Mapiritsi ambiri a hypoglycemic amathandizira kuchotsa shuga wambiri m'magazi a odwala matenda ashuga. Acarbose, gulu la α-glucosidase inhibitors, limagwira ntchito koyambirira. Zimalepheretsa kuwonongeka kwa zovuta zopezeka m'matumbo ndi chakudya, potero zimachepetsa kulowa kwa glucose m'magazi.
Acarbose amagwira ntchito kwanuko kokha, sizikhudza kapangidwe ka insulin ndi chiwindi, samathandizira hypoglycemia. Tsoka ilo, mankhwalawa sakhala otetezeka monga momwe angaoneke. Chifukwa cha zovuta zosasangalatsa zomwe zafotokozedwazi, acarbose amadziwika kuti ndi mankhwala osungirako. Amawerengera mwina ndi kusowa kwa mankhwala ena, kapena zolakwika pafupipafupi pakudya.
Kodi acarbose ndi ntchito bwanji?
Zakudya zamafuta m'zakudya zathu ndizovuta kwambiri. Kamodzi m'matumbo am'mimba, ma hydrolyzed ndi michere yapadera - glycosidases, pambuyo pake amawola monosaccharides. Mashuamu osavuta, amadzalowa mucosa wamatumbo ndikulowa m'magazi.
Acarbose mu kapangidwe kake ndi pseudosaccharide wopezeka ndi njira yachilengedwe. Imachita mpikisano ndi mashuga kuchokera ku chakudya m'matumbo apamwamba: imangiriza ma enzyme, kuwakankhira kwakanthawi mphamvu yokhoza kugwetsa chakudya. Chifukwa cha izi, acarbose imachedwetsa magazi kulowa m'magazi. Glucose wocheperako komanso wolumikizana bwino kwambiri amalowa m'matumbo, ndipo amachichotsa mokwanira. Glycemia imakhala yotsika, kusinthasintha kwake mukatha kudya kumachepetsedwa.
Zotsimikizika Acarbose Zotsatira:
Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale
- Matenda a shuga -95%
- Kuthetsa kwa mitsempha thrombosis - 70%
- Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
- Kuthana ndi kuthamanga kwa magazi - 92%
- Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%
- Naturalizing glycated hemoglobin, bwino kubwezeretsa kwa shuga.
- Ndi kuphwanya komwe kulipo kwa kulolerana kwa glucose ndi 25% kumachepetsa chiopsezo cha matenda a shuga.
- Zimalepheretsa matenda a mtima: chiwopsezo chimachepetsedwa ndi 24% odwala matenda ashuga, ndi 49% mwa odwala NTG.
Acarbose imakhala yothandiza kwambiri kwa odwala omwe ali ndi kudya mwachangu glycemia komanso okwera atatha kudya. Kafukufuku awonetsa kuti kugwiritsidwa ntchito kwake kumatha kuchepetsa kuthamanga kwa glucose ndi 10%, shuga atatha kudya ndi 25%, hemoglobin wa glycated ndi 21%, cholesterol ndi 10%, triglycerides ndi 13%. Pamodzi ndi glycemia, kuchuluka kwa insulin m'mwazi kumachepa. Chifukwa chotsika cha insulin ndi lipids mwa odwala omwe ali ndi matenda ashuga, kukana insulini komanso chiopsezo cha atherosulinosis kumachepetsedwa, kuchepa thupi kumathandizidwa.
Acarbose wagwiritsidwa ntchito ngati hypoglycemic kwazaka zopitilira 20. Ku Russia, ndi mankhwala amodzi okha omwe ali ndi mankhwalawa omwe adalembetsa - Glucobai ku kampani yaku Germany ya Bayer Pharma. Mapiritsiwo ali ndi 2 Mlingo - 50 ndi 100 mg.
Zisonyezero zamankhwala
Ndi matenda a shuga, acarbose akhoza kulembedwa:
- Ngati matendawa ndi ofatsa, koma zakudya sizimatsatiridwa nthawi zonse, kapena sikokwanira kusintha shuga.
- Kuphatikiza pa Metformin, ngati insulin yanu imapangidwa mokwanira.
- Ngati chakudyacho chimapereka glycemia wabwinobwino, koma owonjezera a triglycerides amapezeka m'magazi.
