Type 2 shuga mellitus amasiyana ndi mtundu 1 wa shuga osati wocheperako wa kapamba wamafuta-insulin, koma mwa kulolera minofu kwa icho. Zotsatira zake, insulin imadziunjikira kangapo kuposa momwe imafunikira m'thupi la wodwala yemwe ali ndi matenda osokoneza bongo, omwe amachititsa kuti maselo asinthe.
Tcherani khutu! Pochiza matenda a shuga a mtundu wachiwiri, mankhwalawa amagwiritsidwa ntchito omwe amathandizira kuchepetsa kuyamwa kwa glucose m'mimba, kumawonjezera chidwi cha minofu ndikuwonjezera kugwiritsidwa ntchito kwa shuga.
Imodzi mwa mankhwalawa ndi glyformin. Mankhwalawa ali ndi zonsezi komanso amachepetsa thupi, zomwe nthawi zambiri zimapezeka mu matenda a shuga a 2. Popanga matenda, endocrinologist imapereka mankhwala a glyformin omwe amasankhidwa payekha, poganizira zinthu zonse.
Kodi Gliformin amaphatikiza ndi zochepa za mtengo wake
Mlingo wa mankhwala Glformin akupezeka m'mitundu itatu:
- 250 mg;
- 500 mg;
- 850mg.
Chofunikira chachikulu cha glyformin ndi metformin. Ndi kuchuluka kwake komwe kumatsimikizira kuchuluka kwa mapiritsi.
Kugwiritsa ntchito bwino mankhwalawa kumatheka pokhapokha thupi likupitiliza kupanga zake zake zokha kapena mahomoni akabayidwa. Muyenera kudziwa momwe mungabayire insulin. kukwaniritsa kuchuluka kwa jakisoni wa omn.
Ngati palibe insulini, chithandizo ndi metformin ndichosatheka.
Zotsatira za metformin
- Metformin imabwezeretsa kapena kukulitsa chidwi cha ma cell ku insulin, mwachitsanzo, mu zotumphukira. Kuphatikiza apo, pali kuwonjezeka kwa ubale wa mahomoni ndi ma receptors, pomwe kuchuluka kwa shuga kumachuluka ndi maselo aubongo, chiwindi, matumbo, ndi khungu.
- Mankhwalawa amachepetsa kuchuluka kwa shuga ndi chiwindi, ndipo izi sizingakhudze zomwe zili m'magazi a shuga, zomwe ndizofunikira kwambiri mtundu wa 2 shuga. Kwa odwala omwe ali ndi kunenepa kwambiri, kuchepa kwake kosavuta kumachitika, komwe kumakhudza thanzi la wodwalayo.
- Mankhwala a anorexigenic (kutaya chidwi) ndi chinthu chinanso chabwino cha metformin. Izi zimachitika chifukwa cholumikizana mwachindunji ndi chiphuphu cham'mimba ndi matumbo, osati zomwe zimapangitsa magawo a ubongo. Ndizachilengedwe kuti kuchepa kwa chakudya kumapangitsa kuchepa kwa zakudya za tsiku ndi tsiku komanso kuchepa kwa thupi kwambiri. Kuchuluka kwa glucose pamenepa kumachepera.
- Chifukwa cha metformin, pamakhala kudumphadumpha mu glycemia mukatha kudya. Izi zimachitika chifukwa chakuchepa kwa mayamwidwe am'mimba kuchokera m'matumbo, ma cell omwe amalimbikitsa kuchuluka kwa shuga m'thupi.
Kuchokera pazomwe tafotokozazi, zikuwonekeratu kuti metformin ikhoza kufotokozedwa ngati chinthu cha antihyperglycemic.
Ndiye kuti, osalola kuchuluka kwa shuga m'magazi kuposa kutsika shuga, awa ndi mapiritsi apamwamba kwambiri ochepetsa shuga m'magazi.
Zowonjezera za glyformin, kutengera mlingo, zitha kukhala:
Kashiamu yonyowa.
Calcium calcium phosphate dihydrate.
- Sorbitol.
