Mpaka pano, pali mankhwala angapo omwe amathandiza kuchepetsa cholesterol m'magazi a anthu.
Amagwiritsidwa ntchito pazochitika zomwe kudya ndi osagwiritsa ntchito mankhwala osapereka sikuwapatsa zotsatira zabwino.
Chimodzi mwazomwezi zomwe ndi gawo la mankhwala ena ndi chiprofibrate.
Ciprofibrate ndi mankhwala ochepetsa mphamvu ya lipid omwe amachepetsa cholesterol ya LDL ndi plasma triglycerides, pomwe lipoproteins ("zabwino" cholesterol) zapamwamba, m'malo mwake, zimawonjezera.
Kugwiritsa ntchito mankhwalawa sikulimbikitsidwa ngati chida chodziyimira pawokha, koma mothandizidwa ndi kadyedwe komanso njira zina zochizira mankhwala. Kuchitapo kanthu kumatengera kuthekera kumangiriza ma cell nucleus receptors, momwe amathandizira ndikuwonjezera kapena kuchepetsa ntchito zamtundu zomwe zimayambitsa kusintha kwa lipoprotein m'thupi.
Chithandizo chanthawi yayitali, momwe mumakhala kuchepa kwakukulu kwa seramu cholesterol, kumabweretsa kuchepa kapena kutha kwathunthu kwa ma cholesterol amana.
Ciprofibrate imalepheretsa kuwonongeka kwa magazi kuwundana, imathandizira kuwonongeka kwa ma fibrins, komanso imathandizira kulolerana kwa glucose, chomwe ndichofunikira kwa odwala omwe ali ndi matenda ashuga.
Zimathandizira kuchepetsa njira ya matenda a mtima, koma sikuti chifukwa chochepetsera kufa mukamagwiritsidwa ntchito popewa matenda a mtima. Mapiritsi amatengedwa pakamwa, pambuyo pake amathandizidwa mwachangu komanso pafupifupi. Imatha kupanga zomanga m'mapuloteni a plasma. Amayamwa mu mkodzo osasinthika kapena mawonekedwe a mankhwala okhala ndi glucuronic acid.
Malinga ndi ndemanga ya odwala omwe amamwa mankhwalawo, amadziwika bwino.
Zotsatira zoyipa sizikuwonekera, ndipo zotsatira za mankhwalawa zimakhudza magazi a cholesterol.
Mankhwalawa amagwiritsidwa ntchito atakambirana ndi adokotala, omwe angatsimikizire kufunika kwa kugwiritsidwa ntchito kwake mwa njira iliyonse. Zizindikiro zogwiritsidwa ntchito ndi:
- Zowonjezera pamankhwala azakudya ndi zina zosagwiritsa ntchito mankhwala osokoneza bongo a cholesterol yayikulu;
- Mitundu yayikulu ya hypertriglyceridemia yokhala ndi mafuta ochepa kapena otsika;
- Hyperlipidemia wosakanikirana milandu yomwe imagwiritsidwa ntchito ma statins imatsutsana pazifukwa zilizonse.
Mankhwala amapatsidwa 100 mg kamodzi patsiku. Ngati ndi kotheka, onjezani mlingo wa 200 mg kamodzi patsiku.
M'miyezi 12 yoyambirira ya mankhwala a chiprofibrate, kuwunika mwadongosolo (nthawi 1 m'miyezi ingapo) kuyang'anira ntchito ya plasma ALT ndikulimbikitsidwa.
Mankhwala ali ndi mndandanda wokwanira bwino wa omwe amatsutsana, omwe ndi awa:
- Hypersensitivity ku zilizonse za mankhwala;
- Kulephera kwamkati kapena matenda ena a ziwalo;
- Kulephera kwa chiwindi;
- Nthawi ya pakati mwa azimayi;
- Nthawi yodzala;
- Zaka za ana.
Pambuyo pamagwiritsidwe a fibrate, panali zochitika zowonongeka kwa minofu ya minofu, kuphatikizapo milandu ya rhabdomyolysis. Pankhaniyi, kuwonjezeka kwakukulu kwa chiwopsezo cha zotsatirazi zovuta kwa odwala omwe ali ndi impso. Zotsatira zoyipa zomwe zimakhudzana ndi kuwonongeka kwa minofu nthawi zambiri zimayamba chifukwa cha overdosing.
