Metformin ndi mowa ndi adani okhalitsa komanso osakhazikika. Chowonadi ndi chakuti mankhwalawa amaphatikizidwa m'ndandanda wazomwe mankhwalawa sangaphatikizidwe ndi mowa.
Komanso, ngati mutenga Metmorphine limodzi ndi mowa, mutha kuyamwa poyizoni. Tsoka ilo, palibe aliyense amadziwa za izi, bwanji nthawi zina kufa kwa odwala omwe amapatsidwa mankhwalawa amalembedwa momwe amamwa mowa.
Kodi metformin ndi chiyani?
Pansi pa mankhwala Metformin mumvetsetse mankhwala omwe amagwiritsidwa ntchito pochiza matenda a shuga. Cholinga chake chachikulu ndikuchepetsa kudalira kwa insulin mwa wodwala, komanso kupewa kukula kwa kunenepa kwambiri.
Ngakhale kuti mutatenga Metformin kuchuluka kwa timadzi timene timatulutsa m'magazi sikusintha, mankhwalawa amatha kusintha masinthidwe amomwe thupi lake limagwirira. Chifukwa chake, mwachitsanzo, ntchito yake yogwira ntchito imathandizira kuchepa kwa mafuta acids, chifukwa chomwe njira yosinthira glucose kukhala zinthu zina zofunika ndi thupi imathandizira.
Zotsatira zake, kuchuluka kwa magazi a wodwalayo kumakhala bwino, ndipo kuchuluka kwa shuga m'magazi ake kumachepetsedwa. Ndikofunika kudziwa kuti mankhwalawa amatha kufikira kuchuluka kwa magazi a wodwalayo pokhapokha maola asanu ndi limodzi atatha kumwa. Komanso, kuphatikiza kwake kukuchepa.
Pali mankhwala angapo ochokera ku Metformin, onse omwe ali m'gulu la Biguanide. Mwa mankhwala omwe ali mndandandandawu, mwachitsanzo, wina akhoza kutcha Fenformin, Buformin, ndi Metformin palokha. Sov remen6m awiri oyambirawa sagwiritsa ntchito, chifukwa zotsatira zawo zinali zoyipa za wodwalayo ndi lactic acid.
Ponena za Metformin, pali mayina angapo a mankhwalawa, mwachitsanzo, monga Giliformin kapena Fomu Pliva. Nthawi zambiri, odwala matenda a shuga amapatsidwa mankhwala monga Siofor. Chowonadi ndi chakuti chimakhumudwitsa m'mimba thirakiti la wodwalayo ndipo ndiotsika mtengo kuposa mitundu ina ya Metformin.
Ndizofunikira kudziwa kuti onse omwe alembedwa mankhwalawo ali ndi mawonekedwe ofanana, pomwe akusiyana wina ndi mnzake muyezo wa kuyeretsa kwa mankhwala, komanso kapangidwe kazinthu zothandizira. Mulimonsemo, mankhwala onse omwe ali mgululi ayenera kumwedwa kokha ngati akuwuzidwa ndi adokotala. Kupanda kutero, kuchuluka kwa shuga m'magazi ake kumatha kutsika kwambiri, zomwe zimapangitsa kuti zikomedwe komanso kupitilanso kufa kwa wodwalayo.
Ngati mumamatira ku malangizo a dokotala, komanso malangizo a mankhwalawo, nthawi zambiri pamakhala zotsatirapo zoipa. Nthawi yomweyo, amakhala okhazikika pamalo a wodwalayo, zomwe zimapangitsa kuti chiwonetsero cha matenda a shuga chidziwike.
Zotsatira zake, chikhululukiro chokhazikika cha matenda oyambawa chitha kuchitika.
Pafupipafupi kayendetsedwe ndi zoyipa
Metformin, monga mankhwala aliwonse, ali ndi zovuta zake. Mwachitsanzo, mwachitsanzo, wodwalayo amatha kukumana ndi mavuto ambiri. Nthawi zina, kutsegula m'mimba kumatha kupezeka, komanso zinthu zoipa monga kuchepa kwa magazi m'thupi komanso kuchepa kwa magazi. Zotsatira zoyipa kwambiri zitha kukhala mkaka acidosis, pomwe odwala ambiri amaganiza motere: "Ngati ndimamwa mowa pang'ono, ndiye kuti nditha kugwiritsa ntchito Metformin nthawi yomweyo." Izi sizili choncho, chifukwa ngakhale kumwa mowa wochepa kwambiri kungakulitse kwambiri chitukuko cha lactic acidosis.
