Kuphatikiza pa chithandizo cha zakudya, mankhwalawa amagwiritsidwa ntchito pochiza matenda wamba monga atherosulinosis.
Chimodzi mwa izo ndi fluvastatin, chomwe ndi chinthu cha hypocholesterolemic cholimbana ndi cholesterol yowonjezereka m'magazi a anthu.
Fluvastatin ndi mankhwala onunkhira omwe amakhala ndi mtundu woyera kapena wachikasu pang'ono. Mafuta osungunuka bwino m'madzi, ma alcohols ena, ali ndi mawonekedwe a hygroscopic.
Chimodzi mwazomwe zimagwiritsidwa ntchito ndi mankhwala (majenito), zomwe zimaphatikizapo yogwira thunthu fluvastatin, ndi Leskol Forte. Ndiwo mapiritsi okhala ndiutali wophatikizidwa. Ali ndi mawonekedwe ozungulira, a biconvex okhala ndi mbali zometedwa. Muli 80 mg ya fluvastatin piritsi limodzi.
Ndi mankhwala opangidwa modabwitsa a hypocholesterolemic. Imalepheretsa ntchito ya HMG-CoA reductase, imodzi mwazomwe ntchito yake ndikusintha kwa HMG-CoA kupita patsogolo pa sterols, yomwe ndi cholesterol, mevalonate. Kuchita kwake kumachitika m'chiwindi, komwe kuchepa kwa cholesterol, kuwonjezeka kwa zochita za LDL receptors, kuwonjezeka kwa kuyambitsa kwa ma cell a LDL. Zotsatira zake, chifukwa chakuchita kwa njirazi zonse, pali kuchepa kwa mafuta a m'madzi a m'magazi (plasma cholesterol).
Asayansi atsimikizira kuti ndi kuchuluka kwa cholesterol ya LDL ndi triglycerides m'madzi am'magazi, atherosulinosis imayamba ndipo chiwopsezo chokhala ndi matenda ena a mtima ndi mtima chimakulanso, zomwe nthawi zambiri zimamupha. Komabe, kuwonjezeka kwa milingo ya lipoprotein yapamwamba kwambiri kuli ndi zotsatira zotsutsana.
Mutha kuwona zamankhwala m'mene mumamwa mankhwalawa pambuyo pa masabata awiri, kuuma kwake kumatheka pakatha mwezi umodzi kuchokera pachiyambireni cha mankhwalawa ndipo umakhalabe munthawi yonse yogwiritsira ntchito fluvastatin.
Kwambiri ndende, kutalika kwa zochita ndi theka moyo mwachindunji zimatengera:
- Mawonekedwe a mankhwalawa momwe mankhwalawa amagwiritsidwira ntchito;
- Ubwino ndi nthawi yakudya, zomwe zili m'mafuta momwemo;
- Kutalika kwa nthawi yogwiritsira ntchito;
- Mikhalidwe payokha yamomwe kagayidwe ka munthu amagwirira ntchito.
Pamene fluvastatin sodium imagwiritsidwa ntchito mwa odwala omwe ali ndi hypercholesterolemia kapena dyslipidemia, panali kuchepa kwakukulu kwa LDL ndi triglyceride komanso kuwonjezeka kwa cholesterol ya HDL.
Pakasankhidwa ndikofunika kutsatira malangizo apadera.
Ngati munthu akudwala matenda a chiwindi, njira yodziwira khansa ya rhabdomyolysis, kugwiritsa ntchito mankhwala ena a gulu la statin kapena kumwa zakumwa zoledzeretsa, fluvastatin imayikidwa mosamala. Ichi ndi chifukwa cha zovuta za chiwindi, musanayambe kumwa, pambuyo pa miyezi inayi kapena munthawi yowonjezera mlingo, odwala onse amafunika kuwunika momwe chiwindi chilili. Pali umboni kuti nthawi zosowa kwambiri, kugwiritsa ntchito mankhwalawa kunathandizira kuyambanso kwa chiwindi, komwe kumawonedwa pokhapokha pochita mankhwala, ndipo kumapeto kwake kudatha;
Kugwiritsa ntchito fluvastatin nthawi zina kungayambitse kuwoneka kwa myopathy, myositis ndi rhabdomyolysis. Odwala ayenera kudziwitsa adokotala za maonekedwe a kupweteka kwa minofu, kuwawa kapena kufooka kwa minofu, makamaka pakhale kuwonjezeka kwa kutentha;
Pofuna kupewa kukula kwa rhabdomyolysis musanagwiritse ntchito, tikulimbikitsidwa kuti tidziwe kuchuluka kwa creatine phosphokinase pamaso pa matenda a impso mwa odwala; matenda a chithokomiro; matenda amtundu uliwonse wamatumbo; uchidakwa.
