Mankhwala omwe amagwira ntchito - saxagliptin amagwiritsidwa ntchito pochiza matenda a shuga 2. Amathanso kuphatikizidwa ndi mankhwala ena ochepetsa shuga kuti athandizire kuthandizira. Nkhaniyi ikuthandizani kuti muphunzire za zinthu zazikulu zomwe zimapangidwira, zikuwonetsa, zotsutsana, zosokoneza, mankhwala omwe ali ndi saxagliptin, ndemanga za anthu odwala matenda ashuga ndi mankhwala ofanana.
Mpaka pano, matenda a shuga a 2 amathandizidwa chifukwa cha magawo angapo: zakudya zoyenera, masewera olimbitsa thupi, kuyang'anira shuga wamagazi nthawi zonse. Malo apakati pakuthandizira matendawa ndi kugwiritsa ntchito mankhwala osokoneza bongo.
Kugwiritsa ntchito kwa Onglisa kapena Saxagliptin, Metformin palimodzi kumathandizira kukula kwa shuga mwa wodwalayo. Ndemanga za mankhwalawa zabwino.
Chokhacho chomwe chingabwezeretse ndi mtengo wokwera wa mankhwala a Ongliza ndi mitundu yake. Kuonetsetsa njira yothandizira kwambiri yachipatala komanso kupewa zovuta zambiri, mankhwalawa amayenera kumwedwa mosamala ndi dokotala.
Katundu wa zomwe zimagwira
Saxagliptin ndi chosankha chosinthira chosinthika dipeptidyl peptidase-4 (DPP-4). Pogwiritsa ntchito mankhwalawa odwala omwe ali ndi matenda a shuga 2, ntchito ya DPP-4 enzyme imachepa masana.
Wodwala akangotenga shuga, kuchuluka kwa glucagon kumachepetsedwa kwambiri. Nthawi yomweyo, pali kutulutsidwa kwa mahomoni - insulin ndi kapamba, kapena ndendende - maselo ake a beta. Izi zimathandizira kuchepetsa shuga wamagazi pamimba yopanda kanthu mwa anthu.
Izi zimalumikizana ndi zinthu zambiri za hypoglycemic - metformin, glibenclamide, pioglitazone, ketoconazole, simvastatin kapena dithiazem. Koma kugwiritsa ntchito limodzi ndi ma inducers ena a CYP3A4 / 5 isoenzymes, mwachitsanzo, ketoconazole, itraconazole, indinavir ndi ena, kungachepetse mphamvu ya achire mphamvu ya saxagliptin.
Mu maphunziro ambiri, asayansi sanathe kudziwa mphamvu yapadera ya saxagliptin pa lipid mbiri. Pogwiritsa ntchito mankhwalawa, palibe kuwonda kwakukulu komwe kumawonedwa mwa odwala omwe amafufuza omwe ali ndi matenda a shuga 2.
Tiyenera kudziwa kuti asayansi sanachitepo kafukufuku wokhudzana ndi kukhudzidwa kwa zinthu za hypoglycemic pazinthu monga kusuta fodya, mowa, kudya, komanso kugwiritsa ntchito mankhwala azitsamba.
Chifukwa chake, anthu omwe ali ndi zizolowezi zoyipa komanso kumwa mankhwala achilengedwe ayenera kumwa mankhwalawa mosamala kwambiri.
Malangizo ogwiritsira ntchito mankhwalawa
Mankhwala odziwika omwe ali ndi yogwira - saxagliptin ndi Onglisa.
Imapezeka mu mapiritsi a 5 mg. Phukusi limodzi lili ndi zidutswa 30.
Amatengedwa mosasamala chakudya, osambitsidwa ndi madzi pang'ono.
Zizindikiro zazikulu zogwiritsidwa ntchito kwa mankhwalawa Onglisa, momwe saxagliptin ndiye chinthu chachikulu cha hypoglycemic, amatengedwa:
- Type 2 shuga mellitus, ngati zakudya ndi masewera olimbitsa thupi sizingakhudze kutsika kwa shuga wamagazi, monga monotherapy.
