Mapiritsi a Metformin a 1000 mg ndi oval komanso othandizira mbali zonse ziwiri.
Mankhwala omwe ali m'gulu la mankhwalawo ali ndi mtundu woyera.
Monga gawo la mankhwala Metformin 1000, yogwira popanga ndi metformin hydrochloride. Pulogalamuyi ili ndi ma milligramamu 1000 piritsi limodzi.
Kuphatikiza pa Mlingo wa 1000 mg, mankhwala omwe ali ndi Mlingo wa 850 ndi 500 mg amapangidwa ndi makampani azachipatala.
Kuphatikiza pazomwe zimagwiritsidwa ntchito ndi mankhwala, piritsi lililonse limakhala ndi mitundu ya mankhwala omwe amagwira ntchito zothandiza.
Zomwe zimapanga mankhwala othandizira ndi izi:
- ma cellcose a microcrystalline;
- croscarmellose sodium;
- madzi oyeretsedwa;
- povidone;
- magnesium wakuba.
Mankhwalawa ndi m'gulu la anthu omwe amachepetsa shuga ndipo amagwiritsidwa ntchito pochiza matenda ashuga. Mankhwalawa amapangidwira kuthana ndi magazi, amagwiritsidwa ntchito pakamwa. Ma Active yogwira mankhwala amatanthauza biguanides.
Mankhwalawa atha kugulidwa ku chipatala chilichonse chamankhwala osankhidwa ndi mankhwala. Odwala ambiri amasiyira ndemanga zabwino za mankhwalawa, zomwe zimawonetsa kuwongolera kwa mankhwalawa.
Metformin ozone ili ndi mtengo wa 1000 mg ku Russia, womwe umasiyana ndi dera lomwe likugulitsidwa ku Russian Federation ndipo umachokera ku 193 mpaka 220 rubles pa phukusi lililonse.
Pharmacological zimatha mankhwala
Mutatha kugwiritsa ntchito mankhwala ofunikira, metformin imatengedwa kuchokera m'mimba. Mankhwala ochokera ku lumen am'mimba amamuyamwa kwathunthu. The bioavailability ya mankhwala pafupifupi 50-60%. Zambiri zomwe zimakhala mthupi zimatheka pambuyo pa maola 2-2.5 mutamwa mankhwalawa.
Ndi kukakamiza munthawi yomweyo kwa chakudya ndi mankhwala, kuyamwa kwa kachipangizako kumachepetsa kuchepa kwa magazi ndikukula kwa nthawi.
Zikalowa m'madzi a m'magazi, metformin hydrochloride kwenikweni siyigwirizana ndi mapuloteni a plasma ndipo siipanga zinthu zovuta kupanga.
Metformin imapangidwa pang'ono ndikupukusidwa ndi impso.
Hafu ya moyo wa mankhwalawa imachitika mkati mwa maola 6.5.
Pamaso pa kulephera kwaimpso kwa wodwala yemwe ali ndi matenda osokoneza bongo, theka la moyo limawonjezeka ndipo pamakhala chiwopsezo cha chitukuko cha kupezeka kwa mankhwalawa m'thupi.
Kugwiritsa ntchito mankhwalawa kumakuthandizani kuti muchepetse hyperglycemia m'thupi la wodwalayo, osafufuza mawonekedwe a hypoglycemia. Mankhwala sasokoneza kapangidwe ka insulin ndi beta maselo a pancreatic minofu. Mankhwalawa samatulutsa chitukuko cha dziko la hypoglycemic mwa anthu athanzi
Kugwiritsa ntchito Metformin ozone kumapangitsa kuti chiwonetsero cha cell chizindikirane ndi ma cell omwe amadalira insulin, zomwe zimapangitsa kuchuluka kwa glucose omwe amagwiritsidwa ntchito ndi maselo.
Metformin hydrochloride imatha kulepheretsa kayendedwe ka gluconeogenesis kamene kamapezeka m'maselo a chiwindi ndipo imachedwa kuyamwa kwa glucose kuchokera ku lumen ya m'mimba.
Zomwe zimagwiritsidwa ntchito ndi mankhwala pa glycogen synthetase zimabweretsa kuwonjezeka kwa kapangidwe ka glycogen. Mwa zochita zake pamankhwala a cell, metformin imawonjezera mphamvu za mitundu yonse yaonyamula zimagwirira khungu lonse.
Kulowerera kwa chigawo chogwira ntchito mthupi kumabweretsa chothandiza pa metabolid ya lipid, zomwe zimapangitsa kuchepa kwa cholesterol yathunthu mthupi.
Kulandiridwa kwa Metformin kumathandizira kuti thupi lizilimbitsa thupi, limakhala lokhazikika kapena likuchepera pang'onopang'ono mpaka magawo ovomerezeka.
