1 ampoule (12 ml) wa Berlition 300 ali ndi zomwe zimagwira: ethylenediamine mchere wa α-lipoic (thioctic) acid 0,388 g (malinga ndi α-lipoic (thioctic) acid - 0,300 g ndi zinthu zothandizira: madzi a jakisoni, propylene glycol, ethylene diamine.
Mapiritsi okhala ndi mbali, lililonse la iwo limakhala ndi othandiza-ion-lipoic (thioctic) asidi - 300 mg kapena 600 mg;
Kuphatikiza apo, pali zinthu zothandizira:
- magnesium wakuba;
- lactose monohydrate;
- croscarmellose sodium;
- ma cellcose a microcrystalline;
- colloidal anhydrous silika;
- povidone (mtengo K = 30);
Opadry OY-S-22898 "chikasu" mu chipolopolo, chokhala ndi:
- hypopellose,
- sodium dodecyl sulfate,
- titanium dioxide (E 171),
- Utoto wa lalanje wachikasu (E 110),
- Utoto wa quinoline wachikasu (E 104),
- mafuta parafini.
Mankhwala
Mankhwala Chofunikira chachikulu pa mankhwalawa ndi antioxidant wachilengedwe womwe umaphatikiza ma free radicals. Acid imapangidwa ndi thupi chifukwa cha zotsatira zoyipa za oksidijeni idi-keto acid.
Tcherani khutu! Ndemanga za madotolo zikuwonetsa kuti mankhwalawa ali ndi phindu pochepetsa shuga ya magazi, kuwonjezera chiwindi cha glycogen komanso kuthana ndi insulin.
Mwa mphamvu zawo zamitundu mitundu, mapiritsi a Berlition 300 ndi 600 ali pafupi ndi mavitamini a B.
- Tengani gawo la matenda a metabolism ndi lipid metabolism.
- Sinthani chiwindi ntchito, yambitsani cholesterol metabolism.
- Ali ndi hypoglycemic, hepatoprotective, hypocholesterolemic, hypolipidemic effect.
Kugwiritsa ntchito Berlition 300 ndi 600 mu kulowetsedwa kwa jakisoni wambiri wamitsempha kumatha kuchepetsa zovuta zomwe zimachitika.
Pharmacokinetics Mapiritsi 300 a Berlition ndi 600, moyenera, zinthu zawo, amatha "kudutsa" pachiwindi. Thioctic acid ndi zigawo zake pafupifupi kwathunthu (80-90%) zotulutsidwa ndi impso.
Yankho la jakisoni Berlition. Nthawi yofika ndende kwambiri mthupi ndi mtsempha wama mtsempha ndi 10-11 mphindi. Dera lomwe lili pansi pa curve yamankhwala (nthawi yokhazikika) ndi 5 μg h / ml. Kuzindikira kwakukulu ndi 25-38 mcg / ml.
Mapiritsi a Berlition opaka pakamwa amakhudzidwa mwachangu ndipo amatengeka kwathunthu m'mimba. Mukamamwa ndi chakudya, adsorption imachepetsa. Pazitali zabwino za mankhwalawa zimatheka pambuyo pa mphindi 40-60. Bioavailability ndi 30%.
Hafu ya moyo ndi mphindi 20-50. Chilolezo chonse cha plasma ndi 10-15 ml / min.
Zisonyezero zamankhwala
Matenda a shuga a polyneuropathy omwe amayamba chifukwa cha matenda ashuga kapena uchidakwa. jakisoni yankho imagwiritsidwanso ntchito. Mlingo wa tsiku ndi tsiku wa mankhwala ndi 300 kapena 600 mg. 1 ampoule ili ndi 300 mg.
Berlition imadzipaka mu njira ya 0,9% ya sodium kolorayidi ndipo imaperekedwa kwa wodwala kudzera mu kukhuthala. Nthawi yoyambira ndi pafupifupi mphindi 30.
Kumayambiriro kwa mankhwalawa, Berlition adapangidwira masabata a 2-4. Pambuyo pake, mutha kupitiriza kukonzekera kwa mapiritsi a Berlition pa mlingo wa 300-600 mg patsiku.
Mapiritsi a Berlition amawonetsedwa kuti azigwiritsidwa ntchito mu 600 mg kamodzi tsiku lililonse. Awa ndi magome awiri. Mankhwala ayenera kumwedwa pamimba yopanda kanthu, pafupifupi theka la ola musanadye.
Mapiritsi ayenera kumezedwa kwathunthu osafuna kutafuna. Imwani madzi ambiri. Dokotala yekha ndi amene amasankha kutalika kwa njira yochizira.
Zina mwa mankhwalawa
Ndemanga za madotolo ndi odwala za Berlition ndizabwino kwambiri, koma, monga mankhwala ena aliwonse, ali ndi mawonekedwe ake. Panthawi ya chithandizo, odwala sayenera kumwa zakumwa zoledzeretsa.
