stearate, titanium dioxide, talc. |
| Kusunga | Galvus - zaka 2, Galvus Met - miyezi 18. |
Galvus Met
Metformin ndi mankhwala padziko lonse lapansi a matenda ashuga 2, amawerengedwa pafupifupi kwa odwala onse. Kwa nthawi yayitali yogwiritsa ntchito, sikuti mphamvu ya mankhwalawa yokha idatsimikiziridwa, komanso adapeza zotsatira zambiri zabwino pamtima, mitsempha yamagazi, magazi a lipid. Malinga ndi malingaliro a mayanjano a odwala matenda ashuga, mankhwalawa amaperekedwa pokhapokha ngati metformin sikokwanira kulipiritsa anthu odwala matenda ashuga.
Mapiritsi a Galvus Met amaphatikizidwa, amakhala ndi metformin ndi vildagliptin. Kugwiritsa ntchito mankhwalawa kumatha kuchepetsa kuchuluka kwa mapiritsi, zomwe zimatanthawuza kuti kumachepetsa chiopsezo chakusowa m'modzi wa iwo. Zoyipa za mankhwalawa ndizokwera mtengo kwa mankhwala poyerekeza ndi mlingo wina wa Galvus ndi metformin.
| Mlingo Galvus Met, mg | Mtengo wamba wa 30 tabu, ma ruble. | Mtengo wa mapiritsi 30 a Galvus ndi Glucofage yemweyo mlingo, ma ruble. | Kukweza mtengo,% |
| 50+500 | 1550 | 875 | 44 |
| 50+850 | 890 | 43 | |
| 50+1000 | 950 | 39 |
Analogs ndi choloweza
Popeza Galvus ndi mankhwala atsopano, chitetezo cha patent chimagwiranso ntchito kwa iye. Opanga ena sangatulutse mapiritsi okhala ndi zomwe zimapangidwira, mapikisano apakhomo otchipa kulibe.
DPP-4 zoletsa komanso ma incretin mimetics atha kukhala ngati a Galvus m'malo:
- sitagliptin (Januvius, Xelevia, Yasitara);
- saxagliptin (Onglisa);
- Exenatide (Baeta);
- liraglutide (Viktoza, Saksenda).
Izi zonse ndizotsika mtengo, makamaka Baeta, Viktoza ndi Saksenda. Chithandizo chokhacho cha Russia pamwambapa ndi Yasitar kuchokera ku Pharmasintez-Tyumen. Mankhwalawa adalembetsedwa kumapeto kwa chaka cha 2017, sanapezekenso m'masitolo ogulitsa mankhwala.
Wodwala akatsatira zakudya, amatenga Galvus Met pamlingo wambiri, ndipo shuga akadali wabwinobwino, ndiye kuti kapamba wayandikira kutopa. Pankhaniyi, mutha kuyesa kuphatikiza kapangidwe ka insulin ndi zotumphukira za sulfonylurea, koma zotheka, zimathandizanso. Ngati insulini yanu yatha kupangidwa, odwala matenda ashuga amafunika chithandizo cha insulin. Osachedwetsa chiyambi chake. Mavuto a shuga amapezeka ngakhale ndi shuga wambiri.
Galvus Met kapena Yanumet
Mankhwalawa onse amakhala ndi othandizira a hypoglycemic ochokera pagulu lomwelo: Galvus Met - vildagliptin ndi metformin, Janumet - sitagliptin ndi metformin. Onsewa ali ndi zosankha zomwe zingapangidwe Mlingo ndi mtengo wake wapafupi: mapiritsi 56 a Yanumet - 2600 rubles, 30 tabu. Galvus Meta - ma ruble 1550. Popeza iwonso amachepetsa hemoglobin ya glycated, kugwira ntchito kwawo kumawerengedwa ngati ofanana. Mankhwalawa amatha kutchedwa oyandikira kwambiri.
Kusiyana kwa mankhwala:
- Vildagliptin imasintha mawonekedwe a lipid pamagazi, potero amachepetsa chiopsezo cha angiopathy, sitagliptin sikuti alibe zotsatira zabwino, komanso amatha kuwonjezera cholesterol.
- Metformin silivomerezedwa bwino, tikamatenga, zotsatira zoyipa m'mimba zimawonekera. Mtundu wanthawi yayitali wa metformin umathandizira kusintha kulolerana. Ndi gawo lamapiritsi a Yanumet Long. Galvus Met ndi Yanumet amakhala ndi metformin wokhazikika.
Galvus kapena Metformin
Ku Galvus Mete, zinthu zomwe zikugwira ndizofanana. Zonsezi zimakhudza kuchuluka kwa shuga, koma zimachita zochita zawo mosiyanasiyana. Metformin - makamaka chifukwa cha kuchepa kwa insulin, vildagliptin - kuwonjezeka kwa kaphatikizidwe ka insulin. Mwachilengedwe, momwe multifactorial imathandizira pamavuto. Malinga ndi zotsatira zake, kuwonjezeredwa kwa Galvus ku metformin kumachepetsa hemoglobin ya glycated ndi 0.6% m'miyezi itatu.
Palibe nzeru kuganiza kuti Galvus kapena metformin ndiyabwino. Metformin imatengedwa kumayambiriro kwa matendawa limodzi ndi zakudya ndi masewera, a mankhwalawo, Glucofage woyambirira kapena generic yapamwamba kwambiri ya Siofor imakondedwa. Pomwe sikokwanira, Galvus amawonjezeredwa ku regimen yothandizira kapena metformin yoyera ya Galvus imasinthidwa.
