Momwe mungagwiritsire ntchito mankhwala a Minirin?

Minirin ndi mankhwala omwe ali ndi zotsutsana ndi diuretics (diuretics). Mankhwalawa amagwiritsidwa ntchito kwambiri pothandizira anthu odwala matenda a shuga insipidus ndi polyuria. Mankhwala ndi analogue a vasopressin (mahomoni a hypothalamus).

Dzinalo Losayenerana

Dzinalo lapadziko lonse lamankhwala ku Latin ndi Desmopressin.

Minirin ndi mankhwala omwe ali ndi zotsutsana ndi diuretics (diuretics).

ATX

Khodi ya Minin ya ATX (anatomical and achire mankhwala gulu) ndi H01BA02.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala opangidwa ndi Desmopressin amagwiritsidwa ntchito ngati mapiritsi amkamwa pakamwa komanso utsi wothandizira kugwiritsa ntchito apakhungu (intranasal). Nthawi yolembetsa kuti isanathe yatha. Mapiritsi a Minirin ali ndi izi:

• kutulutsa;
• mawonekedwe ozungulira kapena ozungulira (kumwa modalira);
• zolembedwa ndi zoopsa;
• mtundu woyera;
• muli ndi 100 kapena 200 μg ya desmopressin, yomwe imagwirizana ndi 0,1 ndi 0,2 mg wa mankhwalawo.

Zomwe zimapangidwira mapiritsiwa zimaphatikizaponso zinthu zina zothandiza monga wowuma.

Zomwe zimapangidwira mapiritsiwa zimaphatikizaponso zinthu zina zothandizira (magnesium stearate, wowuma, shuga mkaka ndi povidone). Mapiritsi amadzaza m'mabotolo apulasitiki 30 ma PC. ndi makatoni.

Splopressin yochokera ku mankhwala okhala ndi zinthu zomwe zimagwira, madzi, sodium chloride ndi zinthu zina. 1 ml ya kutsitsi ili ndi 0,5 of ya mankhwalawa.

Zotsatira za pharmacological

Mankhwala ali ndi zotsatirazi:

1. Imathandizira reabsorption (kusinthanso mayamwidwe) amadzi mu gawo lachigawo cha mafupa opunduka a impso, zomwe zimapangitsa kuti madzi asasungidwe.
2. Kuchulukitsa kuchuluka kwa zotengera zazing'ono mu minyewa ya impso.
3. Amachepetsa diuresis (kutulutsa mkodzo).
4. Kuchulukitsa osmolarity (ndende ya zinthu zonse zasungunuka) mkodzo.
5. Amachepetsa magazi osmolarity.
6. Imalimbikitsa kupanga kwa Wil Willebrand factor (glycoprotein wofunikira kuti akhalebe magazi amwazi ndikutchinjiriza kuwonongeka kwake).
7. Pang'onopang'ono zimakhudza minofu yosalala ya ziwalo zamkati ndi mitsempha yamagazi.
8. Zimathandizira kuchepetsa polyuria ndi nocturia.
9. Imaletsa kupanga kwa adrenal gland ACTH mahoni mwa anthu omwe ali ndi matenda a Cushing.

Chuma chofunikira cha mankhwalawa ndikuti samachulukitsa magazi.

Chuma chofunikira cha mankhwalawa ndikuti samachulukitsa magazi. Izi ndizofunikira pakulephera kwa mtima. Mukamamwa mapiritsi, zotsatira zabwino zimawonedwa pambuyo maola 4-7. The achire zotsatira kumatenga maola 4-8, kutengera mlingo wa mankhwalawa.

Pharmacokinetics

Mankhwalawa amakhala ndi bioavailability wotsika pamene atengedwa ngati mapiritsi ochepa. Kudya kumakulitsa mayamwidwe a desmopressin. Kupezeka kwakukulu kwa mankhwalawa m'magazi kumawonedwa patatha maola 2 mutatha mapiritsi. Mankhwala salowerera mkati mwa ubongo (ubongo) ndipo amachotsedwa pang'onopang'ono kuyerekeza ndi vasopressin. Mankhwalawa amachotseredwa makamaka ndi impso ndi mkodzo. Kutha kwa theka la moyo kumapangitsa maola 2-3.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amalembera izi:

1. Matenda a shuga a pakati. Matendawa amadziwika ndi kuchepa kwa kaphatikizidwe ka mankhwala a antidiuretic motsutsana ndi kuwonongeka kwa dongosolo la hypothalamic-pituitary.
2. Enuresis (kwamikodzo kutuluka) kwa ana pambuyo 5 zaka.
3. Nocturia mwa akulu.
4. Polydipsia (kumwa madzi ambiri pakumwa ludzu lalikulu) atamuchita opaleshoni.

Minirin akuwonetsedwa kwa nocturia mwa akulu.

Mankhwalawa amapatsidwa mankhwala othandizira odwala matenda a shuga.

Chida chimathandizira ndi enuresis (kwamikodzo incinuence) mwa ana pambuyo 5 zaka.

