Sizotheka nthawi zonse kuthana ndi matenda a shuga a 2 kokha mothandizidwa ndi zakudya zotsika kwambiri za carb komanso minyewa yozungulira. Ndipo ndikofunikira kulimbana ndi hyperglycemia, chifukwa chithandizo cha kusaphunzira chimabweretsa zovuta zambiri.
Zina mwa zoopsa kwambiri ndi zovuta za mtima. Diabetesalong (Latin Diabetalong), mankhwala a hypoglycemic omwe amatulutsidwa nthawi yayitali kapena amasintha, amathandiza kuchepetsa chiopsezo chokhala ndi CVD.
Kuthekera kwama pharmacological
The antidiabetesic zimatha mankhwala chifukwa yogwira pawiri gliclazide. Mapiritsiwo ali ndi 30 kapena 60 mg pazofunikira ndi zosakaniza: calcium stearate, hypromellose, talc, lactose monohydrate, colloidal silicon dioxide.
Diabetesalong ndi mankhwala a gulu la 2 la sulfonylurea. Ikafika m'magazi, gliclazide imalimbikitsa kuphatikizika kwa mahomoni amkati mwa cells-maselo a kapamba, imathandizira kugwiritsidwa ntchito kwa glucose (imathandizira ntchito ya minofu ya glycogen synthase). Pakupita masiku ochepa kuyambira pomwe maphunzirowa adayamba, mbiri ya glycemic imakhala yofanana. Kutalika kwa nthawi kuchokera pakumeza chakudya m'matumbo am'mimba ndikupanga ma insulin omwe amachepetsa, ndipo zizindikiro za glycemic zomwe zimayambitsidwa ndi chakudya zimachepetsedwa.
Ndizodabwitsa kuti patatha zaka ziwiri atamwa mankhwalawa, anthu ambiri omwe amapezeka ndi postprandial insulin ndi C-peptide amasungidwa. Zokhudza thupi ku Diabetesalong ndizovuta:
- Amalamulira kagayidwe kazakudya;
- Ili ndi dongosolo la antioxidant;
- Imalimbikitsa insulin;
- Imakhala ndi hemovasasmance (imapanikiza kuphatikizika kwa maselo a m'magazi).
Mkulu akalowa m'magazi, gliclazide imathandizira kupanga insulin. Ndi chithandizo chanthawi zonse, mankhwalawa amachenjeza:
- Microvascular mavuto - retinopathy (njira yotupa pa retina) ndi nephropathy (aimpso kukanika);
- Zotsatira zam'maso akulu - stroko, mtima.
Zolemba za Pharmacokinetic
Kuyambira pamimba, mankhwalawa amamwetsa kwathunthu. Zambiri zomwe zimakhala m'magazi zimafikira pambuyo pa maola 2-6, komanso mapiritsi okhala ndi MV - 6-12 maola.
The achire zotsatira kumatenga maola 24, magazi mapuloteni glycazide amamangira 85-99%. Mu chiwindi, chinthu chopangidwa ndi majini chimasinthidwa kukhala metabolites, chimodzi mwazomwe zimathandizira kusintha kwapang'onopang'ono. Hafu ya moyo ndi maola 8-12, mapiritsi okhala ndi MB - 12-16 maola. Mankhwala amatsitsidwa ndi 65% ndi mkodzo, 12% ndi ndowe.
Ndani akuwonetsedwa mankhwalawo
Cholinga choika Diabetesalong ndi matenda amtundu wa 2 shuga, onse monga monotherapy komanso kuphatikiza ndi insulin kapena mankhwala ofanana ndi antidiabetes.
Contraindators ndi malire
- Mtundu woyamba wa shuga;
- Hypersensitivity;
- Matenda a chiwindi;
- Matenda owopsa aimpso;
- Ketoacidosis;
- Hypo- ndi hyperthyroidism;
- Matenda a shuga kapena a hyperosmolar;
- Mimba komanso yoyamwitsa
- Kuvulala kwambiri ndikuwotcha.
Diabetesalong imaphatikizidwa mwa amayi apakati, ngati sangathe kuimitsidwa pamene akuyamwitsa, mwana amasinthidwa ku zakudya zopanda ntchito.