- Wowuma wa mbatata.
- Povidone.
- Stearic acid.
Kupanga chipolopolo cha mankhwalawa kumagwiritsidwa ntchito:
- Talc.
- Hypromellose.
- Macrogol.
Kutengera wopanga, mulingo, kuchuluka kwa mapiritsi omwe ali mgululi, dera lomwe amagulitsa, mtengo wa mankhwalawo umasinthanso. Maphunziro a chithandizo cha pamwezi amawerengeka ndi ma ruble 200-300 pa avareji.
Masiku ano, glyformin imapangidwa ndi makampani angapo azamankhwala. Mankhwala odziwika kwambiri ku Russia ndi awa:
- GNIISKLS (Russia).
- Akrikhin (Russia).
- Nycomed (Switzerland).
Njira yogwiritsira ntchito ndi pharmacodynamics
Kuchita kwa glyformin kumachitika chifukwa cha metformin, yemwe zotsatira zake ndi:
- kuponderezana kwamatenda a chiwindi;
- kuchepetsa kuchuluka kwa shuga omwe amachokera m'matumbo;
- kulimbitsa njira yogawa shuga ndi zakudya zina;
- kuchuluka kwa insulin ndi minofu ndi ma receptors;
- kudya kwakachepa, kuchepa thupi.
Mlingo umodzi ukhoza kukhala 250, 500 ndi 850 mg. ndi 1 g Amatsimikiziridwa ndi endocrinologist payekhapayekha, kutengera zosowa za thupilo.
Poyamba kumwa mankhwalawa m'masiku atatu oyamba, odwala omwe ali ndi insulin amasonyezedwa kuti amagwiritsa ntchito glyformin kawiri pa 1 g, kapena katatu mu 500 mg. M'tsogolomo, mpaka kumapeto kwa sabata yachiwiri, glyformin imagwiritsidwa ntchito katatu patsiku 1 g.
Kuphatikiza apo, njira ya mankhwalawa imasinthidwa malinga ndi mphamvu ya shuga ndikuyenda bwino kwa mankhwalawo kwa wodwala winawake. Nthawi zambiri, pambuyo pake chithandizo sichidutsa kawiri mlingo.
Contraindication ndi zovuta za mankhwalawa
Monga mankhwala ena aliwonse, glyformin ili ndi zotsutsana:
- Ketoacidosis ndi vuto lalikulu komanso loopsa lomwe limachitika motsutsana ndi maziko a kusowa kwenikweni kwa insulin.
- Matenda a shuga - kutaya kwathunthu chikumbumtima, kusowa kwa zochita zina.
- Matenda a impso ndi kwa chiwindi.
- Kuchuluka kwambiri kwa lactic acid ndi lactic acidosis.
- Pulmonary ndi kulephera kwa mtima.
- Myocardial infaration.
- Mimba komanso kuyamwa.
- Zovulala kwambiri.
- Matenda opatsirana.
- Kubwera ntchito.
Glyformin samakumana ndi mavuto ambiri, komabe, ndi:
- kusanza, kutsekula m'mimba;
- zosakomera zachitsulo mkamwa;
- mawonetseredwe khungu pakhungu;
- kuphwanya mayamwidwe a vitamini B ndikugwiritsa ntchito nthawi yayitali;
- ndipo pamapeto pake, vuto loopsa kwambiri ndi lactociadosis. Zikaoneka, kugwiritsa ntchito glyformin kuyenera kutayidwa.
Kodi pali kusiyana kotani pakati pa mankhwalawa ndi mawonekedwe ake
Gliformin ali ndi ma fanizo angapo nthawi imodzi, mwa omwe:
- Siofor;
- Glucophage;
- Metfogram.
Aliyense wa iwo ali ndi mankhwala ofanana, amafunikira njira zomwezi mu shuga mellitus ndi glyformin. Kufanana kwa zochita zawo kumachitika chifukwa cha metformin, yomwe ndi gawo la mankhwala aliwonse. Ndipo kusiyana pakati pawo kumangokhala mtengo komanso mlingo.
