Cholesterol chachikulu pakadali pano chitukuko cha anthu ndichimodzi mwazinthu zovuta kwambiri m'badwo wakale. M'zaka zaposachedwa, kupezeka kwa cholesterol yochulukirapo kumawonekera kwambiri m'badwo wachichepere.
Zomwe zimapangitsa kukonzanso kwa matendawa ndizomwe zimachitika pafupipafupi kupsinjika kwamaganizidwe akuthupi, kuphwanya chikhalidwe, kudya zakudya zambiri zomwe zimakhala zoopsa, ndikutsata moyo wongokhala. Zinthu zonsezi zimayambitsa kusokonekera kwa metabolic m'thupi.
Kuti athetse vuto la kudwala kwamatenda, amafunika kusankha mankhwala abwino komanso othandiza pakuchiritsira cholesterol m'madzi a m'magazi.
Kuchepetsa cholesterol yayikulu mthupi, madokotala nthawi zambiri amalimbikitsa kugwiritsa ntchito mankhwala omwe ali m'gulu la ma statins.
Makamaka otchuka ndi mankhwala awiri omwe ali mgululi - Krestor kapena Roxer.
Mankhwala ochepetsa awa a lipid amapangidwa ndi opanga momwe amapangira mapiritsi amkamwa.
Kuti mugwiritse ntchito moyenera, muyenera kudziwa Roxer kapena Atorvastatin yemwe ali bwino, kuwonjezera pa funsoli, odwala amakhalanso ndi funso lazomwe zili bwino kuposa Rosucard kapena Roxer. Kutuluka kwa mafunso awa kumalumikizidwa ndi kutchuka kwambiri kwa njira izi zakuchitira hypolipidemic mankhwala.
Chovuta pakusankha mankhwala okwanira ndikuti onse ali ndi zotsatira zofanana pa thupi la wodwalayo. Pachifukwa ichi, ndi adokotala okhawo omwe amatha kusankha njira yabwino kwambiri yamankhwala malinga ndi zotsatira za mayeso ndikuzindikira mawonekedwe a thupi la wodwalayo.
Zolemba za Crestor
Mtanda ndi mankhwala oyamba okhala ndi milomo yotsitsa lipid. Kugwiritsa ntchito mankhwalawa kumatha kuchepetsa cholesterol yathunthu, kuchuluka kwa lipoproteins otsika ndi triglycerides.
Mankhwalawa ndi mpikisano wosankha wa HMG-CoA reductase. Enzyme iyi imayang'anira kutembenuka kwa 3-hydroxy-3-methylglutarylcoenzyme A mpaka mevalonate, womwe ndi patsogolo pa mowa wa polycyclic lipophilic.
Cholinga chachikulu cha kupezeka kwa mankhwalawa ndi hepatocytes a chiwindi, momwe kapangidwe ka cholesterol ndi LDL catabolism zimachitikira.
Mukamagwiritsa ntchito mankhwalawa, mawonekedwe a achire amawonedwa sabata limodzi pambuyo poyambitsa makonzedwe.
Kuchuluka kwake kumatheka pofika kumapeto kwa mwezi wa chithandizo.
Excretion ya Krestor imachitika kuchokera mthupi mu mawonekedwe osasinthika ngati gawo la ndowe. Pafupifupi 90% ya mankhwala omwe amagwira ntchito amapezeka m'matumbo. 10% yotsalayi imachotsedwa ndi impso mkodzo.
Chizindikiro pakugwiritsira ntchito mankhwala ndi:
- kupezeka kwa wodwala wa chachikulu hypercholesterolemia malinga ndi Fredrickson;
- wodwala ali ndi banja homozygous hypercholesterolemia;
- kuzindikira kwambiri hypertriglyceridemia mu thupi la munthu;
- kugwiritsa ntchito mankhwalawa monga chinthu chomwe chimachedwetsa kupititsa patsogolo kwa matenda a atherosulinosis.
Mukamagwiritsa ntchito mankhwalawa, chinthu choyambirira ndichofunika kuti muzitsatira zakudya zomwe zimapangitsa kuchepetsa ululu wa lipid.
Zoyeserera pakugwiritsa ntchito Crestor ndi izi:
- Matenda a chiwindi mu gawo yogwira.
- Kuphwanya impso.
- Myopathy
- Kuvomerezedwa ngati othandizira wothandizirana ndi cyclosporine.
- Nthawi ya bere ndi kuyamwitsa.
