Gentamicin: Mankhwala ntchito

Gentamicin ndi mankhwala othandizira omwe ali m'gulu la aminoglycosides. Ili ndi mitundu yosiyanasiyana ya mabakiteriya.

ATX

J01GB03 - Gentamicin

Gentamicin ndi mankhwala othandizira omwe ali m'gulu la aminoglycosides. Ili ndi mitundu yosiyanasiyana ya mabakiteriya.

Kutulutsa mafomu ndi kapangidwe kake

Zomwe zimagwiritsidwa ntchito ndi glamicin sulfate. Amapezeka mu mawonekedwe a ufa kapena yankho la jakisoni (jakisoni muma ampoules), mafuta opaka ndi madontho amaso.

Mapiritsi

Samapezeka mu mawonekedwe a mapiritsi.

Madontho

Lambulani madzi kuti mugwiritse ntchito apamwamba - madontho amaso. 1 ml muli 5 mg yogwira pophika. Atakulungidwa mu 5 ml m'mabotolo opopera. Atadzaza matatoni a makatoni 1 pc. pamodzi ndi malangizo ogwiritsira ntchito.

Njira Zothetsera

Mafuta osalala opanda jekeseni (amatha kuperekedwa kudzera m'mitsempha ndi intramuscularly). 1 ml muli 40 mg yogwira ntchito. Wokhazikika mu 1 kapena 2 ml mu galasi ampoules. Mbale zochulukirapo 5 zimakhazikitsidwa m'matayala amakhaseti, 1 kapena 2 mapaketi okhala pamatoni okhala ndi mpeni wokwanira.

Lambulani madzi kuti mugwiritse ntchito apamwamba - madontho amaso. 1 ml muli 5 mg yogwira pophika.

Mu 1 ml yankho la Gentamicin muli 40 mg yogwira ntchito. Wokhazikika mu 1 kapena 2 ml mu galasi ampoules.

Gentamicin ufa ndizogwiritsidwa ntchito ngati Chowona Zanyama. 1 g ya mankhwala ali ndi 100 mg yogwira ntchito.

Mafuta a Gentamicin amapangidwira kuti azigwiritsa ntchito kunja. 1 g yazogulitsa muli 0,001 g yogwira mankhwala.

Ufa

White kapena kirimu ufa, wokutira matumba a foil 1 lamoned. 1 g ya mankhwala ali ndi 100 mg yogwira ntchito. Ali ndi chochitika chanyama.

Mafuta

Zogwiritsa ntchito panja. 1 g yazogulitsa muli 0,001 g yogwira mankhwala. Chogulikacho chimadzaza mumakina a 15 ndi 25 g, 1 pc. pamodzi ndi malangizo mumatakadi.

Zotsatira za pharmacological

Bactericidal antiotic. Ili ndi zovuta zingapo. Ganizirani izi:

• maerobic gram osasokoneza tizilombo;
• aerobic gram zabwino tizilombo ta ndi cocci.

Kudzichulukitsa m'thupi, kumawononga chotchinga - cytoplasmic membrane ndikupangitsa kufa kwa tizilombo tating'onoting'ono.

Gentamicin ndi bactericidal antiotic. Ili ndi zovuta zingapo.

Gentamicin, kudziunjikira m'thupi, kumawononga chotchinga - cytoplasmic membrane ndikupangitsa kufa kwa tizilombo tating'onoting'ono.

Gentamicin amakhala ndi mayamwidwe otsika ngati amamwa pakamwa. Imaperekedwa kwa kholo lokha.

Kukwezeka kopambana kwambiri m'madzi am'magazi pambuyo pa makonzedwe amtsempha amatsimikizika pambuyo pa mphindi 30-90, pambuyo pakupita kwa mtsempha, pambuyo pa mphindi 15-30.

Gentamicin imapukusidwa makamaka ndi impso. Ndi kukanika kwa aimpso, nthawi ya excretion yafupika.

Gentamicin imagwiritsidwa ntchito ngati matenda mwa akulu ndi ana omwe amayamba chifukwa cha microflora yovuta.