Kugwiritsa ntchito glycoside sikuloledwa mukamamwa pamodzi ndi miconazole.
Zotsatira zoyipa
Zosafunika chifukwa cha m'mimba thirakiti imatha kukhala zovuta m'matumbo mwa kugunda nseru, kusanza, kupweteka m'mimba. Kuchokera kumbali ya kagayidwe kachakudya, hypoglycemia ndiyotheka, kwa dongosolo lozungulira - eosinophilia, cytopenia, kuchepa magazi. Pa khungu, ziwengo ndi photosensitization ndizotheka. Kuchokera ku ziwalo zam'maganizo mumakhala kusokonezeka kwa kulawa, kupweteka mutu, kutayika kwa mgwirizano, kuchepa mphamvu.
Zochita zamankhwala osokoneza bongo
Kuchita bwino kwa glycoside kumatheka chifukwa chogwiritsidwa ntchito limodzi ndi anabolic steroids, ACE inhibitors, β-blockers, cimetidine, fluoxetine, salicylates, MAO inhibitors, Flucanazole, Pentoxifylline, Miconazole, Theophylline, Tetracycline.
Mwayi wa glycoside umakhala wofooka mukamagwiritsidwa ntchito limodzi ndi barbiturates, glucocorticoids, sympathomimetics, saluretics, rifampicin, mapiritsi oteteza kubala, estrogens.
Momwe mungagwiritsire ntchito
Glycloside iyenera kumwedwa ndi chakudya. Piritsi limamezedwa lonse, kutsukidwa ndimadzi kutentha kwa firiji. The endocrinologist amasankha Mlingo ndi mankhwalawa amathandizika payekhapayekha, poganizira gawo lomwe matendawa amachitikira komanso momwe wodwala matenda ashuga amvera. Pa mankhwala a Diabetesalong, malangizo omwe angagwiritsidwe ntchito amalimbikitsa kuyambira kwa 30 mg ndi kukonza kowonjezereka pakuwonjezereka (ngati kuli kofunikira).
Kuti mukwaniritse chithandizo chokwanira, ndikofunikira kutsatira malamulo osavuta.
- Mlingo wa tsiku ndi tsiku amatengedwa kamodzi, koposa zonse - m'mawa;
- Kuchuluka kwa mankhwalawa kumatha kusintha mkati mwa 30 -120 mg / tsiku;
- Ngati nthawi yakuvomerezedwa yaphonya, sikuyenera kuonjezeredwa ndi nthawi yotsatirayo;
- Mukamawerenga mlingo, dokotalayo amaganizira zowerengera za mita ndi HbAlc.
Ndi osakwanira, chizolowezi chimachulukitsa (pambuyo povomerezana ndi adokotala), koma osapitirira mwezi umodzi atamwa koyamba glycoside. Masabata awiri aliwonse, ndikubwezerera kwathunthu kwa glycemia, mutha kuwonjezera mlingo.
Ndikofunikira kudziwa kuti piritsi limodzi la Diabetesalong PV lili ndi 60 mg ya glyclazide, izi zimafanana ndi mapiritsi awiri a Diabetalong MV 30 mg aliyense.
Mukasamutsa munthu wodwala matenda ashuga ku gliclazide kuchokera ku mankhwala ena a hypoglycemic, kupuma sikofunikira, kupatula zotumphukira za sulfonylurea. Mlingo woyambirira pamenepa ndi wokhazikika - 30 mg, ngati endocrinologist sanafotokoze chiwembu chake.
Mankhwalawa ovuta, Diabetesalong imagwiritsidwa ntchito limodzi ndi mitundu yambiri ya insulin, biagudins, α-glucosidase inhibitors. Mosamala, mankhwalawa amalembedwa kwa odwala matenda ashuga kuchokera ku gulu la chiopsezo cha hypoglycemic (uchidakwa, masewera olimbitsa thupi kapena masewera, njala, maziko osautsa). Ntchito za hememopoic zimasokonekera ndi kukula kwa magazi m'thupi, thrombocytopenia, leukopenia, granulocytopenia.
