Metformin ndi mankhwala omwe amathandizidwa kutsitsa shuga m'magazi a 2 shuga. Mankhwalawa ali ndi mapindu ena angapo. Mwachitsanzo, imagwiritsidwa ntchito kuchepa thupi ndipo maphunziro ena amatsimikizira momwe amagwirira ntchito pochiza odwala khansa.
Dzinalo Losayenerana
Dzinso dzina la mankhwalawa ndi Metformin (Metformin).
Metformin ndi mankhwala omwe amathandizidwa kutsitsa shuga m'magazi a 2 shuga.
ATX
Khodiyo ndi A10BA02. Mankhwala amakhudza kugaya chakudya ndi kagayidwe kachakudya, ndi njira yochizira matenda ashuga. Amadziwika kuti ndi mankhwala a hypoglycemic, kupatula insulin. Biguanide.
Kutulutsa mafomu ndi kapangidwe kake
Metformin Long Canon imagulitsidwa pamapiritsi. Kuphatikizikako ndikuphatikiza 500/8/10/2000/2000 mg wa metformin.
Zotsatira za pharmacological
Metformin ili ndi zinthu zosiyanasiyana zomwe zimalola kugwiritsa ntchito mankhwalawa matenda ena.
Kuchiza ndi kupewa matenda a shuga a 2
Metformin imachepetsa glycemia, poteteza ziwalo kuti zisawonongeke, zomwe zingapangitse kuti azikhala ndi vuto lolephera kwakanthawi. Mankhwalawa amagwira ntchito kudzera pa AMPK, yomwe imayambitsa kuyamwa kwa shuga m'magazi kupita m'minyewa. Metformin imakulitsa AMPK, yomwe imalola minofu kugwiritsa ntchito glucose yambiri, yomwe imachepetsa kuchuluka kwa shuga m'magazi.
Kuphatikiza apo, metformin imatha kuchepetsa shuga m'magazi poletsa kupanga kwake (gluconeogeneis).
Kuchuluka kwa insulin
Kukana kwa insulini ndi chinthu chomwe chimayambitsa kukula kwa matenda a shuga a 2, komanso kuwonedwa mu polycystic ovary syndrome komanso ngati njira imodzi yothandizira pakulimbana ndi HIV.
Mankhwalawa amathandizira chidwi cha insulin komanso amawonetsa mavuto omwe amabwera chifukwa cha insulin.
Kulimbana Zizindikiro za PCOS
Polycystic Ovary Syndrome (PCOS) ndi vuto la mahomoni lomwe nthawi zambiri limachulukitsidwa ndi kunenepa kwambiri komanso kukana insulini. Metformin imalepheretsa kudumphira kwa ovulation, kusamba kwa msambo komanso insulin yambiri mthupi. Zimawonjezera mwayi wokhala ndi pakati wopambana komanso zimachepetsa chiopsezo cha kutenga pathupi. Amachepetsa kuchepa kwa matenda ashuga komanso kutupa komwe kumayenderana ndi polycystic ovary syndrome.
Metformin imawonjezera mwayi wokhala ndi pakati wopambana komanso imachepetsa chiopsezo cha kutenga pathupi.
Titha kupewa khansa kapena kugwiritsa ntchito mankhwalawa
Metformin adayimitsa kukula ndikukula kwa mitundu ina ya khansa odwala oposa 300,000 omwe ali ndi matenda amtundu wa 2.
Kufufuza kwa meta kunawonetsa kuchepa 60% kwa chiwopsezo cha khansa ya chiwindi (intrahepatic cholangiocarcinoma) mwa anthu odwala matenda ashuga omwe adayikidwa metformin. Kafukufukuyu adawonetsa kuchepa kwamtundu wa khansa ya pancreatic ndi bere, khansa ya m'matumbo ndi m'mapapo ndi 50-85%.
Kodi pali kusiyana kotani pakati pa Amoxiclav ndi Flemoxin Solutab?
Kodi kiwi ndizothandiza kwa odwala matenda ashuga? Werengani zambiri mu nkhaniyi.
Malangizo ogwiritsira ntchito Detralex 1000.
Kuteteza mtima
Nthawi zambiri, chimodzi mwazinthu zazikulu zomwe zingayambitse matenda a mtima ndi vuto la glucose.
Kafukufuku wa odwala 645,000 omwe ali ndi matenda a shuga adawonetsa kuthekera kwa metformin kuti achepetse zovuta zamtima (atrial fibrillation).
Amachepetsa cholesterol
Metformin imatsitsa cholesterol "yoipa", lipoproteins yotsika kwambiri (LDL).