Mapiritsi amadyedwa mukatha kudya, kutsukidwa ndi madzi oyera ambiri.

Chifukwa chotsutsana ndi zotsatira zake, desmopressin singagwiritsidwe ntchito osati pazithandizo zamankhwala, komanso zolinga zodziwitsa matenda a impso ndikuzindikira matenda a shuga.

Contraindication

Zoyipa zotsutsana ndi desmopressin acetate ndi:

• Hypersensitivity;
• ludzu la psychogenic;
• kobadwa nako polydipsia;
• matenda a kuphwanya kapangidwe ka antidiuretic timadzi;
• kulephera kwa mtima;
• kuchepa kwa osmolarity wamagazi;
• kulephera kwaimpso;
• kudzikundikira kwa madzimadzi mu minofu;
• mawonekedwe osakhazikika a angina pectoris;
• matenda a Willebrand;
• zinthu zofunika kugwiritsa ntchito mankhwala okodzetsa.

Polephera aimpso, mankhwalawa ayenera kugwiritsidwa ntchito mosamala.

Ndi chisamaliro

Mankhwala a Minirin amachitika mosamala mu:

• kulephera kwaimpso;
• m'malo mwa zinchito minyewa ya chikhodzodzo ndi kumangirira;
• electrolyte kusalinganika;
• chiopsezo chachikulu cha matenda oopsa a intracranial;
• onyamula mwana wosabadwayo.

Zinthu zofunika kusamala zimafunikira pochiza ana osakwana chaka chimodzi ndi anthu osafunikira. Pochiritsira okalamba, ndikofunikira kuwongolera zomwe zili ndi sodium m'magazi.

Zinthu zofunika kusamala zimafunikira pochiza ana osakwana chaka chimodzi ndi anthu osafunikira.

Momwe mungatenge Minirin

Mlingo wake umasankhidwa payekha poganizira zaka zake, zikuwonetsa komanso zamomwe zimachitikira. Kwa kuyamwa kwamphamvu kwamkodzo (patsiku kapena usiku), mankhwalawa ayenera kuledzera 200 mgg asanagone. Milandu yayikulu ndikusunga madandaulo, mlingo umakwera kufika pa 400 mcg.

Munthawi yamankhwala, muyenera kuchepetsa kuchepa kwamadzi masana.

Kuchiza kumatha miyezi itatu. Mapiritsi a Desmopressin ayenera kumwedwa mutatha kudya. Nthawi zina mankhwala amapatsidwa mlingo wa 60 ndi 120 mcg.

Chithandizo cha nocturnal polyuria

Ndi nocturnal polyuria, tsiku lililonse mlingo kumayambiriro kwa mankhwala ndi 100 mcg. Ngati wodwala samva bwino patatha sabata kuchokera pa chiyambi cha chithandizo, mlingo umawonjezereka mpaka 200 mcg.

Ngati palibe phindu kwa mwezi, chithandizo ndi Minirin chimayima.

Chithandizo cha matenda ashuga

Mu shuga mellitus, mlingo ndi 100-200 mcg / tsiku. Ndi inshuidus yapakati pa shuga, mankhwalawa amatengedwa katatu patsiku, 100 mcg. Ngati ndi kotheka, sinthani mlingo. Mlingo watsiku ndi tsiku ndi 0,2-1.2 mg. Kuti mupitirize kuchuluka kwa mankhwalawa m'magazi, mukuyenera kutenga ma 200 ma micil a Minirin.

Zotsatira zoyipa za Minirin

Zotsatira zosafunikira nthawi zambiri zimagwirizanitsidwa ndi kumwa mosayenera pakumwa, kuchepa kwa sodium m'magazi (hyponatremia), kusungidwa kwa madzi mthupi, komanso osagwirizana ndi mlingo ndi regimen ya Minirin.

Mutu umatha kuchitika nthawi zina mukamamwa Minirin.

Pakati mantha dongosolo

Mukamamwa Minirin, zovuta zamitsempha zotsatirazi ndizotheka:

• Chizungulire
• kukokana
• mutu.

Matumbo

Pa gawo la chimbudzi, zovuta zosafunikira za mankhwalawo ndizotheka, monga pakamwa youma, nseru, m'mimba kupweteka komanso kusanza.

Matupi omaliza

Thupi lawo siligwirizana ndi mankhwalawa silikupezeka. Mankhwalawa amalekeredwa bwino.

Zokhudza mphamvu pakuwongolera njira

Mankhwala sasokoneza kuthekera kwaukadaulo waukadaulo.

Mankhwala sasokoneza kuthekera kwaukadaulo waukadaulo.