Njira zopewera kupewa ngozi
Pofuna kupewa hypoglycemia, ndikofunikira kuti nthawi yogwiritsa ntchito mankhwalawa idye, kupewa nthawi yayikulu yopumira, kuti muchepetse zakumwa zoledzeretsa. Kukhazikika kwa β-blockers kumatha kupotoza zizindikiro za hypoglycemia.
Mkhalidwe wa hypoglycemic ukhoza kuzindikiridwa ndi kupweteka kwa mutu, kusokonezeka kwa mgwirizano, kugunda kosalamulirika kwa njala, kukhumudwa, kukomoka, kusawona bwino, matenda osokonekera. Zochita za adrenergic zimawonetsedwanso: nkhawa, thukuta, kutsika kwa magazi, matenda a mtima, kusokonekera kwa mtima. Matenda a dyspeptic, kusokonezeka mumtundu wa defecation, komanso kusintha kwa khungu (zotupa, kusapeza bwino, erythema, urticaria, edema ya Quincke) ndi chikhalidwe.
Kuchita bwino mankhwala sikutheka popanda kudya kwapakatikati. Chifukwa cha chiwopsezo cha zovuta zoyipa, oyendetsa amayenera kumwa mankhwalawa mosamala. Malingaliro omwewo amagwiranso ntchito kwa oimira mabungwe omwe amagwirizana ndi kukwera kwakukulu komanso kuchuluka.
Matenda a chiwindi ndi bile ducts amachititsa hepatitis, kuwonjezeka kwa enzyme ntchito.
Ngati wozunzidwayo akudziŵa, ayenera kudya maswiti, kumwa kapu ya tiyi kapena china chakudya chamagulu omwera. Zinthu zikayamba kuyenda bwino, endocrinologist amayenera kufunsidwa kuti asinthe mankhwalawo kapena kusintha mankhwalawo.
Mitu ya mankhwalawa
Malinga ndi gawo lomwe likugwira ntchito ku Diabetesalong, analogue ndiye mankhwala Glidiab ofunika mpaka ma ruble 140. Madokotala amapereka Diabeteson ndi Diabeteson MV mankhwala pamtengo wokwera kuyambira 286 mpaka 318 rubles. Pazokonzekera zomwe zimafananizidwa, Glyclada ingalimbikitsidwenso.
Kukonzekera ndi zotsatira zofanana za hypoglycemic monga Amaril, Glimepiride, Glemaz, Glyurenorm zidzakhala bwino pakupanga. Amalembera hypersensitivity kapena contraindication ena a glycoside.
Fomu yotulutsidwa, malo osungira
Mapiritsi a Diabetesalong opangidwa ndi Synthesis OJSC ndi MS-Vita LLC amapangidwa m'matumba a chithuza. Matumba amaikidwa pabokosi lamakhadi.
Mankhwalawa amatha kusungidwa kwa zaka 3 kutentha kwa firiji, popanda kuwunika mwachindunji ndi ana. M'mafakitala, Diabetesalong imapezeka kuti ipatsidwe mankhwala pamtengo wa 98-127 rubles. mapiritsi 60 a 30 mg.
Ndemanga za Diabetesalong
Anthu odwala matenda ashuga omwe adakumana ndi zovuta za matenda ashuga, mu ndemanga amawona zabwino zake:
- Kusintha pang'onopang'ono kwa zizindikiro za glucometer;
- Kuyanjana kwabwino ndi mankhwala ena;
- Mtengo wotsika mtengo wa mankhwala;
- Kutha kuchepetsa thupi panthawi ya chithandizo.
Sikuti aliyense amakhutitsidwa ndikufunika kosinthika pafupipafupi (mpaka kasanu pa tsiku), koma pakapita nthawi zizindikiritso zake zimachepa komanso kufunika kokhala kudziletsa kumachepa.
Pazonse, Diabetesalong ndi mankhwala odalirika a antidiabetic omwe amasintha bwino mbiri ya glycemic. Ikagwiritsidwa ntchito moyenera, imatha kupewa zochitika za mtima komanso zovuta zina za matenda a shuga a 2.