- Hypersensitivity pamagawo a mankhwala.
Mosamala, mankhwalawa amagwiritsidwa ntchito pamene wodwala amamwa zakumwa zoledzeretsa komanso pankhani ya mankhwala achikulire, wodwala woposa zaka 65.
Mankhwala osokoneza bongo amatha kuchitika makamaka munthawi yomweyo Mlingo wambiri.
Palibe mankhwala enieni, ndipo chithandizo chimachitika ngati chiri chofunikira, ndikuyang'anira ntchito ya ziwalo zofunika kwambiri za anthu.
The zikuchokera mankhwala, njira ntchito ndi Mlingo
Chofunikira chachikulu pa Crestor ndi rosuvastatin. Katunduyu ali ndi mphamvu yochepetsa lipid. Kuphatikiza apo, mapangidwe a mapiritsiwa ali ndi mitundu yonse ya mankhwala omwe amathandizira.
Kumwa mankhwalawa mogwirizana ndi malangizo ogwiritsira ntchito titha kuchitika nthawi ina iliyonse masana. Piritsi imatengedwa pakamwa, osatafuna ndikusambitsidwa ndi madzi okwanira. Mlingo woyambirira wa mankhwalawa ndi 5 mg. Ngati ndi kotheka, kusintha kwa mlingo wogwiritsidwa ntchito kumachitika mwezi umodzi chiyambireni chithandizo.
Posankha mlingo woyambirira, munthu ayenera kutsogoleredwa ndi zotsatira za kafukufuku wa wodwala pazomwe zimakhala m'mafuta a m'magazi. Kuphatikiza apo, posankha kuchuluka kwa mankhwalawa, ndikofunikira kuti muwonenso momwe zingakhalire ndi zotsatira zoyipa.
Pochiza odwala a mtundu wa Mongoloid, mlingo woyambirira wa mankhwalawa ndi 5 mg.
Ngati wodwalayo amakonda kukula kwa myopathy, ndiye kuti mlingo woyambirira wa mankhwalawo umaloledwa
Mukamagwiritsa ntchito mankhwalawa, wodwala amatha kukumana ndi mavuto osiyanasiyana.
Nthawi zambiri, mavuto obwera chifukwa chogwiritsa ntchito Krestor amawonetsedwa ndi dongosolo lamanjenje lamkati, m'mimba, khungu, minofu ndi mafupa.
Mafuta a mankhwalawa ndi awa:
- Mertenyl;
- Rosuvastatin SZ;
- Rosart
- Tevastor
- Rosucard;
- Rosicore;
- Rosulip;
- Rustor;
- Roxer ndi ena.
Mtengo wa Krestor ndi mawonekedwe ake amatha kusiyanasiyana kutengera dera la dzikolo komanso mtundu wa mankhwala omwe wagulidwa ndi wodwala.
Kutsika mtengo kwambiri, koma nthawi yomweyo mawonekedwe abwino a Crestor - Akort. Mtengo wa mankhwalawa ndi pafupifupi ma ruble 511.
Poyerekeza ndi mtengo wa mankhwala oyambira pafupifupi ma ruble 1,676, ndiwotsika kuposa katatu.
Zolemba za Roxer ya mankhwala
Roxera ndi mankhwala amphamvu a hypolipidemic. Chofunikira chachikulu pa mankhwalawa ndi rosuvastatin.
Chizindikiro chogwiritsa ntchito mankhwalawa ndi kupezeka kwa wodwala wa hypercholesterolemia m'njira zosiyanasiyana - zoyambirira komanso zosakanikirana.
Roxer amagwiritsidwanso ntchito pochiza matenda monga atherosulinosis. Kugwiritsa ntchito mankhwalawa kumalepheretsa kukula kwa zovuta zazikulu zomwe zimakhudzana ndi cholesterol yayikulu m'madzi a m'magazi.
Omwe amadziwika kwambiri ndi anzawo a Roxer pakati pa odwala ndi mankhwala monga Atoris ndi Krestor.
Mankhwalawa, pawiri yogwira popanga ndi chinthu chomwecho - rosuvastatin.
Roxera ndi mankhwala omwe madokotala a ku Russia amapanga.
Roxera amapezeka mu mawonekedwe a mapiritsi ofunikira pakamwa.
Mapiritsi a mankhwalawa amatengedwa pakamwa ndikutsukidwa ndi madzi okwanira.