Zimathandizira kuwonda
Pakufufuza komwe azimayi azaka zapakati omwe amakhala ndi insulin yayikulu molingana ndi shuga wamagazi ndi kulemera kwa thupi adatengedwa, zidapezeka kuti metformin imathandizira kuchepetsa thupi.
Pakufufuza kwina, metformin yachepetsa kuchuluka kwa thupi mwa anthu 19 omwe ali ndi kachilombo ka HIV omwe amagawa mafuta ochulukitsa (lipodystrophy).
Atha kuchitira vuto la erectile mwa amuna
Kafukufuku angapo adawonetsa kuti metformin imatha kuchepetsa kusowa kwa erectile mwa amuna omwe ali ndi kunenepa kwambiri, kukana insulini, kapena matenda ashuga.
Imatha kuteteza ku zowonongeka zomwe zimayambitsidwa ndi glamicin
Gentamicin ndi maantibayotiki omwe amachititsa kuwonongeka kwa impso ndi makina owonera. Metformin imatha kuteteza kutayidwa kwamakutu komwe kumayamba chifukwa cha kuyamwa.
Chithandizo cha matenda osokoneza bongo a chiwindi
NAFLD ndimatenda ofala a chiwindi omwe mafuta amayamba mu chiwindi, koma sikugwirizana ndi zakumwa zoledzeretsa. Metformin imachepetsa chizolowezi chodzikhathamiritsa mafuta.
Pharmacokinetics
Wokwanira mokwanira m'mimba thirakiti pambuyo pakamwa. Bioavailability wafika 60%. Mu plasma, zomwe zimakhala kwambiri zimawonedwa pambuyo maola 2,5.
Imafufutidwa ndi impso zosasinthika.
Zizindikiro zogwiritsidwa ntchito
Amagwiritsidwa ntchito ndi odwala omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo a shuga (makamaka othandiza anthu onenepa kwambiri) ngati monotherapy, ngati palibe zotsatira zoyenera kuchokera pakudya komanso kuchita masewera olimbitsa thupi. Amalembedwanso kuphatikiza mankhwala omwe ali ndi vuto la hypoglycemic, kapena insulin.
Contraindication
Iwo contraindicated odwala mu zotsatirazi milandu:
- Hypersensitivity kwa yogwira mankhwala;
- aimpso kuwonongeka;
- aakulu metabolic acidosis, kuphatikizapo matenda ashuga ketoaciadiasis (wokhala ndi chikomokere kapena opanda chikomokere), kulowetsedwa kwadzuwa;
- aimpso kuwonongeka kapena kwa chiwindi ntchito;
- lactic acidosis;
- matenda omwe angapangitse kuti pakhale minofu hypoxia;
- mimba, nthawi yoyamwitsa;
- wazaka 18.
Ndi chisamaliro
Mankhwalawa amaperekedwa mosamala kwa odwala okalamba omwe amagwira ntchito zolimbitsa thupi.
Momwe mungatenge Metformin 1000
Amatengedwa pakamwa. Mlingo patsiku ndi mankhwala.
Asanadye kapena pambuyo chakudya
Mankhwalawa amatengedwa nthawi ya chakudya kapena nthawi yomweyo.
Ndi matenda ashuga
Nthawi zina amagwiritsidwa ntchito limodzi ndi insulin. Dokotala wothandizidwa amapatsidwa malangizo mwatsatanetsatane.
Kuchepetsa thupi
Amakhulupirira kuti mankhwalawa amatha kuthandizira kuchepa thupi. Komabe, asanagwiritse ntchito, upangiri waukatswiri umafunika.
Zotsatira zoyipa za Metformin 1000
Zotsatira zoyipa:
- lactic acidosis, yomwe imabweretsa kupweteka kwa minofu, kutopa, kuzizira, chizungulire, kugona;
- kulawa kwazitsulo mkamwa;
- kutsitsa magazi;
- hypoglycemia;
- kusowa kwa chakudya.
Matumbo
Zingayambitse nseru, kusanza, kutsegula m'mimba, kuchepa magazi kwa impso, kugona msanga.
Kuchokera kumbali ya kagayidwe
Nthawi zambiri samayambitsa lactic acidosis.
Pa khungu
Maonekedwe a zotupa, dermatitis.
Dongosolo la Endocrine
Pali kuthekera kwa hypoglycemia.
Matupi omaliza
Thupi lawo siligwirizana.
Zokhudza mphamvu pakuwongolera njira
Ngati mankhwalawa amangotengedwa, ndiye kuti palibe zotsatira zake. Mukamagwiritsa ntchito mankhwala othandizira odwala matenda ashuga, tikulimbikitsidwa kuti mupewe zochitika zomwe zimafunikira chidwi chachikulu.