Pharmacokinetics

Imakhala ndi mayamwidwe otsika pambuyo pakugwiritsa ntchito pakamwa. Imaperekedwa kwa kholo lokha. Ikaperekedwa, imakumwa kwathunthu. Kukwezeka kopambana kwambiri m'madzi am'magazi pambuyo pa makonzedwe amtsempha amatsimikizika pambuyo pa mphindi 30-90, pambuyo pakupita kwa mtsempha, pambuyo pa mphindi 15-30.

Sachita nawo kagayidwe kachakudya. Nthawi yochotsa theka ndi maola 2-4. Amakhala munthaka ya khutu lamkati ndi buluzi yaimpso. Imapukutidwa makamaka ndi impso. Ndi kukanika kwa aimpso, nthawi ya excretion yafupika.

Kodi chimagwiritsidwa ntchito ndi chiyani?

Ntchito mankhwalawa akuluakulu ndi ana chifukwa cha microflora tcheru. Ndikulimbikitsidwa zochizira mabacteria njira:

• bronchopulmonary dongosolo;
• dongosolo la genitourinary;
• zopindika ndi minofu yofewa.

Amagwiritsidwa ntchito ku gynecology, matenda a bala ndi zotupa, ma atitis media, m'mimba ma bakiteriya, komanso zochizira matenda am'mafupa ndi zida za minofu.

Contraindication

Sizikudziwika ngati mbiriyakaleyo ili ndi zidziwitso monga:

• tsankho limodzi ndi zigawo zikuluzikulu za mankhwala;
• makutu amitsempha;
• kulephera kwa aimpso.

Sikugwira ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere. Zosavomerezeka kwa makanda mpaka mwezi umodzi.

Gentamicin sinafotokozeredwe ngati mbiri yachidziwitso pazochitika monga kufooka kwa impso ilipo.

Mankhwalawa sagwiritsidwa ntchito pa nthawi ya bere komanso nthawi yobereka.

Gentamicin simalimbikitsidwa kwa makanda mpaka miyezi 1.

Mankhwalawa amagwiritsidwa ntchito mosamala odwala okalamba (atatha zaka 60), ndi myasthenia gravis, botulism, matenda a Parkinson komanso kutopa.

Ndi chisamaliro

Kwa odwala okhudzana ndi zaka (pambuyo pa zaka 60), ndi myasthenia gravis, botulism, matenda a Parkinson ndi kutopa.

Mlingo ndi Ulamuliro

Ma regimens wothandizira mankhwalawa operewera kwa odwala akuluakulu popanda aimpso - intramuscularly kapena mtsempha wa magazi, 3 mg pa kilogalamu iliyonse yamaola 8-12. Mitsempha yamkati mwa minyewa imayendetsedwa kwa mphindi 90-120 (mankhwalawa amadziwitsidwa mu 50-300 ml ya sodium chloride solution kapena 5% dextrose solution).

Pazovuta zovuta za matenda opatsirana, mlingo wa tsiku ndi tsiku ndi 5 mg pa kilogalamu iliyonse ya thupi, maola asanu ndi limodzi aliwonse. Pambuyo pakukula, mlingo umachepetsedwa mpaka 3 mg / kg.

Pankhani ya matenda opatsirana ndi kutupa kwamikodzo, amayikidwa kamodzi pa mlingo wa 120-160 g kwa masiku 7-10. Mankhwalawa gonorrhea - kamodzi pa mlingo wa 240-280 mg.

Ma regimens wothandizira mankhwalawa operewera kwa odwala akuluakulu popanda aimpso - intramuscularly kapena mtsempha wa magazi, 3 mg pa kilogalamu iliyonse yamaola 8-12.

Mitsempha yamkati mwa minyewa imayendetsedwa kwa mphindi 90-120 (mankhwalawa amadziwitsidwa mu 50-300 ml ya sodium chloride solution kapena 5% dextrose solution).

Ngati matenda opatsirana ndi zotupa za kwamikodzo, mankhwalawa amaperekedwa kamodzi pa mlingo wa 120-160 g kwa masiku 7-10.