Odwala omwe ali ndi zaka zopitilira 70, kufunikira kwa kudziwa kuchuluka kwa CPK kuyenera kuwunikidwa pamaso pa zinthu zina zomwe zikuwonetsa kukonzekera kwa rhabdomyolysis.
Muzochitika zonsezi, dokotala yemwe amapita amawunika phindu la mankhwalawo komanso mavuto ake. Odwala amayang'aniridwa mosamala komanso mosamala. Pankhani yakuwonjezereka kwakukulu kwa kuchuluka kwa CPK, kumapangidwanso pambuyo pa sabata. Ngati izi zikutsimikiziridwa, chithandizo sichikulimbikitsidwa.
Ndi kutha kwa zizindikiro ndi kuphatikizika kwa ndende ya creatine phosphokinase, kuyambiranso kwa mankhwala ndi fluvastatin kapena ma statin ena ndikulimbikitsidwa kuti ayambe ndi mlingo wotsika kwambiri ndikuyang'aniridwa mosalekeza.
Chofunikira ndikutsuka kwa zakudya za hypocholesterol musanayambe mankhwala komanso panthawi ya chithandizo.
Amadyedwa ndi pakamwa, ngakhale chakudyacho. Ndikofunikira kumeza piritsi lonse, kutsukidwa ndi madzi ochepa, 1 nthawi patsiku.
Popeza kuchuluka kwakukulu kwa hypolipidemic kumadziwika ndi sabata la 4, kuwunika kwa mankhwalawa sikuyenera kuchitika kale kuposa nthawi ino. Zithandizo zochizira za Lescol Forte zimangopitilira pogwiritsa ntchito nthawi yayitali.
Kuti muyambe kuchiza, mlingo woyenera ndi 80 mg kamodzi patsiku, womwe ndi wofanana ndi piritsi limodzi la Leskol Forte 80 mg. Pamaso pa matenda pang'ono, 20 mg ya fluvastatin, kapena 1 kapisozi Leskol 20 mg, akhoza kutumikiridwa. Kusankha mlingo woyambirira, adokotala amawunika kuchuluka kwa cholesterol m'magazi a wodwalayo, amapanga zolinga zamankhwala komanso amaganizira zomwe wodwalayo ali nazo.
Ngati wodwala akudwala matenda a mtima ndipo wachitidwa opaleshoni ya angioneoplastic, mlingo woyambirira ndi kugwiritsa ntchito 80 mg patsiku.
Kusintha kwa Mlingo sikuchitika kwa odwala omwe ali ndi vuto laimpso. Izi ndichifukwa choti ambiri a Fluvastatin amachotsedwa m'chiwindi, ndipo ndi gawo laling'ono chabe la zinthu zomwe zimalandidwa m'thupi zomwe zimathiridwa mkodzo.
Pochita kafukufuku, zidatsimikizika kuti ndizothandiza komanso kulolerana kwabwino osati kwa achinyamata okha, komanso kwa anthu azaka zopitilira 65.
Mu gulu lazaka zopitilira 65, mayankho azamankhwala adatchulidwaponso, pomwe palibe chidziwitso chokwanira chololera chomwe chidapezeka.
Mankhwalawa ali ndi zovuta zingapo:
- Nthawi zambiri, kupezeka kwa thrombocytopenia kumatha kuonedwa;
- Mwina mwadzidzidzi kugona kwakasokonezeka, mutu, paresthesia, dysesthesia, hypesthesia;
- Maonekedwe a vasculitis samachitika kawirikawiri;
- Maonekedwe a zovuta zam'mimba thirakiti - dyspepsia, kupweteka kwam'mimba, nseru;
- Maonekedwe a khungu lawo siligwirizana, chikanga, dermatitis;
- Kupweteka kwa minofu, myopathy, myositis, rhabdomyolysis, ndi lupus ngati zimachitika kawirikawiri sizimachitika.