- Odwala omwe amalimbitsa thupi kwambiri m'malo mwa sulfonylurea, chifukwa nthawi zambiri amayambitsa hypoglycemia.
- Ndi mankhwala a insulin, ngati sizithandiza kuchotsa shuga yemwe akukula msanga mukatha kudya.
- Kuchepetsa mlingo wa insulin yochepa.
Glucobai imagwiritsidwanso ntchito pakuchepetsa thupi, ngakhale kuti malangizo omwe angagwiritsidwe ntchito samawonetsa zotsatira za mankhwalawa.
Mankhwala sangathe kumwa pazochitika zotsatirazi:
| Contraindication | Chifukwa choletsa |
| Ana m'badwo | Kafukufuku wokhudzana ndi chitetezo cha acarbose m'magulu awa odwala sichinachitike. |
| Mimba, GV | |
| Matenda ogaya kwambiri, kuphatikiza omwe ali kunja kwa gawo la kufalikira. | Mankhwalawa amagwira ntchito m'matumbo, chifukwa chake mavuto omwe amayamba kugaya kapena kuperewera kwa michere amakhudzanso mphamvu yake. |
| Matenda omwe amaphatikizidwa ndi kuchuluka kwa mpweya m'matumbo. | Kusungidwa kwa chakudya cham'mimba m'matumbo am'magazi kumathandizira kwambiri kuzizwitsa. |
| Kulephera kwina ngati GFR <25. | Gawo limodzi mwa magawo atatu a acarbose amatsitsidwa kudzera mu impso, motero ayenera kukwaniritsa magwiridwe awo. |
Malangizo ogwiritsira ntchito
Momwe mungayambire kumwa Glucobay mu shuga:
- Mlingo woyambirira ndi 150 mg mu 3 mgulu waukulu. Ndikofunikira kuti acarbose alowe mu kum'mero nthawi yomweyo ndi woyamba mafuta, motero amamwa mapiritsi asanadye.
- Ngati kuchuluka sikokwanira kuteteza matenda a glycemia, mulingo wake umachulukitsidwa. Kuti muchepetse zovuta za zotsatira zoyipa, muyenera kupatsa thupi miyezi iwiri kuti muzolowere mankhwala, kenako onjezani koyamba mlingo.
- Mulingo woyenera kwambiri ndi 300 mg, wogawidwa katatu. Kwa odwala omwe ali ndi vuto lolephereka la glucose, mlingo uyu ndiwovomerezeka.
- Mlingo wapamwamba ndi 600 mg. Imafotokozedwa pokhapokha ngati wodwala matenda ashuga alibe mavuto.
Zotsatira zoyipa mukamagwiritsa ntchito Acarbose
| Pafupipafupi zochitika,% | Zochita zosafunikira malinga ndi malangizo |
| >10 | Vuto lakuchulukitsa, limatha kutsagana ndi kutulutsa, kupangira mpweya wambiri. Kukula kwa mapangidwe a gasi kumachulukitsa ndi milingo yowonjezera ya acarbose ndi kuchuluka kwa chakudya chamagulu muzakudya. |
| <10 | Kupweteka kwam'mimba, kutsekula m'mimba ndikuphwanya zakudya. |
| <1 | Kuchuluka kwa chiwindi michere. Kuphwanya kumeneku kumatha kutha pakokha, chifukwa chake simuyenera kusokoneza chithandizo mwachangu, poyamba ndikokwanira kuwongolera ntchito ya chiwindi. |
| <0,1 | Kutupa, nseru, kusanza, kupweteka m'mimba. |
| milandu yokhayokha | Kusintha kwa kapangidwe ka magazi, kuchepa kwa magazi, kupindika kwamatumbo, hepatitis. Ziwengo kwa mapiritsi. |
Ndi mankhwala osokoneza bongo a acarbose, kuwopsa kwa zoyipa m'mimbamo ya m'mimba kumawonjezera kwambiri, kutsekula m'mimba nthawi zambiri kumachitika. Popewa mavuto, maola 6 otsatira amangodya chakudya chopatsa thanzi chopatsa thanzi ndi zakumwa. Munthawi imeneyi, ambiri mwa mankhwalawa amatha kutuluka m'thupi.