Woopsa pathologies, jakisoni amalimbikitsidwa m'munsi Mlingo, koma pafupipafupi kugwiritsa ntchito.

Ndi kukula kwa phazi la matenda ashuga (kuwopseza kudula), Gentamicin adayikidwa limodzi ndi Clindamycin.

Mu matenda opatsirana akhanda kuyambira mwezi umodzi ndi ana mpaka zaka 2 - 6 mg / kg umagwiritsidwa ntchito maola 8 aliwonse. Ana kuyambira zaka 2 - 3-5 mg / kg katatu patsiku.

Woopsa pathologies, jakisoni amalimbikitsidwa m'munsi Mlingo, koma pafupipafupi kugwiritsa ntchito.

Kwa anthu omwe ali ndi vuto la impso - Mlingo wa 1-1.7 mg / kg, kwa makanda - 2-2.5 mg / kg.

Kodi ndizotheka kumwa mankhwalawa chifukwa cha matenda ashuga?

Ndi kukula kwa phazi la matenda ashuga (kuwopseza kudula), limayikidwa limodzi ndi clindamycin.

Zotsatira zoyipa

Mukamagwiritsa ntchito maantibayotiki, kusintha kosakwanira kwa thupi kumatheka, komwe kumawoneka ngati:

• nseru (mpaka kusanza);
• Chizungulire
• kupweteka mutu;
• kugona
• zovuta zamaganizidwe amisala;
• kusamva kwa makutu;
• ugonthi wosasintha;
• mgwirizano wolakwika;
• hyperbilirubinemia;
• kuchepa magazi
• leukopenia;
• granulocytopenia;
• thrombocytopenia;
• zinthu zopweteketsa mtima;
• aimpso kuwonongeka;
• matupi awo saonekera pakhungu;
• kutupa.

Mukamagwiritsa ntchito mankhwala opha maantibayotiki, zotheka kusintha mthupi zimatha, mwachitsanzo, chizungulire, kupweteka mutu, nseru.

Zotsatira zoyipa za kutenga Gentamicin, kuchepa kwa magazi m'thupi ndi leukopenia ndikotheka.

Pogwiritsa ntchito nthawi yayitali, mankhwalawa amatsogolera pakukula kwa superinfection, mkamwa ndi vagidi candidiasis.

Pogwiritsa ntchito nthawi yayitali, zimapangitsa kuti pakhale kutchuka, pakamwa komanso kumakaso kwa vagidi.

Malangizo apadera

Pamene kutsegula m'mimba kwa nthawi yayitali kumafunikira kupatula kwa pseudomembranous colitis.

Pazithandizo za matenda opatsirana komanso otupa a genitourinary system, ndikofunikira kugwiritsa ntchito kuchuluka kwa madzi.

Popewa kutukuka kwa vuto la kumva, maphunziro omwe amakhala pafupipafupi ayenera kuchitika pafupipafupi. Ndi zizindikiro zokhumudwitsa, mlingo wa antibayotiki umachepetsedwa kapena kuthetsedwa.

Ikamawerengedwa kwa anthu opitirira zaka 60, kuwongolera milingo ya creatine ndikofunikira.

Pamene kutsegula m'mimba kwa nthawi yayitali kumafunikira kupatula kwa pseudomembranous colitis.

Pazithandizo za matenda opatsirana komanso otupa a genitourinary system, ndikofunikira kugwiritsa ntchito kuchuluka kwa madzi.

Popewa kutukuka kwa vuto la kumva, maphunziro omwe amakhala pafupipafupi ayenera kuchitika pafupipafupi.

Ikamawerengedwa kwa anthu opitirira zaka 60, kuwongolera milingo ya creatine ndikofunikira.

Zokhudza mphamvu pakuwongolera njira

Zitha kukhala ndi vuto.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Zosavomerezeka.

Gentamicin ya ana

Amagwiritsidwa ntchito pochiza matenda opatsirana komanso otupa mwa ana kuyambira mwezi umodzi.

Gwiritsani ntchito mu ukalamba

Mosamala.

Bongo

Kukhazikika kosalamulirika kwa antibacterial imeneyi kumapangitsa kuti thupi lizigundika mpaka kupuma kusiya.

