Insulin Rinsulin: kanthu, malangizo, mtengo

Tsopano kusankha kwa njira zomwe shuga ingalipiridwire kuli konsekonse: apa pali ma genetic engineering ndi ma insulin a masiku ano. Rinsulin ndi yekhayo mankhwala omwe adakwanitsa kutenga nawo gawo lalikulu (lopitilira 10%) kumsika wa insulin ku Russia.

Kukula kwa zinthu ndi ukadaulo woyambirira, kupanga zochulukirapo kuyambira 2004, kwachitika ndi Geropharm. Rinsulin ikupezeka m'mitundu iwiri - Rinsulin R -ulin R ndi Rinsulin NPH wocheperapo, ndipo lispro ndi glargine insulin ali pachiwongolero chazachipatala. Ubwino wa chinthucho umatsimikiziridwa ndi ma labotoreti angapo odziimira ku Europe. Malinga ndi iwo, kugwiritsa ntchito bwino kwa mankhwala athu sikwabwinonso kuposa momwe amafananitsira kunja ndi mawonekedwe omwewo.

Rinsulin P - mafomu ofotokozera ndi kumasula

Pansipa pali zambiri zokhudzana ndi mankhwalawa omwe angapereke chithunzi chonse cha insulin.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

Machitidwe

Rinsulin P imatengedwa mwachangu m'magazi kuchokera ku minyewa yokhala ndi subcutaneous, zotsatira za hypoglycemic zimayamba pambuyo pa theka la ola. Timadzi timene timalumikizana ndi ma cell receptors, omwe amalola kutulutsa kwa glucose kuchokera m'mitsempha yamagazi kupita ku minofu. Kutha kwa Rinsulin kuyambitsa kupangika kwa glycogen ndikuchepetsa kuchuluka kwa kaphatikizidwe ka shuga mu chiwindi kumakhudzanso kuchepa kwa glycemia.

Zotsatira za mankhwalawa zimatengera kuchuluka kwa mayamwidwe, ndikuti, pamakulidwe ndi magazi omwe amapezeka ndi minyewa yolumikizira malo a jekeseni. Pafupifupi, pharmacodynamics ya Rinsulin P imafanana ndi ma insulin ena apafupi:

• nthawi yoyambira ndi mphindi 30
• nsapato - pafupifupi 2 hours
• chochitika chachikulu ndi maola 5,
• kutalika kwa ntchito - mpaka maola 8.

Mutha kufulumizitsa kuchitapo kanthu ka insulin mwa kuilowetsa m'mimba kapena mkono wapamwamba, ndikuchepetsa pang'onopang'ono ndi kubayidwa patsogolo pa ntchafu.

Kuti alipire shuga ya matenda a shuga ku Rinsulin, wodwalayo ayenera kutsatira zakudya zisanu ndi chimodzi patsiku, zopangidwira pakati pa chakudya chachikulu 3 ziyenera kukhala maola 5, pakati pawo zakudya zazing'ono za 10-20 g zimafunikira.

Kupanga

Rinsulin P imangokhala ndi chinthu chimodzi chogwira - insulin yaumunthu. Amapangidwa ndi njira yobwererera, ndiye kuti, pogwiritsa ntchito ma bakiteriya osinthika ma genetic. Nthawi zambiri E. coli kapena yisiti imagwiritsidwa ntchito pazolinga izi. Popanga ndi kapangidwe kake, insulini iyi siyosiyana ndi mahomoni omwe kapamba amapanga.

Pali magawo othandiza ochepa ku Rinsulin P kuposa ma analogues. Kuphatikiza pa insulini, imangokhala ndi madzi, metacresol yosungirako komanso glycerol yokhazikika. Kumbali imodzi, chifukwa cha izi, mwayi wokhudzana ndi thupi lawo m'malo a jakisoni ndiwotsika. Komabe, kunyowa m'magazi ndi kutsika kwa shuga kwa Rinsulin kungakhale kosiyana pang'ono. Chifukwa chake, kusinthana ndi mankhwala ena omwe ali ndi mphamvu yomweyo kungatenge masiku angapo, pomwe kubwezeretsedwa kwa matenda a shuga kumakulirakulira.

Kutulutsa Mafomu

Rinsulin P ndi njira yopanda utoto, wowonekera kwathunthu, m'mililita yama 100 ya mahomoni.

Kutulutsa Mafomu:

1. Mbale zokhala ndi yankho la 10 ml, mankhwala kuchokera kwa iwo adzafunikira jekeseni wa insulin.
2. 3 ml makatiriji. Zitha kuyikidwa mu cholembera chilichonse chomwe chimapangidwira cartridge yokhazikika: HumaPen, BiomaticPen, Autopen Classic. Kuti athe kuloza muyezo weniweni wa insulin, makonda ayenera kuperekedwa kwa zolembera zama syringe ndi kuchuluka kocheperako. Mwachitsanzo, HumaPen Luxura imakuthandizani kuti mupeze mayunitsi 0,5.
3. Syringe zolembera zotayidwa Rinastra 3 ml. Kusintha cartridge mwa iwo sizotheka, gawo 1.

Malangizo ogwiritsira ntchito Rinsulin

Zotheka zosafunikira

Kuchuluka kwa zoyipa za Rinsulin ndizochepa, odwala ambiri amangodziwa hypoglycemia wofatsa.

