Glucovans - malangizo, m'malo ndi kuwunika kwa odwala

Glucovans ndi magawo awiri okonzekera omwe ali ndi mitundu iwiri yomwe yaphunziridwa kwambiri kuchepetsa shuga, glibenclamide ndi metformin. Zinthu zonsezi zawonetsa chitetezo chawo komanso kugwira bwino kwawo maphunziro ambiri. Zimatsimikiziridwa kuti samangokulitsa shuga, komanso amachepetsa chiopsezo cha zovuta za angiopathic ndikuwonjezera moyo wa wodwala matenda ashuga.

Kuphatikiza kwa metformin ndi glibenclamide kuli ponseponse. Komabe, ma Glucovans amatha, popanda kukokomeza, amatchedwa mankhwala apadera omwe alibe ma analogues, chifukwa glibenclamide ili mwapadera, mawonekedwe owoneka ndi michere mkati mwake, omwe amachepetsa kwambiri chiopsezo cha hypoglycemia. Mapiritsi a Glucovans amapangidwa ku France ndi Merck Sante.

Zomwe zimayikidwa poika glucovans

Kuchepetsa kukula kwa zovuta za anthu odwala matenda ashuga kumatheka pokhapokha kuwongolera matenda ashuga. Chiwerengero chobwezeretsera ndalama chakhala chovuta kwambiri m'zaka makumi angapo zapitazi. Izi ndichifukwa choti madokotala anasiya kuganizira mtundu wa matenda ashuga mtundu wachiwiri kuposa matenda 1. Zakhazikitsidwa kuti uwu ndi matenda ovuta, aukali, opita patsogolo omwe amafunikira chithandizo chanthawi zonse.

Kuti mukwaniritse glycemia wabwinobwino, nthawi zambiri pamafunika mankhwala ochulukirapo a shuga. Njira yovuta yochizira ndichinthu chodziwika bwino kwa ambiri odwala matenda ashuga omwe akudziwa. Monga lamulo wamba, mapiritsi atsopano amawonjezeredwa atangomaliza omwe sakupatsanso gawo la hemoglobin ya glycated. Mankhwala oyambira ku maiko onse padziko lapansi ndi metformin. Zomwe zimachokera ku sulfonylureas nthawi zambiri zimawonjezeredwa kwa icho, chotchuka kwambiri chomwe ndi glibenclamide. Glucovans ndi kuphatikiza kwa zinthu ziwiri izi, zimakupatsani mwayi wochepetsera njira yothandizira odwala matenda ashuga, osachepetsa mphamvu yake.

Glucovans yemwe ali ndi matenda ashuga amalembedwa:

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

1. Ngati mwazindikira mochedwa matenda ake kapena mwachangu, mwamwano. Chizindikiro chakuti metformin yokhayo siyokwanira kuthana ndi matenda ashuga komanso kuti Glucovans ndiyofunikira - glucose yofulumira ya oposa 9.3.
2. Ngati pa gawo loyamba la matenda a shuga musadye chakudya chopatsa mphamvu, kulimbitsa thupi ndi metformin musamachepetse glycated hemoglobin pansipa 8%.
3. Ndi kuchepa pakupanga insulin. Izi mwina mwina labotale zimatsimikiziridwa kapena kunenedwa potengera kuchuluka kwa glycemia.
4. Ndi kulekerera bwino kwa metformin, komwe kumawonjezera nthawi yomweyo ndi kuwonjezeka kwa mlingo wake.
5. Ngati metformin yapamwamba Mlingo wambiri.
6. Pamene wodwalayo kale adatenga metformin ndi glibenclamide ndipo akufuna kuchepetsa kuchuluka kwa mapiritsi.

Zotsatira za pharmacological

Mankhwala a Glucovans ndi kuphatikiza kosakanikirana kwa othandizira awiri a hypoglycemic omwe ali ndi zotsatira zambiri.

Metformin imatsitsa shuga m'magazi mwakuwonjezera mphamvu ya minofu, mafuta, ndi chiwindi ku insulin yotulutsa. Zimakhudza kuchuluka kwa kaphatikizidwe ka timadzi tokha mwa njira zina: ntchito ya maselo a beta imayenda bwino ndi kuphatikizika kwa magazi. Komanso mapiritsi a metformin Glucovans amachepetsa kuchuluka kwa shuga ndi chiwindi (ndi matenda amtundu wa 2 shuga ndiwokwera katatu kuposa momwe zimakhalira), amachepetsa kuchuluka kwa shuga m'matumbo am'magazi kulowa m'magazi, kupatsanso matenda a lipids, ndikuthandizira kuchepa kwa thupi.