- Monga chida china chowonjezera cha metformin koyambirira kwamankhwala kuti mugwiritse ntchito njira ya hypoglycemic.
- Kuphatikiza pa monotherapy ndi metformin, sulfonylureas, thiazolidinediones, ngati sizingatheke kuyendetsa bwino shuga.
Musanayambe chithandizo, malangizo a mankhwalawa ayenera kuphunziridwa mosamala. Dokotala wokhayo amene angakupatseni mankhwala omwe mungamwe ndi mankhwalawa, simungagule popanda mankhwala. Ndi monotherapy kapena kuphatikiza ndi njira zina, wodwalayo amangodya zosaposa 5 mg za mankhwala Onglisa patsiku. Pa gawo loyamba la chithandizo ndi saxagliptin, Metformin imatengedwa patsiku pa 500 mg. Ngati wodwalayo wayiwala kuti ndikofunikira kumwa piritsi la Onglisa, izi ziyenera kuchitika mwachangu. Kwa magulu ena a odwala, mlingo wa tsiku ndi tsiku umatha kuchepetsedwa mpaka 2,5 mg. Choyamba, awa ndi anthu omwe ali ndi hemodialysis komanso kulephera kwa impso. Nthawi yomweyo, Ongliz amayenera kumwedwa pokhapokha pochita njira ya hemodialysis.
Mapiritsi amasungidwa kuti ana asawatenthedwe kutentha kosakwana 30C. Alumali moyo wa mankhwala ndi zaka 3.
Contraindication ndi zoyipa
Monga mankhwala ena ambiri, mankhwala a Ongliz akhoza kukhala oletsedwa.
Nthawi yomweyo, Ongliza adayikidwa ndi dokotala mosamala kwambiri kwa odwala omwe ali ndi vuto la impso, okalamba ndi odwala omwe amatenga mankhwala a sulfonylurea.
Ngati wodwala aphatikiza mankhwala awiri - Onglizu ndi Metformin, nasopharyngitis, kutupa kwa nasopharynx komwe kumachitika chifukwa cha matupi osagwirizana ndi matendawa. Onetsetsani kufunsa dokotala momwe mungagwiritsire ntchito Metformin ndi mankhwala ena.
Simungagwiritse ntchito mankhwalawa kwa anthu:
- wosakwana zaka 18;
- mtundu 1 matenda a shuga;
- kuchitira insulin mankhwala ndi mankhwala;
- ndi galactose tsankho, kuchepa kwa lactase, kubadwa kwa shuga-galactose malabsorption;
- ndi matenda ashuga ketoacidosis;
- pa mimba ndi mkaka wa m`mawere;
- ndi tsankho la munthu pazigawo za mankhwala.
Pa monotherapy, mankhwalawa amatha kuyambitsa mavuto ena mwa anthu, monga:
- chapamwamba kupuma thirakiti matenda;
- kutupa kwamikodzo;
- kusanza ndi kusanza
- kupweteka mutu;
- sinusitis (complication ya pachimake rhinitis);
- gastroenteritis (kutukusira kwa m'mimba ndi matumbo ochepa).
Malangizo ogwiritsidwira ntchito sakusonyeza zomwe zingachitike ndi mankhwala osokoneza bongo. Koma ngati zidachitika, chithandizo chamankhwala chimalimbikitsidwa.
Kuphatikiza apo, mankhwala a saxagliptin amatha kuchotsedwa pogwiritsa ntchito njira ya hemodialysis.
Ndemanga ndi mitengo yamankhwala
Mankhwala Onglisa akhoza kugulidwa ku pharmacy iliyonse ndi mankhwala kapena kuyitanidwa pa intaneti. Kuti muchite izi, pitani pa webusayiti ya masamba azamalonda pa intaneti ndikutsatira malangizo kuti mupeze dongosolo. Popeza mankhwalawa amapangidwa ku United States, mtengo wake ndi wokwera kwambiri. Mtengo wa mankhwala ochepetsa shuga umachokera ku 1890 mpaka 2045 rubles.