Njira zotsika mtengo zotsalira ku Galvus
Mapiritsi ndi otsika mtengo kuposa a Galvus, koma omwe amatetezeka komanso othandiza pano palibe. Mutha kuchepetsa kukula kwa matenda a shuga ndi kuphunzitsidwa pafupipafupi, zakudya zamafuta ochepa, komanso metformin yotsika mtengo. Kubwezeredwa kwabwino kwa matenda ashuga, mankhwala enanso okwanira safunika.
Kukonzekera kodziwika bwino kwa sulfonyl urea, monga Galvus, kumapangitsa kaphatikizidwe ka insulin. Izi zikuphatikiza Maninil wamphamvu, koma osakhala wotetezeka, Amaryl ndi Diabeteson MV wamakono. Sangatengedwe ngati fanizo la Galvus, popeza kapangidwe ka mankhwala ndiosiyana kwambiri. Zomwe zimachokera ku sulfonylureas zimayambitsa hypoglycemia, zochulukitsa zikondamoyo, zimathandizira kuwonongeka kwa maselo a beta, kotero mukazitenga, muyenera kukhala okonzekera kuti mu zaka zochepa mudzafunika insulin. Galvus imalepheretsa kufa kwa maselo a beta, kukulitsa kugwira ntchito kwa kapamba.
Malamulo Ovomerezeka
Mlingo Wovomerezeka wa Vildagliptin:
- 50 mg kumayambiriro kwa makonzedwe, akagwiritsidwa ntchito limodzi ndi kukonzekera kwa sulfonylurea, amatenga piritsi m'mawa;
- 100 mg ya odwala matenda ashuga kwambiri kuphatikizapo insulin. Mankhwalawa amagawidwa pawiri.
Kwa metformin, mulingo woyenera kwambiri ndi 2000 mg, omwe ndi 3000 mg.
Galvus imatha kuledzera pachabe kapena pamimba yonse, Galvus Met - kokha ndi chakudya.
Kuchepetsa chiopsezo cha mavuto
Malinga ndi odwala matenda ashuga, Galvus Met amalekeredwa pang'ono kuposa metformin koyera, koma nthawi zambiri amayambitsa zovuta zam'mimba: kutsegula m'mimba, kusanza, komanso kusamva bwino m'mimba. Kukana chithandizo ndi zizindikiro zotere sikuli koyenera. Kuti muchepetse kuwopsa kwa zovuta, muyenera kupatsa thupi nthawi kuti lizolowere mankhwala. Chithandizo chimayamba ndi mlingo wocheperako, pang'onopang'ono kuwonjezerera kuti ukhale wokwanira.
Algorithm yoyeneranso kuti muwonjezere mlingo:
- Tikugula paketi ya Galvus Met ya mlingo wocheperako (50 + 500), sabata yoyamba yomwe timatenga piritsi limodzi.
- Ngati palibe vuto logaya chakudya, timasinthira ku kashiamu awiri m'mawa ndi madzulo. Simungathe kumwa Galvus Met 50 + 1000 mg, ngakhale mulinso chimodzimodzi.
- Paketi itatha, mugule 50 + 850 mg, imwani mapiritsi awiri.
- Ngati shuga akadali pamwamba pa chizolowezi, kumapeto kwa mapaketi, timasinthira ku Galvus Met 50 + 1000 mg. Simungachulukenso mlingo.
- Ngati malipiro a shuga sakwanira, timawonjezera sulfonylurea kapena insulin.
Odwala onenepa omwe ali ndi matenda ashuga amalangizidwa kuti azimwa mlingo waukulu wa metformin. Pankhaniyi, madzulo, iwo amamwa Glucofage kapena Siofor 1000 kapena 850 mg.
Ngati shuga osala kudya amakwezedwa, ndipo mutatha kudya pafupipafupi m'njira zambiri, chithandizo chimatha kusintha: imwani Galvus kawiri, ndipo Glucofage Long - kamodzi pamadzulo pa 2000 mg. Glucofage yowonjezera imagwira ntchito mwachangu usiku wonse, potero kuonetsetsa kuti glycemia imayamba m'mawa. Kuopsa kwa hypoglycemia kulibe.
Kuyenderana ndi mowa
M'mayendedwe a Galvus, mowa satchulidwa, zomwe zikutanthauza kuti mowa samakhudza magwiridwe antchito komanso samawonjezera mavuto. Koma mukamagwiritsa Galvus Meta, kuledzera ndi kuledzera kumatsutsana, chifukwa zimachulukitsa mwayi wa lactic acidosis. Kuphatikiza apo, kumamwa mowa nthawi zonse, ngakhale pang'ono, kumapangitsa kubwezeretsa shuga. Kumwa mowa osawerengeka kumawoneka kotetezeka ngati kumwa pang'ono kuli kochepa. Pafupifupi, ndi 60 g ya mowa kwa akazi ndi 90 g ya amuna.
Zokhudza kulemera
Galvus Met ilibe phindu lililonse mwachindunji, koma zonse zomwe zimagwira pakapangidwe kazake zimasintha mafuta kagayidwe ndipo zimachepetsa njala. Malinga ndi ndemanga, chifukwa cha metformin, odwala matenda a shuga amatha kutaya mapaundi ochepa. Zotsatira zabwino ndi za anthu odwala matenda ashuga omwe ali ndi kulemera kambiri komanso amatchulidwa ndi insulin.