Glibenclamide, monga onse a sulfonylurea derivatives (PSM), imakhudza mwachindunji insulin ya insulin pomangirira kwa beta-cell receptors. Zowopsa za mankhwalawa ndizochepa: chifukwa cha kuchuluka kwa insulin m'magazi komanso kuchepa kwa zovuta za glucose pamisempha, kugwiritsa ntchito shuga kumapangitsa, ndipo kupanga kwake kumalepheretsa chiwindi. Glibenclamide ndi mankhwala amphamvu kwambiri m'gulu la PSM; lagwiritsidwa ntchito kwazachipatala kwazaka zopitilira 40. Madokotala tsopano amakonda mtundu wa glibenclamide wopangidwa mwaluso kwambiri, womwe ndi gawo la Glucovans.

Ubwino wake:

• imagwira ntchito bwino kwambiri kuposa masiku onse, yomwe imalola kuchepetsa kuchuluka kwa mankhwalawa;
• glibenclamide tinthu tating'onoting'ono ta piritsiyo tili ndi miyeso 4 yosiyanasiyana. Amasungunuka nthawi zosiyanasiyana, potero amatha kugwiritsa ntchito mankhwala kulowa m'magazi ndikuchepetsa chiopsezo cha hypoglycemia;
• tinthu tating'onoting'ono kwambiri ta glibenclamide kuchokera ku Glucovans timaloledwa kulowa m'magazi ndipo timachepetsa glycemia m'maola atatha kudya.

Kuphatikiza kwa zinthu ziwiri piritsi limodzi sikungawonongeke kugwira ntchito kwawo. M'malo mwake, kafukufukuyu adapeza data m'malo mwa a Glucovans. Pambuyo pa kusintha kwa odwala matenda ashuga omwe amamwa metformin ndi glibenclamide kupita ku Glucovans, hemoglobin ya glycated inatsika pafupifupi 0,6% kwa miyezi isanu ndi umodzi yamankhwala.

Malinga ndi wopanga, Glucovans ndi mankhwala azodziwika bwino kwambiri padziko lonse lapansi, kugwiritsa ntchito kwawo kuvomerezedwa m'maiko 87.

Momwe mungamwe mankhwalawa pakumwa

Mankhwala a Glukovans amapangidwa m'mitundu iwiri, kotero mutha kusankha bwino mlingo woyambirira ndikuwonjezera mtsogolo. Chowonetsera pa paketi ya 2,5 mg + 500 mg chikuwonetsa kuti glibenclamide ya microformated ya 2,5 imayikidwa piritsi, 500 mg metformin. Mankhwalawa akuwonetsedwa koyambirira kwamankhwala pogwiritsa ntchito PSM. Njira 5 mg + 500 mg ndiyofunikira kuti mulimbitse mankhwala. Kwa odwala omwe ali ndi hyperglycemia amalandira mlingo woyenera wa metformin (2000 mg patsiku), kuchuluka kwa glibenclamide kumawonetsedwa pakuwongolera matenda osokoneza bongo.

Malangizo a Glucovans pa malangizo ake:

1. Mlingo woyambira nthawi zambiri ndi 2.5 mg + 500 mg. Mankhwalawa amatengedwa ndi chakudya, chomwe chimayenera kukhala chakudya.
2. Ngati m'mbuyomu mtundu wachiwiri wa matenda ashuga atenga zonse zodwala muyezo waukulu, mulingo woyambira ungakhale wokwera: kawiri 2.5 mg / 500 mg. Malinga ndi odwala matenda ashuga, glibenclamide monga gawo la Glucovans imakhala yothandiza kwambiri kuposa masiku onse, chifukwa chake mlingo wapitawu ungayambitse hypoglycemia.
3. Sinthani mlingo pambuyo masabata awiri. Choyipa chake ngati wodwala matenda ashuga amaloleza kulandira chithandizo cha mankhwala a metformin, kumakhala kotalikirapo chilangocho kumalimbikitsa kuti chisiye mankhwala. Kukula msanga kwa mankhwalawa kumangobweretsera mavuto ndi m'mimba, komanso kutsika kwamphamvu kwa magazi.
4. Mlingo wambiri ndi 20 mg ya microsized glibenclamide, 3000 mg ya metformin. Pankhani ya mapiritsi: 2.5 mg / 500 mg - 6 zidutswa, 5 mg / 500 mg - zidutswa 4.

Malangizo pa malangizo omwe mungamwe mapiritsi:

Zotsatira zoyipa

Zambiri kuchokera ku malangizo ogwiritsira ntchito pafupipafupi zotsatira zoyipa:

Malinga ndi ndemanga, zovuta zazikulu za odwala omwe amamwa mankhwalawa Glukovans, zimayambitsa kusapeza bwino m'mimba. Amatha kupewedwa pochulukitsa pang'onopang'ono komanso kugwiritsa ntchito mapiritsi ndi chakudya basi.