Malangizo apadera

Mukamamwa Minirin, muyenera kutsatira malangizo awa:

• osamwa madzi amtundu wa 1 ola limodzi musanadye maola 8 mutatha kumwa mapiritsi;
• kuchita kuyezetsa magazi kuti adziwe mawonekedwe a ionic;
• Chiritsani nthenda zonse ndi matenda am'mbuyo musanachiritsidwe, limodzi ndi ludzu, matenda osokoneza bongo komanso kusokonekera kwamkodzo kwamkodzo;
• sanitize foci a pachimake ndi matenda kwamikodzo matenda;
• Imani mankhwalawa chifukwa cha zochitika zamtundu wa mankhwalawa chifukwa cha malungo ndi gastroenteritis (kutukusira kwa m'mimba ndi matumbo ang'onoang'ono).

Kusankhidwa kwa Minirin kukhala ana

Mapiritsi ang'onoang'ono (oyamwa) amatha kupatsidwa kwa ana.

Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere

Mankhwalawa amalembedwa mosamala kwa oyamwitsa ndi amayi oyembekezera. Mu maphunziro, panalibe zoyipa za desmopressin pa mwana wosabadwayo.

Mankhwalawa amalembedwa mosamala kwa oyamwitsa ndi amayi oyembekezera.

Gwiritsani ntchito mu ukalamba

Malangizo ogwiritsira ntchito Minirin akuwonetsa kuti odwala omwe ali ndi zaka zopitilira 65 nthawi zambiri amakhala ndi hyponatremia. Achepetsa plasma sodium.

The ntchito aimpso kuwonongeka

Ndi creatinine chilolezo chochepera 50 ml / min, mankhwala oletsedwa.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Mwina kugwiritsa ntchito Minirin pa matenda a chiwindi.

Mankhwala ochulukirapo a Minirin

Mankhwala osokoneza bongo amawonetsedwa ndikuwonetsa kuchepa kwa madzi m'thupi (kukomoka, matenda a edematous, kusokonezeka kwa chikumbumtima) komanso kuwonjezereka. Thandizo limaphatikizapo kuyimitsa chithandizo. Ngati ndi kotheka, njira zamagetsi zimayambitsidwa. Ndi edema, diuretic (Furosemide) ndi mankhwala.

Mankhwala osokoneza bongo amawonetsedwa ndikuwonetsa kuchepa kwa madzi m'thupi (kukhudzika, kutupa, kusokonezeka kwa chikumbumtima).

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi kwa Minirin ndi mankhwala otsatirawa sikulimbikitsidwa:

• Loperamide;
• NSAIDs (Indomethacin);
• mankhwala omwe amayamba kuyenda m'mimba;
• dimethicone;
• ma tridclic antidepressants;
• chlorpromazine;
• carbamazepine;
• serotonin reuptake zoletsa.

Zotsatira za Minirin zimafooketsedwa pamene mankhwalawo amaphatikizidwa ndi ma tetracyclines, kukonzekera kwa lithiamu, norepinephrine ndi glibutide. Desmopressin imapititsa patsogolo zotsatira zamagazi enaake.

Kuyenderana ndi mowa

Kugwiritsa ntchito mowa panthawi ya mankhwala ndi Minirin sikofunikira.

Kugwiritsa ntchito mowa panthawi ya mankhwala ndi Minirin sikofunikira.

Analogi

Mankhwala otsatirawa ndi okhudzana ndi fanizo la a Minirin:

1. Desmopressin.
2. Nativa.
3. Antiqua Yovomerezeka.
4. Nourem.
5. Presinex (ikupezeka mu mawonekedwe a mphuno ya mphuno).
6. Vasomirin.

Mankhwala a Minirina Melt sagulitsidwa.

Kupita kwina mankhwala

Mankhwala ndi mankhwala.

Mtengo wa Minirin

Mankhwala omwe amapezeka m'mafakisoni amatenga 1300 rubles.

Zosungidwa zamankhwala

Amasungidwa pamatenthedwe 25 ° C m'malo owuma osavomerezeka ndi ana.

Kugwiritsa ntchito nthawi yomweyo kwa Minirin ndi Loperamide sikulimbikitsidwa.

Tsiku lotha ntchito

Mapiritsiwo ndi oyenera zaka 2 kuyambira tsiku lomwe adapanga.

Wopanga

Mankhwalawa ndi mawonekedwe ake amapangidwa ku Russia (Nativa), Germany, Switzerland, Italy (Presinex), Iceland, Norway, Georgia ndi Canada.

Ndemanga za Minirin

Galina, wazaka 35, ku Moscow: "Mwana wanga wamwamuna wazaka 9 adwala. Dotoloyo adapereka mankhwala a desmopressin. Atamwa mapiritsi oyamba, mwana wamwamuna adasiya kukodza pabedi."

Zlata, wazaka 38, Kirov: "Mwana wathu wamwamuna ndi mwana wamkazi wa bwenzi langa anali ndi matenda omwewo - adagona. Adawunikiridwa ndi kuthandizidwa. Dotolo adandiwuza kuti ndigwiritse ntchito Minirin. Ana aakazi a mwana wanga sanathandize, koma tinali ndi njira imodzi yothandizira 1. Tsopano mwana wathu wamwamuna Osamakodzera pabedi ndikukhala ndi moyo wathanzi. "