Malangizo apadera
Mankhwalawa sangathe kugwiritsidwa ntchito masiku awiri asanachitike opaleshoni komanso maola 48 atatha (pokhapokha ngati wodwalayo ali ndi ntchito yofanana ndi impso).
Ndikulimbikitsidwa kuti kuyesedwa kuchitike pafupipafupi kuti muchepetse matenda a shuga.
Musanagwiritse ntchito, ndikofunikira kuwerenga malangizo oti mugwiritse ntchito.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Kugwiritsa ntchito panthawi yoyembekezera sikovomerezeka. Pa nthawi ya chithandizo, kuyamwitsa kuyenera kuyimitsidwa.
Kupangira Metformin kwa ana 1000
Mankhwalawa amalembedwa kwa odwala azaka za 18.
Gwiritsani ntchito mu ukalamba
Mukamapereka mankhwala kwa odwala okalamba, kuwunikira owonjezera aumoyo wofunikira kumafunika.
The ntchito aimpso kuwonongeka
Zosavomerezeka.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Zosavomerezeka.
Mankhwala ochulukirapo a Metformin 1000
Pankhani ya bongo wambiri, kuwonetsa kwa zoyipa kumakulirakulira.
Mukapitilira muyeso, funsani dokotala nthawi yomweyo.
Kuchita ndi mankhwala ena
Osakanizika ndi ayodini okhala ndi radiopaque wothandizira amatsutsana.
Akaphatikizidwa ndi danazol, chlorpromazine, glucocorticosteroids, diuretics, jekeseni wa beta2-adrenergic agonist, kusamala komanso kuwunika pafupipafupi shuga.
Amaphatikizidwa kuphatikiza metformin ndi mankhwala okhala ndi ayodini omwe amakhala ndi radiopaque.
Mukamagwiritsa ntchito mankhwala othandizira odwala matenda ashuga, kuwonetsa kwa hypoglycemia ndikotheka.
Yang'anani kuyanjana kwamankhwala onse omwe mumamwa mukamalandira metformin.
Kuyenderana ndi mowa
Sayenera kuphatikizidwa ndi zakumwa zoledzeretsa, monga mwayi wa lactic acidosis ukuwonjezeka.
Analogi
Ngati mukufuna, ma fanizo otsatirawa angagwiritsidwe ntchito m'malo mwa Metformin:
- Siofor;
- Glycometer;
- Metformin Richter;
- Metformin-Teva;
- Diaformin;
- Glucophage;
- Insufor ndi ena
Kupita kwina mankhwala
Kugulitsa mankhwalawa Metformin 1000 (m'Chilatini - Metforminum) ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Ku Russia, kugulitsa mankhwala osokoneza bongo osalandira mankhwala ndizoletsedwa.
Mtengo wa Metformin 1000
Mtengo wa mankhwalawa m'masitolo aku Russia umasiyanasiyana kuyambira 190 mpaka 250 ma ruble.
Zosungidwa zamankhwala
Ndikulimbikitsidwa kusunga mankhwalawa pamtunda osapitirira + 25 ° C pamalo amdima ndi owuma osapezeka kwa ana.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
LLC "Center Yogawa Nycomed" (Russia, Moscow).
Ndemanga za Metformin 1000
Akatswiri amavomereza chida ichi pochiza matenda osiyanasiyana.
Madokotala
Bobkov E.V., katswiri wamkulu, wazaka 45, Ufa: "Mankhwala okhazikika omwe amagwiritsidwa ntchito pochiza matenda a shuga a 2."
Danilov S.P., katswiri wamkulu, wazaka 34, Kazan: "Kwa zaka zonsezi, awonetsedwa kuti amagwira ntchito mopitirira muyeso. Amathandiza kukwaniritsa zotsatira zabwino munthawi yochepa."
Odwala
Dmitry, wazaka 43, Vladivostok: "Ndili ndi matenda a shuga a mtundu wa 2. Ndimamwa mankhwalawa limodzi ndi jakisoni wa insulin pafupifupi chaka chimodzi. Amatsitsa shuga m'magazi."
Vladimir, wazaka 39, ku Ekaterinburg: "Ndinatenga Glibenclamide kwa nthawi yayitali, koma patapita nthawi Metformin adawonetsedwa. Amasinthidwa bwino, ndipo shuga wanga wamagazi adayambanso kuyenda bwino."
Kuchepetsa thupi
Svetlana, wazaka 37, Rostov-on-Don: "Ndinagula mankhwalawa pothandizidwa ndi wathanzi. Sindinamve bwino."
Valeria, wazaka 33, Orenburg: "Kuyambira ali mwana, amakonda kupsa mtima. Dotolo yemwe adapezekapo adalangiza Metformin. Patatha mwezi umodzi, adasiya kumwa, chifukwa anali chizungulire komanso osazindikira."