Mu odwala matenda ashuga, makamaka hypoglycemia imachitika. Amachotsedwa msanga ndi glucose mukangoyamba kumene kwa zizindikiro. Kwa odwala omwe samva kuchepa kwa shuga, malangizowo salimbikitsa kumwa mapiritsi a Glucovans ndi magulu awo am'magulu. Amawonetsa kuphatikiza kwa metformin ndi glisitins: Galvus Met kapena Yanumet.

Contraindication

Kugwiritsa ntchito Glucovans ndizowopsa kwa odwala matenda ashuga omwe ali ndi zotsutsana ndi metformin kapena glibenclamide:

• matupi awo sagwirizana ndi metformin kapena PSM iliyonse;
• Mtundu 1 wa shuga;
• matenda a impso, ngati creatinine> 110 mmol / l mwa akazi,> 135 mwa amuna;
• vuto la matenda pachimake, funso loti mungathe kugwiritsa ntchito mankhwalawa wodwala limasankhidwa ndi adokotala;
• mimba, mkaka wa m`mawere;
• ketoacidosis, lactic acidosis;
• chizolowezi cha lactic acidosis, chiopsezo chake chachikulu;
• zakudya zazitali zopatsa mphamvu zama calorie (<1000 kcal / tsiku);
• kumwa mankhwala omwe, kuphatikizapo Glucovans, amathandizira pakukula kwa hypoglycemia. Zowopsa zoletsa ma antifungal agents. Mankhwala omwe amakhudza pang'ono glycemia (mndandanda wathunthu m'malangizo a pepala) amatha kugwiritsidwa ntchito nthawi yomweyo ndi a Glucovans atatha kusintha kwa mlingo.

Zitha kusintha

Glucovans alibe mndandanda wonse, chifukwa mitundu ina yonse yolembedwa ku Russia yokhala ndi mawonekedwe omwewo imakhala ndi glibenclamide wamba, komanso yopanda micron. Ndi kuthekera kwakukulu azikhala othandiza pang'ono kuposa a Glucovans, kotero mlingo wawo uyenera kuchulukitsidwa.

Mankhwala ophatikizidwa metformin + wamba glibenclamide ndi Glibenfage; Gluconorm ndi Gluconorm Plus; Mphamvu ya Metglib ndi Metglib; Glibomet; Bagomet Plus.

Ma analogi a gulu la Glucovans ndi Amaril M ndi Glimecomb. Amawerengedwa kuti ndi amakono kwambiri kuposa mankhwala omwe ali pamwambapa ndipo sangathe kuyambitsa hypoglycemia.

Masiku ano, DPP4 inhibitors (glyptins) ndi kuphatikiza kwawo ndi metformin - Yanuviya ndi Yanumet, Galvus ndi Galvus Met, Ongliza ndi Combogliz Prolong, Trazhenta ndi Gentadueto - akufalikira kwambiri. Iwo, monga a Glucovans, amalimbikitsa kapangidwe ka insulin, koma osayambitsa hypoglycemia. Mankhwalawa satchuka ngati a Glucovans chifukwa cha mtengo wawo wokwera. Ma CD mwezi uliwonse amatulutsa kuchokera ku ma ruble 1,500.

Glucovans kapena Glucophage - zomwe zili bwino

Glucofage ya mankhwala imangokhala ndi metformin, chifukwa chake, mankhwalawa azigwira ntchito pokhapokha pachiwopsezo cha matenda ashuga, pamene kuphatikizika kwa insulin kumakhala kokwanira kusintha glycemia. Mankhwala sangathe kulepheretsa kuwonongeka kwa maselo a beta mu mtundu 2 wa shuga. Mu odwala matenda ashuga, njirayi imatenga nthawi yosiyana, kuyambira zaka 5 mpaka makumi. Malingana ndi kuchepa kwa insulini kukakhala kovuta, Glucophage yokha siyingathe kugawidwa, ngakhale itengedwa pa mlingo waukulu. Pakadali pano, akulimbikitsidwa kuti ayambe kumwa Glucovans pamene 2000 mg ya Glucophage sapereka shuga wabwinoko.

Zosungirako ndi mtengo

Mtengo wa mlingo wotsika wa Glucovans - kuchokera ku ma ruble 215., Mwapamwamba - kuchokera ku ma ruble 300., Phukusi la mapiritsi 30. Kukonzekera kophatikizidwa kwa Russia ndi glibenclamide kumawononga pafupifupi ma ruble 200. Mtengo wa Amaril uli pafupifupi 800, Glimecomb - pafupifupi rubles 500.

Glucovans amasungidwa zaka 3. Malinga ndi malangizo, mapiritsi amayenera kusungidwa pamatenthedwe 30 ° C.

Ndemanga Zahudwala