Ndemanga za anthu ambiri odwala matenda ashuga ndizokhutiritsa. Odwala ambiri omwe amamwa mankhwalawa amadziwa kuti amagwira ntchito kwambiri. Pambuyo pa kumwa mapiritsi, kudya ndi kuchita masewera olimbitsa thupi, kusintha kwa shuga kwa nthawi yayitali kumawonedwa. Odwala omwe amagwiritsa ntchito Ongliza amakhutira ndi kugwiritsa ntchito mankhwalawa mosavuta. Zotsatira zoyipa zawonedwa kawirikawiri. Choyipa chokha cha mankhwalawo ndi mtengo wake wokwera, chifukwa chakuti ndi mankhwala ochokera kunja.
Nthawi yomweyo, panali ndemanga za madalaivala omwe amayendetsa magalimoto omwe mankhwalawo amayambitsa chizungulire.
Chifukwa chake, anthu omwe amayanjana ndi kasamalidwe ka mayendedwe, ndibwino kusiya ntchito zawo munthawi ya chithandizo kuti mupewe mavuto.
Mndandanda wa mankhwala ofanana
Ngati wodwala akuletsedwa kugwiritsa ntchito Ongliza kapena ali ndi mavuto ena, dokotala yemwe akupezekapo amatha kusintha njira yake yochiritsirayo mwa kupereka mankhwala ena.
Onglisa alibe fanizo lazinthu zomwe zingagwire ntchito, koma malinga ndi momwe thupi limapangidwira, pali mankhwala otere:
- Januvia ndi mankhwala a piritsi omwe amachepetsa kuchuluka kwa shuga m'magazi. Dziko lomwe likubala ndi Netherlands. Mankhwalawa angagwiritsidwe ntchito ndi monotherapy, komanso ophatikizidwa ndi ena othandizira a hypoglycemic monga Metformin wopanda chakudya komanso kuchita masewera olimbitsa thupi. Mosiyana ndi Onglisa, Januvia ali ndi zotsutsana zochepa. Mtengo wapakati ndi ma ruble 1670.
- Trazenta imakhala ndi yogwira mankhwala linagliptin, yomwe imachepetsa shuga. Mankhwalawa amapangidwa ku United States. Monotherapy pankhaniyi siyothandiza, mankhwalawa amagwiritsidwa ntchito limodzi ndi mankhwala ena ochepetsa shuga (Metformin, insulin, zotumphukira za sulfonylurea, Pioglitazone, etc.). Komabe, mankhwalawa amadziwika kuti ndi otetezeka, chifukwa samayambitsa mavuto. Mtengo wapakati ndi ma ruble 1790.
- Nesina ndi mankhwala ochepetsa matenda a shuga. Wopanga mankhwalawa ndi kampani ya zamankhwala ku America Takeda Pharmaceuticals. Wothandizira wa hypoglycemic amagwiritsidwanso ntchito ndi monotherapy komanso ndi chithandizo chowonjezera ndi mankhwala ena. Nthawi zambiri, zotsatira zoyipa zomwe zimakhudzana ndi matenda am'mimba zimachitika. Mtengo wapakati pama pharmacies ndi 965 rubles.
- Galvus ndi mankhwala ena othandizira odwala matenda ashuga. Zimapangidwa ndi kampani yaku Swiss mankhwala. Mankhwalawa amatha kugwiritsidwa ntchito ndi mankhwala a insulin komanso mankhwala ena ambiri ochepetsa shuga. Ili ndi zotsutsana zambiri, koma milandu yotsutsa imasinthidwa kukhala zero. Mtengo wapakati ndi ma ruble 800.
Komanso, odwala matenda ashuga nthawi zambiri amapatsidwa Metformin 850 kapena mlingo wa 1000 mg.
Dziwani kuti palibe mankhwala omwe ali pamwambawa omwe angagwiritsidwe ntchito paubwana (mpaka zaka 18), chifukwa momwe adagwiritsira ntchito mankhwalawa pazaka zazing'ono ngati izi sanaphunzire. Mankhwala onse ndiokwera mtengo ndipo si wodwala aliyense amene angakwanitse.
Kanemayo munkhaniyi akukamba za mapiritsi ochepetsa shuga.
