Ofufuzawo aku Russia apanga zinthu zomwe mankhwala amatha kupanga kuti abwezeretse ndikukhalanso ndi thanzi la pancreatic mu mtundu 1 wa shuga.
Mu kapamba, pali malo apadera omwe amatchedwa Langerhans Islands - ndi omwe amapanga insulin m'thupi. Hormone iyi imathandizira maselo kutulutsa shuga m'magazi, ndipo kuchepa kwake - pang'ono kapena kokwanira - kumayambitsa kuchuluka kwa shuga, komwe kumayambitsa matenda a shuga.
Mafuta ochulukirapo amakhumudwitsa kuchuluka kwa zamankhwala m'thupi, kupanikizika kwa oxidative kumachitika, komanso mawonekedwe aulere ambiri m'maselo, omwe amasokoneza kukhulupirika kwa maselo awa, ndikupangitsa kuwonongeka ndi kufa.
Komanso, glycation amapezeka m'thupi, momwe glucose amaphatikiza ndi mapuloteni. Mwa anthu athanzi, njirayi imachitikanso, koma pang'onopang'ono, ndipo mu shuga imathandizira ndikuwononga minofu.
Bwalo lowopsa kwambiri limawonedwa mwa anthu omwe ali ndi matenda ashuga 1. Ndi iyo, maselo a Langerhans Islets amayamba kufa (madokotala akukhulupirira kuti izi zimachitika chifukwa cha kuwonongeka kwa autoimmune palokha), ndipo ngakhale amatha kugawanitsa, sangabwezeretse kuchuluka kwake koyambira, chifukwa cha kupsinjika kwa glycation ndi oxidative chifukwa cha glucose owonjezera kufa mwachangu kwambiri.
Tsiku lina, magazini ya Biomedicine & Pharmacotherapy inafalitsa nkhani yokhudza zotsatira zakufufuza kwatsopano kwa asayansi ochokera ku Ural Federal University (Ural Federal University) ndi Institute of Immunology and Physiology (IIF UB RAS). Akatswiri adawona kuti zinthu zomwe zimapangidwa pamaziko a 1,3,4-thiadiazine zimachepetsa zochita za autoimmune zomwe zatchulidwa pamwambapa, zomwe zimawononga maselo a insulin, ndipo, nthawi yomweyo, zimathetsa zovuta za glycation ndi oxidative nkhawa.
Mu mbewa yokhala ndi matenda a shuga 1 amtundu, omwe amayesa mankhwala a 1,3,4-thiadiazine, kuchuluka kwa mapuloteni oteteza magazi m'magazi kunachepetsedwa kwambiri ndipo hemoglobin ya glycated inazimiririka. Koma koposa zonse, mwa nyama kuchuluka kwa maselo omwe amapanga insulini mu kapamba kumakulirakonso katatu ndipo mulingo wa insulini womwewo umawonjezeka, zomwe zimachepetsa kuchuluka kwa shuga m'magazi.
Mwina mankhwala atsopano omwe adapangidwa pamaziko a zinthu zomwe zatchulidwa pamwambapa asinthira chithandizo cha matenda amtundu wa 1 ndikupatsa odwala mamiliyoni ambiri chiyembekezo cham'tsogolo.