Kutengedwa ndi wodwala matenda ashuga, Metformin nthawi zambiri imalowetsedwa m'magazi kudzera m'mimba. Popeza mphamvu zake zimatenga maola awiri kapena asanu ndi awiri, mankhwalawa amayenera kumwedwa katatu patsiku. Pomwe mungadumphe kumwa mankhwalawa, kutha kwake kumachepetsedwa kwambiri. Ichi ndichifukwa chake simungalole kukhazikitsidwa kwa mowa mukamalandira mankhwalawa.
Ngati timalankhula za zakumwa monga vodka, ndiye kuti mowa umalowa m'magazi pafupifupi nthawi yomweyo. Zotsatira zake, pakukhudzana ndi mankhwala omwe amafotokozeredwa ndi mowa, lactic acid imayamba, lactic acidosis imayamba. Tiyenera kudziwa kuti zipangiri zake, mowa ukhoza kutha pambuyo pa maola asanu ndi limodzi mpaka asanu ndi awiri atatha kumwa mankhwalawa. Komabe, zakumwa zoledzeretsa zimaletsa ntchito za ma enzymes ena a chiwindi, ndipo izi, zimayambitsa glycimia.
Chifukwa chake, simungamwe mowa ndi Metformin, pokhapokha ngati wodwala yemwe ali ndi matenda ashuga ayenera kuvala kuti aletse mankhwalawo ndikusowa muyeso umodzi wa mankhwalawa. Komanso, nthawi zambiri, samaphonya kamodzi, koma awiri Mlingo wa mankhwalawa. Zotsatira zake, kugwiritsa ntchito bwino mankhwalawa kumatsika kwambiri ndipo wodwalayo amamva kuwonongeka mu thanzi lawo.
Mulimonsemo, mankhwala omwe akufotokozedwayi ayenera kumwedwa moyang'aniridwa ndi dokotala. Chowonadi ndi chakuti chithandizo chilichonse munthawi yake chikuyenera kusinthidwa, kutengera zotsatira zomwe zikuyembekezeka.
Ngati mungadzipangire nokha, kuthandizira kwake kumakhala kopanda zero, ndipo nthawi zina vuto lalikulu lingachitike kwa wodwalayo.
Kodi lactic acidosis ndi chiani?
Popeza mankhwala omwe amafotokozedwawo ali ndi zovuta kupanga, munthawi ya mankhwalawa amatha kukhala ndi zovuta za metabolic. Makamaka akamwetsa mowa.
Pankhaniyi, anthu ambiri omwe amamwa amakhala ndi poizoni, popeza ali ndi vuto la metabolic. Chowonadi ndi chakuti munthu woledzeretsa atamwa mankhwala osambitsidwa, osambitsidwa ndi mowa, thupi lake limatha kupanga kuchuluka kwa lactic acid.
Chifukwa chake, wodwala yemwe amamwa mowa wotsatira amalandila poyizoni, zomwe zingayambitse kuchepa kwa magazi, aimpso, mtima kapena chiwindi kulephera, mavuto am'mapapo. Zizindikiro za lactic acidosis ndi:
- Kupezeka kwa nseru kwambiri, kuchuluka, kusanza.
- Kufooka ndi kupanda chidwi.
- Zowawa zakuthwa kumbuyo kwa sternum ndi m'misempha.
- Maonekedwe akaphokoso komanso kupuma kwambiri.
- Mutu wowopsa wa matenda ashuga.
Pazowopsa kwambiri, zotsatira za kutenga Metformin zimatha kuwoneka ngati zakomoka. Amamveka ngati dontho lakuthwa pakukakamiza, pomwe khungu limakhala lotuwa kwambiri, nkhope imaloza, ndipo manja ndi miyendo zimatha “kuwundana”. Zotsatira za poyizoni zimatha kuchitika kwambiri, mwachitsanzo, zimakhala zosemphana ndi magwiridwe antchito a mtima
Kupitilira apo, zinthu zitha kuyamba kukhala zowonjezereka popeza m'thupi la wodwalayo magazi ake azingokulirakulira, zomwe zimakulitsa mkhalidwe wa wodwalayo. Pomaliza matendawa, hypoxia ya ubongo imayamba. Zotsatira zake, wodwalayo amakumananso ndi vuto loti amwalira msanga.