Gentamicin ikhoza kukhala ndi vuto lililonse pakuwongolera njira.

Kugwiritsa ntchito kwa Gentamicin pa nthawi yoyembekezera komanso mkaka wa m'mawere sikulimbikitsidwa.

Mankhwalawa amagwiritsidwa ntchito pochiza matenda opatsirana komanso otupa mwa ana kuyambira mwezi umodzi.

Kukhazikika kosalamulirika kwa antibacterial imeneyi kumapangitsa kuti thupi lizigundika mpaka kupuma kusiya.

Pamafunika kuchipatala msanga.

Kuchita ndi mankhwala ena

Simungathe kulowa nthawi yomweyo ndimankhwala ena (kupatula njira zothetsera isotonic kwa intravenous management).

Imalimbitsa minofu yopuma ngati mankhwala osokoneza bongo. Imachepetsa mphamvu ya anti-myasthenic mankhwala.

Kugwiritsa ntchito munthawi yomweyo ndi diuretics kapena Cisplatin kumawonjezera nephrotoxicity yawo.

Kuphatikiza ndi maantibayotiki, mndandanda wa penicillin umawonjezera mphamvu zawo zotsutsana.

Gentamicin sayenera kutumikiridwa nthawi yomweyo ndi mankhwala ena (kupatula njira zothetsera isotonic kwa intravenous makonzedwe).

Kugwiritsa ntchito munthawi yomweyo ndi diuretics kapena Cisplatin kumawonjezera nephrotoxicity yawo.

Kuphatikiza ndi maantibayotiki, mndandanda wa penicillin umawonjezera mphamvu zawo zotsutsana.

Kuphatikiza ndi indomethacin kumawonjezera mwayi wokhala ndi poizoni.

Ngakhale mndandanda waukulu wazofanana wa mankhwalawa, Garamycin ndi wabwino kuposa mankhwala ena.

Kuphatikiza ndi indomethacin kumawonjezera mwayi wokhala ndi poizoni.

Analogi

Ngakhale pali mndandanda waukulu wa mankhwala omwe ali ndi antibayotiki, adziwonetsa bwino kuposa mankhwala ena:

• Garamycin;
• Gentamicin Akos.

Kupita kwina mankhwala

Ipezeka ndi mankhwala mchilatini.

Mtengo wa Gentamicin

Mtengo umatengera mtundu wa mankhwalawa amasulidwe. Mtengo wochepetsetsa m'mafakitoreti aku Russia amachokera ku ma ruble 35.

Kusungidwa kwa mankhwala Gentamicin

Kutentha mpaka + 25˚С. Pewani kufikira ana.

Tsiku lotha ntchito

Zaka 5

Ndemanga za madotolo ndi odwala za Gentamicin

Minina T.V., wothandizira, Novosibirsk.

Aminoglycoside angapo antibacterial mankhwala osiyanasiyana osiyanasiyana. Ili ndi mndandanda waukulu wazotsatira zoyipa. Gwiritsani ntchito pazifukwa zaumoyo monga momwe dokotala wakupangirani.

Kosyanov E.D., wazachipatala, Krasnoyarsk.

Mankhwala othandizira olimba. Amagwiritsidwa ntchito pochiza matenda opatsirana komanso otupa. Orthopedics amadziwika kuti athandizire komanso kupewa matenda opatsirana pambuyo pa arthroplasty. Ili ndi contraindication ndi zoletsa kugwiritsa ntchito. Ayenera kutumizidwa ndi dokotala.

Marina, wazaka 36, ​​mzinda wa Tomsk.

Mwana wanga anali ndi conjunctivitis yoopsa. Dokotala wamaso adalimbikitsa chida ichi ngati mawonekedwe amaso. Ntchito 1 dontho katatu patsiku. Kusintha kwawoneka kale pa tsiku lachiwiri la chithandizo. Pambuyo pa masiku 5 a maphunzirowa, zizindikiro zosasangalatsa zidasoweka. Chidacho ndichotsika mtengo komanso chothandiza. Ndine wokhutira ndi zotsatira zake.