Mankhwala amalimbikitsidwa kuti agwiritsidwe ntchito ndi odwala akuluakulu:
- Mukazindikira kuchuluka kwa cholesterol okwanira, triglycerides, otsika kachulukidwe lipoprotein cholesterol, apolipoprotein B, wokhala ndi hypercholesterolemia ndi hyperlipidemia;
- Pamaso pa matenda a mtima kuti muchepetse kukula kwa atherosulinosis;
- Monga njira yothanirana ndi mankhwala pambuyo pa angioplasty.
Thupi limaphatikizidwa kuti ligwiritsidwe ntchito pamaso pa ziwengo; odwala matenda a chiwindi, ndi kuchuluka kwa michere ya chiwindi; pa mimba ndi mkaka wa m`mawere akazi; ana ochepera zaka 10.
Mosamala, ndikofunikira kupereka njira yothandizira odwala omwe ali ndi khunyu, ndi uchidakwa, kulephera kwa impso ndikusokoneza myalgia.
Zotsatira zoyipa sizikuwoneka ndi gawo limodzi la 80 mg.
Pankhani yoika mankhwala kwa odwala mwanjira ya mapiritsi ndi kuchedwa kutulutsidwa mu 640 mg kwa masiku 14, mawonekedwe a zovuta kuchokera m'matumbo am'mimba, kuwonjezeka kwa plasma ambiri a transaminases, ALT, AST.
Ma cytochrome isoenzymes amatenga nawo mbali mu kagayidwe ka mankhwala. Poona kuti kuthekera kwa imodzi mwazigawo za metabolic kumabuka, imalipidwa pang'onopang'ono chifukwa cha ena.
Kugwiritsa ntchito mankhwala Fluvastatin ndi HMG-CoA reductase inhibitors sikulimbikitsidwa.
Ma gawo ndi zoletsa za CYP3A4 dongosolo, erythromycin, cyclosporin, intraconazole zimatanthauzira pang'ono pa pharmacology yamankhwala.
Kuti muwonjezere zowonjezera, colestyramine akulimbikitsidwa kuti isagwiritsidwe ntchito kale kuposa maola 4 pambuyo pa fluvastatin.
Palibe zotsutsana pakuphatikizidwa kwa mankhwalawa ndi digoxin, erythromycin, itraconazole, gemfibrozil.
Kuphatikizika kwa mankhwalawa ndi phenytoin kungayambitse kuchuluka kwa plasma kwa omalizirawo, chifukwa chake kusamala kuyenera kugwiritsidwa ntchito popereka mankhwala. Nthawi zina, kusintha kwa mlingo kungafunike.
Pali kuwonjezeka kwa ndende ya madzi a m'magazi a diclofenac pamene atengedwa limodzi ndi fluvastatin.
Tolbutamide ndi losartan angagwiritsidwe ntchito nthawi imodzi.
Ngati munthu akudwala mtundu wachiwiri wa matenda ashuga ndipo amatenga fluvastatin, ayenera kusamala kwambiri ndikuyang'aniridwa ndi achipatala, makamaka pamene akuwonjezera mlingo wa fluvastatin tsiku lililonse mpaka 80 mg tsiku lililonse.
Mankhwala akaphatikizidwa ndi ranitidine, cimetidine ndi omeprazole, kuwonjezeka kwakukulu kwa plasma ndende ndi AUC ya thunthu kumawonedwa, pomwe chilolezo cha plasma cha Fluvastatin chikuchepetsedwa.
Mosamala, phatikizani mankhwala awa ndi anticoagulants a warfarin mndandanda. Ndikulimbikitsidwa kuwunika nthawi ndi nthawi prothrombin, ngati kuli kotheka, musinthe.
Pakadali pano, mankhwalawa amakhala ndi ndemanga zingapo zabwino kuchokera kwa odwala omwe adamwa ngati chithandizo chamankhwala. Tiyenera kudziwa kuti kuti mukwaniritse bwino, ndikofunikira kutsatira moyo wabwino, kudya moyenerera komanso kuchita masewera olimbitsa thupi moyenera. Kuphatikiza apo, kugwiritsa ntchito njira yayitali kumalimbikitsidwa, popeza mankhwalawa amakhala ndi mphamvu yayitali, momwe amathandizira kuchuluka kwa cholesterol m'mwazi.
Mankhwala okhala ndi fluvastatin ayenera kugulidwa m'masitolo ogulitsa mankhwala.
Akatswiri amalankhula za ma statins mu kanema munkhaniyi.