Kugwiritsa ntchito Acarbose Glucobai pakuchepetsa thupi
Mukamamwa ma acarbose, ena mwa zakudya zamafuta alibe nthawi yophulika ndipo amachotsedwa m'thupi ndi ndowe, ndipo kudya calorie kumachepetsedwa. Adayesa kugwiritsa ntchito malowa koposa kamodzi chifukwa chochepetsa thupi, ngakhale maphunziro adachitidwa pakugwiritsa ntchito mankhwalawa pofuna kuchepetsa thupi. Odwala omwe ali ndi matenda ashuga, kuyambitsidwa kwa acarbose mu regimen yamankhwala kumapangitsa kuti muchepetse kulemera kwa 0,4 kg. Nthawi yomweyo, caloric kudya komanso kuchuluka kwa mitolo idakhalabe yomweyo.
Zinapezekanso kuti kugwiritsa ntchito Acarbose pakuchepetsa thupi ndizothandiza kwambiri kuphatikiza ndi zakudya komanso masewera. Pano, phunziroli linkachitika mwa anthu athanzi. Zotsatira zake zinali zolimbikitsa: kupitirira miyezi isanu, odwala adachepetsa BMI yawo ndi 2.3, pagulu lolamulira popanda acarbose - 0,7 yokha. Madokotala amati izi zimachitika chifukwa cha mankhwalawa. Akayamba kuchepa thupi ndi chakudya chambiri, nthawi yomweyo amalimbitsa machitidwe a nayonso mphamvu m'matumbo, flatulence kapena m'mimba akuyamba. Acarbose pano amachita ngati chisonyezo cha chakudya choyenera, kuphwanya kulikonse kwa zakudya kumakhala ndi zotsatirapo zosasangalatsa.
Zitha kusintha
Glucobai ilibe mndandanda wathunthu. Kuphatikiza pa acarbose, gulu la cy-glucosidase inhibitors limaphatikizanso zinthu monga voglibose ndi miglitol. Kutengera kwa iwo, German Diastabol, Turkey Alumina, Ukraine Voksid adapangidwa. Amakhala ndi zofanana, motero amatha kuwonedwa ngati fanizo. Muzipatala za ku Russia, palibe mankhwala omwe amaperekedwa, kuti odwala matenda ashuga azikhala okha ku Glucobai kapena abweretse mankhwala ochokera kunja.
Mtengo
Acarbose sakuphatikizidwa pamndandanda wa mankhwala osokoneza bongo a Vital and Essential, chifukwa chake odwala omwe ali ndi matenda ashuga amakakamizidwa kugula Glucobay okha. Mtengo ku Russia umachokera ku 500 mpaka 590 rubles. mapiritsi 30 a 50 mg. Mlingo wa 100 mg ndiwotsika mtengo pang'ono: ma ruble 650-830. kuchuluka komweko.
Pafupifupi, chithandizo chidzafunika ma ruble 2200. kwa mwezi. M'masitolo ogulitsa pa intaneti, mankhwalawa ndi otsika mtengo pang'ono, koma ambiri mwaiwo muyenera kulipira kuti atumize.
Ndemanga za Odwala
Malinga ndi odwala matenda ashuga, Glucobai ndi mankhwala "osasangalatsa". Odwala amakakamizidwa kuti azingotsatira zakudya zamafuta ochepa, koma nthawi zina kusiya zamkaka, chifukwa lactose imathanso kubweretsa zovuta m'matumbo. Mphamvu yotsitsa shuga ya acarbose imawunikidwa bwino. Mankhwala amatha kusintha shuga pambuyo pakudya, amachepetsa kusinthasintha kwake masana.
Ndemanga kuchepetsa thupi sikuyembekeza kwenikweni. Amamwa mankhwalawa makamaka mano okoma, omwe sangachite popanda mchere kwa nthawi yayitali. Amapeza mapiritsiwo kukhala osavulaza, koma okwera mtengo kwambiri. Kuphatikiza apo, chifukwa cha zovuta, zakudya zamatumbo zimatha kudyedwa kunyumba, osawopa zotsatira zake. Poyerekeza ndi Xenical, Glucobay imalekeredwa bwino, koma zotsatira zake ndizochepa.