Ngati munthu waikidwa poizoni chifukwa chomwa mankhwalawa komanso mowa, amafunika kuyimbidwa mwachangu, komanso kulandira chithandizo chamankhwala ena.
Mwachilengedwe, ndibwino kuti musalole izi, chifukwa chake, choyamba, zidzakhala zofunikira kuphunzira malamulo otenga Metformin, omwe amati sayenera kutengedwa makamaka ngati wodwalayo anali atamwa kale mowa. Nzika zomwe zimanyalanyaza lamuloli zimapwetekedwa ndi njira yofotokozedwayo, ndikupititsa patsogolo thanzi lawo.
Zoopsa ndizowopsa poyizoni pomwe wodwalayo adalakwitsanso mlingo wa mankhwalawo. Pankhaniyi, kufa kumatha kuchitika mu maola ochepa.
Chifukwa chake, tikulimbikitsidwa kuti odwala matenda ashuga omwe amathandizidwa motere amasiya kumwa.
Choyamba thandizo poizoni
Mulimonsemo, wodwala aliyense wa shuga ndi abale ake ayenera kudziwa zoyenera kuchita poyizoni. Chowonadi ndi chakuti zotsatira zake ndi zazikulu kwambiri, kotero chinthu choyamba chomwe chidzafunika kuchitidwa ndikupereka nzika yovulala kuchipatala posachedwa. Mofananamo, pakumangidwa kwamapumidwe ndikukhazikika pang'onopang'ono pakuyenda magazi, ndikofunikira kuti musangoyitanitsa ambulansi, komanso khalani ndi njira zotsitsimutsa m'malo mwake.
Ma ambulansi isanafike, mulimonse momwe zingakhalire kupatsa ozunzidwayo mpweya wabwino. Chifukwa chake ngati ali poyizoni chifukwa chakumwa mankhwala ndi mowa waposachedwa, afunika kupereka mpweya wabwino watsopano.
Kuphatikiza apo, ngakhale adotolo asanafike kwa wodwala, ndikofunikira kuti azitsuka mwachangu zam'mimba kuti alepheretse kuyamwa kwa mowa ndi mankhwala ena m'magazi a wodwalayo. Pa chifukwa chomwechi, mutha kupatsa munthu wovulalayo kuti amwe pafupifupi malita asanu a madzi ofunda pa 38-40 ° C. Kudzakhala kofunikira kumusambitsa, popeza muzu wa lilime ndi pansi pa pharynx uyamba kukwiyitsa. Kusanza kuyambika, mudzafunika muperekenso chakumwa china chofunda ndikubwereza njirayi kanayi kasanu ndi kamodzi.
Ponena za poizoni wa Metformin poyizoni, makamaka amatanthauza kutaya thupi kwa wodwalayo kuchokera kuzakumwa ndi poizoni. Chifukwa chaichi, kukakamiza diuresis ndi munthawi yomweyo magazi ambiri amagwiritsidwa ntchito. Kuphatikiza apo, zotsatira zabwino komanso zosatha zimaperekedwa ndi mankhwala a antidote, omwe amaphatikiza kuyambitsa kwa 20% shuga mkati mwa mtsempha wa wodwalayo kuti abwezeretse mulingo wake wabwinobwino m'magazi. Komanso muzochitika zotere, glycogen imayendetsedwa ndi intramuscularly.
Komanso, ngati pali chiopsezo cha chikomokere, njira yothetsera adrenaline imabayidwa mosavuta, ndipo atatha kumwa mankhwala opatsirana, amapereka njira yothetsera sodium chloride, yomwe imayambitsa kusanza. Kenako, sodium sulfate imapatsidwa muyeso wa supuni imodzi pa lita imodzi yamadzi, yomwe imatsukidwa ndi tiyi wokoma kapena madzi. Mtsogolomo, wodwalayo akuwonetsedwa chithandizo chamankhwala.
Pa mankhwala a lactic acidosis omwe ali ndi matenda ashuga, amaletsedwa kumwa mowa. Kuphatikiza apo, wodwalayo adzafunika kutetezedwa kuti asayerekezedwe ndi dzuwa. Chakudya champhamvu chokhazikika chimapangidwanso.
Panthawi yomwe acidosis imatchulidwa pang'ono ndipo palibe chizindikiro chododometsa ndipo impso imagwira ntchito pafupipafupi, zidzakhala zofunikira kuchita mayeso a labotale ya alkalization ndi sodium bicarbonate.
Kanemayo munkhaniyi ayankhula za kuchepa kwa shuga kwa Metformin.