Malangizo ogwiritsira ntchito mankhwalawa
Maziko ogwiritsira ntchito mankhwalawa ndi kupezeka kwa mtundu wachiwiri wa matenda ashuga mwa munthu, pakalibe kusintha kosintha kwakukulu mu kuchuluka kwa shuga potenga thupi la wodwalayo ndi mankhwala olimbitsa thupi komanso kuchita masewera olimbitsa thupi. Izi zimachitika makamaka kwa anthu onenepa kwambiri.
Mapiritsi angagwiritsidwe ntchito pochiza akuluakulu mu mawonekedwe a monotherapy kapena kuphatikiza ndi mankhwala ena amkamwa a hypoglycemic kapena insulin.
Metformin 1000 ingagwiritsidwe ntchito pochiza matenda osokoneza bongo kwa ana opitirira zaka 10, monga othandizira monotherapeutic kapena osakaniza jakisoni wa insulin.
Mukamamwa mankhwalawa, mapiritsi amayenera kumeza onse osafuna kutafuna, pomwe mankhwalawa amayenera kutsatiridwa ndi kumwa madzi ambiri. Kugwiritsa ntchito mankhwalawa kuyenera kuchitika musanadye kapena nthawi ya chakudya.
Pogwiritsa ntchito mankhwalawa kwa achikulire pa mono kapena mankhwala ovuta, zotsatirazi ziyenera kutsatiridwa:
- Mlingo woyambirira wa mankhwalawa akumwa sayenera kupitirira 500 mg katatu patsiku. M'tsogolo, ngati kuli kotheka, mlingo wa mankhwalawo ungasinthidwe kupita m'mwamba. Mlingo wa mankhwala omwe amwedwa amatengera kuchuluka kwa chakudya chamagulu am'magazi a munthu amene akudwala matenda ashuga.
- Mlingo wokonza mankhwalawa ndi 1500-2000 mg patsiku. Kuti muchepetse kupezeka kwa zotsatira zoyipa za thupi, mlingo wa tsiku lililonse umalimbikitsidwa kuti ugaledwe mu Mlingo wa 2-3. Mlingo wapamwamba tsiku lililonse ndi 3000 mg patsiku. Mlingo wokwanira uyenera kugawidwa mu Mlingo wa 2-3 patsiku.
- Metformin 1000 ikulimbikitsidwa kwa odwala omwe ali ndi Mlingo wa mankhwala tsiku lililonse kuyambira 2000 mpaka 3,000 mg tsiku lililonse.
Mukasankha kumwa Metformin 1000, muyenera kukana kumwa mankhwala ena a hypoglycemic.
Contraindication ndi zoyipa
Monga mankhwala ena aliwonse, Metformin ili ndi zotsutsana zina kuti zigwiritsidwe ntchito.
Kuphatikiza apo, popereka mankhwala, munthu ayenera kuganizira za mwayi wokhala ndi zovuta kuchokera ku mankhwalawo.
Musanayambe kugwiritsa ntchito mankhwalawa ngati othandizira, muyenera kuonana ndi endocrinologist.
Ma contraindication omwe amagwiritsidwa ntchito ndi awa:
- kukhalapo kwa hypersensitivity kwa metformin hydrochloride kapena magawo othandizira;
- kukhalapo kwa zizindikiro za matenda a diabetesic ketoacidosis;
- matenda okhudza magwiridwe antchito, kupezeka kwa matenda opatsirana;
- matenda osiyanasiyana omwe amachititsa kuti minyewa ya okosijeni ilowe m'thupi la wodwalayo;
- kuchitapo kanthu pochita opaleshoni kumene kugwiritsa ntchito mankhwala a insulin kumalimbikitsidwa;
- zosokoneza mu ntchito yofanana ndi chiwindi;
- kukhalapo kwa uchidakwa wambiri kapena zakumwa zoopsa zakumwa;
- lactic acidosis;
- nthawi ya kulowa kwa intrauterine ndi nthawi ya mkaka wa m`mawere;
- wodwala mpaka zaka 10.
Zotsatira zoyipa chachikulu mukamagwiritsa ntchito Metformin ndizowoneka ngati zovuta m'mimba, zomwe zimasonyezedwa ndi kusanza, nseru ndi matenda am'mimba, komanso kuchepa kwa chilimbikitso. Pakhungu, zotupa ndi kuyamwa zimatha. Ngati pali zovuta mu chiwindi, kukula kwa chiwindi kumatha atasiya mankhwalawa.
Zambiri pazamankhwala Metformin zikufotokozedwa mu kanema munkhaniyi.