Anthu odwala matenda ashuga amafunika kuwunika pafupipafupi kuchuluka kwa shuga m'magazi. Izi ndizofunikira kwambiri kumayambiriro kwa chithandizo. Nthawi zina zimakhala zofunikira kuti muchepetse mlingo wa insulin kapena mankhwala a hypoglycemic omwe amatengedwa ndi odwala mkati. Chifukwa chake, chiopsezo cha hypoglycemia chimapewedwa.
Berlition 300 kapena 600 jakisoni njira ayenera kutetezedwa UV UV. Izi zimachitika ndikakulunga botolo mu zotayidwa zojambulazo. Yankho lotetezedwa motere lingathe kusungidwa kwa maola 7.
Zotsatira zoyipa
Nthawi zambiri, sizichitika, koma kawirikawiri, pambuyo pakugwa kwa yankho, kupweteka, mfundo zazing'onoting'ono zotupa m'matumbo amkamwa ndi pakhungu, zotupa za hemorrhagic, thrombocytosis ndizotheka. Ndi makonzedwe achangu kwambiri, pamakhala mwayi woti munthu azitha kupanikizika komanso kuti azipuma movutikira.
Ndemanga kuchokera kwa odwala ndi madokotala akuti zizindikiro zonsezi zimapita popanda kuchitapo kanthu.
Pali zotulukapo zakumalo zomwe zimawoneka m'gawo la jakisoni. Itha kukhala chiwonetsero cha urticaria kapena mawonekedwe ena onse, mpaka kugwedezeka kwa anaphylactic. Kukula kwa hypoglycemia, komwe kungayambike chifukwa cha kuyamwa kwa shuga, sikutsutsidwa.
Mapiritsi a Berlition nthawi zambiri amaloledwa popanda mavuto. Koma nthawi zina zovuta zotsatirazi ndizotheka:
- kulephera kupuma;
- kutentha kwa mtima;
- nseru
- kusanza
- hypoglycemia pa mimba;
- urticaria.
Kuchita ndi mankhwala ena
Berlition "mu vitro" amakumana ndi zida zachitsulo za ionic. Mwachitsanzo, chisplatin chitha kuganiziridwa. Chifukwa chake, kugwiritsa ntchito pamodzi ndi chisplatin kumachepetsa zotsatira zake.
Koma zotsatira za mankhwala amkamwa a hypoglycemic ndi insulin, Berlition 300 kapena 600, m'malo mwake, zimakulirakulira. Ethanol, yemwe amapezeka mu zakumwa zoledzeretsa, amachepetsa kuchiritsa kwa mankhwalawa (werengani ndemanga).
The yogwira thunthu la Berlition, atakhudzidwa ndi shuga, mitundu pafupifupi insoluble mankhwala. Izi zikuchokera pamenepa kuti yankho la thioctic acid silingaphatikizidwe ndi kulowetsedwa kwa dextrose, Ringer, ndi njira zina zotere.
Ngati Berlition 300, mapiritsi a 600 adatengedwa m'mawa, mutha kugwiritsa ntchito zinthu zamkaka, magnesium ndi kukonzekera kwachitsulo pokhapokha masana kapena madzulo. Pokhudzana ndi zinthu zamkaka, izi zimachitika chifukwa chakuti zimakhala ndi calcium yambiri.
Zoyipidwa zomwe zilipo
- Nthawi ya pakati komanso yoyamwitsa. Ngakhale zovuta za mankhwalawa sizitsimikiziridwa, chifukwa palibe kuwunika ndi maphunziro a dongosolo lotere.
- Kuzindikira kwakukulu pazigawo za Berlition.
- Mankhwalawa sanalembedwera ana (palibe ndemanga pa chitetezo ndi kugwira ntchito).
Zizindikiro Zonenepa Kwambiri
- nseru
- kusanza
- mutu.
Palibe mankhwala enieni, ndi omwe matendawa amathandizidwa.
Kusunga, tchuthi, kunyamula
Mankhwalawa ndi a mndandanda B. Uyenera kusungidwa pamtunda wolephera kupitirira 25 ° C, m'malo osavomerezeka ndi ana.
Nthawi yogwiritsira ntchito imatengera mtundu wa kumasulidwa:
- yankho la jakisoni - zaka 3;
- mapiritsi - 2 years.
Berlition amatulutsidwa pokhapokha atachokera kuchipatala. Njira yothetsera jakisoni imapezeka mu ampoules amdima a 25 mg / ml. Makatoni ama katoni (matrakiti) ali ndi ma ampoules 5. Nawa malangizo ogwiritsira ntchito.
Mapiritsi a Berlition adakutidwa ndikuwakhomeka zidutswa 10 m'matumba opangidwa ndi opaque PVC zakuthupi kapena zojambulazo za aluminium. Makatoni okhala ndi matuza atatu ndi malangizo ogwiritsira ntchito.