Mndandanda wazotsatira zosafunikira malinga ndi malangizo:

1. Hypoglycemia ndiyotheka ngati mankhwalawa amawerengedwa molakwika ndipo amaposa kufunikira kwa mahomoni. Kusagwirizana ndi malangizo ogwiritsira ntchito kumapangitsanso kutsika kwa shuga: njira yolakwika ya jakisoni (insulin idalowa mu minofu), kutentha kwa malo a jekeseni (kutentha kwambiri kwa mpweya, kuponderezana, kukangana), cholembera cholakwika, syringe zolimbitsa thupi. Hypoglycemia iyenera kuthetsedwa zizindikiro zake zoyambirira zikaoneka: malaise, kugwedezeka, njala, mutu. Nthawi zambiri 10-15 g yazakudya zamafuta othamanga ndizokwanira izi: shuga, madzi, mapiritsi a shuga. Hypoglycemia ingayambitse kuwonongeka kwamitsempha yamagetsi, ndikupangitsa kukomoka.
2. Vuto lachiwiri lodziwika bwino ndi kugwidwa ndi thupi lanu. Nthawi zambiri, amawonetsedwa mwachangu kapena pakawonekanso jakisoni ndikusowa milungu ingapo atapatsidwa insulin. Ngati kuyanika kulipo, ma antihistamines akhoza kutengedwa. Ngati ziwopsezo zasintha kukhala mtundu, urticaria kapena edema ya Quincke zachitika, Rinsulin R idzasinthidwa.
3. Ngati wodwalayo akhala ndi hyperglycemia kwa nthawi yayitali, mlingo woyambirira wa insulin amawerengedwa kotero kuti shuga ya magazi imatsika bwino, wopitilira mwezi. Ndi dontho lakuthwa la glucose kukhala labwinobwino, kuwonongeka kwakanthawi kwakukhalapo ndikutheka: kusawona bwino, kutupa, kupweteka miyendo - momwe mungawerengere kuchuluka kwa insulin.

Zinthu zingapo zimasonkhezera kuchititsa insulini, chifukwa chake odwala omwe ali ndi matenda a shuga pamankhwala othandizira insulin amayenera kugwirizanirana ndi dokotala mankhwala onse, wowerengeka azitsamba komanso bioadditives omwe akukonzekera kugwiritsa ntchito.

Malangizowo amalangizanso kusamalira mwapadera magulu otsatirawa a mankhwalawa:

• mankhwala a mahomoni: njira zakulera, mahomoni a chithokomiro, glucocorticosteroids;
• mankhwala ochizira matenda oopsa: okodzetsa a gulu la thiazide, mankhwala onse omwe amatha mu -pril ndi - sartan, lazartan;
• vitamini B3;
• kukonzekera kwa lithiamu;
• tetracyclines;
• aliyense wothandizira wa hypoglycemic;
• acetylsalicylic acid;
• antidepressants.

Kulipiritsa kwa matenda a shuga amayamba kulipira ndipo mankhwalawa onse komanso zakumwa zoledzeretsa zingayambitse hypoglycemia - onani zomwe matenda obwezeretsawa amayambitsa. Mankhwala a Beta-blocker ogwiritsidwa ntchito ngati matenda a mtima amachepetsa zizindikiro za hypoglycemia ndikuletsa kuti asapezeke nthawi.

Zolemba ntchito

Pambuyo pa kuchitapo kanthu, insulin imawonongeka m'chiwindi ndi impso. Ngati wodwala matenda ashuga ali ndi matenda amodzi mwa ziwalo izi, mlingo wa Rinsulin ungafunike kusintha. Kufunika kwakukulu kwa insulin kumawonedwa munthawi ya kusintha kwa mahomoni, ndimatenda opatsirana, malungo, zoopsa, kupsinjika, kutopa kwamanjenje. Mlingo wa mankhwalawa ukhoza kukhala wolakwika ngati wodwala matenda ashuga asanza, amatsegula m'mimba, komanso kutupa m'mimba.

Ma fanizo odziwika kwambiri a Rinsulin R ndi Danish Actrapid ndi American Humulin Regular. Zambiri zakufufuza zikuwonetsa kuti zisonyezo za Rinsulin zili pamlingo wofanana ndi European.

Ngati kulimbana kosalekeza kumachitika, Rinsulin iyenera kusiyidwa. Nthawi zambiri, ma insulin ena aumunthu amayambitsa zomwezo, motero amagwiritsa ntchito njira za ultrashort - Humalog kapena NovoRapid.

Mtengo wa Rinsulin P - kuchokera ku ma ruble 400. pa botolo lililonse mpaka 1150 pa zolembera 5 za syringe.

Kusiyana pakati pa Rinsulin P ndi NPH

Rinsulin NPH ndi mankhwala osokoneza bongo opanga omwewo. Malinga ndi malangizo, umagwiritsidwa ntchito potipitsira shuga osala kudya. Rinsulin NPH ili ndi mfundo yomweyo yochitira zinthu, mawonekedwe omasulira, zofananira, ma contraindication ndi zovuta monga Rinsulin R. Monga lamulo, ndi insulin mitundu yonse ya insulin imaphatikizidwa - yochepa komanso yapakati. Ngati gawo lanu la mahomoni anu litasungidwa pang'ono (mtundu 2 ndi matenda ashuga), mutha kugwiritsa ntchito mankhwala amodzi okha.

Zambiri za Rinsulin NPH:

Mtengo wa botolo la Rinsulin NPH ~ 400 ma ruble., Makatoni asanu ~ 1000 ma ruble., Ma syringe pensulo ~ 1200 rubles.