Odwala omwe ali ndi vuto la kuchepa kwa mahomoni a chithokomiro, kusintha kwachiwiri kwa mapangidwe a mafuta m'magazi kumaonedwa. Ndikofunikira kusintha manambala awo musanamwe mankhwalawo. Nthawi ya hypothyroidism, matenda othandizira oyenda m'magazi amatha kupezeka, amadziwika ndi kuwonongeka kwa minofu yoyamba, komwe mtsogolomo kungayambitse kuwonjezereka kwa poizoni wamafupa m'thupi.
Zotsatira zoyipa za mankhwalawa:
- Kupezeka kwa mutu wosiyanasiyana mwamphamvu;
- Maonekedwe a nseru;
- Kufooka kwathunthu kwa thupi, kuchuluka kwa kutopa;
- Myositis;
- Myalgia;
- Kuchulukitsa kwakanthawi mu ntchito ya ALT, CPK ndi LDH, zomwe zili za creatinine m'madzi a m'magazi;
- Kuchulukitsa kwa cholelithiasis;
- Maonekedwe a pakhungu pakukhazikika kwachilengedwe;
- Matenda am'mimba am'mimba - dyspepsia, nseru, kusanza, kutsegula m'mimba, kupweteka kwam'mimba, kupweteka kwamatumbo komanso matenda osachiritsika.
Mankhwala osokoneza bongo a ciprofibrate samayambitsa zizindikiro zenizeni, komabe, mukamamwa mankhwala ambiri, pitani kuchipatala.
Simalimbikitsidwa kugwiritsidwa ntchito molumikizana ndi ma fiber ena, chifukwa izi zimawonjezera chiopsezo cha rhabdomyolysis ndi antaconism wa pharmacodynamic.
Mankhwala akamagwiritsidwa ntchito limodzi ndi mafuta amkamwa, zimawonjezera mphamvu pa thupi, zomwe zimawonjezera ngozi yotulutsa magazi.
Nthawi zina, zimawonjezera zotsatira za mankhwala a shuga. Kuphatikiza ndi ma statins ndi ma fiber ena, zimatha kuyambitsa kuchuluka kwa myopathy, komwe kumadziwika ndi kuwonongeka kwa minofu ya minofu, kuwonjezeka kwakukulu kwa ntchito ya creatine kinase, kuwonjezeka kwa creatine ndende ndi myoglobinuria, komwe kungayambitse kulephera kwa impso.
Titha kuyesa mankhwala ena pamankhwala apuloteni pomanga mapuloteni a plasma.
Ngati, motsutsana ndi kumbuyo kwa chithandizo ndi ciprofibrate, kuchepa kwa kuchuluka kwa ma seramu lipids sikunachitike pakadutsa miyezi 3-6, ndiye kuti owonjezera kapena othandizira ena ayenera kuikidwa.
Odwala ena, kumwa mankhwala a gululi kumayambitsa kuchepa kwakanthawi kwamankhwala, zomwe zimapangitsa kuti azikhala ndi nthawi yokwanira kudziwa kuchuluka kwa miyezi ingapo chaka choyamba chamankhwala.
Ndi kuwonjezeka kwa ntchito ya seramu alanine transamylase zoposa mayunitsi 100, chithandizo chikuyenera kutha.
Kugwiritsa ntchito mankhwala ena a gulu la fibrate molumikizana ndi ciprofibrate sikulimbikitsidwa.
Mafuta a chinthu ichi ndi mankhwala odziwika kwambiri, omwe ali gawo lake, ndi Lipanor. Ndi mankhwala omwe amagulitsidwa mu mankhwala ndi mankhwala. Amapezeka m'makapisozi okhala ndi 100 mg ya ciprofibrate. Makapisozi ali mumachimake, mu phukusi - 3 matuza.
Mankhwala ena, omwe amagwira ntchito omwe ndi Ciprofibrate, sanapezekepo, komabe, pali mankhwala ogulitsa omwe ali amtundu wa gulu: Roxer, Lipantil, Lipantil 200 mg, Vitrum Cardio omega-3.
Mtengo wa mankhwalawa umasiyana kuchokera ku 850.00 mpaka 1300.00 rubles. Kugwiritsa ntchito kwawo kuyenera kuvomerezana ndi adokotala kuti asatenge tsankho la munthu payekha ndikuwoneka ngati alibe mayankho mthupi.
Chithandizo cha atherosclerosis akufotokozedwa mu kanema munkhaniyi.