Mlingo Roxers wogwiritsidwa ntchito mankhwalawa ndiwofanana ndi omwe amagwiritsidwa ntchito pochiza Crestor.
Contraindication ogwiritsa ntchito ndi awa:
- Hypersensitivity ku gawo lalikulu kapena mankhwala othandizira.
- Nthawi ya bere ndi nthawi yoyamwitsa.
- Zaka za wodwalayo zili ndi zaka 18.
- Wodwala amakhala ndi lactose tsankho komanso kuchepa kwa thupi la lactase.
- Myopathy
- Kulephera kwamkati ndi chiwindi.
Pankhani yogwiritsa ntchito mankhwalawa, kukulitsa zovuta zomwe zimakhala ndi chizungulire ndikotheka; mutu; zotupa pakhungu; kukulitsa kwa jaundice; chitukuko cha chiwindi; kuiwalika; kupweteka pamimba; kupezeka kwa kudzimbidwa ndi kutsegula m'mimba; nseru myopathy.
Zofanizira zazikulu za Roxers pazogwiritsa ntchito ndi:
- Rosulip.
- Rosucard.
- Crestor.
- Tevastor
- Mertenil.
- Akorta.
- Rustor.
Mndandanda wa mankhwalawa, omwe ali m'gulu la ma statins, ndi Zokor, Vazator, Lipona. Lipostat, Apextatin ndi njira zina.
Kusiyana kwakukulu pakati pa Crestor ndi Roxer
Kuti muyankhe funso poti ndi mankhwala ati a Krestor kapena Roxer omwe ali bwino, amafunikira kuti aphunzire kusiyana kwakukulu pakati pa mankhwala.
Mankhwalawa onse ndi a gulu limodzi ndipo ali ndi chiwalo chimodzi chomwe chikugwira ntchito, kusiyana pakati pa mankhwalawo kumagona pazinthu zothandizika zomwe zimagwiritsidwa ntchito ngati mankhwala. Mankhwalawa onse amachepetsa mulidi wa lipids m'thupi la wodwalayo.
Mukamasankha mankhwala, kusiyana komwe kulipo pakati pa mankhwala, omwe ali motere:
- Roxer amatha kudziunjikira njira yothandizira kwambiri chifukwa chake mphamvu zabwino zimawonekera mukamagwiritsa ntchito mankhwala kumapeto kwa sabata lachiwiri lokonzekera. Mtanda ndi mankhwala omwe zochita zake zimathamanga, zotsatira zake zimadziwika kale patsiku la 5 la mankhwalawa.
- Mukamamwa Krestor wodwala, kukula kwa matenda ashuga a 2 ndikotheka. Pankhani yogwiritsa ntchito mankhwala apakhomo, kuphwanya mbali kotereku sikumawonedwa.
- Mankhwala am'nyumba amatha kupangitsa kuti mapuloteni awoneke poyesa magazi, pomwe kufotokoza kwakeko sikuyambitsa kuphwanya.
- Mtanda ukhoza kugwiritsidwa ntchito ndi odwala omwe ali ndi zaka 18, ndipo mankhwala am'nyumba ndi oletsedwa kugwiritsidwa ntchito mpaka zaka 18.
Mukamagwiritsa ntchito limodzi komanso mankhwalawa, muyenera kudya zakudya zowonjezera za hypolipedymic ndikuwongolera kowonjezereka kwa ntchito yogwira chiwindi.
Musanaganize zosankha zamankhwala, ndikofunikira kuti mufunsane ndi dokotala kuti mudziwe zowunika za madokotala ndi odwala za amodzi ndi amodzi.
Ndemanga za kugwiritsidwa ntchito kwa mankhwala omwe mwalowetsedwa nthawi zambiri amatsala ndi odwala omwe ali ndi vuto la atherosulinosis. Malinga ndi iwo, kugwiritsa ntchito mankhwalawa kumakupatsani mwayi wowonjezera nthawi yochulukirapo komanso kuchepetsa kuchuluka kwa zomwe zimachitika, ndipo kugwiritsa ntchito mankhwalawa nthawi zina kumapewetsa kuchipatala.
Malinga ndi odwala, kugwiritsa ntchito mankhwala osokoneza bongo kumalumikizidwa ndi kupezeka kwa zotsatira zoyipa zosiyanasiyana mwa wodwala. Zoterezi zimakhudza thupi la wodwalayo zimayambitsa cholinga chosowa cha Krestor.
Ndingatenge ma statins ndikamuuza katswiri mu kanemayu pankhaniyi.
